Entrez Gene

Basic Information
Gene ID	6869
Name	TACR1
Synonymous	tachykinin receptor 1;TACR1;tachykinin receptor 1
Definition	NK-1 receptor\|NK-1R\|substance-P receptor\|tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)
Position	2p12
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.564G>A; p.P188P; 2:75120594-75120594	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.564G>A; p.P188P; 2:75120594-75120594	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.564G>A; p.P188P; 2:75120594-75120594	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.564G>A; p.P188P; 2:75120594-75120594	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.530G>C; p.R177T; 2:75120628-75120628	breast	carcinoma	Substitution - Missense
c.385G>C; p.D129H; 2:75198550-75198550	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1132T>C; p.S378P; 2:75049524-75049524	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1132T>C; p.S378P; 2:75049524-75049524	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.687C>T; p.P229P; 2:75053653-75053653	autonomic_ganglia	neuroblastoma	Substitution - coding silent
c.1019G>A; p.R340Q; 2:75049637-75049637	pancreas	carcinoma	Substitution - Missense
c.1019G>A; p.R340Q; 2:75049637-75049637	pancreas	carcinoma	Substitution - Missense
c.148A>C; p.N50H; 2:75198787-75198787	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.534C>T; p.V178V; 2:75120624-75120624	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.534C>T; p.V178V; 2:75120624-75120624	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.180C>T; p.H60H; 2:75198755-75198755	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.523C>T; p.P175S; 2:75120635-75120635	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.137C>A; p.S46Y; 2:75198798-75198798	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.185G>T; p.R62I; 2:75198750-75198750	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.342C>T; p.A114A; 2:75198593-75198593	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.659G>A; p.G220E; 2:75053681-75053681	urinary_tract; bladder	carcinoma	Substitution - Missense
c.860_861AC>TA; p.Y287L; 2:75051322-75051323	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.912C>A; p.I304I; 2:75051271-75051271	breast	carcinoma	Substitution - coding silent
c.741C>A; p.V247V; 2:75051442-75051442	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.198G>A; p.V66V; 2:75198737-75198737	pancreas	carcinoma	Substitution - coding silent
c.165G>A; p.W55*; 2:75198770-75198770	skin	malignant_melanoma	Substitution - Nonsense
c.674C>T; p.A225V; 2:75053666-75053666	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.547G>T; p.E183*; 2:75120611-75120611	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1133C>A; p.S378*; 2:75049523-75049523	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.905C>T; p.P302L; 2:75051278-75051278	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.625delC; p.L209fs*3; 2:75053715-75053715	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.1132T>G; p.S378A; 2:75049524-75049524	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.295T>C; p.Y99H; 2:75198640-75198640	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1138C>T; p.L380L; 2:75049518-75049518	ovary	other; neoplasm	Substitution - coding silent
c.1015A>G; p.T339A; 2:75049641-75049641	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.69T>A; p.N23K; 2:75198866-75198866	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.962_963GG>AA; p.R321Q; 2:75049693-75049694	skin; neck	malignant_melanoma	Substitution - Missense
c.301G>A; p.G101S; 2:75198634-75198634	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.546C>T; p.I182I; 2:75120612-75120612	skin	malignant_melanoma	Substitution - coding silent
c.187A>C; p.M63L; 2:75198748-75198748	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.546C>T; p.I182I; 2:75120612-75120612	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.296A>G; p.Y99C; 2:75198639-75198639	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1221C>T; p.S407S; 2:75049435-75049435	skin	malignant_melanoma	Substitution - coding silent
c.987C>A; p.G329G; 2:75049669-75049669	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1191G>A; p.E397E; 2:75049465-75049465	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.178C>G; p.H60D; 2:75198757-75198757	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.535G>A; p.V179M; 2:75120623-75120623	stomach	adenocarcinoma	Substitution - Missense
c.365C>T; p.S122F; 2:75198570-75198570	skin	malignant_melanoma	Substitution - Missense
c.1088G>T; p.G363V; 2:75049568-75049568	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.659delG; p.G220fs*30; 2:75053681-75053681	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.334C>T; p.P112S; 2:75198601-75198601	skin	malignant_melanoma	Substitution - Missense
c.1114_1115GG>AA; p.G372N; 2:75049541-75049542	skin	malignant_melanoma	Substitution - Missense
c.609G>A; p.L203L; 2:75053731-75053731	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.720C>G; p.V240V; 2:75053620-75053620	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.657G>A; p.V219V; 2:75053683-75053683	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1189G>T; p.E397*; 2:75049467-75049467	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.787C>T; p.P263S; 2:75051396-75051396	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.390G>C; p.R130S; 2:75120768-75120768	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.787C>T; p.P263S; 2:75051396-75051396	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.722C>A; p.S241Y; 2:75053618-75053618	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.229G>A; p.A77T; 2:75198706-75198706	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1095C>T; p.H365H; 2:75049561-75049561	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.233A>G; p.E78G; 2:75198702-75198702	liver	carcinoma	Substitution - Missense
c.756C>T; p.V252V; 2:75051427-75051427	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.495G>C; p.Q165H; 2:75120663-75120663	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1096G>A; p.E366K; 2:75049560-75049560	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.38C>T; p.P13L; 2:75198897-75198897	skin	malignant_melanoma	Substitution - Missense
c.928G>A; p.D310N; 2:75051255-75051255	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.609G>T; p.L203L; 2:75053731-75053731	breast	carcinoma	Substitution - coding silent
c.1115G>T; p.G372V; 2:75049541-75049541	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.830T>A; p.L277H; 2:75051353-75051353	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.336C>T; p.P112P; 2:75198599-75198599	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.351C>T; p.F117F; 2:75198584-75198584	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.70C>T; p.Q24*; 2:75198865-75198865	skin	malignant_melanoma	Substitution - Nonsense
c.91C>A; p.Q31K; 2:75198844-75198844	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.176C>T; p.A59V; 2:75198759-75198759	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.711C>T; p.H237H; 2:75053629-75053629	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.712G>A; p.E238K; 2:75053628-75053628	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.798C>A; p.I266I; 2:75051385-75051385	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.699T>C; p.S233S; 2:75053641-75053641	breast	carcinoma	Substitution - coding silent
c.175G>T; p.A59S; 2:75198760-75198760	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.175G>T; p.A59S; 2:75198760-75198760	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.201G>A; p.T67T; 2:75198734-75198734	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.201G>A; p.T67T; 2:75198734-75198734	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.201G>A; p.T67T; 2:75198734-75198734	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.201G>A; p.T67T; 2:75198734-75198734	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.201G>A; p.T67T; 2:75198734-75198734	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.938G>A; p.R313H; 2:75049718-75049718	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1096G>T; p.E366*; 2:75049560-75049560	skin; trunk	malignant_melanoma	Substitution - Nonsense
c.81A>G; p.Q27Q; 2:75198854-75198854	skin	malignant_melanoma	Substitution - coding silent
c.1224G>A; p.408; 2:75049432-75049432	ovary	other; neoplasm	Substitution - coding silent
c.373G>A; p.A125T; 2:75198562-75198562	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.75C>T; p.F25F; 2:75198860-75198860	breast	carcinoma	Substitution - coding silent
c.233_239delAGGCCTC; p.E78fs*9; 2:75198696-75198702	pancreas	carcinoma	Deletion - Frameshift
c.233_239delAGGCCTC; p.E78fs*9; 2:75198696-75198702	pancreas	carcinoma; ductal_carcinoma	Deletion - Frameshift
c.516G>A; p.E172E; 2:75120642-75120642	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.72G>A; p.Q24Q; 2:75198863-75198863	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.500A>G; p.Y167C; 2:75120658-75120658	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1165C>T; p.R389*; 2:75049491-75049491	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1134G>A; p.S378S; 2:75049522-75049522	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.73T>C; p.F25L; 2:75198862-75198862	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.365_366CC>TT; p.S122F; 2:75198569-75198570	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.289G>A; p.E97K; 2:75198646-75198646	skin	malignant_melanoma	Substitution - Missense
c.189G>A; p.M63I; 2:75198746-75198746	breast	carcinoma	Substitution - Missense
c.945C>A; p.G315G; 2:75049711-75049711	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1166G>A; p.R389Q; 2:75049490-75049490	skin	malignant_melanoma	Substitution - Missense
c.1166G>A; p.R389Q; 2:75049490-75049490	skin	malignant_melanoma	Substitution - Missense
c.389+1G>A; p.?; 2:75198545-75198545	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.1111G>A; p.D371N; 2:75049545-75049545	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.412C>T; p.L138F; 2:75120746-75120746	skin	malignant_melanoma	Substitution - Missense
c.258A>T; p.T86T; 2:75198677-75198677	breast	carcinoma	Substitution - coding silent
c.324C>G; p.H108Q; 2:75198611-75198611	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.340G>A; p.A114T; 2:75198595-75198595	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.861C>A; p.Y287*; 2:75051322-75051322	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.340G>A; p.A114T; 2:75198595-75198595	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1003G>T; p.E335*; 2:75049653-75049653	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.860A>T; p.Y287F; 2:75051323-75051323	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]