Entrez Gene

Basic Information
Gene ID	94015
Name	TTYH2
Synonymous	tweety family member 2;TTYH2;tweety family member 2
Definition	hTTY2\|protein tweety homolog 2\|tweety homolog 2
Position	17q25.1
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1532C>A; p.P511H; 17:74260136-74260136	liver	carcinoma	Substitution - Missense
c.77G>C; p.R26P; 17:74213664-74213664	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.9G>A; p.A3A; 17:74213596-74213596	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.846G>A; p.L282L; 17:74249052-74249052	breast	carcinoma	Substitution - coding silent
c.1141A>T; p.I381F; 17:74252258-74252258	skin	malignant_melanoma	Substitution - Missense
c.990G>A; p.L330L; 17:74249995-74249995	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.632A>G; p.Y211C; 17:74237511-74237511	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.541G>A; p.V181I; 17:74237420-74237420	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.883C>A; p.R295S; 17:74249352-74249352	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.467G>A; p.R156Q; 17:74237346-74237346	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.420C>T; p.S140S; 17:74237299-74237299	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1129G>A; p.A377T; 17:74252246-74252246	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.534G>A; p.A178A; 17:74237413-74237413	breast	carcinoma	Substitution - coding silent
c.1000G>A; p.V334M; 17:74250005-74250005	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1000G>A; p.V334M; 17:74250005-74250005	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1516C>T; p.P506S; 17:74253825-74253825	skin	malignant_melanoma	Substitution - Missense
c.762C>T; p.L254L; 17:74244007-74244007	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1544C>T; p.A515V; 17:74260148-74260148	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.706A>G; p.K236E; 17:74243444-74243444	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1226C>A; p.A409E; 17:74252343-74252343	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.749C>T; p.A250V; 17:74243994-74243994	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1295C>T; p.P432L; 17:74253116-74253116	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.568delG; p.V190fs*9; 17:74237447-74237447	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.324C>A; p.F108L; 17:74230909-74230909	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1543G>A; p.A515T; 17:74260147-74260147	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.664C>A; p.L222M; 17:74243402-74243402	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1529C>T; p.S510F; 17:74260133-74260133	skin	malignant_melanoma	Substitution - Missense
c.1227A>G; p.A409A; 17:74252344-74252344	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1389G>A; p.Q463Q; 17:74253210-74253210	central_nervous_system; brain	glioma	Substitution - coding silent
c.396C>A; p.F132L; 17:74230981-74230981	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.316G>A; p.V106I; 17:74230901-74230901	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Missense
c.316G>A; p.V106I; 17:74230901-74230901	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Missense
c.1197C>T; p.A399A; 17:74252314-74252314	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.337G>A; p.E113K; 17:74230922-74230922	breast	carcinoma	Substitution - Missense
c.1083G>A; p.L361L; 17:74250324-74250324	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.337G>A; p.E113K; 17:74230922-74230922	large_intestine	adenoma	Substitution - Missense
c.523C>T; p.Q175*; 17:74237402-74237402	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.731+1G>C; p.?; 17:74243470-74243470	ovary	carcinoma; serous_carcinoma	Unknown
c.67G>T; p.V23F; 17:74213654-74213654	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.414G>T; p.L138L; 17:74230999-74230999	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1117-10C>T; p.?; 17:74252224-74252224	stomach	carcinoma; adenocarcinoma	Unknown
c.417T>A; p.V139V; 17:74237296-74237296	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.225G>A; p.R75R; 17:74222580-74222580	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.894G>T; p.L298L; 17:74249363-74249363	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.509C>T; p.T170I; 17:74237388-74237388	liver	carcinoma	Substitution - Missense
c.183C>G; p.I61M; 17:74222538-74222538	breast	carcinoma	Substitution - Missense
c.1322C>T; p.A441V; 17:74253143-74253143	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.849C>T; p.N283N; 17:74249055-74249055	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.419_420CC>TT; p.S140F; 17:74237298-74237299	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.491delG; p.G165fs*7; 17:74237370-74237370	lung	carcinoma; small_cell_carcinoma	Deletion - Frameshift
c.129+1G>A; p.?; 17:74213717-74213717	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Unknown
c.785C>T; p.A262V; 17:74244030-74244030	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1208T>C; p.F403S; 17:74252325-74252325	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.375G>T; p.L125F; 17:74230960-74230960	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1231C>T; p.P411S; 17:74252348-74252348	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.555C>G; p.L185L; 17:74237434-74237434	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1005C>T; p.P335P; 17:74250010-74250010	central_nervous_system; brain	glioma	Substitution - coding silent
c.1405C>T; p.P469S; 17:74253226-74253226	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.468G>T; p.R156R; 17:74237347-74237347	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1315C>T; p.R439C; 17:74253136-74253136	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1315C>T; p.R439C; 17:74253136-74253136	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1315C>T; p.R439C; 17:74253136-74253136	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1315C>T; p.R439C; 17:74253136-74253136	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.890A>G; p.Y297C; 17:74249359-74249359	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1315C>T; p.R439C; 17:74253136-74253136	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1539G>A; p.M513I; 17:74260143-74260143	urinary_tract; bladder	carcinoma	Substitution - Missense
c.924C>T; p.F308F; 17:74249393-74249393	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1539G>A; p.M513I; 17:74260143-74260143	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1188C>T; p.S396S; 17:74252305-74252305	skin	malignant_melanoma	Substitution - coding silent
c.1077C>T; p.H359H; 17:74250318-74250318	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.534G>T; p.A178A; 17:74237413-74237413	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.491G>T; p.R164L; 17:74237370-74237370	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1479C>T; p.R493R; 17:74253788-74253788	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1198G>T; p.A400S; 17:74252315-74252315	breast	carcinoma	Substitution - Missense
c.492G>A; p.R164R; 17:74237371-74237371	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.490C>T; p.R164W; 17:74237369-74237369	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.490C>T; p.R164W; 17:74237369-74237369	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1465G>A; p.G489S; 17:74253774-74253774	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1273G>A; p.D425N; 17:74253094-74253094	urinary_tract; bladder	carcinoma	Substitution - Missense
c.990G>T; p.L330L; 17:74249995-74249995	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1167G>T; p.L389F; 17:74252284-74252284	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.654G>T; p.L218L; 17:74243392-74243392	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.784G>A; p.A262T; 17:74244029-74244029	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.784G>A; p.A262T; 17:74244029-74244029	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1437C>T; p.S479S; 17:74253258-74253258	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1086C>T; p.T362T; 17:74250327-74250327	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.66C>T; p.H22H; 17:74213653-74213653	pancreas	carcinoma	Substitution - coding silent
c.415G>A; p.V139I; 17:74237294-74237294	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1304C>A; p.P435H; 17:74253125-74253125	breast	carcinoma	Substitution - Missense
c.495C>T; p.G165G; 17:74237374-74237374	central_nervous_system; brain	glioma	Substitution - coding silent
c.160G>A; p.V54I; 17:74222515-74222515	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.24C>T; p.Y8Y; 17:74213611-74213611	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.131C>T; p.S44L; 17:74222486-74222486	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.932C>T; p.T311I; 17:74249937-74249937	skin	malignant_melanoma	Substitution - Missense
c.867C>T; p.I289I; 17:74249073-74249073	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.598A>T; p.K200*; 17:74237477-74237477	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.709C>T; p.R237C; 17:74243447-74243447	pancreas	carcinoma; adenocarcinoma	Substitution - Missense
c.294C>T; p.L98L; 17:74222649-74222649	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1269C>A; p.D423E; 17:74253090-74253090	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.139T>C; p.F47L; 17:74222494-74222494	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.280G>T; p.V94L; 17:74222635-74222635	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.1477C>T; p.R493C; 17:74253786-74253786	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.853A>T; p.T285S; 17:74249059-74249059	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1399C>T; p.Q467*; 17:74253220-74253220	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.770G>T; p.W257L; 17:74244015-74244015	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1482C>T; p.Y494Y; 17:74253791-74253791	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.410C>A; p.A137D; 17:74230995-74230995	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1473C>A; p.N491K; 17:74253782-74253782	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.957T>C; p.L319L; 17:74249962-74249962	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.957T>C; p.L319L; 17:74249962-74249962	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.335G>T; p.S112I; 17:74230920-74230920	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.345C>T; p.N115N; 17:74230930-74230930	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1123C>T; p.L375L; 17:74252240-74252240	breast	carcinoma	Substitution - coding silent
c.1485G>C; p.E495D; 17:74253794-74253794	breast	carcinoma	Substitution - Missense
c.1047C>T; p.L349L; 17:74250288-74250288	skin	malignant_melanoma	Substitution - coding silent
c.1338G>A; p.P446P; 17:74253159-74253159	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.900C>T; p.C300C; 17:74249369-74249369	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1517C>T; p.P506L; 17:74253826-74253826	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1517C>T; p.P506L; 17:74253826-74253826	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1323G>A; p.A441A; 17:74253144-74253144	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.220C>T; p.R74W; 17:74222575-74222575	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.180C>T; p.L60L; 17:74222535-74222535	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1446-1G>A; p.?; 17:74253754-74253754	stomach	carcinoma; adenocarcinoma	Unknown
c.1434C>A; p.V478V; 17:74253255-74253255	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1051C>T; p.L351L; 17:74250292-74250292	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1296C>T; p.P432P; 17:74253117-74253117	skin	malignant_melanoma	Substitution - coding silent
c.275C>T; p.T92M; 17:74222630-74222630	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.234G>A; p.A78A; 17:74222589-74222589	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.793T>G; p.S265A; 17:74244038-74244038	thyroid	other; neoplasm	Substitution - Missense
c.1195G>A; p.A399T; 17:74252312-74252312	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.793T>G; p.S265A; 17:74244038-74244038	breast	carcinoma	Substitution - Missense
c.793T>G; p.S265A; 17:74244038-74244038	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.490C>A; p.R164R; 17:74237369-74237369	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.171C>G; p.G57G; 17:74222526-74222526	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1512C>T; p.S504S; 17:74253821-74253821	skin	malignant_melanoma	Substitution - coding silent
c.1293C>A; p.D431E; 17:74253114-74253114	pancreas	carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]