Entrez Gene

Basic Information
Gene ID	7706
Name	TRIM25
Synonymous	tripartite motif containing 25;TRIM25;tripartite motif containing 25
Definition	E3 ubiquitin/ISG15 ligase TRIM25\|RING finger protein 147\|estrogen-responsive finger protein\|tripartite motif protein TRIM25\|tripartite motif-containing 25\|tripartite motif-containing protein 25\|ubiquitin/ISG15-conjugating enzyme TRIM25\|zinc finger protein
Position	17q23.2
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1132delC; p.R378fs*3; 17:56899136-56899136	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1577T>C; p.V526A; 17:56892016-56892016	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1467G>A; p.R489R; 17:56892126-56892126	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.68C>T; p.P23L; 17:56913921-56913921	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.258C>T; p.P86P; 17:56913731-56913731	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1133G>A; p.R378H; 17:56899135-56899135	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1886C>G; p.P629R; 17:56891707-56891707	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1791C>T; p.V597V; 17:56891802-56891802	skin	malignant_melanoma	Substitution - coding silent
c.1153+1G>A; p.?; 17:56899114-56899114	urinary_tract; bladder	carcinoma	Unknown
c.1153+1G>A; p.?; 17:56899114-56899114	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Unknown
c.1360G>T; p.E454*; 17:56895346-56895346	kidney	other; neoplasm	Substitution - Nonsense
c.609G>A; p.R203R; 17:56908552-56908552	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.798G>A; p.E266E; 17:56904384-56904384	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.249G>A; p.R83R; 17:56913740-56913740	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.808G>A; p.V270I; 17:56904374-56904374	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1292C>A; p.P431Q; 17:56895414-56895414	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.903G>C; p.K301N; 17:56904279-56904279	breast	carcinoma	Substitution - Missense
c.292G>A; p.A98T; 17:56913697-56913697	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1054A>G; p.I352V; 17:56901452-56901452	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.39C>A; p.C13*; 17:56913950-56913950	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1657T>A; p.W553R; 17:56891936-56891936	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1827G>A; p.E609E; 17:56891766-56891766	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.864C>G; p.I288M; 17:56904318-56904318	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1069G>A; p.E357K; 17:56901437-56901437	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1381C>A; p.L461M; 17:56892212-56892212	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1050G>A; p.Q350Q; 17:56901456-56901456	pancreas	carcinoma	Substitution - coding silent
c.1180+1G>A; p.?; 17:56895925-56895925	oesophagus	carcinoma; adenocarcinoma	Unknown
c.1387T>G; p.Y463D; 17:56892206-56892206	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.1270G>A; p.A424T; 17:56895436-56895436	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.910G>C; p.E304Q; 17:56904272-56904272	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.766G>T; p.E256*; 17:56904416-56904416	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1727G>C; p.R576P; 17:56891866-56891866	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.71T>A; p.V24D; 17:56913918-56913918	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.894C>A; p.S298R; 17:56904288-56904288	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.522C>T; p.C174C; 17:56913467-56913467	breast	carcinoma	Substitution - coding silent
c.1164G>T; p.K388N; 17:56895942-56895942	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1164G>T; p.K388N; 17:56895942-56895942	breast	carcinoma	Substitution - Missense
c.1618delA; p.S540fs*60; 17:56891975-56891975	skin; mucosal	malignant_melanoma	Deletion - Frameshift
c.644G>C; p.G215A; 17:56908517-56908517	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1848G>A; p.W616*; 17:56891745-56891745	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.636G>A; p.Q212Q; 17:56908525-56908525	liver	carcinoma	Substitution - coding silent
c.672A>C; p.R224S; 17:56908489-56908489	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.902A>G; p.K301R; 17:56904280-56904280	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.902A>G; p.K301R; 17:56904280-56904280	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1104T>C; p.H368H; 17:56899164-56899164	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1056C>T; p.I352I; 17:56901450-56901450	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.387G>A; p.E129E; 17:56913602-56913602	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.841C>A; p.L281I; 17:56904341-56904341	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1679C>G; p.A560G; 17:56891914-56891914	ovary	other; neoplasm	Substitution - Missense
c.1679C>G; p.A560G; 17:56891914-56891914	ovary	other; neoplasm	Substitution - Missense
c.53A>T; p.E18V; 17:56913936-56913936	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.713T>G; p.V238G; 17:56904469-56904469	breast	carcinoma	Substitution - Missense
c.1828G>C; p.A610P; 17:56891765-56891765	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.773C>A; p.T258N; 17:56904409-56904409	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.783G>A; p.R261R; 17:56904399-56904399	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.674A>T; p.N225I; 17:56908487-56908487	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.67C>T; p.P23S; 17:56913922-56913922	skin	malignant_melanoma	Substitution - Missense
c.944G>T; p.R315L; 17:56901562-56901562	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.944G>T; p.R315L; 17:56901562-56901562	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.655G>T; p.A219S; 17:56908506-56908506	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1604G>A; p.R535Q; 17:56891989-56891989	breast	carcinoma	Substitution - Missense
c.1714A>C; p.T572P; 17:56891879-56891879	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1631G>A; p.R544H; 17:56891962-56891962	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.634C>T; p.Q212*; 17:56908527-56908527	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1050G>C; p.Q350H; 17:56901456-56901456	breast	carcinoma	Substitution - Missense
c.669G>C; p.V223V; 17:56908492-56908492	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1590C>T; p.Y530Y; 17:56892003-56892003	pancreas	carcinoma	Substitution - coding silent
c.606G>A; p.L202L; 17:56908555-56908555	lung	carcinoma; non_small_cell_carcinoma	Substitution - coding silent
c.1192G>T; p.A398S; 17:56895593-56895593	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.1632C>T; p.R544R; 17:56891961-56891961	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1449G>T; p.E483D; 17:56892144-56892144	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.857G>A; p.S286N; 17:56904325-56904325	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1422G>T; p.E474D; 17:56892171-56892171	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.880G>A; p.E294K; 17:56904302-56904302	skin	malignant_melanoma	Substitution - Missense
c.1259T>C; p.L420S; 17:56895526-56895526	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1142A>T; p.K381M; 17:56899126-56899126	ovary	other; neoplasm	Substitution - Missense
c.177G>A; p.A59A; 17:56913812-56913812	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1224C>T; p.A408A; 17:56895561-56895561	skin	malignant_melanoma	Substitution - coding silent
c.901A>T; p.K301*; 17:56904281-56904281	breast	carcinoma; ductal_carcinoma	Substitution - Nonsense
c.1613C>T; p.P538L; 17:56891980-56891980	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.279C>T; p.P93P; 17:56913710-56913710	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1395C>T; p.T465T; 17:56892198-56892198	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1470G>A; p.P490P; 17:56892123-56892123	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1241_1242insT; p.L415fs*37; 17:56895543-56895544	lung	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1597A>T; p.M533L; 17:56891996-56891996	liver	carcinoma	Substitution - Missense
c.1597A>T; p.M533L; 17:56891996-56891996	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1837C>T; p.P613S; 17:56891756-56891756	skin	malignant_melanoma	Substitution - Missense
c.1781C>A; p.A594D; 17:56891812-56891812	urinary_tract; bladder	carcinoma	Substitution - Missense
c.179G>C; p.R60P; 17:56913810-56913810	liver	carcinoma	Substitution - Missense
c.179G>C; p.R60P; 17:56913810-56913810	liver	carcinoma	Substitution - Missense
c.179G>C; p.R60P; 17:56913810-56913810	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.52G>A; p.E18K; 17:56913937-56913937	urinary_tract; bladder	carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]