Entrez Gene

Basic Information
Gene ID	9908
Name	G3BP2
Synonymous	GTPase activating protein (SH3 domain) binding protein 2;G3BP2;GTPase activating protein (SH3 domain) binding protein 2
Definition	G3BP-2\|GAP SH3 domain-binding protein 2\|Ras-GTPase activating protein SH3 domain-binding protein 2\|ras GTPase-activating protein-binding protein 2
Position	4q21.1
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1408A>G; p.T470A; 4:75645471-75645471	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1313G>A; p.R438H; 4:75645566-75645566	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1296A>G; p.R432R; 4:75645583-75645583	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.518G>A; p.S173N; 4:75655795-75655795	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.518G>A; p.S173N; 4:75655795-75655795	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1218G>C; p.E406D; 4:75645661-75645661	breast	carcinoma	Substitution - Missense
c.648G>C; p.K216N; 4:75655144-75655144	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.116C>T; p.S39F; 4:75658904-75658904	breast	carcinoma	Substitution - Missense
c.1312C>T; p.R438C; 4:75645567-75645567	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.179A>G; p.D60G; 4:75657729-75657729	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.884G>T; p.R295L; 4:75648683-75648683	breast	carcinoma	Substitution - Missense
c.207C>T; p.N69N; 4:75657701-75657701	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1106G>A; p.G369E; 4:75646408-75646408	skin	malignant_melanoma	Substitution - Missense
c.633A>G; p.P211P; 4:75655159-75655159	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.37C>T; p.R13W; 4:75661989-75661989	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1010A>C; p.N337T; 4:75647076-75647076	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.37C>T; p.R13W; 4:75661989-75661989	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.37C>T; p.R13W; 4:75661989-75661989	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.479G>T; p.R160I; 4:75655834-75655834	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1265A>G; p.D422G; 4:75645614-75645614	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.346C>T; p.P116S; 4:75657562-75657562	breast	carcinoma	Substitution - Missense
c.1253G>C; p.R418T; 4:75645626-75645626	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.372T>C; p.F124F; 4:75656994-75656994	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.943G>A; p.E315K; 4:75647143-75647143	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.943G>A; p.E315K; 4:75647143-75647143	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1355G>C; p.R452T; 4:75645524-75645524	urinary_tract; bladder	carcinoma	Substitution - Missense
c.477A>T; p.E159D; 4:75655836-75655836	liver	carcinoma	Substitution - Missense
c.1191A>G; p.R397R; 4:75645688-75645688	pleura	pulmonary_blastoma	Substitution - coding silent
c.767C>T; p.P256L; 4:75654041-75654041	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1194G>T; p.G398G; 4:75645685-75645685	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1301C>T; p.P434L; 4:75645578-75645578	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.976C>T; p.R326C; 4:75647110-75647110	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.976C>T; p.R326C; 4:75647110-75647110	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1337T>C; p.M446T; 4:75645542-75645542	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1091C>T; p.T364I; 4:75646423-75646423	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.802_803insC; p.H268fs*3; 4:75654005-75654006	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.859C>G; p.Q287E; 4:75648708-75648708	urinary_tract; bladder	carcinoma	Substitution - Missense
c.859C>G; p.Q287E; 4:75648708-75648708	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1178C>T; p.P393L; 4:75645701-75645701	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.179A>T; p.D60V; 4:75657729-75657729	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.977G>A; p.R326H; 4:75647109-75647109	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.638T>C; p.V213A; 4:75655154-75655154	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.125A>G; p.H42R; 4:75658895-75658895	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.869G>A; p.R290H; 4:75648698-75648698	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1285C>A; p.R429S; 4:75645594-75645594	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1363C>A; p.P455T; 4:75645516-75645516	breast	carcinoma	Substitution - Missense
c.619G>A; p.E207K; 4:75655173-75655173	urinary_tract; bladder	carcinoma	Substitution - Missense
c.456A>C; p.E152D; 4:75655857-75655857	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1193G>T; p.G398V; 4:75645686-75645686	pleura	pulmonary_blastoma	Substitution - Missense
c.1264G>T; p.D422Y; 4:75645615-75645615	breast	carcinoma	Substitution - Missense
c.545+1G>C; p.?; 4:75655767-75655767	liver	carcinoma	Unknown
c.1087A>G; p.N363D; 4:75646427-75646427	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.958G>C; p.D320H; 4:75647128-75647128	urinary_tract; bladder	carcinoma	Substitution - Missense
c.895C>T; p.R299*; 4:75648672-75648672	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.443-1G>C; p.?; 4:75655871-75655871	breast	carcinoma; ductal_carcinoma	Unknown
c.1442G>A; p.R481H; 4:75645437-75645437	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1353A>G; p.G451G; 4:75645526-75645526	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1303G>T; p.G435C; 4:75645576-75645576	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1271G>T; p.R424L; 4:75645608-75645608	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.371T>G; p.F124C; 4:75656995-75656995	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1147G>A; p.E383K; 4:75646367-75646367	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.319A>G; p.K107E; 4:75657589-75657589	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.319A>G; p.K107E; 4:75657589-75657589	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; follicular_lymphoma	Substitution - Missense
c.1082G>A; p.R361H; 4:75646432-75646432	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1082G>A; p.R361H; 4:75646432-75646432	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.757A>G; p.N253D; 4:75654051-75654051	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1338G>A; p.M446I; 4:75645541-75645541	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1338G>A; p.M446I; 4:75645541-75645541	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1338G>A; p.M446I; 4:75645541-75645541	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1338G>A; p.M446I; 4:75645541-75645541	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.443-10G>A; p.?; 4:75655880-75655880	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.1189C>T; p.R397*; 4:75645690-75645690	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.950A>G; p.N317S; 4:75647136-75647136	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1445G>A; p.R482H; 4:75645434-75645434	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1445G>A; p.R482H; 4:75645434-75645434	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.313G>C; p.E105Q; 4:75657595-75657595	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1233T>A; p.A411A; 4:75645646-75645646	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.983C>T; p.P328L; 4:75647103-75647103	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.788C>T; p.S263F; 4:75654020-75654020	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1302C>A; p.P434P; 4:75645577-75645577	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.622G>C; p.E208Q; 4:75655170-75655170	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.232C>T; p.R78C; 4:75657676-75657676	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.232C>T; p.R78C; 4:75657676-75657676	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.232C>T; p.R78C; 4:75657676-75657676	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.232C>T; p.R78C; 4:75657676-75657676	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.232C>T; p.R78C; 4:75657676-75657676	skin; neck	malignant_melanoma	Substitution - Missense
c.232C>T; p.R78C; 4:75657676-75657676	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.351+9C>G; p.?; 4:75657548-75657548	ovary	other; neoplasm	Unknown
c.97T>G; p.F33V; 4:75658923-75658923	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1123G>C; p.G375R; 4:75646391-75646391	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1261G>T; p.G421C; 4:75645618-75645618	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.546-18_546-9delCTAAATATTT; p.?; 4:75655255-75655264	stomach	adenocarcinoma	Unknown
c.1286G>A; p.R429H; 4:75645593-75645593	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1081C>T; p.R361C; 4:75646433-75646433	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.466G>A; p.E156K; 4:75655847-75655847	liver	carcinoma	Substitution - Missense
c.1081C>T; p.R361C; 4:75646433-75646433	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.934G>T; p.G312*; 4:75647152-75647152	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1270C>T; p.R424C; 4:75645609-75645609	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.394C>T; p.R132C; 4:75656972-75656972	skin	malignant_melanoma	Substitution - Missense
c.561G>C; p.E187D; 4:75655231-75655231	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.637G>C; p.V213L; 4:75655155-75655155	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]