Entrez Gene

Basic Information
Gene ID	84171
Name	LOXL4
Synonymous	lysyl oxidase-like 4;LOXL4;lysyl oxidase-like 4
Definition	lysyl oxidase homolog 4\|lysyl oxidase related C\|lysyl oxidase-like 4 pseudogene\|lysyl oxidase-like protein 4\|lysyl oxidase-related protein C
Position	10q24
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.954_955GG>AT; p.V319L; 10:98258131-98258132	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1573G>A; p.G525R; 10:98255595-98255595	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1092C>A; p.A364A; 10:98257994-98257994	liver	carcinoma	Substitution - coding silent
c.1092C>A; p.A364A; 10:98257994-98257994	liver	carcinoma	Substitution - coding silent
c.2088+7C>A; p.?; 10:98251559-98251559	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.540G>A; p.E180E; 10:98261044-98261044	skin	malignant_melanoma	Substitution - coding silent
c.843C>T; p.H281H; 10:98259087-98259087	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.688G>A; p.D230N; 10:98259404-98259404	skin	malignant_melanoma	Substitution - Missense
c.843C>T; p.H281H; 10:98259087-98259087	thyroid	other; neoplasm	Substitution - coding silent
c.843C>T; p.H281H; 10:98259087-98259087	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1280G>A; p.R427H; 10:98256928-98256928	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.109C>A; p.P37T; 10:98262911-98262911	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.1354G>A; p.E452K; 10:98256854-98256854	skin	malignant_melanoma	Substitution - Missense
c.1124T>C; p.L375P; 10:98257786-98257786	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.793G>T; p.V265L; 10:98259137-98259137	thyroid	other; neoplasm	Substitution - Missense
c.554G>A; p.G185D; 10:98261030-98261030	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.61C>G; p.P21A; 10:98262959-98262959	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1734C>A; p.Y578*; 10:98253654-98253654	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1790G>A; p.R597H; 10:98253598-98253598	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1789C>T; p.R597C; 10:98253599-98253599	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1294G>A; p.G432R; 10:98256914-98256914	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1789C>T; p.R597C; 10:98253599-98253599	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2198C>T; p.T733I; 10:98251067-98251067	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.660C>A; p.Y220*; 10:98260924-98260924	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1105+7G>C; p.?; 10:98257974-98257974	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.2109T>G; p.Y703*; 10:98251156-98251156	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Nonsense
c.2101C>T; p.P701S; 10:98251164-98251164	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.332A>G; p.Q111R; 10:98262159-98262159	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1632G>A; p.E544E; 10:98253756-98253756	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.946G>A; p.G316R; 10:98258140-98258140	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.946G>A; p.G316R; 10:98258140-98258140	skin	malignant_melanoma	Substitution - Missense
c.1533G>A; p.G511G; 10:98255635-98255635	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2046G>T; p.W682C; 10:98251608-98251608	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1144_1145GG>AA; p.G382K; 10:98257765-98257766	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1527G>A; p.R509R; 10:98255641-98255641	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1003G>A; p.V335I; 10:98258083-98258083	skin	malignant_melanoma	Substitution - Missense
c.1706C>A; p.A569E; 10:98253682-98253682	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.961G>A; p.E321K; 10:98258125-98258125	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1680C>T; p.H560H; 10:98253708-98253708	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.169G>A; p.V57M; 10:98262851-98262851	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1863C>A; p.T621T; 10:98252441-98252441	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1075G>C; p.E359Q; 10:98258011-98258011	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.728_729CC>AT; p.S243Y; 10:98259201-98259202	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.845C>T; p.A282V; 10:98259085-98259085	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1848C>T; p.S616S; 10:98252456-98252456	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2096T>C; p.V699A; 10:98251169-98251169	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1848C>T; p.S616S; 10:98252456-98252456	breast	carcinoma; ductal_carcinoma	Substitution - coding silent
c.1945C>T; p.P649S; 10:98252359-98252359	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.381C>T; p.D127D; 10:98262110-98262110	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1884C>T; p.L628L; 10:98252420-98252420	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.381C>T; p.D127D; 10:98262110-98262110	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1706C>T; p.A569V; 10:98253682-98253682	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.161G>A; p.W54*; 10:98262859-98262859	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.228C>T; p.F76F; 10:98262792-98262792	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.461G>A; p.R154Q; 10:98261123-98261123	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.563G>A; p.R188Q; 10:98261021-98261021	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.472G>A; p.E158K; 10:98261112-98261112	skin	malignant_melanoma	Substitution - Missense
c.591G>C; p.M197I; 10:98260993-98260993	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.421C>A; p.L141I; 10:98262070-98262070	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1042G>A; p.V348M; 10:98258044-98258044	skin; sole	malignant_melanoma; acral_lentiginous	Substitution - Missense
c.1279C>T; p.R427C; 10:98256929-98256929	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2023C>T; p.R675W; 10:98251631-98251631	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1214A>C; p.D405A; 10:98257696-98257696	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1214A>C; p.D405A; 10:98257696-98257696	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1214A>C; p.D405A; 10:98257696-98257696	thyroid	other; neoplasm	Substitution - Missense
c.1214A>C; p.D405A; 10:98257696-98257696	thyroid	other; neoplasm	Substitution - Missense
c.1214A>C; p.D405A; 10:98257696-98257696	thyroid	other; neoplasm	Substitution - Missense
c.188C>T; p.A63V; 10:98262832-98262832	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.605T>C; p.V202A; 10:98260979-98260979	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1476G>T; p.M492I; 10:98255692-98255692	breast	carcinoma	Substitution - Missense
c.2070delC; p.N692fs*6; 10:98251584-98251584	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.435C>T; p.V145V; 10:98262056-98262056	breast	carcinoma	Substitution - coding silent
c.6G>A; p.A2A; 10:98263014-98263014	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.6G>A; p.A2A; 10:98263014-98263014	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1457G>T; p.R486M; 10:98255711-98255711	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1261G>A; p.V421M; 10:98256947-98256947	skin; trunk	malignant_melanoma	Substitution - Missense
c.1960C>T; p.R654W; 10:98251694-98251694	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.805C>T; p.R269W; 10:98259125-98259125	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1681G>A; p.E561K; 10:98253707-98253707	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1172C>A; p.P391H; 10:98257738-98257738	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1325G>A; p.G442E; 10:98256883-98256883	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1917C>T; p.A639A; 10:98252387-98252387	central_nervous_system; brain	glioma	Substitution - coding silent
c.1143G>A; p.R381R; 10:98257767-98257767	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1144G>A; p.G382R; 10:98257766-98257766	skin	malignant_melanoma	Substitution - Missense
c.1143G>A; p.R381R; 10:98257767-98257767	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1531G>C; p.G511R; 10:98255637-98255637	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1486C>T; p.R496C; 10:98255682-98255682	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1486C>T; p.R496C; 10:98255682-98255682	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.403C>T; p.R135W; 10:98262088-98262088	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2167G>A; p.G723R; 10:98251098-98251098	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.935G>A; p.R312H; 10:98258151-98258151	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1212T>C; p.N404N; 10:98257698-98257698	breast	carcinoma	Substitution - coding silent
c.1443G>C; p.W481C; 10:98255725-98255725	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1728C>T; p.Y576Y; 10:98253660-98253660	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1896G>T; p.K632N; 10:98252408-98252408	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1087G>A; p.G363R; 10:98257999-98257999	skin	malignant_melanoma	Substitution - Missense
c.1548C>T; p.S516S; 10:98255620-98255620	skin	malignant_melanoma	Substitution - coding silent
c.1390C>T; p.R464*; 10:98256818-98256818	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1195G>A; p.G399S; 10:98257715-98257715	skin	malignant_melanoma	Substitution - Missense
c.913T>C; p.W305R; 10:98259017-98259017	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.457G>A; p.G153S; 10:98261127-98261127	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1846A>G; p.S616G; 10:98252458-98252458	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1200C>T; p.C400C; 10:98257710-98257710	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.946_947GG>AA; p.G316K; 10:98258139-98258140	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.878G>A; p.R293H; 10:98259052-98259052	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1816G>T; p.V606F; 10:98253572-98253572	pancreas	carcinoma	Substitution - Missense
c.1860C>T; p.F620F; 10:98252444-98252444	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.2248C>T; p.R750C; 10:98248944-98248944	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.301C>T; p.R101C; 10:98262190-98262190	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.301C>T; p.R101C; 10:98262190-98262190	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1561C>T; p.R521C; 10:98255607-98255607	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1034C>T; p.A345V; 10:98258052-98258052	oesophagus; upper_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1561C>T; p.R521C; 10:98255607-98255607	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2033T>C; p.I678T; 10:98251621-98251621	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1778G>A; p.R593Q; 10:98253610-98253610	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1580C>T; p.S527F; 10:98255588-98255588	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1580C>T; p.S527F; 10:98255588-98255588	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1747C>A; p.R583S; 10:98253641-98253641	breast	carcinoma	Substitution - Missense
c.716C>T; p.T239M; 10:98259214-98259214	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2082C>T; p.I694I; 10:98251572-98251572	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1049G>A; p.R350H; 10:98258037-98258037	stomach	adenocarcinoma	Substitution - Missense
c.1191G>A; p.Q397Q; 10:98257719-98257719	skin	malignant_melanoma	Substitution - coding silent
c.1739G>A; p.R580H; 10:98253649-98253649	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1985G>C; p.G662A; 10:98251669-98251669	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1100G>A; p.G367D; 10:98257986-98257986	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1747C>T; p.R583C; 10:98253641-98253641	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.692C>T; p.P231L; 10:98259400-98259400	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.247G>A; p.A83T; 10:98262773-98262773	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.487C>T; p.P163S; 10:98261097-98261097	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.369T>C; p.S123S; 10:98262122-98262122	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.805C>G; p.R269G; 10:98259125-98259125	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1707G>A; p.A569A; 10:98253681-98253681	thyroid	other; neoplasm	Substitution - coding silent
c.927G>A; p.P309P; 10:98258159-98258159	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1644G>A; p.L548L; 10:98253744-98253744	skin	malignant_melanoma	Substitution - coding silent
c.2262C>A; p.N754K; 10:98248930-98248930	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1656G>A; p.P552P; 10:98253732-98253732	central_nervous_system; brain	glioma	Substitution - coding silent
c.2173C>T; p.R725W; 10:98251092-98251092	skin; upper_leg	malignant_melanoma	Substitution - Missense
c.1096C>T; p.L366L; 10:98257990-98257990	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1348T>C; p.C450R; 10:98256860-98256860	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1040T>C; p.V347A; 10:98258046-98258046	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1226G>C; p.R409T; 10:98257684-98257684	breast	carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]