Cancer metastasis gene database Home
Cancer metastasis database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

102

Name

ADAM10

Synonymous

ADAM metallopeptidase domain 10;ADAM10;ADAM metallopeptidase domain 10

Definition

CDw156|a disintegrin and metalloprotease domain 10|disintegrin and metalloproteinase domain-containing protein 10|kuzbanian protein homolog|mammalian disintegrin-metalloprotease

Position

15q22

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Translational Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors   [Top]

Regulation From TransFac database

adam10(h) + Eve-1c(h) <==> adam10(h):Eve-1c(h) (binding)
adam10(h) + Eve-1d(h) <==> adam10(h):Eve-1d(h) (binding)
ADAM10(h) --> adam10(h) (expression).
APP(h) --adam10(h)--> alphaAPPs(h) + APP-C83(h) (processing)
N-cadherin(h) --adam10(h)--> N-cadherin-CTF1(h) + protein remnants (cleavage)
ADAM10(h) --> adam10(h) (expression).
APP770(h) --adam10(h)--> sAPP770alpha(h) + APP-C83(h) (cleavage)
HB-EGF(h) --adam10(h)--> HB-EGF-p16.4(h) + protein remnants (cleavage)
HB-EGF(h) --adam10(h)--> HB-EGF-p15(h) + protein remnants (cleavage)

Post Translational Modification   [Top]

Location (AA)

PTM type

Literature

Database

267N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
278N-linked (GlcNAc...).Swiss-Prot 53.0
439N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
551N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr15

Promoter: 56828969 - 56830969Agilent_014791

chr15

Promoter: 56828969 - 56830969GSE27584

chr15

Promoter: 56828969 - 56830969Agilent_014791_44K