Entrez Gene

Basic Information
Gene ID	9586
Name	CREB5
Synonymous	cAMP responsive element binding protein 5;CREB5;cAMP responsive element binding protein 5
Definition	cAMP response element-binding protein CRE-BPa\|cyclic AMP-responsive element-binding protein 5
Position	7p15.1
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.43C>T; p.P15S; 7:28488214-28488214	skin	malignant_melanoma	Substitution - Missense
c.1517C>T; p.P506L; 7:28819269-28819269	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1517C>T; p.P506L; 7:28819269-28819269	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.208G>A; p.E70K; 7:28507654-28507654	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1369G>T; p.E457*; 7:28819121-28819121	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1363+2T>G; p.?; 7:28818181-28818181	liver	carcinoma	Unknown
c.1363+2T>G; p.?; 7:28818181-28818181	liver	carcinoma	Unknown
c.827C>T; p.S276L; 7:28804323-28804323	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.430A>G; p.I144V; 7:28570503-28570503	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1484G>T; p.S495I; 7:28819236-28819236	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.699A>C; p.K233N; 7:28724329-28724329	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.281G>A; p.S94N; 7:28507727-28507727	skin	malignant_melanoma	Substitution - Missense
c.189G>A; p.T63T; 7:28507635-28507635	skin	malignant_melanoma	Substitution - coding silent
c.1144C>A; p.L382M; 7:28809304-28809304	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1125C>T; p.D375D; 7:28809285-28809285	skin	malignant_melanoma	Substitution - coding silent
c.37G>C; p.E13Q; 7:28488208-28488208	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.752A>G; p.N251S; 7:28804248-28804248	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.21G>T; p.K7N; 7:28488192-28488192	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.407C>T; p.P136L; 7:28570480-28570480	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.300G>A; p.S100S; 7:28570373-28570373	skin	malignant_melanoma	Substitution - coding silent
c.143C>A; p.S48*; 7:28494973-28494973	liver	carcinoma	Substitution - Nonsense
c.956A>C; p.H319P; 7:28804452-28804452	breast	carcinoma	Substitution - Missense
c.198G>A; p.L66L; 7:28507644-28507644	skin	malignant_melanoma	Substitution - coding silent
c.1325C>T; p.P442L; 7:28818141-28818141	skin	malignant_melanoma	Substitution - Missense
c.1345G>T; p.E449*; 7:28818161-28818161	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.139C>T; p.P47S; 7:28494969-28494969	skin	malignant_melanoma	Substitution - Missense
c.139C>T; p.P47S; 7:28494969-28494969	skin; mucosal	malignant_melanoma	Substitution - Missense
c.134A>C; p.K45T; 7:28494964-28494964	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.575C>T; p.S192F; 7:28718863-28718863	skin; upper_leg	malignant_melanoma	Substitution - Missense
c.1100G>A; p.R367Q; 7:28809260-28809260	skin	malignant_melanoma	Substitution - Missense
c.361C>T; p.R121W; 7:28570434-28570434	breast	carcinoma	Substitution - Missense
c.641C>T; p.P214L; 7:28724271-28724271	ovary	other; neoplasm	Substitution - Missense
c.353G>T; p.S118I; 7:28570426-28570426	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1117G>A; p.D373N; 7:28809277-28809277	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.180G>A; p.P60P; 7:28507626-28507626	breast	carcinoma	Substitution - coding silent
c.807G>A; p.T269T; 7:28804303-28804303	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1157G>A; p.R386Q; 7:28809317-28809317	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.449C>T; p.T150I; 7:28570522-28570522	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.1157G>A; p.R386Q; 7:28809317-28809317	liver	carcinoma	Substitution - Missense
c.1157G>A; p.R386Q; 7:28809317-28809317	liver	carcinoma	Substitution - Missense
c.1132C>T; p.R378W; 7:28809292-28809292	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.318T>G; p.G106G; 7:28570391-28570391	breast	carcinoma	Substitution - coding silent
c.1130G>A; p.R377K; 7:28809290-28809290	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.533C>T; p.S178F; 7:28718821-28718821	skin	malignant_melanoma	Substitution - Missense
c.384C>A; p.N128K; 7:28570457-28570457	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1426C>A; p.H476N; 7:28819178-28819178	urinary_tract; bladder	carcinoma	Substitution - Missense
c.872C>A; p.P291Q; 7:28804368-28804368	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1279G>T; p.E427*; 7:28818095-28818095	prostate	adenoma	Substitution - Nonsense
c.1322G>T; p.C441F; 7:28818138-28818138	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.708G>A; p.L236L; 7:28804204-28804204	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1071G>A; p.Q357Q; 7:28809231-28809231	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1078C>T; p.Q360*; 7:28809238-28809238	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.778G>A; p.E260K; 7:28804274-28804274	breast	carcinoma	Substitution - Missense
c.291G>T; p.R97R; 7:28507737-28507737	breast	carcinoma	Substitution - coding silent
c.1364-2A>G; p.?; 7:28819114-28819114	stomach	carcinoma; adenocarcinoma	Unknown
c.1355G>A; p.G452E; 7:28818171-28818171	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.178C>T; p.P60S; 7:28507624-28507624	skin	malignant_melanoma	Substitution - Missense
c.359C>T; p.A120V; 7:28570432-28570432	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1507G>T; p.D503Y; 7:28819259-28819259	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.998C>T; p.P333L; 7:28804494-28804494	pancreas	carcinoma	Substitution - Missense
c.455G>T; p.R152L; 7:28570528-28570528	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.455G>T; p.R152L; 7:28570528-28570528	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.299C>T; p.S100L; 7:28570372-28570372	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.417G>A; p.Q139Q; 7:28570490-28570490	skin	malignant_melanoma	Substitution - coding silent
c.812A>G; p.H271R; 7:28804308-28804308	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.577G>A; p.A193T; 7:28718865-28718865	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.1459G>T; p.E487*; 7:28819211-28819211	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1199T>G; p.V400G; 7:28809359-28809359	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.766G>T; p.G256*; 7:28804262-28804262	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.313G>A; p.V105I; 7:28570386-28570386	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.259A>C; p.R87R; 7:28507705-28507705	ovary	other; neoplasm	Substitution - coding silent
c.76-6C>G; p.?; 7:28494900-28494900	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.800A>C; p.D267A; 7:28804296-28804296	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1015A>G; p.N339D; 7:28804511-28804511	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1210G>C; p.E404Q; 7:28809370-28809370	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1272G>A; p.L424L; 7:28818088-28818088	skin	malignant_melanoma	Substitution - coding silent
c.1324C>A; p.P442T; 7:28818140-28818140	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1360C>T; p.L454L; 7:28818176-28818176	skin	malignant_melanoma	Substitution - coding silent
c.252C>T; p.H84H; 7:28507698-28507698	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1209G>T; p.L403F; 7:28809369-28809369	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.411G>A; p.S137S; 7:28570484-28570484	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.411G>A; p.S137S; 7:28570484-28570484	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.242C>T; p.S81F; 7:28507688-28507688	skin	malignant_melanoma	Substitution - Missense
c.1099C>G; p.R367G; 7:28809259-28809259	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1422C>T; p.I474I; 7:28819174-28819174	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.15A>G; p.E5E; 7:28488186-28488186	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.228C>T; p.S76S; 7:28507674-28507674	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.228C>T; p.S76S; 7:28507674-28507674	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1026G>A; p.Q342Q; 7:28804522-28804522	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.576C>T; p.S192S; 7:28718864-28718864	skin; upper_leg	malignant_melanoma	Substitution - coding silent
c.576C>T; p.S192S; 7:28718864-28718864	skin	malignant_melanoma	Substitution - coding silent
c.989C>T; p.S330L; 7:28804485-28804485	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.772A>G; p.M258V; 7:28804268-28804268	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.260G>A; p.R87K; 7:28507706-28507706	ovary	other; neoplasm	Substitution - Missense
c.803A>G; p.Q268R; 7:28804299-28804299	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.580G>A; p.V194I; 7:28718868-28718868	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.1302G>A; p.L434L; 7:28818118-28818118	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.407C>G; p.P136R; 7:28570480-28570480	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1135C>T; p.R379W; 7:28809295-28809295	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.121G>A; p.E41K; 7:28494951-28494951	skin	malignant_melanoma	Substitution - Missense
c.806C>A; p.T269K; 7:28804302-28804302	stomach	adenocarcinoma	Substitution - Missense
c.1011C>T; p.T337T; 7:28804507-28804507	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1011C>T; p.T337T; 7:28804507-28804507	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.645T>G; p.N215K; 7:28724275-28724275	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.91G>C; p.D31H; 7:28494921-28494921	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.258C>T; p.F86F; 7:28507704-28507704	skin	malignant_melanoma	Substitution - coding silent
c.371A>G; p.N124S; 7:28570444-28570444	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1512G>A; p.L504L; 7:28819264-28819264	skin	malignant_melanoma	Substitution - coding silent
c.791C>T; p.S264F; 7:28804287-28804287	skin	malignant_melanoma	Substitution - Missense
c.624C>T; p.I208I; 7:28724254-28724254	skin	malignant_melanoma	Substitution - coding silent
c.1121C>T; p.P374L; 7:28809281-28809281	prostate	carcinoma	Substitution - Missense
c.6T>C; p.I2I; 7:28488177-28488177	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1121C>T; p.P374L; 7:28809281-28809281	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.660T>A; p.C220*; 7:28724290-28724290	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.613A>G; p.N205D; 7:28724243-28724243	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1126G>A; p.E376K; 7:28809286-28809286	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1126G>A; p.E376K; 7:28809286-28809286	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.145A>G; p.I49V; 7:28494975-28494975	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.378C>T; p.D126D; 7:28570451-28570451	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1053G>A; p.Q351Q; 7:28809213-28809213	breast	carcinoma	Substitution - coding silent
c.94C>G; p.H32D; 7:28494924-28494924	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.336C>A; p.P112P; 7:28570409-28570409	skin	malignant_melanoma	Substitution - coding silent
c.61C>A; p.P21T; 7:28488232-28488232	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1396C>T; p.P466S; 7:28819148-28819148	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1408C>T; p.Q470*; 7:28819160-28819160	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1152G>A; p.R384R; 7:28809312-28809312	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1156C>A; p.R386R; 7:28809316-28809316	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.920A>C; p.H307P; 7:28804416-28804416	breast	carcinoma	Substitution - Missense
c.1404C>G; p.C468W; 7:28819156-28819156	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1172G>A; p.R391H; 7:28809332-28809332	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1404C>G; p.C468W; 7:28819156-28819156	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1297C>T; p.Q433*; 7:28818113-28818113	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.993A>T; p.P331P; 7:28804489-28804489	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.760A>G; p.T254A; 7:28804256-28804256	ovary	other; neoplasm	Substitution - Missense
c.154G>C; p.D52H; 7:28494984-28494984	urinary_tract; bladder	carcinoma	Substitution - Missense
c.289C>T; p.R97W; 7:28507735-28507735	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.330G>A; p.T110T; 7:28570403-28570403	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.195C>T; p.F65F; 7:28507641-28507641	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.179C>T; p.P60L; 7:28507625-28507625	skin	malignant_melanoma	Substitution - Missense
c.331G>A; p.G111R; 7:28570404-28570404	skin	malignant_melanoma	Substitution - Missense
c.331G>A; p.G111R; 7:28570404-28570404	skin	malignant_melanoma	Substitution - Missense
c.188C>T; p.T63M; 7:28507634-28507634	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1399G>T; p.A467S; 7:28819151-28819151	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.81C>T; p.F27F; 7:28494911-28494911	skin	malignant_melanoma	Substitution - coding silent
c.1156C>T; p.R386W; 7:28809316-28809316	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.31G>A; p.E11K; 7:28488202-28488202	skin	malignant_melanoma	Substitution - Missense

COSMIC somatic mutation [Top]