Cancer metastasis gene database Home
Cancer metastasis database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

6938

Name

TCF12

Synonymous

transcription factor 12;TCF12;transcription factor 12

Definition

DNA-binding protein HTF4|E-box-binding protein|class B basic helix-loop-helix protein 20|helix-loop-helix transcription factor 4|transcription factor HTF-4

Position

15q21

Gene Type

protein-coding

COSMIC somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1413C>A; p.L471L; 15:57253414-57253414

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.899G>A; p.G300D; 15:57232785-57232785

 skin; trunkmalignant_melanomaSubstitution - Missense

c.1876C>T; p.R626*; 15:57273160-57273160

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; myelofibrosisSubstitution - Nonsense

c.1256G>A; p.C419Y; 15:57252488-57252488

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1256G>A; p.C419Y; 15:57252488-57252488

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1256G>A; p.C419Y; 15:57252488-57252488

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1256G>A; p.C419Y; 15:57252488-57252488

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1256G>A; p.C419Y; 15:57252488-57252488

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1256G>A; p.C419Y; 15:57252488-57252488

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1157C>T; p.S386F; 15:57251392-57251392

 skinmalignant_melanomaSubstitution - Missense

c.1256G>A; p.C419Y; 15:57252488-57252488

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1157C>T; p.S386F; 15:57251392-57251392

 skinmalignant_melanomaSubstitution - Missense

c.1256G>A; p.C419Y; 15:57252488-57252488

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1256G>A; p.C419Y; 15:57252488-57252488

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1256G>A; p.C419Y; 15:57252488-57252488

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1256G>A; p.C419Y; 15:57252488-57252488

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.31A>T; p.I11L; 15:56919944-56919944

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.336_337delAG; p.G115fs*17; 15:57166412-57166413

 stomachadenocarcinomaDeletion - Frameshift

c.1863C>T; p.F621F; 15:57273147-57273147

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.833C>T; p.P278L; 15:57232719-57232719

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1289G>C; p.R430T; 15:57253290-57253290

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.508C>T; p.H170Y; 15:57192275-57192275

 skinmalignant_melanomaSubstitution - Missense

c.359A>G; p.Y120C; 15:57166435-57166435

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.2110G>T; p.G704C; 15:57282576-57282576

 breastcarcinomaSubstitution - Missense

c.648A>C; p.P216P; 15:57231220-57231220

 breastcarcinomaSubstitution - coding silent

c.1838G>A; p.R613H; 15:57273122-57273122

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1156T>C; p.S386P; 15:57251391-57251391

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1879A>T; p.M627L; 15:57273163-57273163

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.554A>G; p.K185R; 15:57197800-57197800

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1837C>T; p.R613C; 15:57273121-57273121

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1158C>A; p.S386S; 15:57251393-57251393

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.701C>A; p.S234Y; 15:57232306-57232306

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.535C>T; p.Q179*; 15:57197781-57197781

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.2039C>T; p.A680V; 15:57282505-57282505

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.463G>A; p.A155T; 15:57192230-57192230

 prostatecarcinomaSubstitution - Missense

c.818A>G; p.D273G; 15:57232423-57232423

 breastcarcinomaSubstitution - Missense

c.283G>T; p.E95*; 15:57091849-57091849

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Nonsense

c.1828G>A; p.E610K; 15:57273112-57273112

 central_nervous_system; brainstemglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1482G>T; p.R494R; 15:57262108-57262108

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.543A>C; p.K181N; 15:57197789-57197789

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.250G>T; p.D84Y; 15:57091816-57091816

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1144C>T; p.Q382*; 15:57251379-57251379

 pancreascarcinomaSubstitution - Nonsense

c.1144C>T; p.Q382*; 15:57251379-57251379

 pancreascarcinomaSubstitution - Nonsense

c.151A>T; p.I51F; 15:57063752-57063752

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.2085G>C; p.G695G; 15:57282551-57282551

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.203C>T; p.P68L; 15:57063804-57063804

 skinmalignant_melanomaSubstitution - Missense

c.1267C>T; p.R423*; 15:57253268-57253268

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.1976G>T; p.R659I; 15:57273260-57273260

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1267C>G; p.R423G; 15:57253268-57253268

 skinmalignant_melanomaSubstitution - Missense

c.1020A>G; p.G340G; 15:57234092-57234092

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1429G>T; p.G477*; 15:57253430-57253430

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.1507A>C; p.N503H; 15:57262133-57262133

 breastcarcinomaSubstitution - Missense

c.220A>C; p.R74R; 15:57063821-57063821

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.895C>T; p.R299C; 15:57232781-57232781

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1182C>G; p.H394Q; 15:57251417-57251417

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1182C>G; p.H394Q; 15:57251417-57251417

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1941C>A; p.A647A; 15:57273225-57273225

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1405G>C; p.G469R; 15:57253406-57253406

 skin; head_neckmalignant_melanoma; superficial_spreadingSubstitution - Missense

c.1831C>T; p.R611C; 15:57273115-57273115

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1831C>T; p.R611C; 15:57273115-57273115

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.901A>C; p.S301R; 15:57232787-57232787

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1831C>T; p.R611C; 15:57273115-57273115

 large_intestineadenomaSubstitution - Missense

c.1807C>T; p.R603W; 15:57273091-57273091

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1330G>T; p.G444*; 15:57253331-57253331

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.1807C>T; p.R603W; 15:57273091-57273091

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1346_1349delTGCC; p.P450fs*68; 15:57253347-57253350

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.1844G>T; p.R615L; 15:57273128-57273128

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.970+1G>T; p.?; 15:57232857-57232857

 lungcarcinoma; adenocarcinomaUnknown

c.268C>T; p.R90*; 15:57091834-57091834

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.598_601delAATT; p.N200fs*44; 15:57231170-57231173

 kidneycarcinoma; clear_cell_renal_cell_carcinomaDeletion - Frameshift

c.1445C>T; p.A482V; 15:57253446-57253446

 breastcarcinoma; basal_(triple-negative)_carcinomaSubstitution - Missense

c.553A>G; p.K185E; 15:57197799-57197799

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1808delG; p.M604fs*29; 15:57273092-57273092

 central_nervous_system; brainstemglioma; astrocytoma_Grade_IVDeletion - Frameshift

c.1224G>C; p.L408F; 15:57252456-57252456

 biliary_tract; bile_ductcarcinoma; adenocarcinomaSubstitution - Missense

c.1054A>G; p.T352A; 15:57243490-57243490

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1337C>T; p.S446F; 15:57253338-57253338

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; acute_lymphoblastic_leukaemiaSubstitution - Missense

c.379C>T; p.P127S; 15:57166455-57166455

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1103C>T; p.S368L; 15:57243539-57243539

 skinmalignant_melanomaSubstitution - Missense

c.1124A>G; p.Q375R; 15:57251359-57251359

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.353C>T; p.S118F; 15:57166429-57166429

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.842C>G; p.S281*; 15:57232728-57232728

 breastcarcinomaSubstitution - Nonsense

c.358T>C; p.Y120H; 15:57166434-57166434

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.361A>G; p.S121G; 15:57166437-57166437

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.1524T>C; p.S508S; 15:57262150-57262150

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.1763A>C; p.E588A; 15:57273047-57273047

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1925T>G; p.L642R; 15:57273209-57273209

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.327A>G; p.G109G; 15:57166403-57166403

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1816A>C; p.N606H; 15:57273100-57273100

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.202C>T; p.P68S; 15:57063803-57063803

 skinmalignant_melanomaSubstitution - Missense

c.259A>G; p.N87D; 15:57091825-57091825

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.821G>A; p.R274H; 15:57232426-57232426

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.185C>T; p.T62I; 15:57063786-57063786

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; hairy_cell_leukaemiaSubstitution - Missense

c.1863C>A; p.F621L; 15:57273147-57273147

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1808G>A; p.R603Q; 15:57273092-57273092

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1808G>A; p.R603Q; 15:57273092-57273092

 pancreascarcinoma; acinar_carcinomaSubstitution - Missense

c.1808G>A; p.R603Q; 15:57273092-57273092

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.220A>G; p.R74G; 15:57063821-57063821

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.979G>A; p.G327R; 15:57234051-57234051

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1693G>C; p.D565H; 15:57263222-57263222

 breastcarcinomaSubstitution - Missense

c.44A>G; p.K15R; 15:56919957-56919957

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.295C>T; p.P99S; 15:57091861-57091861

 skinmalignant_melanomaSubstitution - Missense

c.1016_1026delTTGGAAAGGCT; p.K341fs*6; 15:57234088-57234098

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.594C>T; p.S198S; 15:57231166-57231166

 skinmalignant_melanomaSubstitution - coding silent

c.928G>A; p.A310T; 15:57232814-57232814

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1936C>G; p.Q646E; 15:57273220-57273220

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.539_540insA; p.V183fs*21; 15:57197785-57197786

 central_nervous_system; brainstemglioma; astrocytoma_Grade_IVInsertion - Frameshift

c.539_540insA; p.V183fs*21; 15:57197785-57197786

 large_intestine; coloncarcinoma; adenocarcinomaInsertion - Frameshift

c.1315C>T; p.R439W; 15:57253316-57253316

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1315C>T; p.R439W; 15:57253316-57253316

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1451G>A; p.S484N; 15:57253452-57253452

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.354C>A; p.S118S; 15:57166430-57166430

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.354C>A; p.S118S; 15:57166430-57166430

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.233A>G; p.D78G; 15:57091799-57091799

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1488_1489delCT; p.S497fs*12; 15:57262114-57262115

 central_nervous_system; brainglioma; astrocytoma_Grade_IVDeletion - Frameshift

c.339G>T; p.E113D; 15:57166415-57166415

 breastcarcinomaSubstitution - Missense

c.160A>T; p.R54*; 15:57063761-57063761

 prostatecarcinoma; adenocarcinomaSubstitution - Nonsense

c.1830A>G; p.E610E; 15:57273114-57273114

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1316G>A; p.R439Q; 15:57253317-57253317

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1270A>G; p.M424V; 15:57253271-57253271

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1364A>T; p.D455V; 15:57253365-57253365

 soft_tissue; fatliposarcoma; myxoid-round_cellSubstitution - Missense

c.415G>A; p.G139R; 15:57192182-57192182

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.578C>T; p.S193F; 15:57197824-57197824

 skinmalignant_melanomaSubstitution - Missense

c.1515A>C; p.S505S; 15:57262141-57262141

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - coding silent

c.1515A>C; p.S505S; 15:57262141-57262141

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.1908A>C; p.K636N; 15:57273192-57273192

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1325C>A; p.A442D; 15:57253326-57253326

 breastcarcinomaSubstitution - Missense

c.1195C>T; p.R399*; 15:57252427-57252427

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense