Entrez Gene

Basic Information
Gene ID	7216
Name	TRO
Synonymous	trophinin;TRO;trophinin
Definition	MAGE superfamily protein\|MAGE-D3 antigen\|magphinin\|melanoma antigen, family D, 3
Position	Xp11.22-p11.21
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.474C>T; p.G158G; 23:54923006-54923006	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1989T>G; p.I663M; 23:54931206-54931206	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1226G>T; p.R409I; 23:54923758-54923758	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.46-2A>G; p.?; 23:54922576-54922576	stomach	carcinoma; adenocarcinoma	Unknown
c.422A>T; p.K141M; 23:54922954-54922954	liver	carcinoma	Substitution - Missense
c.434T>C; p.V145A; 23:54922966-54922966	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1315C>T; p.R439*; 23:54924529-54924529	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1446C>A; p.F482L; 23:54925029-54925029	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1315C>T; p.R439*; 23:54924529-54924529	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1315C>T; p.R439*; 23:54924529-54924529	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1815C>A; p.F605L; 23:54927718-54927718	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1815C>A; p.F605L; 23:54927718-54927718	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1815C>A; p.F605L; 23:54927718-54927718	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1123G>A; p.V375I; 23:54923655-54923655	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1147G>T; p.A383S; 23:54923679-54923679	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.719A>G; p.N240S; 23:54923251-54923251	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.923G>A; p.R308K; 23:54923455-54923455	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1856A>G; p.K619R; 23:54927759-54927759	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1665C>A; p.I555I; 23:54926590-54926590	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1182G>C; p.L394L; 23:54923714-54923714	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1072C>T; p.P358S; 23:54923604-54923604	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2012C>T; p.P671L; 23:54931229-54931229	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.721G>C; p.E241Q; 23:54923253-54923253	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.1446C>T; p.F482F; 23:54925029-54925029	skin	malignant_melanoma	Substitution - coding silent
c.1446C>T; p.F482F; 23:54925029-54925029	skin	malignant_melanoma	Substitution - coding silent
c.1446C>T; p.F482F; 23:54925029-54925029	skin	malignant_melanoma	Substitution - coding silent
c.683C>T; p.A228V; 23:54923215-54923215	breast	carcinoma	Substitution - Missense
c.1022C>T; p.S341F; 23:54923554-54923554	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1597C>A; p.L533M; 23:54926429-54926429	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1808A>G; p.Y603C; 23:54927711-54927711	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1690C>A; p.L564M; 23:54926615-54926615	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.58C>A; p.P20T; 23:54922590-54922590	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1605C>T; p.L535L; 23:54926437-54926437	skin	malignant_melanoma	Substitution - coding silent
c.1595A>G; p.K532R; 23:54926427-54926427	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.847G>A; p.A283T; 23:54923379-54923379	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.926G>A; p.G309D; 23:54923458-54923458	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1569A>C; p.I523I; 23:54925675-54925675	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1280G>T; p.R427M; 23:54924494-54924494	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1231C>T; p.R411*; 23:54923763-54923763	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1333C>T; p.Q445*; 23:54924547-54924547	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.765G>T; p.K255N; 23:54923297-54923297	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1237-1G>T; p.?; 23:54924450-54924450	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1793G>T; p.S598I; 23:54927696-54927696	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1887G>A; p.K629K; 23:54928611-54928611	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.300C>A; p.P100P; 23:54922832-54922832	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.1466C>A; p.A489E; 23:54925049-54925049	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1232G>A; p.R411Q; 23:54923764-54923764	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1070C>T; p.T357I; 23:54923602-54923602	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1232G>A; p.R411Q; 23:54923764-54923764	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.677C>T; p.A226V; 23:54923209-54923209	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.29G>A; p.R10K; 23:54922275-54922275	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.382C>G; p.Q128E; 23:54922914-54922914	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1118C>T; p.T373I; 23:54923650-54923650	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.974T>A; p.I325K; 23:54923506-54923506	breast	carcinoma	Substitution - Missense
c.400G>A; p.A134T; 23:54922932-54922932	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1215C>A; p.T405T; 23:54923747-54923747	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1828C>T; p.R610C; 23:54927731-54927731	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1828C>T; p.R610C; 23:54927731-54927731	thyroid	carcinoma	Substitution - Missense
c.1272T>C; p.S424S; 23:54924486-54924486	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1796G>A; p.R599K; 23:54927699-54927699	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.22G>A; p.G8R; 23:54922268-54922268	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1603C>A; p.L535I; 23:54926435-54926435	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.518T>G; p.L173R; 23:54923050-54923050	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.917C>A; p.A306D; 23:54923449-54923449	soft_tissue; blood_vessel	angiosarcoma	Substitution - Missense
c.1919G>A; p.R640H; 23:54928643-54928643	breast	carcinoma	Substitution - Missense
c.1370T>G; p.V457G; 23:54924698-54924698	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.873A>G; p.S291S; 23:54923405-54923405	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1886A>G; p.K629R; 23:54928610-54928610	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1428A>G; p.Q476Q; 23:54925011-54925011	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1141C>G; p.Q381E; 23:54923673-54923673	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.888G>A; p.R296R; 23:54923420-54923420	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1002C>A; p.T334T; 23:54923534-54923534	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.416C>T; p.A139V; 23:54922948-54922948	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.72G>A; p.L24L; 23:54922604-54922604	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1833C>T; p.S611S; 23:54927736-54927736	skin	malignant_melanoma	Substitution - coding silent
c.225T>G; p.P75P; 23:54922757-54922757	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1720_1721insG; p.E575fs*23; 23:54927062-54927063	stomach	carcinoma; intestinal_adenocarcinoma	Insertion - Frameshift
c.2T>C; p.M1T; 23:54922248-54922248	liver	carcinoma	Substitution - Missense
c.968C>G; p.T323S; 23:54923500-54923500	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1180C>A; p.L394M; 23:54923712-54923712	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.7A>G; p.R3G; 23:54922253-54922253	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1293G>A; p.W431*; 23:54924507-54924507	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.706G>T; p.G236C; 23:54923238-54923238	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.149C>A; p.A50E; 23:54922681-54922681	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.149C>A; p.A50E; 23:54922681-54922681	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.125T>G; p.V42G; 23:54922657-54922657	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.21C>T; p.Y7Y; 23:54922267-54922267	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.21C>T; p.Y7Y; 23:54922267-54922267	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1048G>A; p.A350T; 23:54923580-54923580	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.216G>T; p.K72N; 23:54922748-54922748	breast	carcinoma	Substitution - Missense
c.1836_1837CC>TA; p.H613N; 23:54927739-54927740	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1341+1G>T; p.?; 23:54924556-54924556	breast	carcinoma	Unknown
c.192C>A; p.N64K; 23:54922724-54922724	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1297C>T; p.R433W; 23:54924511-54924511	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1297C>T; p.R433W; 23:54924511-54924511	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.359C>A; p.P120H; 23:54922891-54922891	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.2011C>G; p.P671A; 23:54931228-54931228	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1429G>T; p.E477*; 23:54925012-54925012	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1429G>T; p.E477*; 23:54925012-54925012	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.901A>T; p.K301*; 23:54923433-54923433	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1649C>G; p.A550G; 23:54926481-54926481	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.353C>A; p.A118D; 23:54922885-54922885	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1366T>C; p.L456L; 23:54924694-54924694	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1537C>T; p.L513F; 23:54925643-54925643	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1511T>A; p.I504N; 23:54925617-54925617	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1785C>A; p.V595V; 23:54927688-54927688	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.626A>C; p.K209T; 23:54923158-54923158	stomach	adenocarcinoma	Substitution - Missense
c.626A>C; p.K209T; 23:54923158-54923158	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1920C>T; p.R640R; 23:54928644-54928644	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.758G>A; p.R253Q; 23:54923290-54923290	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.342G>C; p.Q114H; 23:54922874-54922874	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1181T>A; p.L394Q; 23:54923713-54923713	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.172A>G; p.M58V; 23:54922704-54922704	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1694G>A; p.R565H; 23:54926619-54926619	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1831T>C; p.S611P; 23:54927734-54927734	breast	carcinoma	Substitution - Missense
c.1958C>A; p.A653D; 23:54928682-54928682	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1316G>A; p.R439Q; 23:54924530-54924530	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.603G>T; p.K201N; 23:54923135-54923135	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.832C>G; p.L278V; 23:54923364-54923364	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1944A>T; p.Q648H; 23:54928668-54928668	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1410G>T; p.M470I; 23:54924993-54924993	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.58C>T; p.P20S; 23:54922590-54922590	skin	malignant_melanoma	Substitution - Missense
c.1693C>T; p.R565C; 23:54926618-54926618	central_nervous_system; brain	glioma	Substitution - Missense
c.1696C>A; p.P566T; 23:54926621-54926621	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1865A>C; p.K622T; 23:54927768-54927768	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1572G>C; p.L524L; 23:54925678-54925678	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.149C>T; p.A50V; 23:54922681-54922681	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1434T>C; p.Y478Y; 23:54925017-54925017	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2109G>T; p.E703D; 23:54931326-54931326	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1039G>A; p.A347T; 23:54923571-54923571	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1167G>A; p.L389L; 23:54923699-54923699	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1167G>A; p.L389L; 23:54923699-54923699	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.193C>T; p.R65W; 23:54922725-54922725	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.819G>T; p.E273D; 23:54923351-54923351	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.1298G>A; p.R433Q; 23:54924512-54924512	pancreas	carcinoma	Substitution - Missense
c.1666T>C; p.W556R; 23:54926591-54926591	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.323A>C; p.N108T; 23:54922855-54922855	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.2056C>A; p.P686T; 23:54931273-54931273	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.648A>T; p.I216I; 23:54923180-54923180	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.648A>T; p.I216I; 23:54923180-54923180	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1507G>T; p.E503*; 23:54925613-54925613	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense

COSMIC somatic mutation [Top]