Entrez Gene

Basic Information
Gene ID	79971
Name	WLS
Synonymous	wntless Wnt ligand secretion mediator;WLS;wntless Wnt ligand secretion mediator
Definition	G protein-coupled receptor 177\|integral membrane protein GPR177\|protein evenness interrupted homolog\|protein wntless homolog\|putative NF-kappa-B-activating protein 373\|putative NFkB activating protein 373
Position	1p31.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.144G>T; p.V48V; 1:68194190-68194190	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.190G>A; p.V64M; 1:68194144-68194144	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.543C>T; p.V181V; 1:68155222-68155222	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.686G>T; p.G229V; 1:68153634-68153634	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.158C>T; p.A53V; 1:68194176-68194176	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.327C>T; p.F109F; 1:68194007-68194007	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1553T>A; p.L518H; 1:68126299-68126299	prostate	carcinoma	Substitution - Missense
c.1490A>C; p.K497T; 1:68137806-68137806	breast	carcinoma	Substitution - Missense
c.54T>C; p.G18G; 1:68232246-68232246	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.961G>A; p.E321K; 1:68150199-68150199	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.424G>A; p.D142N; 1:68159203-68159203	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.1402C>T; p.Q468*; 1:68137894-68137894	skin	malignant_melanoma	Substitution - Nonsense
c.938C>T; p.S313F; 1:68150222-68150222	skin	malignant_melanoma	Substitution - Missense
c.926C>T; p.A309V; 1:68150234-68150234	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1060_1061delAT; p.M354fs*2; 1:68148572-68148573	breast	carcinoma; ductal_carcinoma	Deletion - Frameshift
c.1393G>A; p.V465I; 1:68137903-68137903	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1393G>A; p.V465I; 1:68137903-68137903	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1393G>A; p.V465I; 1:68137903-68137903	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1393G>A; p.V465I; 1:68137903-68137903	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.982G>A; p.E328K; 1:68148651-68148651	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.455C>T; p.A152V; 1:68159172-68159172	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1024A>G; p.I342V; 1:68148609-68148609	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1057G>T; p.D353Y; 1:68148576-68148576	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.147A>G; p.K49K; 1:68194187-68194187	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.781C>T; p.R261*; 1:68153539-68153539	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.969G>A; p.M323I; 1:68150191-68150191	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1390G>T; p.G464C; 1:68137906-68137906	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1085C>T; p.T362M; 1:68148185-68148185	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.47T>C; p.I16T; 1:68232253-68232253	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.578A>T; p.K193M; 1:68155187-68155187	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.223C>T; p.R75*; 1:68194111-68194111	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.66C>T; p.L22L; 1:68232234-68232234	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.437C>T; p.A146V; 1:68159190-68159190	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.307A>T; p.M103L; 1:68194027-68194027	ovary	other; neoplasm	Substitution - Missense
c.1606C>T; p.R536C; 1:68126246-68126246	skin	malignant_melanoma	Substitution - Missense
c.1580G>A; p.G527E; 1:68126272-68126272	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.814G>A; p.A272T; 1:68150346-68150346	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1522C>T; p.L508L; 1:68126330-68126330	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.296C>G; p.P99R; 1:68194038-68194038	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1050C>T; p.F350F; 1:68148583-68148583	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.693C>T; p.T231T; 1:68153627-68153627	skin	malignant_melanoma	Substitution - coding silent
c.472C>G; p.R158G; 1:68159155-68159155	breast	carcinoma	Substitution - Missense
c.474G>T; p.R158R; 1:68159153-68159153	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.76A>T; p.I26F; 1:68232224-68232224	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.729C>T; p.P243P; 1:68153591-68153591	thyroid	carcinoma	Substitution - coding silent
c.257A>G; p.E86G; 1:68194077-68194077	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.257A>G; p.E86G; 1:68194077-68194077	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1203T>G; p.F401L; 1:68145944-68145944	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.65T>A; p.L22H; 1:68232235-68232235	urinary_tract; bladder	carcinoma	Substitution - Missense
c.657C>G; p.I219M; 1:68155108-68155108	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1334T>C; p.M445T; 1:68144597-68144597	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.469C>G; p.P157A; 1:68159158-68159158	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.432G>A; p.A144A; 1:68159195-68159195	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.446C>T; p.T149I; 1:68159181-68159181	breast	carcinoma	Substitution - Missense
c.432G>A; p.A144A; 1:68159195-68159195	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1167C>G; p.L389L; 1:68145980-68145980	ovary	other; neoplasm	Substitution - coding silent
c.382G>C; p.E128Q; 1:68159245-68159245	breast	carcinoma	Substitution - Missense
c.1455C>G; p.V485V; 1:68137841-68137841	breast	carcinoma	Substitution - coding silent
c.479T>C; p.L160P; 1:68159148-68159148	breast	carcinoma	Substitution - Missense
c.1340T>C; p.V447A; 1:68144591-68144591	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.190G>C; p.V64L; 1:68194144-68194144	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1262G>A; p.R421Q; 1:68145885-68145885	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1353C>T; p.I451I; 1:68144578-68144578	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.343C>A; p.Q115K; 1:68193991-68193991	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.629A>G; p.N210S; 1:68155136-68155136	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.274T>G; p.F92V; 1:68194060-68194060	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1228A>G; p.K410E; 1:68145919-68145919	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.422G>A; p.R141H; 1:68159205-68159205	breast	carcinoma	Substitution - Missense
c.1564A>G; p.I522V; 1:68126288-68126288	oesophagus	carcinoma	Substitution - Missense
c.1389C>T; p.G463G; 1:68137907-68137907	stomach	adenocarcinoma	Substitution - coding silent
c.1389C>T; p.G463G; 1:68137907-68137907	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1389C>T; p.G463G; 1:68137907-68137907	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1012C>T; p.Q338*; 1:68148621-68148621	prostate	carcinoma	Substitution - Nonsense
c.1017C>T; p.V339V; 1:68148616-68148616	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.589T>G; p.L197V; 1:68155176-68155176	ovary	other; neoplasm	Substitution - Missense
c.1282C>A; p.L428I; 1:68144649-68144649	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1delA; p.?; 1:68232299-68232299	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.610A>G; p.N204D; 1:68155155-68155155	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.530A>G; p.Y177C; 1:68155235-68155235	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1011G>T; p.K337N; 1:68148622-68148622	prostate	carcinoma	Substitution - Missense
c.918C>T; p.I306I; 1:68150242-68150242	breast	carcinoma	Substitution - coding silent
c.177G>T; p.K59N; 1:68194157-68194157	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1273T>C; p.Y425H; 1:68145874-68145874	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.824T>C; p.I275T; 1:68150336-68150336	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.259G>A; p.A87T; 1:68194075-68194075	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1070+2T>C; p.?; 1:68148561-68148561	ovary	other; neoplasm	Unknown
c.698T>G; p.V233G; 1:68153622-68153622	breast	carcinoma	Substitution - Missense
c.548C>A; p.P183H; 1:68155217-68155217	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.140C>T; p.S47L; 1:68194194-68194194	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.140C>T; p.S47L; 1:68194194-68194194	skin	malignant_melanoma	Substitution - Missense

COSMIC somatic mutation [Top]