Entrez Gene

Basic Information
Gene ID	7991
Name	TUSC3
Synonymous	tumor suppressor candidate 3;TUSC3;tumor suppressor candidate 3
Definition	Putative prostate cancer tumor suppressor\|magnesium uptake/transporter TUSC3\|oligosaccharyltransferase 3 homolog A
Position	8p22
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.813G>A; p.G271G; 8:15730680-15730680	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.52C>T; p.R18W; 8:15540482-15540482	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.52C>T; p.R18W; 8:15540482-15540482	haematopoietic_and_lymphoid_tissue; spleen	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.838G>T; p.E280*; 8:15730705-15730705	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.967G>T; p.V323F; 8:15748404-15748404	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.204G>A; p.M68I; 8:15623145-15623145	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.976T>C; p.F326L; 8:15748413-15748413	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.38C>A; p.A13E; 8:15540468-15540468	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.934C>T; p.R312W; 8:15743609-15743609	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.934C>T; p.R312W; 8:15743609-15743609	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.344C>T; p.S115F; 8:15650732-15650732	skin	malignant_melanoma	Substitution - Missense
c.313G>T; p.A105S; 8:15650701-15650701	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.384C>T; p.F128F; 8:15650772-15650772	skin	malignant_melanoma	Substitution - coding silent
c.976T>G; p.F326V; 8:15748413-15748413	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.520G>A; p.A174T; 8:15659600-15659600	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.690T>G; p.G230G; 8:15662278-15662278	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.187C>T; p.R63C; 8:15623128-15623128	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.187C>T; p.R63C; 8:15623128-15623128	large_intestine; colon	carcinoma	Substitution - Missense
c.637G>T; p.G213C; 8:15662225-15662225	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.187C>T; p.R63C; 8:15623128-15623128	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.187C>T; p.R63C; 8:15623128-15623128	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.626C>T; p.S209L; 8:15662214-15662214	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.663C>T; p.N221N; 8:15662251-15662251	skin	malignant_melanoma	Substitution - coding silent
c.415G>A; p.V139I; 8:15650803-15650803	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.415G>A; p.V139I; 8:15650803-15650803	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.913A>G; p.K305E; 8:15743588-15743588	skin	malignant_melanoma	Substitution - Missense
c.918C>T; p.G306G; 8:15743593-15743593	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.387T>C; p.S129S; 8:15650775-15650775	breast	carcinoma	Substitution - coding silent
c.601A>G; p.T201A; 8:15662189-15662189	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.245G>T; p.R82L; 8:15623186-15623186	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.267G>A; p.M89I; 8:15623208-15623208	liver	carcinoma	Substitution - Missense
c.267G>A; p.M89I; 8:15623208-15623208	liver	carcinoma	Substitution - Missense
c.196T>G; p.F66V; 8:15623137-15623137	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.196T>G; p.F66V; 8:15623137-15623137	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.196T>G; p.F66V; 8:15623137-15623137	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.799-2A>G; p.?; 8:15730664-15730664	ovary	carcinoma; serous_carcinoma	Unknown
c.139-1G>T; p.?; 8:15623079-15623079	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.388A>G; p.M130V; 8:15650776-15650776	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.19C>A; p.P7T; 8:15540449-15540449	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.535G>C; p.A179P; 8:15659615-15659615	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.509G>T; p.R170I; 8:15659589-15659589	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1000C>T; p.R334C; 8:15748437-15748437	skin	malignant_melanoma	Substitution - Missense
c.1000C>T; p.R334C; 8:15748437-15748437	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.196T>A; p.F66I; 8:15623137-15623137	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1000C>T; p.R334C; 8:15748437-15748437	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1000C>T; p.R334C; 8:15748437-15748437	skin	malignant_melanoma	Substitution - Missense
c.1000C>T; p.R334C; 8:15748437-15748437	skin	malignant_melanoma	Substitution - Missense
c.1000C>T; p.R334C; 8:15748437-15748437	skin	malignant_melanoma	Substitution - Missense
c.431A>G; p.N144S; 8:15659511-15659511	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.587C>T; p.P196L; 8:15662175-15662175	skin	malignant_melanoma	Substitution - Missense
c.247A>C; p.N83H; 8:15623188-15623188	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.704C>A; p.S235Y; 8:15662292-15662292	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.868G>A; p.A290T; 8:15743543-15743543	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.350G>A; p.R117H; 8:15650738-15650738	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.350G>A; p.R117H; 8:15650738-15650738	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.368delG; p.C123fs*23; 8:15650756-15650756	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.819C>T; p.S273S; 8:15730686-15730686	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.67G>C; p.G23R; 8:15540497-15540497	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.695C>A; p.A232D; 8:15662283-15662283	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.960C>T; p.G320G; 8:15748397-15748397	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.473G>T; p.G158V; 8:15659553-15659553	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.401A>T; p.D134V; 8:15650789-15650789	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.445C>T; p.P149S; 8:15659525-15659525	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.349C>T; p.R117C; 8:15650737-15650737	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.349C>T; p.R117C; 8:15650737-15650737	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.586C>A; p.P196T; 8:15662174-15662174	liver	carcinoma	Substitution - Missense
c.567+7T>C; p.?; 8:15659654-15659654	liver	carcinoma	Unknown
c.567+7T>C; p.?; 8:15659654-15659654	liver	carcinoma	Unknown
c.750T>C; p.H250H; 8:15673788-15673788	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.750T>C; p.H250H; 8:15673788-15673788	pancreas	carcinoma	Substitution - coding silent
c.167T>C; p.L56P; 8:15623108-15623108	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.754C>T; p.R252C; 8:15673792-15673792	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.615C>A; p.A205A; 8:15662203-15662203	ovary	other; neoplasm	Substitution - coding silent
c.339G>A; p.A113A; 8:15650727-15650727	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.608C>A; p.A203D; 8:15662196-15662196	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.339G>A; p.A113A; 8:15650727-15650727	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.352T>G; p.Y118D; 8:15650740-15650740	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.139-9T>C; p.?; 8:15623071-15623071	pancreas	carcinoma	Unknown
c.435G>A; p.M145I; 8:15659515-15659515	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1001G>A; p.R334H; 8:15748438-15748438	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.553A>G; p.R185G; 8:15659633-15659633	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.221G>A; p.R74Q; 8:15623162-15623162	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.993A>G; p.S331S; 8:15748430-15748430	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.221G>A; p.R74Q; 8:15623162-15623162	skin	malignant_melanoma	Substitution - Missense
c.545T>C; p.I182T; 8:15659625-15659625	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.558G>A; p.T186T; 8:15659638-15659638	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.545T>C; p.I182T; 8:15659625-15659625	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.337G>T; p.A113S; 8:15650725-15650725	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.577T>C; p.F193L; 8:15662165-15662165	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.577T>C; p.F193L; 8:15662165-15662165	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.85C>T; p.L29F; 8:15540515-15540515	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.747C>A; p.N249K; 8:15673785-15673785	liver	carcinoma	Substitution - Missense
c.747C>A; p.N249K; 8:15673785-15673785	liver	carcinoma	Substitution - Missense
c.309-6T>C; p.?; 8:15650691-15650691	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.925G>T; p.G309*; 8:15743600-15743600	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.784C>T; p.H262Y; 8:15673822-15673822	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelofibrosis	Substitution - Missense
c.223A>C; p.K75Q; 8:15623164-15623164	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.290G>T; p.R97L; 8:15623231-15623231	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Missense
c.494C>T; p.T165I; 8:15659574-15659574	liver	carcinoma	Substitution - Missense
c.494C>T; p.T165I; 8:15659574-15659574	liver	carcinoma	Substitution - Missense
c.466C>T; p.P156S; 8:15659546-15659546	skin; mucosal	malignant_melanoma	Substitution - Missense
c.378C>G; p.L126L; 8:15650766-15650766	liver	carcinoma	Substitution - coding silent
c.408G>T; p.G136G; 8:15650796-15650796	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.254C>G; p.S85C; 8:15623195-15623195	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.759A>T; p.G253G; 8:15673797-15673797	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.463C>T; p.P155S; 8:15659543-15659543	skin	malignant_melanoma	Substitution - Missense
c.757G>A; p.G253R; 8:15673795-15673795	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.919G>A; p.D307N; 8:15743594-15743594	skin	malignant_melanoma	Substitution - Missense
c.919G>A; p.D307N; 8:15743594-15743594	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.193A>C; p.I65L; 8:15623134-15623134	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.245G>A; p.R82Q; 8:15623186-15623186	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.245G>A; p.R82Q; 8:15623186-15623186	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.245G>A; p.R82Q; 8:15623186-15623186	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.559G>A; p.D187N; 8:15659639-15659639	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.504C>T; p.L168L; 8:15659584-15659584	skin	malignant_melanoma	Substitution - coding silent
c.29G>A; p.R10H; 8:15540459-15540459	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.289C>T; p.R97W; 8:15623230-15623230	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.727A>G; p.T243A; 8:15673765-15673765	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.160G>T; p.E54*; 8:15623101-15623101	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.402T>G; p.D134E; 8:15650790-15650790	skin	malignant_melanoma	Substitution - Missense
c.13G>A; p.G5S; 8:15540443-15540443	large_intestine; colon	carcinoma	Substitution - Missense
c.13G>A; p.G5S; 8:15540443-15540443	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.756T>C; p.R252R; 8:15673794-15673794	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1021C>A; p.P341T; 8:15748458-15748458	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.139A>G; p.N47D; 8:15623080-15623080	skin	malignant_melanoma	Substitution - Missense
c.571C>T; p.R191W; 8:15662159-15662159	breast	carcinoma	Substitution - Missense
c.221G>T; p.R74L; 8:15623162-15623162	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.151_152insA; p.V53fs*19; 8:15623092-15623093	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.509G>C; p.R170T; 8:15659589-15659589	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.60G>A; p.L20L; 8:15540490-15540490	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.421C>T; p.Q141*; 8:15650809-15650809	skin	malignant_melanoma	Substitution - Nonsense
c.421C>T; p.Q141*; 8:15650809-15650809	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.911C>T; p.S304L; 8:15743586-15743586	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.911C>T; p.S304L; 8:15743586-15743586	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.366T>C; p.F122F; 8:15650754-15650754	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.294G>T; p.Q98H; 8:15623235-15623235	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.310C>T; p.Q104*; 8:15650698-15650698	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense

COSMIC somatic mutation [Top]