Entrez Gene

Basic Information
Gene ID	680
Name	BRS3
Synonymous	bombesin-like receptor 3;BRS3;bombesin-like receptor 3
Definition	BRS-3\|G-protein coupled receptor\|bombesin receptor subtype 3\|bombesin receptor subtype-3
Position	Xq26.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.290T>C; p.L97P; 23:136488404-136488404	ovary	other; neoplasm	Substitution - Missense
c.379C>T; p.R127W; 23:136488493-136488493	breast	carcinoma	Substitution - Missense
c.363G>A; p.K121K; 23:136488477-136488477	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.422T>G; p.L141R; 23:136488536-136488536	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.44C>A; p.S15*; 23:136488158-136488158	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.714C>A; p.S238S; 23:136490412-136490412	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.996G>A; p.W332*; 23:136492171-136492171	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.435-2A>G; p.?; 23:136490131-136490131	stomach	carcinoma; adenocarcinoma	Unknown
c.972C>T; p.C324C; 23:136492147-136492147	central_nervous_system; brain	glioma	Substitution - coding silent
c.409A>C; p.T137P; 23:136488523-136488523	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.384C>T; p.L128L; 23:136488498-136488498	skin	malignant_melanoma	Substitution - coding silent
c.187C>T; p.L63F; 23:136488301-136488301	skin	malignant_melanoma	Substitution - Missense
c.68C>T; p.S23L; 23:136488182-136488182	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.479C>T; p.A160V; 23:136490177-136490177	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.772C>T; p.H258Y; 23:136490470-136490470	skin	malignant_melanoma	Substitution - Missense
c.299G>T; p.C100F; 23:136488413-136488413	prostate	carcinoma	Substitution - Missense
c.696_708del13; p.S234fs*2; 23:136490394-136490406	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.4G>T; p.A2S; 23:136488118-136488118	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.244C>T; p.P82S; 23:136488358-136488358	skin	malignant_melanoma	Substitution - Missense
c.463C>T; p.R155*; 23:136490161-136490161	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.779G>A; p.R260H; 23:136490477-136490477	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.917C>A; p.A306D; 23:136492092-136492092	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.779G>A; p.R260H; 23:136490477-136490477	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.779G>A; p.R260H; 23:136490477-136490477	pancreas	carcinoma	Substitution - Missense
c.55G>T; p.D19Y; 23:136488169-136488169	breast	carcinoma	Substitution - Missense
c.988C>T; p.L330F; 23:136492163-136492163	skin	malignant_melanoma	Substitution - Missense
c.111C>T; p.S37S; 23:136488225-136488225	thyroid	carcinoma; anaplastic_carcinoma	Substitution - coding silent
c.147C>A; p.A49A; 23:136488261-136488261	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.809C>A; p.A270D; 23:136491984-136491984	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.675C>A; p.F225L; 23:136490373-136490373	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.962G>A; p.S321N; 23:136492137-136492137	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.968C>A; p.S323Y; 23:136492143-136492143	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.616T>A; p.Y206N; 23:136490314-136490314	kidney	other; neoplasm	Substitution - Missense
c.350G>A; p.R117K; 23:136488464-136488464	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.808G>T; p.A270S; 23:136491983-136491983	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.356G>C; p.G119A; 23:136488470-136488470	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.562G>A; p.V188I; 23:136490260-136490260	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.87C>T; p.N29N; 23:136488201-136488201	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.71G>C; p.S24T; 23:136488185-136488185	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3G>T; p.M1I; 23:136488117-136488117	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.304C>T; p.P102S; 23:136488418-136488418	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.601G>T; p.E201*; 23:136490299-136490299	central_nervous_system; brain	glioma	Substitution - Nonsense
c.538C>T; p.L180L; 23:136490236-136490236	skin	malignant_melanoma	Substitution - coding silent
c.909C>A; p.D303E; 23:136492084-136492084	breast	carcinoma	Substitution - Missense
c.801G>A; p.K267K; 23:136491976-136491976	liver	carcinoma	Substitution - coding silent
c.1073C>A; p.A358D; 23:136492248-136492248	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.421C>A; p.L141I; 23:136488535-136488535	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.725G>A; p.R242K; 23:136490423-136490423	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.168G>A; p.V56V; 23:136488282-136488282	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1192A>G; p.R398G; 23:136492367-136492367	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1192A>G; p.R398G; 23:136492367-136492367	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.83C>T; p.S28F; 23:136488197-136488197	skin	malignant_melanoma	Substitution - Missense
c.83C>T; p.S28F; 23:136488197-136488197	skin	malignant_melanoma	Substitution - Missense
c.289C>A; p.L97M; 23:136488403-136488403	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.946C>T; p.R316W; 23:136492121-136492121	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1101G>A; p.V367V; 23:136492276-136492276	breast	carcinoma	Substitution - coding silent
c.653C>A; p.S218Y; 23:136490351-136490351	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.653C>A; p.S218Y; 23:136490351-136490351	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1157C>A; p.S386*; 23:136492332-136492332	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.837G>A; p.L279L; 23:136492012-136492012	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.409delA; p.T137fs*2; 23:136488523-136488523	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.787-1G>T; p.?; 23:136491961-136491961	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.1109C>T; p.T370M; 23:136492284-136492284	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.426C>A; p.S142R; 23:136488540-136488540	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1109C>T; p.T370M; 23:136492284-136492284	skin	malignant_melanoma	Substitution - Missense
c.817G>A; p.V273I; 23:136491992-136491992	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2T>G; p.M1R; 23:136488116-136488116	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2T>G; p.M1R; 23:136488116-136488116	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1007G>T; p.S336I; 23:136492182-136492182	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.32A>G; p.Q11R; 23:136488146-136488146	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.580C>T; p.P194S; 23:136490278-136490278	skin; mucosal	malignant_melanoma	Substitution - Missense
c.350G>T; p.R117I; 23:136488464-136488464	breast	carcinoma	Substitution - Missense
c.914C>T; p.S305F; 23:136492089-136492089	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.672G>T; p.V224V; 23:136490370-136490370	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.672G>T; p.V224V; 23:136490370-136490370	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - coding silent
c.672G>T; p.V224V; 23:136490370-136490370	soft_tissue; striated_muscle	rhabdomyosarcoma	Substitution - coding silent
c.1162A>G; p.T388A; 23:136492337-136492337	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.328G>A; p.A110T; 23:136488442-136488442	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.349A>C; p.R117R; 23:136488463-136488463	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.61G>A; p.E21K; 23:136488175-136488175	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.692C>G; p.S231C; 23:136490390-136490390	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.437A>G; p.Y146C; 23:136490135-136490135	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.437A>G; p.Y146C; 23:136490135-136490135	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.44C>G; p.S15*; 23:136488158-136488158	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1055G>A; p.R352Q; 23:136492230-136492230	pancreas	carcinoma; adenocarcinoma	Substitution - Missense
c.326T>A; p.L109H; 23:136488440-136488440	haematopoietic_and_lymphoid_tissue; spleen	lymphoid_neoplasm; marginal_zone_lymphoma	Substitution - Missense
c.489G>T; p.K163N; 23:136490187-136490187	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.489G>T; p.K163N; 23:136490187-136490187	pancreas	carcinoma	Substitution - Missense
c.836T>A; p.L279Q; 23:136492011-136492011	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.477T>C; p.N159N; 23:136490175-136490175	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.231C>T; p.S77S; 23:136488345-136488345	oesophagus	carcinoma	Substitution - coding silent
c.325C>A; p.L109I; 23:136488439-136488439	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.90T>C; p.D30D; 23:136488204-136488204	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.574C>G; p.R192G; 23:136490272-136490272	urinary_tract; bladder	carcinoma	Substitution - Missense
c.690C>T; p.L230L; 23:136490388-136490388	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.962G>T; p.S321I; 23:136492137-136492137	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.574C>T; p.R192*; 23:136490272-136490272	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.871T>C; p.Y291H; 23:136492046-136492046	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1014G>T; p.Q338H; 23:136492189-136492189	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.577G>A; p.D193N; 23:136490275-136490275	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]