Entrez Gene

Basic Information
Gene ID	8079
Name	MLF2
Synonymous	myeloid leukemia factor 2;MLF2;myeloid leukemia factor 2
Definition	myelodysplasia-myeloid leukemia factor 2
Position	12p13
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.417G>C; p.R139S; 12:6749990-6749990	skin	malignant_melanoma	Substitution - Missense
c.315C>T; p.S105S; 12:6750261-6750261	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.326C>T; p.S109F; 12:6750250-6750250	skin	malignant_melanoma	Substitution - Missense
c.664C>T; p.R222*; 12:6748878-6748878	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.664C>T; p.R222*; 12:6748878-6748878	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.472C>T; p.R158W; 12:6749935-6749935	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.472C>T; p.R158W; 12:6749935-6749935	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.396C>T; p.G132G; 12:6750180-6750180	pancreas	carcinoma	Substitution - coding silent
c.233A>G; p.D78G; 12:6750750-6750750	liver	carcinoma	Substitution - Missense
c.233A>G; p.D78G; 12:6750750-6750750	liver	carcinoma	Substitution - Missense
c.516G>A; p.T172T; 12:6749891-6749891	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.610C>T; p.R204W; 12:6748932-6748932	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.440G>A; p.G147E; 12:6749967-6749967	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.726G>T; p.Q242H; 12:6748816-6748816	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.471C>T; p.I157I; 12:6749936-6749936	skin	malignant_melanoma	Substitution - coding silent
c.239T>G; p.F80C; 12:6750744-6750744	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.338C>T; p.T113M; 12:6750238-6750238	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.731G>A; p.R244H; 12:6748811-6748811	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.718T>C; p.S240P; 12:6748824-6748824	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.718T>C; p.S240P; 12:6748824-6748824	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.718T>C; p.S240P; 12:6748824-6748824	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.718T>C; p.S240P; 12:6748824-6748824	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.718T>C; p.S240P; 12:6748824-6748824	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.718T>C; p.S240P; 12:6748824-6748824	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.718T>C; p.S240P; 12:6748824-6748824	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.718T>C; p.S240P; 12:6748824-6748824	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.718T>C; p.S240P; 12:6748824-6748824	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.718T>C; p.S240P; 12:6748824-6748824	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.529_531delGAG; p.E177delE; 12:6749876-6749878	large_intestine	carcinoma; adenocarcinoma	Deletion - In frame
c.529_531delGAG; p.E177delE; 12:6749876-6749878	large_intestine	carcinoma; adenocarcinoma	Deletion - In frame
c.511C>T; p.R171C; 12:6749896-6749896	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.148G>A; p.G50R; 12:6751957-6751957	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.56C>T; p.P19L; 12:6752049-6752049	skin	malignant_melanoma	Substitution - Missense
c.229A>G; p.M77V; 12:6750754-6750754	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.595G>C; p.E199Q; 12:6748947-6748947	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.319G>A; p.V107I; 12:6750257-6750257	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.181-6C>A; p.?; 12:6751682-6751682	urinary_tract; bladder	carcinoma	Unknown
c.412C>T; p.R138W; 12:6749995-6749995	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.134A>G; p.D45G; 12:6751971-6751971	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.412C>T; p.R138W; 12:6749995-6749995	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.520G>C; p.D174H; 12:6749887-6749887	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.382C>T; p.R128C; 12:6750194-6750194	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.127A>T; p.I43F; 12:6751978-6751978	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.638G>A; p.R213Q; 12:6748904-6748904	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.238T>C; p.F80L; 12:6750745-6750745	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.582C>T; p.D194D; 12:6748960-6748960	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.582C>T; p.D194D; 12:6748960-6748960	breast	carcinoma	Substitution - coding silent
c.582C>T; p.D194D; 12:6748960-6748960	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.582C>T; p.D194D; 12:6748960-6748960	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.240T>C; p.F80F; 12:6750743-6750743	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.240T>C; p.F80F; 12:6750743-6750743	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.160G>A; p.A54T; 12:6751945-6751945	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.516G>T; p.T172T; 12:6749891-6749891	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.526G>C; p.E176Q; 12:6749881-6749881	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.157C>T; p.P53S; 12:6751948-6751948	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.621T>C; p.R207R; 12:6748921-6748921	breast	carcinoma	Substitution - coding silent
c.721C>T; p.R241*; 12:6748821-6748821	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense

COSMIC somatic mutation [Top]