Cancer metastasis gene database Home
Cancer metastasis database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

9622

Name

KLK4

Synonymous

kallikrein-related peptidase 4;KLK4;kallikrein-related peptidase 4

Definition

androgen-regulated message 1|enamel matrix serine protease 1|enamel matrix serine proteinase 1|kallikrein-4|kallikrein-like protein 1|prostase|serine protease 17

Position

19q13.41

Gene Type

protein-coding

COSMIC somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.370G>A; p.E124K; 19:50908684-50908684

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.681G>T; p.P227P; 19:50907018-50907018

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.279G>T; p.G93G; 19:50908775-50908775

 lungcarcinoma; small_cell_carcinomaSubstitution - coding silent

c.582C>T; p.G194G; 19:50908389-50908389

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.598A>G; p.K200E; 19:50908373-50908373

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.208G>A; p.A70T; 19:50909268-50909268

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.285G>T; p.Q95H; 19:50908769-50908769

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.208G>A; p.A70T; 19:50909268-50909268

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.750C>A; p.T250T; 19:50906949-50906949

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.56T>C; p.V19A; 19:50910683-50910683

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.624G>C; p.G208G; 19:50907075-50907075

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.579C>A; p.A193A; 19:50908392-50908392

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.392C>A; p.T131N; 19:50908662-50908662

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.592G>T; p.D198Y; 19:50908379-50908379

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.432G>T; p.A144A; 19:50908622-50908622

 prostatecarcinoma; adenocarcinomaSubstitution - coding silent

c.697G>A; p.V233M; 19:50907002-50907002

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.432G>T; p.A144A; 19:50908622-50908622

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.165C>T; p.F55F; 19:50909311-50909311

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.695G>C; p.G232A; 19:50907004-50907004

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.248T>C; p.L83P; 19:50908806-50908806

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.475G>A; p.G159S; 19:50908579-50908579

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.447C>T; p.L149L; 19:50908607-50908607

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.475G>A; p.G159S; 19:50908579-50908579

 central_nervous_system; braingliomaSubstitution - Missense

c.364T>C; p.L122L; 19:50908690-50908690

 skinmalignant_melanomaSubstitution - coding silent

c.61G>T; p.G21*; 19:50910678-50910678

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.428C>T; p.T143I; 19:50908626-50908626

 skinmalignant_melanomaSubstitution - Missense

c.116C>T; p.P39L; 19:50909360-50909360

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.295G>C; p.A99P; 19:50908759-50908759

 thyroidother; neoplasmSubstitution - Missense

c.295G>C; p.A99P; 19:50908759-50908759

 thyroidother; neoplasmSubstitution - Missense

c.295G>C; p.A99P; 19:50908759-50908759

 thyroidother; neoplasmSubstitution - Missense

c.263C>T; p.A88V; 19:50908791-50908791

 skinmalignant_melanomaSubstitution - Missense

c.219C>T; p.F73F; 19:50909257-50909257

 skinmalignant_melanomaSubstitution - coding silent

c.57C>T; p.V19V; 19:50910682-50910682

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.731C>G; p.T244S; 19:50906968-50906968

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.251A>G; p.H84R; 19:50908803-50908803

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.492G>T; p.V164V; 19:50908479-50908479

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.19C>T; p.P7S; 19:50910720-50910720

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.306C>T; p.S102S; 19:50908748-50908748

 skinmalignant_melanomaSubstitution - coding silent

c.305C>T; p.S102F; 19:50908749-50908749

 skinmalignant_melanomaSubstitution - Missense

c.435G>A; p.G145G; 19:50908619-50908619

 skinmalignant_melanomaSubstitution - coding silent

c.416C>T; p.S139L; 19:50908638-50908638

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.416C>T; p.S139L; 19:50908638-50908638

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.416C>T; p.S139L; 19:50908638-50908638

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.346G>A; p.D116N; 19:50908708-50908708

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.476-7G>A; p.?; 19:50908502-50908502

 breastcarcinomaUnknown

c.579C>T; p.A193A; 19:50908392-50908392

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.579C>T; p.A193A; 19:50908392-50908392

 upper_aerodigestive_tract; mouthcarcinomaSubstitution - coding silent

c.579C>T; p.A193A; 19:50908392-50908392

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.579C>T; p.A193A; 19:50908392-50908392

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.756G>A; p.Q252Q; 19:50906943-50906943

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.101G>A; p.G34D; 19:50909375-50909375

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.66G>T; p.S22S; 19:50909410-50909410

 livercarcinoma; hepatocellular_carcinomaSubstitution - coding silent

c.381C>T; p.S127S; 19:50908673-50908673

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.66G>T; p.S22S; 19:50909410-50909410

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.157G>A; p.E53K; 19:50909319-50909319

 skinmalignant_melanomaSubstitution - Missense

c.66G>T; p.S22S; 19:50909410-50909410

 thyroidother; neoplasmSubstitution - coding silent

c.655G>A; p.G219S; 19:50907044-50907044

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.655G>A; p.G219S; 19:50907044-50907044

 skinmalignant_melanomaSubstitution - Missense

c.265G>A; p.D89N; 19:50908789-50908789

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.265G>A; p.D89N; 19:50908789-50908789

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.265G>A; p.D89N; 19:50908789-50908789

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.265G>A; p.D89N; 19:50908789-50908789

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.265G>A; p.D89N; 19:50908789-50908789

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.265G>A; p.D89N; 19:50908789-50908789

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.265G>A; p.D89N; 19:50908789-50908789

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.265G>A; p.D89N; 19:50908789-50908789

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.265G>A; p.D89N; 19:50908789-50908789

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.413C>T; p.A138V; 19:50908641-50908641

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.265G>A; p.D89N; 19:50908789-50908789

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.265G>A; p.D89N; 19:50908789-50908789

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.729C>T; p.F243F; 19:50906970-50906970

 endometriumcarcinoma; serous_carcinomaSubstitution - coding silent

c.729C>T; p.F243F; 19:50906970-50906970

 skinmalignant_melanomaSubstitution - coding silent

c.64T>G; p.S22A; 19:50909412-50909412

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.64T>G; p.S22A; 19:50909412-50909412

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.375C>T; p.S125S; 19:50908679-50908679

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.58G>C; p.A20P; 19:50910681-50910681

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.201G>A; p.L67L; 19:50909275-50909275

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.310C>A; p.R104R; 19:50908744-50908744

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.129C>A; p.P43P; 19:50909347-50909347

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - coding silent

c.332C>A; p.P111H; 19:50908722-50908722

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.448G>A; p.V150I; 19:50908606-50908606

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.508G>A; p.V170M; 19:50908463-50908463

 pancreascarcinomaSubstitution - Missense

c.508G>A; p.V170M; 19:50908463-50908463

 pancreascarcinomaSubstitution - Missense

c.490G>A; p.V164M; 19:50908481-50908481

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.737G>C; p.W246S; 19:50906962-50906962

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.648C>A; p.Y216*; 19:50907051-50907051

 autonomic_ganglianeuroblastomaSubstitution - Nonsense

c.107A>G; p.D36G; 19:50909369-50909369

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.65C>A; p.S22*; 19:50909411-50909411

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.182T>G; p.V61G; 19:50909294-50909294

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.37G>T; p.G13W; 19:50910702-50910702

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.501C>T; p.C167C; 19:50908470-50908470

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.189G>A; p.P63P; 19:50909287-50909287

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.716A>T; p.N239I; 19:50906983-50906983

 breastcarcinomaSubstitution - Missense

c.289G>A; p.V97M; 19:50908765-50908765

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.676G>T; p.A226S; 19:50907023-50907023

 breastcarcinomaSubstitution - Missense

c.285G>A; p.Q95Q; 19:50908769-50908769

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.152A>G; p.E51G; 19:50909324-50909324

 skinmalignant_melanomaSubstitution - Missense

c.628C>G; p.P210A; 19:50907071-50907071

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.628C>G; p.P210A; 19:50907071-50907071

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.643G>A; p.G215R; 19:50907056-50907056

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.374C>T; p.S125F; 19:50908680-50908680

 skin; anklemalignant_melanoma; acral_lentiginousSubstitution - Missense

c.397C>T; p.R133W; 19:50908657-50908657

 skinmalignant_melanomaSubstitution - Missense

c.470C>T; p.A157V; 19:50908584-50908584

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.552G>A; p.P184P; 19:50908419-50908419

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent