Entrez Gene

Basic Information
Gene ID	1072
Name	CFL1
Synonymous	cofilin 1 (non-muscle);CFL1;cofilin 1 (non-muscle)
Definition	18 kDa phosphoprotein\|cofilin, non-muscle isoform\|cofilin-1\|epididymis secretory protein Li 15\|p18
Position	11q13
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
cofilin-1(h) + ATP --LIMK1-isoform1(h)--> cofilin-1(h){pS3} + ADP (phosphorylation)
CFL1(h) --> cofilin-1(h) (expression).
cofilin-1(h) + SM22(h) <==> cofilin-1(h):SM22(h) (binding)
beta-actin(h) + cofilin-1(h) <==> beta-actin(h):cofilin-1(h) (binding)
gamma-actin(h) + cofilin-1(h) <==> gamma-actin(h):cofilin-1(h) (binding)
cofilin-1(h) + ATP --> cofilin-1(h){pS3} + ADP (phosphorylation)
CFL1(h) --> cofilin-1(h) (expression).
cofilin-1(h){pS3} --SSH1L(h)--> cofilin-1(h) + p (dephosphorylation)

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]
2	N-acetylalanine.		Swiss-Prot 53.0
3	Phosphoserine (by NRK).		Swiss-Prot 53.0
25	Phosphothreonine.		Swiss-Prot 53.0
132	N6-acetyllysine.		Swiss-Prot 53.0
140	Phosphotyrosine.		Swiss-Prot 53.0
156	Phosphoserine.		Swiss-Prot 53.0
139	Phosphotyrosine	15592455	Phospho.ELM 6.0
2	Phosphoserine (LIMK1;LIMK2;)	9655398;11418599;11340065	Phospho.ELM 6.0
24	Phosphothreonine	17081983	Phospho.ELM 6.0
67	Phosphotyrosine	16497976	Phospho.ELM 6.0

Transcription Factors [Top]