Entrez Gene

Basic Information
Gene ID	8404
Name	SPARCL1
Synonymous	SPARC-like 1 (hevin);SPARCL1;SPARC-like 1 (hevin)
Definition	SPARC-like protein 1\|high endothelial venule protein\|proliferation-inducing protein 33
Position	4q22.1
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.20delT; p.F7fs*29; 4:87499555-87499555	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.20delT; p.F7fs*29; 4:87499555-87499555	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.20delT; p.F7fs*29; 4:87499555-87499555	lung	carcinoma; small_cell_carcinoma	Deletion - Frameshift
c.1550A>G; p.D517G; 4:87482542-87482542	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.888A>G; p.Q296Q; 4:87493912-87493912	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.743A>G; p.D248G; 4:87494057-87494057	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.468T>C; p.S156S; 4:87494332-87494332	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.904C>A; p.L302I; 4:87493896-87493896	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.995C>G; p.P332R; 4:87493805-87493805	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1157A>G; p.Q386R; 4:87493643-87493643	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.882G>T; p.Q294H; 4:87493918-87493918	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.644A>C; p.N215T; 4:87494156-87494156	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1762T>A; p.Y588N; 4:87480427-87480427	kidney	other; neoplasm	Substitution - Missense
c.1688A>T; p.D563V; 4:87480501-87480501	liver	carcinoma	Substitution - Missense
c.1688A>T; p.D563V; 4:87480501-87480501	liver	carcinoma	Substitution - Missense
c.21C>T; p.F7F; 4:87499554-87499554	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.719C>G; p.S240C; 4:87494081-87494081	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.918C>A; p.S306R; 4:87493882-87493882	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1434C>T; p.T478T; 4:87490370-87490370	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1550A>T; p.D517V; 4:87482542-87482542	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.419T>C; p.F140S; 4:87494381-87494381	breast	carcinoma	Substitution - Missense
c.676A>G; p.R226G; 4:87494124-87494124	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1305C>A; p.S435R; 4:87490865-87490865	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.561T>A; p.D187E; 4:87494239-87494239	thyroid	carcinoma	Substitution - Missense
c.1323C>T; p.G441G; 4:87490847-87490847	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1546A>G; p.T516A; 4:87482546-87482546	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1180G>A; p.E394K; 4:87493620-87493620	skin	malignant_melanoma	Substitution - Missense
c.1078G>A; p.D360N; 4:87493722-87493722	breast	carcinoma	Substitution - Missense
c.1418G>C; p.G473A; 4:87490386-87490386	breast	carcinoma	Substitution - Missense
c.112G>A; p.D38N; 4:87495070-87495070	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.176C>T; p.S59F; 4:87495006-87495006	breast	carcinoma	Substitution - Missense
c.880C>T; p.Q294*; 4:87493920-87493920	breast	carcinoma	Substitution - Nonsense
c.816C>A; p.S272S; 4:87493984-87493984	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1984C>G; p.L662V; 4:87473786-87473786	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.634G>A; p.G212S; 4:87494166-87494166	liver	carcinoma	Substitution - Missense
c.1881_1892del12; p.T628_F631delTRFF; 4:87479504-87479515	skin	malignant_melanoma	Deletion - In frame
c.1061G>A; p.R354K; 4:87493739-87493739	skin	malignant_melanoma	Substitution - Missense
c.1499A>G; p.Q500R; 4:87490305-87490305	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1349G>A; p.G450E; 4:87490821-87490821	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1890C>A; p.F630L; 4:87479506-87479506	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1337C>T; p.A446V; 4:87490833-87490833	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.823G>T; p.E275*; 4:87493977-87493977	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.823G>T; p.E275*; 4:87493977-87493977	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Nonsense
c.304G>A; p.D102N; 4:87494496-87494496	skin	malignant_melanoma	Substitution - Missense
c.393G>T; p.E131D; 4:87494407-87494407	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.74C>G; p.S25C; 4:87495108-87495108	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1482G>A; p.G494G; 4:87490322-87490322	skin	malignant_melanoma	Substitution - coding silent
c.1697G>A; p.R566K; 4:87480492-87480492	skin; trunk	malignant_melanoma; nodular	Substitution - Missense
c.963C>T; p.L321L; 4:87493837-87493837	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.633T>C; p.V211V; 4:87494167-87494167	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.934G>A; p.E312K; 4:87493866-87493866	skin	malignant_melanoma	Substitution - Missense
c.1387C>A; p.P463T; 4:87490783-87490783	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1035C>T; p.G345G; 4:87493765-87493765	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1618G>T; p.E540*; 4:87482474-87482474	ovary	carcinoma; clear_cell_carcinoma	Substitution - Nonsense
c.1852G>A; p.A618T; 4:87479544-87479544	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1255A>G; p.T419A; 4:87491654-87491654	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1915G>A; p.D639N; 4:87479481-87479481	skin	malignant_melanoma	Substitution - Missense
c.907G>A; p.E303K; 4:87493893-87493893	skin	malignant_melanoma	Substitution - Missense
c.1529A>G; p.K510R; 4:87490275-87490275	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1049C>A; p.T350N; 4:87493751-87493751	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.146C>A; p.A49D; 4:87495036-87495036	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.146C>A; p.A49D; 4:87495036-87495036	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.146C>A; p.A49D; 4:87495036-87495036	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.146C>A; p.A49D; 4:87495036-87495036	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.146C>A; p.A49D; 4:87495036-87495036	kidney	other; neoplasm	Substitution - Missense
c.1116G>A; p.E372E; 4:87493684-87493684	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1116G>A; p.E372E; 4:87493684-87493684	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.845C>T; p.S282L; 4:87493955-87493955	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.845C>T; p.S282L; 4:87493955-87493955	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.845C>T; p.S282L; 4:87493955-87493955	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.667G>C; p.E223Q; 4:87494133-87494133	breast	carcinoma	Substitution - Missense
c.1881A>G; p.I627M; 4:87479515-87479515	skin	malignant_melanoma	Substitution - Missense
c.749C>T; p.P250L; 4:87494051-87494051	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.415G>A; p.D139N; 4:87494385-87494385	skin	malignant_melanoma	Substitution - Missense
c.879G>C; p.W293C; 4:87493921-87493921	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.884G>T; p.S295I; 4:87493916-87493916	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1975G>A; p.D659N; 4:87473795-87473795	skin	malignant_melanoma	Substitution - Missense
c.529A>G; p.R177G; 4:87494271-87494271	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.529A>G; p.R177G; 4:87494271-87494271	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1075G>C; p.D359H; 4:87493725-87493725	urinary_tract; bladder	carcinoma	Substitution - Missense
c.116A>G; p.N39S; 4:87495066-87495066	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1075G>C; p.D359H; 4:87493725-87493725	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.828G>A; p.M276I; 4:87493972-87493972	skin	malignant_melanoma	Substitution - Missense
c.1024G>A; p.D342N; 4:87493776-87493776	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1024G>A; p.D342N; 4:87493776-87493776	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.431G>A; p.G144D; 4:87494369-87494369	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.627T>G; p.G209G; 4:87494173-87494173	breast	carcinoma	Substitution - coding silent
c.382G>A; p.E128K; 4:87494418-87494418	skin; mucosal	malignant_melanoma	Substitution - Missense
c.1674G>A; p.K558K; 4:87480515-87480515	skin	malignant_melanoma	Substitution - coding silent
c.1679T>G; p.I560S; 4:87480510-87480510	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.205G>C; p.E69Q; 4:87494595-87494595	liver	carcinoma	Substitution - Missense
c.205G>C; p.E69Q; 4:87494595-87494595	liver	carcinoma	Substitution - Missense
c.1994G>C; p.*665S; 4:87473776-87473776	urinary_tract; bladder	carcinoma	Nonstop extension
c.1160G>C; p.R387T; 4:87493640-87493640	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.303G>T; p.E101D; 4:87494497-87494497	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.740C>G; p.S247C; 4:87494060-87494060	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.129C>A; p.P43P; 4:87495053-87495053	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.399_400insA; p.L134fs*6; 4:87494400-87494401	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.460C>G; p.Q154E; 4:87494340-87494340	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.593C>T; p.S198F; 4:87494207-87494207	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1519G>A; p.G507R; 4:87490285-87490285	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.1972A>G; p.I658V; 4:87473798-87473798	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.54G>A; p.P18P; 4:87499521-87499521	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.865C>A; p.Q289K; 4:87493935-87493935	ovary	other; neoplasm	Substitution - Missense
c.1434C>A; p.T478T; 4:87490370-87490370	breast	carcinoma	Substitution - coding silent
c.1625A>G; p.N542S; 4:87482467-87482467	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.618A>G; p.K206K; 4:87494182-87494182	lung	carcinoma; non_small_cell_carcinoma	Substitution - coding silent
c.1060A>G; p.R354G; 4:87493740-87493740	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1439C>T; p.A480V; 4:87490365-87490365	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1858C>A; p.L620M; 4:87479538-87479538	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.844T>A; p.S282T; 4:87493956-87493956	skin	malignant_melanoma	Substitution - Missense
c.861C>T; p.H287H; 4:87493939-87493939	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.784G>A; p.D262N; 4:87494016-87494016	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1459G>A; p.A487T; 4:87490345-87490345	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1955G>A; p.G652E; 4:87479441-87479441	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.186C>T; p.D62D; 4:87494996-87494996	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.316C>G; p.H106D; 4:87494484-87494484	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.316C>G; p.H106D; 4:87494484-87494484	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.316C>G; p.H106D; 4:87494484-87494484	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.316C>G; p.H106D; 4:87494484-87494484	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.78T>G; p.D26E; 4:87495104-87495104	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.534C>A; p.S178R; 4:87494266-87494266	skin; ear	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1510G>A; p.D504N; 4:87490294-87490294	skin	malignant_melanoma	Substitution - Missense
c.532A>T; p.S178C; 4:87494268-87494268	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1635C>T; p.H545H; 4:87482457-87482457	thyroid	other; neoplasm	Substitution - coding silent
c.1635C>T; p.H545H; 4:87482457-87482457	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1746G>C; p.K582N; 4:87480443-87480443	urinary_tract; bladder	carcinoma	Substitution - Missense
c.108A>C; p.A36A; 4:87495074-87495074	thyroid	other; neoplasm	Substitution - coding silent
c.1746delG; p.N584fs*25; 4:87480443-87480443	breast	carcinoma; basal_(triple-negative)_carcinoma	Deletion - Frameshift
c.1040A>G; p.D347G; 4:87493760-87493760	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1233G>T; p.E411D; 4:87491676-87491676	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]