Entrez Gene

Basic Information
Gene ID	7098
Name	TLR3
Synonymous	toll-like receptor 3;TLR3;toll-like receptor 3
Definition	-
Position	4q35
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.2426G>T; p.R809I; 4:186084112-186084112	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1516C>T; p.R506C; 4:186083202-186083202	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1516C>T; p.R506C; 4:186083202-186083202	skin	malignant_melanoma	Substitution - Missense
c.1516C>T; p.R506C; 4:186083202-186083202	skin	malignant_melanoma	Substitution - Missense
c.2606G>T; p.G869V; 4:186084764-186084764	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1271G>T; p.S424I; 4:186082957-186082957	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1180C>T; p.R394*; 4:186082866-186082866	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.331C>A; p.L111I; 4:186076950-186076950	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1277C>T; p.A426V; 4:186082963-186082963	skin	malignant_melanoma	Substitution - Missense
c.558A>G; p.L186L; 4:186078956-186078956	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2037T>C; p.T679T; 4:186083723-186083723	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.137C>G; p.P46R; 4:186076756-186076756	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.933G>A; p.Q311Q; 4:186082619-186082619	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.2516C>A; p.A839D; 4:186084674-186084674	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.2331G>A; p.M777I; 4:186084017-186084017	skin; extremity	malignant_melanoma	Substitution - Missense
c.1030C>T; p.P344S; 4:186082716-186082716	skin	malignant_melanoma	Substitution - Missense
c.1265T>C; p.I422T; 4:186082951-186082951	breast	carcinoma	Substitution - Missense
c.1648A>C; p.N550H; 4:186083334-186083334	pancreas	carcinoma	Substitution - Missense
c.2606G>A; p.G869E; 4:186084764-186084764	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1336G>T; p.E446*; 4:186083022-186083022	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1928G>A; p.R643H; 4:186083614-186083614	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.693C>G; p.V231V; 4:186082379-186082379	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1859A>G; p.N620S; 4:186083545-186083545	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2092G>A; p.D698N; 4:186083778-186083778	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1872C>T; p.S624S; 4:186083558-186083558	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2692G>T; p.G898*; 4:186084850-186084850	liver	carcinoma	Substitution - Nonsense
c.2692G>T; p.G898*; 4:186084850-186084850	liver	carcinoma	Substitution - Nonsense
c.1405C>G; p.L469V; 4:186083091-186083091	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2004C>T; p.I668I; 4:186083690-186083690	skin	malignant_melanoma	Substitution - coding silent
c.2178G>A; p.E726E; 4:186083864-186083864	skin	malignant_melanoma	Substitution - coding silent
c.1815C>A; p.V605V; 4:186083501-186083501	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2219G>A; p.R740Q; 4:186083905-186083905	skin	malignant_melanoma	Substitution - Missense
c.1477delA; p.N494fs*15; 4:186083163-186083163	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2046C>T; p.H682H; 4:186083732-186083732	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2348C>G; p.S783C; 4:186084034-186084034	urinary_tract; bladder	carcinoma	Substitution - Missense
c.263C>G; p.S88*; 4:186076882-186076882	breast	carcinoma	Substitution - Nonsense
c.1774G>A; p.D592N; 4:186083460-186083460	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1223C>T; p.P408L; 4:186082909-186082909	skin	malignant_melanoma	Substitution - Missense
c.1688A>C; p.H563P; 4:186083374-186083374	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1130G>A; p.G377E; 4:186082816-186082816	skin; head_neck	malignant_melanoma; superficial_spreading	Substitution - Missense
c.1716C>T; p.N572N; 4:186083402-186083402	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1435G>A; p.V479I; 4:186083121-186083121	liver	carcinoma	Substitution - Missense
c.580T>G; p.F194V; 4:186078978-186078978	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1234C>T; p.L412F; 4:186082920-186082920	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1234C>T; p.L412F; 4:186082920-186082920	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2532G>A; p.L844L; 4:186084690-186084690	pancreas	carcinoma	Substitution - coding silent
c.445T>G; p.L149V; 4:186078843-186078843	pancreas	carcinoma	Substitution - Missense
c.445T>G; p.L149V; 4:186078843-186078843	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.158T>C; p.I53T; 4:186076777-186076777	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.512A>G; p.E171G; 4:186078910-186078910	skin	malignant_melanoma	Substitution - Missense
c.2661T>C; p.G887G; 4:186084819-186084819	ovary	other; neoplasm	Substitution - coding silent
c.2459A>G; p.H820R; 4:186084145-186084145	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2473C>T; p.P825S; 4:186084159-186084159	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1086G>A; p.M362I; 4:186082772-186082772	skin	malignant_melanoma	Substitution - Missense
c.1406T>C; p.L469P; 4:186083092-186083092	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1738G>C; p.E580Q; 4:186083424-186083424	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1738G>C; p.E580Q; 4:186083424-186083424	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2514A>T; p.Q838H; 4:186084672-186084672	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.383T>C; p.L128P; 4:186077002-186077002	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1884G>A; p.K628K; 4:186083570-186083570	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1525A>G; p.T509A; 4:186083211-186083211	central_nervous_system; brain	glioma	Substitution - Missense
c.2334A>T; p.E778D; 4:186084020-186084020	skin	malignant_melanoma	Substitution - Missense
c.1405C>A; p.L469M; 4:186083091-186083091	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2421C>T; p.I807I; 4:186084107-186084107	skin	malignant_melanoma	Substitution - coding silent
c.1854G>A; p.Q618Q; 4:186083540-186083540	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.266A>C; p.K89T; 4:186076885-186076885	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.369G>A; p.T123T; 4:186076988-186076988	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1841C>T; p.S614L; 4:186083527-186083527	skin	malignant_melanoma	Substitution - Missense
c.2317_2321delCATTT; p.H773fs*20; 4:186084003-186084007	breast	carcinoma	Deletion - Frameshift
c.752G>A; p.R251Q; 4:186082438-186082438	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1864A>G; p.I622V; 4:186083550-186083550	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2184G>C; p.W728C; 4:186083870-186083870	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2570A>C; p.D857A; 4:186084728-186084728	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.751C>T; p.R251W; 4:186082437-186082437	breast	carcinoma	Substitution - Missense
c.1102C>T; p.P368S; 4:186082788-186082788	skin	malignant_melanoma	Substitution - Missense
c.1252A>C; p.K418Q; 4:186082938-186082938	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1102C>T; p.P368S; 4:186082788-186082788	skin; scalp	malignant_melanoma	Substitution - Missense
c.652C>T; p.H218Y; 4:186082338-186082338	breast	carcinoma	Substitution - Missense
c.905A>G; p.Y302C; 4:186082591-186082591	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2064G>T; p.V688V; 4:186083750-186083750	skin	malignant_melanoma	Substitution - coding silent
c.1828G>C; p.V610L; 4:186083514-186083514	breast	carcinoma	Substitution - Missense
c.2435A>C; p.K812T; 4:186084121-186084121	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2435A>C; p.K812T; 4:186084121-186084121	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1191A>G; p.T397T; 4:186082877-186082877	liver	carcinoma	Substitution - coding silent
c.1585C>T; p.L529F; 4:186083271-186083271	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1191A>G; p.T397T; 4:186082877-186082877	liver	carcinoma	Substitution - coding silent
c.39C>T; p.G13G; 4:186076658-186076658	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.20G>T; p.C7F; 4:186076639-186076639	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1723G>C; p.D575H; 4:186083409-186083409	breast	carcinoma	Substitution - Missense
c.764T>A; p.L255Q; 4:186082450-186082450	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.32delG; p.G13fs*28; 4:186076651-186076651	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1381A>C; p.I461L; 4:186083067-186083067	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1637_1638GG>AA; p.W546*; 4:186083323-186083324	skin	malignant_melanoma	Substitution - Nonsense
c.187C>T; p.L63F; 4:186076806-186076806	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2187G>A; p.R729R; 4:186083873-186083873	skin	malignant_melanoma	Substitution - coding silent
c.1240C>T; p.L414L; 4:186082926-186082926	skin	malignant_melanoma	Substitution - coding silent
c.1671C>T; p.F557F; 4:186083357-186083357	skin	malignant_melanoma	Substitution - coding silent
c.2650G>C; p.E884Q; 4:186084808-186084808	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1671C>T; p.F557F; 4:186083357-186083357	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2039C>T; p.P680L; 4:186083725-186083725	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.961C>A; p.L321I; 4:186082647-186082647	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.707G>C; p.S236T; 4:186082393-186082393	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2693G>T; p.G898V; 4:186084851-186084851	liver	carcinoma	Substitution - Missense
c.2693G>T; p.G898V; 4:186084851-186084851	liver	carcinoma	Substitution - Missense
c.288G>T; p.Q96H; 4:186076907-186076907	skin	malignant_melanoma	Substitution - Missense
c.288G>T; p.Q96H; 4:186076907-186076907	skin	malignant_melanoma	Substitution - Missense
c.1755A>G; p.L585L; 4:186083441-186083441	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1755A>G; p.L585L; 4:186083441-186083441	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.165G>A; p.V55V; 4:186076784-186076784	prostate	carcinoma	Substitution - coding silent
c.555G>A; p.A185A; 4:186078953-186078953	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.676C>A; p.L226I; 4:186082362-186082362	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2175T>C; p.F725F; 4:186083861-186083861	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2166C>T; p.L722L; 4:186083852-186083852	breast	carcinoma; ER-PR-positive_carcinoma	Substitution - coding silent
c.1579G>T; p.E527*; 4:186083265-186083265	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1153A>G; p.S385G; 4:186082839-186082839	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1473C>T; p.A491A; 4:186083159-186083159	skin	malignant_melanoma	Substitution - coding silent
c.125T>A; p.L42*; 4:186076744-186076744	liver	carcinoma	Substitution - Nonsense
c.245T>C; p.V82A; 4:186076864-186076864	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.125T>A; p.L42*; 4:186076744-186076744	liver	carcinoma	Substitution - Nonsense
c.2338G>A; p.E780K; 4:186084024-186084024	skin	malignant_melanoma	Substitution - Missense
c.31_32insG; p.L14fs*18; 4:186076650-186076651	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.31_32insG; p.L14fs*18; 4:186076650-186076651	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.31_32insG; p.L14fs*18; 4:186076650-186076651	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.446T>G; p.L149*; 4:186078844-186078844	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.204C>T; p.A68A; 4:186076823-186076823	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2416A>G; p.S806G; 4:186084102-186084102	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1890C>T; p.F630F; 4:186083576-186083576	skin	malignant_melanoma	Substitution - coding silent
c.1726G>A; p.E576K; 4:186083412-186083412	oesophagus	carcinoma	Substitution - Missense
c.748A>G; p.I250V; 4:186082434-186082434	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2486G>A; p.R829K; 4:186084172-186084172	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2486+8A>C; p.?; 4:186084180-186084180	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.2669G>A; p.R890H; 4:186084827-186084827	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.937T>G; p.L313V; 4:186082623-186082623	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.912C>T; p.F304F; 4:186082598-186082598	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2669G>A; p.R890H; 4:186084827-186084827	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.1208C>A; p.S403*; 4:186082894-186082894	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.2669G>A; p.R890H; 4:186084827-186084827	pancreas	carcinoma	Substitution - Missense
c.1863C>G; p.L621L; 4:186083549-186083549	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.1986C>T; p.N662N; 4:186083672-186083672	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1315G>T; p.G439C; 4:186083001-186083001	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.809G>A; p.G270E; 4:186082495-186082495	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1645G>A; p.A549T; 4:186083331-186083331	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1016C>A; p.S339Y; 4:186082702-186082702	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.126G>A; p.L42L; 4:186076745-186076745	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1314G>T; p.L438L; 4:186083000-186083000	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1555G>T; p.A519S; 4:186083241-186083241	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2629T>A; p.L877M; 4:186084787-186084787	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2599C>T; p.R867*; 4:186084757-186084757	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.2599C>T; p.R867*; 4:186084757-186084757	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.813A>G; p.L271L; 4:186082499-186082499	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1179G>A; p.L393L; 4:186082865-186082865	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1377C>T; p.F459F; 4:186083063-186083063	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1377C>T; p.F459F; 4:186083063-186083063	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1488T>C; p.D496D; 4:186083174-186083174	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.346G>C; p.D116H; 4:186076965-186076965	liver	carcinoma	Substitution - Missense
c.1871C>T; p.S624F; 4:186083557-186083557	breast	carcinoma	Substitution - Missense
c.384C>T; p.L128L; 4:186077003-186077003	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.916G>A; p.E306K; 4:186082602-186082602	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.523G>C; p.E175Q; 4:186078921-186078921	thyroid	carcinoma	Substitution - Missense
c.2081C>T; p.S694L; 4:186083767-186083767	skin	malignant_melanoma	Substitution - Missense
c.458A>G; p.D153G; 4:186078856-186078856	liver	carcinoma	Substitution - Missense
c.1181G>A; p.R394Q; 4:186082867-186082867	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.54G>A; p.G18G; 4:186076673-186076673	skin	malignant_melanoma	Substitution - coding silent
c.784A>G; p.T262A; 4:186082470-186082470	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1378G>A; p.E460K; 4:186083064-186083064	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1378G>A; p.E460K; 4:186083064-186083064	skin	malignant_melanoma	Substitution - Missense
c.665G>A; p.R222K; 4:186082351-186082351	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]