Entrez Gene

Basic Information
Gene ID	7169
Name	TPM2
Synonymous	tropomyosin 2 (beta);TPM2;tropomyosin 2 (beta)
Definition	epididymis secretory protein Li 273\|nemaline myopathy type 4\|tropomyosin beta chain
Position	9p13
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.261C>T; p.S87S; 9:35685760-35685760	skin	malignant_melanoma	Substitution - coding silent
c.46G>A; p.E16K; 9:35689772-35689772	skin	malignant_melanoma	Substitution - Missense
c.288G>A; p.E96E; 9:35685733-35685733	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.272G>A; p.R91H; 9:35685749-35685749	breast	carcinoma	Substitution - Missense
c.640-11_640-10delGT; p.?; 9:35684560-35684561	oesophagus	carcinoma; adenocarcinoma	Unknown
c.640-2A>G; p.?; 9:35684552-35684552	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.564-9C>T; p.?; 9:35684816-35684816	breast	carcinoma	Unknown
c.75C>G; p.A25A; 9:35689743-35689743	skin	malignant_melanoma	Substitution - coding silent
c.25C>G; p.Q9E; 9:35689793-35689793	large_intestine; rectum	NS	Substitution - Missense
c.188C>T; p.S63F; 9:35689198-35689198	skin	malignant_melanoma	Substitution - Missense
c.64G>A; p.A22T; 9:35689754-35689754	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.432G>T; p.Q144H; 9:35685494-35685494	stomach	adenocarcinoma	Substitution - Missense
c.727G>A; p.E243K; 9:35684291-35684291	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.462C>T; p.I154I; 9:35685464-35685464	skin	malignant_melanoma	Substitution - coding silent
c.327C>G; p.A109A; 9:35685694-35685694	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.369C>A; p.S123R; 9:35685652-35685652	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.238G>A; p.D80N; 9:35689148-35689148	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.238G>A; p.D80N; 9:35689148-35689148	liver	carcinoma	Substitution - Missense
c.82G>A; p.D28N; 9:35689736-35689736	skin	malignant_melanoma	Substitution - Missense
c.561G>A; p.E187E; 9:35685271-35685271	breast	carcinoma	Substitution - coding silent
c.6C>T; p.D2D; 9:35689812-35689812	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.640-2A>C; p.?; 9:35684552-35684552	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.640-2A>C; p.?; 9:35684552-35684552	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.640-2A>C; p.?; 9:35684552-35684552	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.462C>A; p.I154I; 9:35685464-35685464	thyroid	other; neoplasm	Substitution - coding silent
c.652G>T; p.E218*; 9:35684538-35684538	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.353A>C; p.K118T; 9:35685668-35685668	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.479G>A; p.R160H; 9:35685447-35685447	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.479G>A; p.R160H; 9:35685447-35685447	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.498C>T; p.A166A; 9:35685334-35685334	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.190G>C; p.V64L; 9:35689196-35689196	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.269G>A; p.R90H; 9:35685752-35685752	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.305C>T; p.A102V; 9:35685716-35685716	skin	malignant_melanoma	Substitution - Missense
c.67G>A; p.E23K; 9:35689751-35689751	urinary_tract; bladder	carcinoma	Substitution - Missense
c.369C>T; p.S123S; 9:35685652-35685652	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.369C>T; p.S123S; 9:35685652-35685652	liver	carcinoma	Substitution - coding silent
c.508G>T; p.V170L; 9:35685324-35685324	central_nervous_system; brain	glioma	Substitution - Missense
c.740C>T; p.A247V; 9:35684278-35684278	breast	carcinoma	Substitution - Missense
c.265A>G; p.N89D; 9:35685756-35685756	ovary	carcinoma	Substitution - Missense
c.387C>A; p.V129V; 9:35685539-35685539	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.96T>C; p.A32A; 9:35689722-35689722	breast	carcinoma	Substitution - coding silent
c.191T>C; p.V64A; 9:35689195-35689195	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.844A>C; p.T282P; 9:35683170-35683170	ovary	other; neoplasm	Substitution - Missense
c.133G>A; p.A45T; 9:35689253-35689253	urinary_tract; bladder	carcinoma	Substitution - Missense
c.50A>G; p.N17S; 9:35689768-35689768	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.40G>C; p.D14H; 9:35689778-35689778	ovary	other; neoplasm	Substitution - Missense
c.478C>T; p.R160C; 9:35685448-35685448	skin	malignant_melanoma	Substitution - Missense
c.40G>C; p.D14H; 9:35689778-35689778	ovary	other; neoplasm	Substitution - Missense
c.361G>A; p.D121N; 9:35685660-35685660	urinary_tract; bladder	carcinoma	Substitution - Missense
c.390C>T; p.I130I; 9:35685536-35685536	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.221C>T; p.A74V; 9:35689165-35689165	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.533G>A; p.R178H; 9:35685299-35685299	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.108C>T; p.C36C; 9:35689710-35689710	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.314G>A; p.R105H; 9:35685707-35685707	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.114+6G>T; p.?; 9:35689698-35689698	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.13_15delAAG; p.K7delK; 9:35689803-35689805	prostate	carcinoma; adenocarcinoma	Deletion - In frame
c.415G>T; p.E139*; 9:35685511-35685511	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.366G>C; p.E122D; 9:35685655-35685655	NS	NS	Substitution - Missense
c.829G>A; p.A277T; 9:35683185-35683185	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.521G>A; p.G174E; 9:35685311-35685311	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.773-3_773-2insC; p.?; 9:35683243-35683244	liver	carcinoma	Unknown

COSMIC somatic mutation [Top]