Entrez Gene

Basic Information
Gene ID	9211
Name	LGI1
Synonymous	leucine-rich, glioma inactivated 1;LGI1;leucine-rich, glioma inactivated 1
Definition	epitempin-1\|leucine-rich glioma-inactivated protein 1
Position	10q24
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1474C>T; p.L492F; 10:93797603-93797603	skin	malignant_melanoma	Substitution - Missense
c.193G>A; p.V65I; 10:93758337-93758337	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.259T>G; p.F87V; 10:93758803-93758803	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.658G>A; p.D220N; 10:93792897-93792897	skin	malignant_melanoma	Substitution - Missense
c.658G>A; p.D220N; 10:93792897-93792897	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1625A>T; p.K542M; 10:93797754-93797754	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.607C>T; p.P203S; 10:93792846-93792846	skin	malignant_melanoma	Substitution - Missense
c.1453A>C; p.N485H; 10:93797582-93797582	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1381G>A; p.G461R; 10:93797510-93797510	skin	malignant_melanoma	Substitution - Missense
c.474T>G; p.I158M; 10:93790141-93790141	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.709T>C; p.L237L; 10:93793221-93793221	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.446A>T; p.N149I; 10:93790113-93790113	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1017G>T; p.K339N; 10:93797146-93797146	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.967G>A; p.D323N; 10:93797096-93797096	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1011A>T; p.T337T; 10:93797140-93797140	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - coding silent
c.432G>T; p.L144F; 10:93790099-93790099	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.845C>T; p.S282F; 10:93796974-93796974	skin	malignant_melanoma	Substitution - Missense
c.218C>G; p.S73C; 10:93758762-93758762	breast	carcinoma	Substitution - Missense
c.1546G>A; p.E516K; 10:93797675-93797675	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.419C>T; p.S140L; 10:93777605-93777605	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.673+4A>T; p.?; 10:93792916-93792916	liver	carcinoma	Unknown
c.1206T>C; p.S402S; 10:93797335-93797335	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.673+4A>T; p.?; 10:93792916-93792916	liver	carcinoma	Unknown
c.1305G>T; p.V435V; 10:93797434-93797434	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1391C>T; p.S464L; 10:93797520-93797520	skin	malignant_melanoma	Substitution - Missense
c.644C>T; p.S215F; 10:93792883-93792883	skin	malignant_melanoma	Substitution - Missense
c.63T>C; p.Y21Y; 10:93758207-93758207	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1391C>T; p.S464L; 10:93797520-93797520	prostate	adenoma	Substitution - Missense
c.1073C>T; p.T358I; 10:93797202-93797202	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1070C>T; p.T357I; 10:93797199-93797199	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1474C>A; p.L492I; 10:93797603-93797603	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.626G>A; p.R209H; 10:93792865-93792865	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.310G>T; p.D104Y; 10:93777401-93777401	breast	carcinoma	Substitution - Missense
c.703C>T; p.Q235*; 10:93793215-93793215	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.990delA; p.K331fs*55; 10:93797119-93797119	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1438C>A; p.Q480K; 10:93797567-93797567	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.504G>A; p.V168V; 10:93792743-93792743	skin	malignant_melanoma	Substitution - coding silent
c.637A>G; p.S213G; 10:93792876-93792876	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.127C>A; p.P43T; 10:93758271-93758271	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.860A>T; p.K287M; 10:93796989-93796989	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1112A>C; p.Q371P; 10:93797241-93797241	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1318G>T; p.V440L; 10:93797447-93797447	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1134G>T; p.R378S; 10:93797263-93797263	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1582G>A; p.V528M; 10:93797711-93797711	breast	carcinoma	Substitution - Missense
c.1587C>T; p.S529S; 10:93797716-93797716	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.225G>A; p.V75V; 10:93758769-93758769	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.499A>C; p.N167H; 10:93790166-93790166	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.13A>T; p.R5*; 10:93758157-93758157	skin	malignant_melanoma	Substitution - Nonsense
c.48_49insA; p.R18fs*16; 10:93758192-93758193	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1601A>C; p.N534T; 10:93797730-93797730	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.224T>C; p.V75A; 10:93758768-93758768	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1116C>A; p.S372S; 10:93797245-93797245	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1485T>A; p.D495E; 10:93797614-93797614	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1090G>A; p.G364R; 10:93797219-93797219	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.577G>A; p.A193T; 10:93792816-93792816	central_nervous_system; midbrain	glioma; oligoastrocytoma_Grade_III	Substitution - Missense
c.1291G>A; p.D431N; 10:93797420-93797420	skin	malignant_melanoma	Substitution - Missense
c.67C>A; p.L23I; 10:93758211-93758211	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.275C>T; p.S92L; 10:93758819-93758819	skin	malignant_melanoma	Substitution - Missense
c.1269A>T; p.Q423H; 10:93797398-93797398	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1365C>T; p.S455S; 10:93797494-93797494	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.390T>A; p.I130I; 10:93777576-93777576	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1402A>G; p.I468V; 10:93797531-93797531	central_nervous_system; brain	glioma	Substitution - Missense
c.226A>T; p.R76*; 10:93758770-93758770	pancreas	carcinoma	Substitution - Nonsense
c.1055C>T; p.S352L; 10:93797184-93797184	skin	malignant_melanoma	Substitution - Missense
c.790G>C; p.E264Q; 10:93793302-93793302	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.441A>G; p.A147A; 10:93790108-93790108	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.967G>C; p.D323H; 10:93797096-93797096	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1405C>G; p.Q469E; 10:93797534-93797534	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1512G>A; p.W504*; 10:93797641-93797641	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.83C>T; p.A28V; 10:93758227-93758227	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1197A>T; p.L399F; 10:93797326-93797326	breast	carcinoma	Substitution - Missense
c.555G>A; p.V185V; 10:93792794-93792794	skin	malignant_melanoma	Substitution - coding silent
c.795G>A; p.W265*; 10:93793307-93793307	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.255G>A; p.G85G; 10:93758799-93758799	skin; back	malignant_melanoma	Substitution - coding silent
c.742G>T; p.E248*; 10:93793254-93793254	skin	malignant_melanoma	Substitution - Nonsense
c.462C>T; p.L154L; 10:93790129-93790129	breast	carcinoma	Substitution - coding silent
c.1123G>A; p.A375T; 10:93797252-93797252	breast	carcinoma	Substitution - Missense
c.498A>T; p.T166T; 10:93790165-93790165	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1095C>T; p.N365N; 10:93797224-93797224	thyroid	carcinoma	Substitution - coding silent
c.1625A>G; p.K542R; 10:93797754-93797754	liver	carcinoma	Substitution - Missense
c.511A>G; p.R171G; 10:93792750-93792750	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1288G>T; p.E430*; 10:93797417-93797417	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1625A>G; p.K542R; 10:93797754-93797754	liver	carcinoma	Substitution - Missense
c.931C>T; p.R311*; 10:93797060-93797060	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.84G>A; p.A28A; 10:93758228-93758228	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.227G>A; p.R76K; 10:93758771-93758771	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.605_606insC; p.E205fs*9; 10:93792844-93792845	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.135G>A; p.V45V; 10:93758279-93758279	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.647C>T; p.S216L; 10:93792886-93792886	skin	malignant_melanoma	Substitution - Missense
c.647C>T; p.S216L; 10:93792886-93792886	skin	malignant_melanoma	Substitution - Missense
c.1299C>T; p.Y433Y; 10:93797428-93797428	pancreas	carcinoma	Substitution - coding silent
c.549G>T; p.W183C; 10:93792788-93792788	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.55A>G; p.I19V; 10:93758199-93758199	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.55A>G; p.I19V; 10:93758199-93758199	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1085G>A; p.W362*; 10:93797214-93797214	skin	malignant_melanoma	Substitution - Nonsense
c.1521G>T; p.E507D; 10:93797650-93797650	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1490C>T; p.S497F; 10:93797619-93797619	skin	malignant_melanoma	Substitution - Missense
c.1490C>T; p.S497F; 10:93797619-93797619	skin	malignant_melanoma	Substitution - Missense
c.1421G>A; p.R474Q; 10:93797550-93797550	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.611C>G; p.P204R; 10:93792850-93792850	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1484A>T; p.D495V; 10:93797613-93797613	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1229T>C; p.I410T; 10:93797358-93797358	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1376A>C; p.K459T; 10:93797505-93797505	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1116C>T; p.S372S; 10:93797245-93797245	skin	malignant_melanoma	Substitution - coding silent
c.804G>A; p.V268V; 10:93793316-93793316	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.477C>T; p.F159F; 10:93790144-93790144	skin	malignant_melanoma	Substitution - coding silent
c.1013T>A; p.F338Y; 10:93797142-93797142	central_nervous_system; brain	glioma; astrocytoma_Grade_III	Substitution - Missense
c.805G>A; p.E269K; 10:93793317-93793317	skin	malignant_melanoma	Substitution - Missense
c.1096G>A; p.G366R; 10:93797225-93797225	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1427C>G; p.S476C; 10:93797556-93797556	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1220G>A; p.R407H; 10:93797349-93797349	central_nervous_system; brain	glioma	Substitution - Missense
c.1172C>A; p.P391H; 10:93797301-93797301	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.534C>A; p.D178E; 10:93792773-93792773	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.699_700insA; p.Y234fs*14; 10:93793211-93793212	lung	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1220G>A; p.R407H; 10:93797349-93797349	breast	carcinoma	Substitution - Missense
c.1668C>A; p.S556R; 10:93797797-93797797	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.764C>A; p.P255H; 10:93793276-93793276	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.185C>A; p.P62Q; 10:93758329-93758329	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1598G>A; p.R533H; 10:93797727-93797727	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1598G>A; p.R533H; 10:93797727-93797727	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1598G>A; p.R533H; 10:93797727-93797727	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1021G>A; p.E341K; 10:93797150-93797150	skin	malignant_melanoma	Substitution - Missense
c.1424G>A; p.G475E; 10:93797553-93797553	skin	malignant_melanoma	Substitution - Missense
c.1424G>A; p.G475E; 10:93797553-93797553	skin	malignant_melanoma	Substitution - Missense
c.1506T>C; p.Y502Y; 10:93797635-93797635	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1214_1215CC>TT; p.S405F; 10:93797343-93797344	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1407G>T; p.Q469H; 10:93797536-93797536	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1407G>T; p.Q469H; 10:93797536-93797536	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.254G>A; p.G85E; 10:93758798-93758798	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1409G>A; p.R470K; 10:93797538-93797538	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.328G>A; p.A110T; 10:93777419-93777419	urinary_tract; bladder	carcinoma	Substitution - Missense
c.328G>A; p.A110T; 10:93777419-93777419	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.963C>T; p.I321I; 10:93797092-93797092	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.963C>T; p.I321I; 10:93797092-93797092	skin	malignant_melanoma	Substitution - coding silent
c.151G>T; p.D51Y; 10:93758295-93758295	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.791A>G; p.E264G; 10:93793303-93793303	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1392G>A; p.S464S; 10:93797521-93797521	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1392G>A; p.S464S; 10:93797521-93797521	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1156G>T; p.E386*; 10:93797285-93797285	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.927T>C; p.Y309Y; 10:93797056-93797056	liver	carcinoma	Substitution - coding silent
c.405C>T; p.F135F; 10:93777591-93777591	skin	malignant_melanoma	Substitution - coding silent
c.1201C>A; p.L401M; 10:93797330-93797330	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.932G>A; p.R311Q; 10:93797061-93797061	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.144T>A; p.C48*; 10:93758288-93758288	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.792A>G; p.E264E; 10:93793304-93793304	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent

COSMIC somatic mutation [Top]