| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 10155 |
Name | TRIM28 |
Synonymous | tripartite motif containing 28;TRIM28;tripartite motif containing 28 |
Definition | E3 SUMO-protein ligase TRIM28|KAP-1|KRAB [Kruppel-associated box domain]-associated protein 1|KRAB-associated protein 1|KRAB-interacting protein 1|KRIP-1|RING finger protein 96|TIF1-beta|nuclear corepressor KAP-1|protein phosphatase 1, regulatory subunit |
Position | 19q13.4 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | RNF96(h) + sumo1(m.s.) --> RNF96(h){sumo} (sumoylation) | RNF96(h) + sumo1(m.s.) --Aos1(m.s.):SAE2(m.s.),Ubc9(m.s.),RanBP2(m.s.)--> RNF96(h){sumo} (sumoylation) | RNF96(h) --/ CDKN1A(h) (transrepression) | RNF96(h) + mdm2-isoform1(h) <==> RNF96(h):mdm2-isoform1(h) (binding) | RNF96(h) + mdm2(h) <==> RNF96(h):mdm2(h) (binding) | RNF96(h) + mdm2-isoform1(h) + p53(h) <==> RNF96(h):mdm2-isoform1(h):p53(h) (binding) | RNF96(h) --/ mdm2(h) (decrease of abundance) | RNF96(h) --/ p21Cip1(h) (decrease of abundance) | RNF96(h) --/ Bax(h) (decrease of abundance) | TFEA(h) + RNF96(h) <==> TFEA(h):RNF96(h) (binding) | DCR2(h) + RNF96(h) <==> DCR2(h):RNF96(h) (binding) | ESET(h) + RNF96(h) <==> ESET(h):RNF96(h) (binding) | RNF96(h) + Mi2-alpha(h) <==> RNF96(h):Mi2-alpha(h) (binding) | HDAC1(h) + RNF96(h) + Apak(h) + ATM(h) + p53(h) <==> HDAC1(h):RNF96(h):Apak(h):ATM(h):p53(h) (binding) | RNF96(h) + HDAC1(h) + Apak(h) <==> RNF96(h):HDAC1(h):Apak(h) (binding) | RNF96(h) --/ bbc3(h) (transrepression) | RNF96(h) --/ P53AIP1(h) (transrepression) | RNF96(h) --/ PMAIP1(h) (transrepression) | RNF96(h) --/ SFN(h) (transrepression) | Pax-3(m) + RNF96(h) <==> Pax-3(m):RNF96(h) (binding) | TRIM28(h) --> RNF96(h) (expression). | histone H3(m.s.) + S-adenosylmethionine --RNF96(h)--> histone H3(m.s.){met} + S-adenosylhomocysteine (methylation) | histone H3(c) + S-adenosylmethionine --RNF96(h)--> histone H3(c){met} + S-adenosylhomocysteine (methylation) | histone H3(m.s.) + S-adenosylmethionine --RNF96(h)--> histone H3(m.s.){metK10} + S-adenosylhomocysteine (methylation) | MM-1(m.s.) + RNF96-isoform1(h) <==> MM-1(m.s.):RNF96-isoform1(h) (binding) | c-Myc(h) + HDAC1(h) + sin3a(h) + RNF96-isoform1(h) + MM-1(m.s.) <==> c-Myc(h):HDAC1(h):sin3a(h):RNF96-isoform1(h):MM-1(m.s.) (binding) | RNF96-isoform1(h) + 3 sumo1(m.s.) --> RNF96-isoform1(h){sumoK554}{sumoK779}{sumoK804} (sumoylation) | mdm2-isoform1(h) + RNF96-isoform1(h) <==> mdm2-isoform1(h):RNF96-isoform1(h) (binding) | RNF96-isoform1(h) --> HDAC1(m.s.):p53(h) (increase of binding) | RNF96-isoform1(h) --> p53(h){ub} (increase of ubiquitination) | RNF96-isoform1(h) --> p16INK4a(h):mdm2-isoform1(h) (decrease of binding) | RNF96-isoform1(h) --> YY1(m.s.):mdm2(h) (decrease of binding) | TRIM28(h) --> RNF96-isoform1(h) (expression). | TRIM28(h) --> RNF96-isoform2(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 2 | N-acetylalanine. | Swiss-Prot 53.0 | 19 | Phosphoserine. | Swiss-Prot 53.0 | 50 | Phosphoserine. | Swiss-Prot 53.0 | 473 | Phosphoserine. | Swiss-Prot 53.0 | 541 | Phosphothreonine. | Swiss-Prot 53.0 | 681 | Phosphoserine. | Swiss-Prot 53.0 | 683 | Phosphoserine. | Swiss-Prot 53.0 | 757 | Phosphoserine. | Swiss-Prot 53.0 | 472 | Phosphoserine | 15302935;16083285;17081983 | Phospho.ELM 6.0 | 18 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 49 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 827 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr19 |
Promoter: 63746148 - 63748148 | Agilent_014791 |
chr19 |
Promoter: 63746148 - 63748148 | GSE27584 |
chr19 |
Promoter: 63746148 - 63748148 | Agilent_014791_44K |