Entrez Gene

Basic Information
Gene ID	11214
Name	AKAP13
Synonymous	A kinase (PRKA) anchor protein 13;AKAP13;A kinase (PRKA) anchor protein 13
Definition	A-kinase anchor protein 13\|A-kinase anchoring protein\|LBC oncogene\|breast cancer nuclear receptor-binding auxiliary protein\|guanine nucleotide exchange factor Lbc\|human thyroid-anchoring protein 31\|lymphoid blast crisis oncogene\|non-oncogenic Rho GTPase-s
Position	15q24-q25
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
AKAP13(h) --> AKAP13-cLbc(h) (expression).
RhoA(v.s.):GDP + GTP --AKAP13-cLbc(h)--> RhoA(v.s.):GTP + GDP (exchange)
AKAP13(h) + RhoA(h) <==> AKAP13(h):RhoA(h) (binding)
Alpha-catulin(m.s.) + AKAP13(h) <==> Alpha-catulin(m.s.):AKAP13(h) (binding)
Bak(h) + AKAP13(h) <==> Bak(h):AKAP13(h) (binding)
14-3-3beta(h) + AKAP13(h) <==> 14-3-3beta(h):AKAP13(h) (binding)
AKAP13(h) --> IL-8(h) (increase of abundance)
AKAP13(h) --> MCP-1(h) (increase of abundance)
AKAP13(h) --> JNK1(h){pT183}{pY185} (increase of phosphorylation)
AKAP13(h) --> JNK2(h){pT183}{pY185} (increase of phosphorylation)
AKAP13(h) --> AKAP13(h) (expression).
RhoA(v.s.):GDP + GTP --AKAP13(h)--> RhoA(v.s.):GTP + GDP (exchange)
G-alpha-q(m.s.) + AKAP13-Proto-Lbc(h) <==> G-alpha-q(m.s.):AKAP13-Proto-Lbc(h) (binding)
G-alpha-12(m.s.) + AKAP13-Proto-Lbc(h) <==> G-alpha-12(m.s.):AKAP13-Proto-Lbc(h) (binding)
G-alpha-13(m.s.) + AKAP13-Proto-Lbc(h) <==> G-alpha-13(m.s.):AKAP13-Proto-Lbc(h) (binding)
AKAP13(h) --> AKAP13-Proto-Lbc(h) (expression).
PKAc(h) + AKAP13-Lbc(h) <==> PKAc(h):AKAP13-Lbc(h) (binding)
AKAP13-Lbc(h) + PKA-RII(h) <==> AKAP13-Lbc(h):PKA-RII(h) (binding)
AKAP13-Lbc(h) + RhoA(m.s.) <==> AKAP13-Lbc(h):RhoA(m.s.) (binding)
RhoA(h) + AKAP13-Lbc(h) <==> RhoA(h):AKAP13-Lbc(h) (binding)
RhoA(h) + AKAP13-Lbc(h) + PKA-RII(h) <==> RhoA(h):AKAP13-Lbc(h):PKA-RII(h) (binding)
AKAP13(h) --> AKAP13-Lbc(h) (expression).

Location (AA)	PTM type	Database
Post Translational Modification [Top]
983	Phosphoserine.	Swiss-Prot 53.0
1929	Phosphoserine.	Swiss-Prot 53.0
1932	Phosphoserine.	Swiss-Prot 53.0
2728	Phosphoserine.	Swiss-Prot 53.0

Transcription Factors [Top]