Entrez Gene

Basic Information
Gene ID	8525
Name	DGKZ
Synonymous	diacylglycerol kinase, zeta;DGKZ;diacylglycerol kinase, zeta
Definition	DAG kinase zeta\|diacylglycerol kinase zeta\|diacylglycerol kinase, zeta 104kDa\|diglyceride kinase zeta
Position	11p11.2
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.378C>G; p.F126L; 11:46367708-46367708	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.378C>G; p.F126L; 11:46367708-46367708	urinary_tract; bladder	carcinoma	Substitution - Missense
c.797G>A; p.R266Q; 11:46371593-46371593	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1971G>A; p.V657V; 11:46375863-46375863	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2525C>T; p.T842M; 11:46379049-46379049	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.275C>T; p.P92L; 11:46367353-46367353	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1467G>T; p.E489D; 11:46374412-46374412	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.711C>T; p.C237C; 11:46371507-46371507	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1763C>T; p.A588V; 11:46375436-46375436	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.539A>G; p.N180S; 11:46369540-46369540	liver	carcinoma	Substitution - Missense
c.2539G>A; p.A847T; 11:46379063-46379063	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2051A>T; p.K684M; 11:46375943-46375943	pancreas	carcinoma	Substitution - Missense
c.305G>A; p.S102N; 11:46367383-46367383	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2687A>G; p.E896G; 11:46379534-46379534	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1776C>T; p.G592G; 11:46375449-46375449	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2049C>T; p.L683L; 11:46375941-46375941	breast	carcinoma	Substitution - coding silent
c.624C>T; p.F208F; 11:46371318-46371318	skin	malignant_melanoma	Substitution - coding silent
c.2510A>G; p.D837G; 11:46379034-46379034	skin	malignant_melanoma	Substitution - Missense
c.703G>A; p.V235M; 11:46371499-46371499	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.338G>T; p.G113V; 11:46367668-46367668	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1443C>A; p.H481Q; 11:46374225-46374225	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.729C>T; p.I243I; 11:46371525-46371525	skin	malignant_melanoma	Substitution - coding silent
c.1935G>T; p.R645R; 11:46375608-46375608	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2390+5G>T; p.?; 11:46377217-46377217	liver	carcinoma	Unknown
c.1935G>T; p.R645R; 11:46375608-46375608	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.367T>G; p.S123A; 11:46367697-46367697	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1035G>A; p.L345L; 11:46372487-46372487	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.991C>T; p.Q331*; 11:46372443-46372443	skin; acral	malignant_melanoma	Substitution - Nonsense
c.440G>A; p.C147Y; 11:46368027-46368027	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2735G>A; p.R912Q; 11:46379844-46379844	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.252C>T; p.P84P; 11:46367330-46367330	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2389C>T; p.R797W; 11:46377211-46377211	skin	malignant_melanoma	Substitution - Missense
c.2407G>T; p.A803S; 11:46378214-46378214	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.723G>A; p.Q241Q; 11:46371519-46371519	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1072C>G; p.R358G; 11:46372630-46372630	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2362C>T; p.P788S; 11:46377184-46377184	skin	malignant_melanoma	Substitution - Missense
c.2052G>T; p.K684N; 11:46375944-46375944	urinary_tract; bladder	carcinoma	Substitution - Missense
c.541G>A; p.V181I; 11:46369542-46369542	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.510G>T; p.K170N; 11:46369511-46369511	kidney	other; neoplasm	Substitution - Missense
c.2288A>T; p.E763V; 11:46377110-46377110	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1504G>A; p.A502T; 11:46374449-46374449	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.875C>T; p.P292L; 11:46371771-46371771	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2466+1G>A; p.?; 11:46378501-46378501	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.1425C>T; p.H475H; 11:46374207-46374207	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.520C>T; p.R174C; 11:46369521-46369521	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1090C>T; p.R364W; 11:46372648-46372648	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.258G>A; p.P86P; 11:46367336-46367336	prostate	carcinoma	Substitution - coding silent
c.2033A>G; p.Y678C; 11:46375925-46375925	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.942G>T; p.L314L; 11:46372137-46372137	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.278G>T; p.C93F; 11:46367356-46367356	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2125G>C; p.E709Q; 11:46376131-46376131	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.410G>A; p.R137K; 11:46367740-46367740	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1576G>A; p.D526N; 11:46374769-46374769	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1542C>T; p.S514S; 11:46374636-46374636	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1105G>A; p.G369R; 11:46372663-46372663	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2611G>A; p.V871M; 11:46379226-46379226	skin	malignant_melanoma	Substitution - Missense
c.1920G>A; p.Q640Q; 11:46375593-46375593	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1920G>A; p.Q640Q; 11:46375593-46375593	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1862G>A; p.C621Y; 11:46375535-46375535	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2281C>G; p.Q761E; 11:46377103-46377103	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.698G>A; p.S233N; 11:46371494-46371494	skin	malignant_melanoma	Substitution - Missense
c.388G>A; p.G130R; 11:46367718-46367718	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.263C>T; p.T88I; 11:46367341-46367341	skin	malignant_melanoma	Substitution - Missense
c.927C>T; p.L309L; 11:46372122-46372122	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.224_225CC>TT; p.T75I; 11:46367302-46367303	skin	malignant_melanoma	Substitution - Missense
c.749G>T; p.G250V; 11:46371545-46371545	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.828_829insC; p.K277fs*17; 11:46371724-46371725	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.779C>T; p.T260I; 11:46371575-46371575	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1426G>A; p.V476I; 11:46374208-46374208	bone; femur	chondrosarcoma	Substitution - Missense
c.355G>C; p.E119Q; 11:46367685-46367685	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2238C>T; p.I746I; 11:46376552-46376552	pancreas	NS	Substitution - coding silent
c.2238C>T; p.I746I; 11:46376552-46376552	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.887G>A; p.R296H; 11:46372082-46372082	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.292C>T; p.R98W; 11:46367370-46367370	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1026C>G; p.V342V; 11:46372478-46372478	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.880-1G>A; p.?; 11:46372074-46372074	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1136C>T; p.S379F; 11:46372787-46372787	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2384C>T; p.T795M; 11:46377206-46377206	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.662C>T; p.A221V; 11:46371356-46371356	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2235G>A; p.R745R; 11:46376549-46376549	breast	carcinoma	Substitution - coding silent
c.1852G>A; p.G618S; 11:46375525-46375525	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.161C>T; p.P54L; 11:46333436-46333436	pancreas	carcinoma	Substitution - Missense
c.1688A>G; p.H563R; 11:46374975-46374975	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.370G>A; p.G124R; 11:46367700-46367700	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2278G>A; p.A760T; 11:46377100-46377100	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2364C>T; p.P788P; 11:46377186-46377186	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2146G>A; p.D716N; 11:46376334-46376334	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2683G>A; p.V895M; 11:46379530-46379530	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.456T>C; p.I152I; 11:46368043-46368043	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1093A>G; p.I365V; 11:46372651-46372651	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2225G>A; p.R742H; 11:46376539-46376539	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.562C>T; p.R188W; 11:46369953-46369953	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.1657G>A; p.G553S; 11:46374944-46374944	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1429A>G; p.T477A; 11:46374211-46374211	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.828G>GC; p.K277fs*17; 11:46371724-46371724	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Complex - frameshift
c.2512G>T; p.E838*; 11:46379036-46379036	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2739G>T; p.Q913H; 11:46379848-46379848	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.430C>A; p.R144R; 11:46368017-46368017	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1453+9C>T; p.?; 11:46374244-46374244	oesophagus; lower_third	carcinoma; adenocarcinoma	Unknown
c.233G>C; p.G78A; 11:46367311-46367311	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2187C>T; p.S729S; 11:46376375-46376375	skin	malignant_melanoma	Substitution - coding silent
c.674C>T; p.S225L; 11:46371368-46371368	skin	malignant_melanoma	Substitution - Missense
c.2711C>G; p.T904R; 11:46379558-46379558	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.909G>A; p.R303R; 11:46372104-46372104	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2277C>T; p.I759I; 11:46377099-46377099	skin	malignant_melanoma	Substitution - coding silent
c.2526G>A; p.T842T; 11:46379050-46379050	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1070A>G; p.Y357C; 11:46372628-46372628	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.730G>A; p.E244K; 11:46371526-46371526	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2182C>A; p.L728M; 11:46376370-46376370	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.796C>T; p.R266W; 11:46371592-46371592	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1707G>T; p.Q569H; 11:46374994-46374994	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2000G>A; p.R667H; 11:46375892-46375892	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; chronic_myeloid_leukaemia	Substitution - Missense
c.2569C>T; p.R857C; 11:46379093-46379093	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.858G>A; p.K286K; 11:46371754-46371754	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2445C>T; p.A815A; 11:46378479-46378479	skin	malignant_melanoma	Substitution - coding silent
c.905T>C; p.I302T; 11:46372100-46372100	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1877C>T; p.S626L; 11:46375550-46375550	liver	carcinoma	Substitution - Missense
c.468G>A; p.T156T; 11:46368055-46368055	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.412A>T; p.M138L; 11:46367742-46367742	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.412A>T; p.M138L; 11:46367742-46367742	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.2533C>T; p.H845Y; 11:46379057-46379057	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1392C>G; p.F464L; 11:46374174-46374174	central_nervous_system; brain	glioma; astrocytoma_Grade_III	Substitution - Missense
c.594C>T; p.D198D; 11:46369985-46369985	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1897C>T; p.R633C; 11:46375570-46375570	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.543C>T; p.V181V; 11:46369544-46369544	skin	malignant_melanoma	Substitution - coding silent
c.252C>A; p.P84P; 11:46367330-46367330	skin	malignant_melanoma	Substitution - coding silent
c.156_157insC; p.V55fs*116; 11:46333431-46333432	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift

COSMIC somatic mutation [Top]