Entrez Gene

Basic Information
Gene ID	943
Name	TNFRSF8
Synonymous	tumor necrosis factor receptor superfamily, member 8;TNFRSF8;tumor necrosis factor receptor superfamily, member 8
Definition	CD30L receptor\|Ki-1 antigen\|cytokine receptor CD30\|lymphocyte activation antigen CD30\|tumor necrosis factor receptor superfamily member 8
Position	1p36
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1436A>G; p.Y479C; 1:12138329-12138329	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1363G>T; p.E455*; 1:12138256-12138256	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.162G>A; p.P54P; 1:12097111-12097111	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.162G>A; p.P54P; 1:12097111-12097111	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1338G>A; p.Q446Q; 1:12138231-12138231	thyroid	other; neoplasm	Substitution - coding silent
c.172T>C; p.C58R; 1:12097121-12097121	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1244G>A; p.R415Q; 1:12126041-12126041	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.155T>A; p.L52Q; 1:12097104-12097104	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.790C>T; p.R264*; 1:12112011-12112011	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.793+1G>A; p.?; 1:12112015-12112015	large_intestine; caecum	carcinoma; adenocarcinoma	Unknown
c.83C>A; p.T28N; 1:12084483-12084483	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1786T>C; p.*596R; 1:12142529-12142529	liver	carcinoma	Nonstop extension
c.1662G>T; p.A554A; 1:12142405-12142405	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.482C>T; p.A161V; 1:12109626-12109626	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1786T>C; p.*596R; 1:12142529-12142529	liver	carcinoma; hepatocellular_carcinoma	Nonstop extension
c.670G>T; p.D224Y; 1:12110198-12110198	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.843C>T; p.C281C; 1:12115626-12115626	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.428C>T; p.A143V; 1:12109572-12109572	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.97C>A; p.P33T; 1:12084497-12084497	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.405G>A; p.M135I; 1:12104515-12104515	skin	malignant_melanoma	Substitution - Missense
c.386C>T; p.S129F; 1:12104496-12104496	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.270C>T; p.D90D; 1:12104380-12104380	thyroid	other; neoplasm	Substitution - coding silent
c.386C>T; p.S129F; 1:12104496-12104496	skin	malignant_melanoma	Substitution - Missense
c.270C>T; p.D90D; 1:12104380-12104380	thyroid	other; neoplasm	Substitution - coding silent
c.424A>C; p.T142P; 1:12109568-12109568	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1238G>A; p.R413K; 1:12126035-12126035	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.968C>T; p.T323I; 1:12123305-12123305	skin	malignant_melanoma	Substitution - Missense
c.146C>T; p.P49L; 1:12084546-12084546	skin	malignant_melanoma	Substitution - Missense
c.78G>T; p.E26D; 1:12084478-12084478	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.915C>G; p.I305M; 1:12115698-12115698	urinary_tract; bladder	carcinoma	Substitution - Missense
c.92G>A; p.G31E; 1:12084492-12084492	skin	malignant_melanoma	Substitution - Missense
c.95A>C; p.N32T; 1:12084495-12084495	breast	carcinoma	Substitution - Missense
c.1705C>T; p.L569L; 1:12142448-12142448	skin	malignant_melanoma	Substitution - coding silent
c.997C>T; p.P333S; 1:12123334-12123334	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.280G>A; p.E94K; 1:12104390-12104390	skin	malignant_melanoma	Substitution - Missense
c.1441G>T; p.E481*; 1:12138334-12138334	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1212C>T; p.F404F; 1:12126009-12126009	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.98_99CC>AA; p.P33Q; 1:12084498-12084499	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.882C>A; p.T294T; 1:12115665-12115665	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.140G>A; p.R47H; 1:12084540-12084540	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.685C>T; p.P229S; 1:12111906-12111906	NS	malignant_melanoma	Substitution - Missense
c.91G>A; p.G31R; 1:12084491-12084491	skin	malignant_melanoma	Substitution - Missense
c.109T>C; p.Y37H; 1:12084509-12084509	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1521G>T; p.T507T; 1:12138414-12138414	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1657G>C; p.E553Q; 1:12142400-12142400	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1412C>A; p.T471N; 1:12138305-12138305	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.192C>T; p.D64D; 1:12097141-12097141	liver	carcinoma	Substitution - coding silent
c.192C>T; p.D64D; 1:12097141-12097141	liver	carcinoma	Substitution - coding silent
c.364T>C; p.C122R; 1:12104474-12104474	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.523C>T; p.P175S; 1:12110051-12110051	skin	malignant_melanoma	Substitution - Missense
c.680T>A; p.L227Q; 1:12111901-12111901	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.111T>G; p.Y37*; 1:12084511-12084511	skin	malignant_melanoma	Substitution - Nonsense
c.1355C>T; p.S452L; 1:12138248-12138248	skin	malignant_melanoma	Substitution - Missense
c.1637C>T; p.P546L; 1:12142380-12142380	skin	malignant_melanoma	Substitution - Missense
c.596G>A; p.R199H; 1:12110124-12110124	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.551C>G; p.P184R; 1:12110079-12110079	oesophagus	carcinoma	Substitution - Missense
c.1788A>T; p.*596C; 1:12142531-12142531	liver	carcinoma; hepatocellular_carcinoma	Nonstop extension
c.325C>T; p.R109*; 1:12104435-12104435	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.1440G>A; p.L480L; 1:12138333-12138333	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1206C>T; p.S402S; 1:12126003-12126003	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.603C>A; p.A201A; 1:12110131-12110131	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.176C>T; p.P59L; 1:12097125-12097125	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.319G>A; p.E107K; 1:12104429-12104429	skin	malignant_melanoma	Substitution - Missense
c.992C>A; p.T331N; 1:12123329-12123329	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.992C>A; p.T331N; 1:12123329-12123329	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1344G>A; p.R448R; 1:12138237-12138237	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1027G>C; p.E343Q; 1:12123364-12123364	urinary_tract; bladder	carcinoma	Substitution - Missense
c.287C>T; p.T96M; 1:12104397-12104397	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.907T>A; p.Y303N; 1:12115690-12115690	breast	carcinoma	Substitution - Missense
c.488C>T; p.P163L; 1:12109632-12109632	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.366T>C; p.C122C; 1:12104476-12104476	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.359A>G; p.N120S; 1:12104469-12104469	liver	carcinoma	Substitution - Missense
c.359A>G; p.N120S; 1:12104469-12104469	liver	carcinoma	Substitution - Missense
c.627G>T; p.T209T; 1:12110155-12110155	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.158T>A; p.F53Y; 1:12097107-12097107	liver	carcinoma	Substitution - Missense
c.232G>T; p.A78S; 1:12097181-12097181	breast	carcinoma	Substitution - Missense
c.158T>A; p.F53Y; 1:12097107-12097107	liver	carcinoma	Substitution - Missense
c.1107C>T; p.S369S; 1:12123781-12123781	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1349G>A; p.G450D; 1:12138242-12138242	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1249C>T; p.R417W; 1:12126046-12126046	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.68G>A; p.R23Q; 1:12084468-12084468	skin	malignant_melanoma	Substitution - Missense
c.1249C>T; p.R417W; 1:12126046-12126046	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1249C>T; p.R417W; 1:12126046-12126046	skin	malignant_melanoma	Substitution - Missense
c.1249C>T; p.R417W; 1:12126046-12126046	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.947-1G>C; p.?; 1:12123283-12123283	pancreas	carcinoma	Unknown
c.1249C>T; p.R417W; 1:12126046-12126046	skin	malignant_melanoma	Substitution - Missense
c.1249C>T; p.R417W; 1:12126046-12126046	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.468C>T; p.V156V; 1:12109612-12109612	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1378G>A; p.E460K; 1:12138271-12138271	skin	malignant_melanoma	Substitution - Missense
c.796G>A; p.D266N; 1:12115579-12115579	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1605G>A; p.P535P; 1:12142348-12142348	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.311G>A; p.R104H; 1:12104421-12104421	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.161C>T; p.P54L; 1:12097110-12097110	skin	malignant_melanoma	Substitution - Missense
c.873A>G; p.T291T; 1:12115656-12115656	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.574A>T; p.M192L; 1:12110102-12110102	bone; tibia	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.75C>T; p.F25F; 1:12084475-12084475	ovary	other; neoplasm	Substitution - coding silent
c.983C>T; p.P328L; 1:12123320-12123320	skin	malignant_melanoma	Substitution - Missense
c.75C>T; p.F25F; 1:12084475-12084475	skin	malignant_melanoma	Substitution - coding silent
c.915C>A; p.I305I; 1:12115698-12115698	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1359G>A; p.V453V; 1:12138252-12138252	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1668T>C; p.H556H; 1:12142411-12142411	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1103C>A; p.T368N; 1:12123777-12123777	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.630G>A; p.R210R; 1:12110158-12110158	skin	malignant_melanoma	Substitution - coding silent
c.785G>C; p.C262S; 1:12112006-12112006	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1226G>A; p.R409Q; 1:12126023-12126023	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.841T>A; p.C281S; 1:12115624-12115624	liver	carcinoma	Substitution - Missense
c.841T>A; p.C281S; 1:12115624-12115624	liver	carcinoma	Substitution - Missense
c.662C>A; p.P221H; 1:12110190-12110190	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.693G>A; p.Q231Q; 1:12111914-12111914	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.76G>A; p.E26K; 1:12084476-12084476	skin	malignant_melanoma	Substitution - Missense
c.1673C>T; p.P558L; 1:12142416-12142416	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.454G>A; p.A152T; 1:12109598-12109598	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.318C>T; p.C106C; 1:12104428-12104428	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.967A>C; p.T323P; 1:12123304-12123304	breast	carcinoma	Substitution - Missense
c.592A>C; p.T198P; 1:12110120-12110120	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.592A>C; p.T198P; 1:12110120-12110120	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.592A>C; p.T198P; 1:12110120-12110120	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1375G>A; p.E459K; 1:12138268-12138268	skin	malignant_melanoma	Substitution - Missense
c.233C>T; p.A78V; 1:12097182-12097182	skin	malignant_melanoma	Substitution - Missense
c.543G>A; p.P181P; 1:12110071-12110071	skin	malignant_melanoma	Substitution - coding silent
c.225G>T; p.L75L; 1:12097174-12097174	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.753C>T; p.D251D; 1:12111974-12111974	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.600C>T; p.L200L; 1:12110128-12110128	skin	malignant_melanoma	Substitution - coding silent
c.753C>T; p.D251D; 1:12111974-12111974	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.543G>A; p.P181P; 1:12110071-12110071	skin	malignant_melanoma	Substitution - coding silent
c.818G>A; p.C273Y; 1:12115601-12115601	liver	carcinoma	Substitution - Missense
c.277G>A; p.V93M; 1:12104387-12104387	pancreas	NS	Substitution - Missense
c.277G>A; p.V93M; 1:12104387-12104387	pancreas	carcinoma	Substitution - Missense
c.211C>T; p.P71S; 1:12097160-12097160	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.864C>A; p.I288I; 1:12115647-12115647	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.67C>T; p.R23*; 1:12084467-12084467	skin	malignant_melanoma	Substitution - Nonsense
c.600C>A; p.L200L; 1:12110128-12110128	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.67C>T; p.R23*; 1:12084467-12084467	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.305C>A; p.S102Y; 1:12104415-12104415	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.643C>T; p.P215S; 1:12110171-12110171	skin	malignant_melanoma	Substitution - Missense
c.643C>T; p.P215S; 1:12110171-12110171	skin	malignant_melanoma	Substitution - Missense
c.252C>T; p.C84C; 1:12097201-12097201	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.616T>A; p.S206T; 1:12110144-12110144	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.943C>T; p.Q315*; 1:12115726-12115726	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.943C>T; p.Q315*; 1:12115726-12115726	skin	malignant_melanoma	Substitution - Nonsense
c.765C>T; p.R255R; 1:12111986-12111986	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.595C>T; p.R199C; 1:12110123-12110123	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.401G>A; p.G134E; 1:12104511-12104511	skin	malignant_melanoma	Substitution - Missense
c.395C>T; p.P132L; 1:12104505-12104505	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.395C>T; p.P132L; 1:12104505-12104505	urinary_tract; bladder	carcinoma	Substitution - Missense
c.477C>A; p.A159A; 1:12109621-12109621	lung	carcinoma; adenocarcinoma	Substitution - coding silent

COSMIC somatic mutation [Top]