| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 7170 |
Name | TPM3 |
Synonymous | tropomyosin 3;TPM3;tropomyosin 3 |
Definition | alpha-tropomyosin, slow skeletal|cytoskeletal tropomyosin TM30|epididymis luminal protein 189|epididymis secretory sperm binding protein Li 82p|heat-stable cytoskeletal protein 30 kDa|tropomyosin alpha-3 chain|tropomyosin gamma|tropomyosin-5 |
Position | 1q21.2 |
Gene Type | protein-coding |
COSMIC somatic mutation [Top] | |||
Mutation (CDS; AA; Chr) | Site | Histology | Mutation Type |
|---|---|---|---|
c.681C>T; p.T227T; 1:154157705-154157705 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.616G>A; p.A206T; 1:154170448-154170448 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.351C>A; p.H117Q; 1:154173117-154173117 |
upper_aerodigestive_tract; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.425G>A; p.R142H; 1:154172938-154172938 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.574C>A; p.L192I; 1:154170669-154170669 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.601A>G; p.T201A; 1:154170463-154170463 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.552A>G; p.K184K; 1:154170691-154170691 |
ovary | other; neoplasm | Substitution - coding silent |
c.28G>A; p.V10M; 1:154183092-154183092 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.206G>A; p.R69H; 1:154176175-154176175 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.723C>G; p.T241T; 1:154157663-154157663 |
urinary_tract; bladder | carcinoma | Substitution - coding silent |
c.29T>G; p.V10G; 1:154183091-154183091 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.437G>A; p.R146Q; 1:154172926-154172926 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.354T>C; p.I118I; 1:154173114-154173114 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.441T>C; p.A147A; 1:154172922-154172922 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.291G>A; p.R97R; 1:154173177-154173177 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.152C>T; p.S51F; 1:154176229-154176229 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.540A>C; p.Q180H; 1:154170703-154170703 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.67G>A; p.D23N; 1:154183053-154183053 |
breast | carcinoma | Substitution - Missense |
c.170A>C; p.Q57P; 1:154176211-154176211 |
breast | carcinoma | Substitution - Missense |
c.544G>T; p.E182*; 1:154170699-154170699 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.597A>G; p.A199A; 1:154170467-154170467 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - coding silent |
c.51G>A; p.L17L; 1:154183069-154183069 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.565A>G; p.I189V; 1:154170678-154170678 |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.200A>G; p.Q67R; 1:154176181-154176181 |
pancreas | carcinoma | Substitution - Missense |
c.205C>T; p.R69C; 1:154176176-154176176 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.205C>T; p.R69C; 1:154176176-154176176 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.547G>C; p.D183H; 1:154170696-154170696 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.376T>C; p.Y126H; 1:154173092-154173092 |
thyroid | carcinoma | Substitution - Missense |
c.364G>A; p.A122T; 1:154173104-154173104 |
stomach | carcinoma; intestinal_adenocarcinoma | Substitution - Missense |
c.451G>A; p.E151K; 1:154172912-154172912 |
skin; abdomen | malignant_melanoma | Substitution - Missense |
c.281T>C; p.I94T; 1:154173187-154173187 |
central_nervous_system; brain | glioma | Substitution - Missense |
c.421G>T; p.E141*; 1:154172942-154172942 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Nonsense |
c.237A>C; p.E79D; 1:154176144-154176144 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.522T>G; p.A174A; 1:154172038-154172038 |
breast | carcinoma | Substitution - coding silent |
c.347A>T; p.K116M; 1:154173121-154173121 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |