Entrez Gene

Basic Information
Gene ID	6768
Name	ST14
Synonymous	suppression of tumorigenicity 14 (colon carcinoma);ST14;suppression of tumorigenicity 14 (colon carcinoma)
Definition	membrane-type serine protease 1\|prostamin\|serine protease 14\|serine protease TADG-15\|suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)\|suppressor of tumorigenicity 14 protein\|tumor associated differentially expressed gene 15 protein\|
Position	11q24-q25
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1622G>T; p.S541I; 11:130198559-130198559	breast	carcinoma	Substitution - Missense
c.1820G>T; p.R607L; 11:130199963-130199963	thyroid	other; neoplasm	Substitution - Missense
c.144A>C; p.E48D; 11:130188176-130188176	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1931C>T; p.S644F; 11:130200074-130200074	skin	malignant_melanoma	Substitution - Missense
c.1155C>T; p.F385F; 11:130196380-130196380	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1931C>T; p.S644F; 11:130200074-130200074	skin	malignant_melanoma	Substitution - Missense
c.1557C>T; p.D519D; 11:130198405-130198405	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.486G>A; p.P162P; 11:130189784-130189784	kidney	other; neoplasm	Substitution - coding silent
c.1336T>A; p.S446T; 11:130196682-130196682	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2199G>A; p.P733P; 11:130208614-130208614	prostate	carcinoma	Substitution - coding silent
c.223C>A; p.L75M; 11:130188255-130188255	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.223C>A; p.L75M; 11:130188255-130188255	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1090A>T; p.I364F; 11:130194714-130194714	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.264G>T; p.K88N; 11:130188552-130188552	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1819C>T; p.R607W; 11:130199962-130199962	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1098C>T; p.C366C; 11:130194722-130194722	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2050C>T; p.R684C; 11:130208465-130208465	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1191C>T; p.C397C; 11:130196416-130196416	skin	malignant_melanoma	Substitution - coding silent
c.834G>T; p.V278V; 11:130190653-130190653	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.545C>T; p.P182L; 11:130189843-130189843	skin	malignant_melanoma	Substitution - Missense
c.134A>G; p.K45R; 11:130188166-130188166	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.983A>G; p.E328G; 11:130194256-130194256	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1309G>A; p.D437N; 11:130196655-130196655	skin	malignant_melanoma	Substitution - Missense
c.1638G>A; p.G546G; 11:130198575-130198575	skin	malignant_melanoma	Substitution - coding silent
c.1142G>A; p.R381H; 11:130196367-130196367	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2223C>T; p.A741A; 11:130208638-130208638	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2175C>T; p.S725S; 11:130208590-130208590	skin	malignant_melanoma	Substitution - coding silent
c.295G>T; p.E99*; 11:130188583-130188583	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.331A>G; p.T111A; 11:130188619-130188619	skin	malignant_melanoma	Substitution - Missense
c.760T>G; p.S254A; 11:130190579-130190579	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1923C>T; p.C641C; 11:130200066-130200066	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.584C>T; p.S195L; 11:130189882-130189882	urinary_tract; bladder	carcinoma	Substitution - Missense
c.982G>C; p.E328Q; 11:130194255-130194255	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.314A>G; p.Y105C; 11:130188602-130188602	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2409T>G; p.G803G; 11:130209664-130209664	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.105C>T; p.G35G; 11:130188137-130188137	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.827T>A; p.V276E; 11:130190646-130190646	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.92G>T; p.G31V; 11:130188124-130188124	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1851G>A; p.G617G; 11:130199994-130199994	skin	malignant_melanoma	Substitution - coding silent
c.1851G>A; p.G617G; 11:130199994-130199994	skin	malignant_melanoma	Substitution - coding silent
c.1840C>T; p.R614C; 11:130199983-130199983	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.160C>T; p.R54C; 11:130188192-130188192	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.431C>T; p.T144M; 11:130188930-130188930	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1631G>A; p.C544Y; 11:130198568-130198568	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.139G>A; p.V47M; 11:130188171-130188171	skin	malignant_melanoma	Substitution - Missense
c.2174C>T; p.S725F; 11:130208589-130208589	breast	carcinoma	Substitution - Missense
c.978C>T; p.G326G; 11:130194251-130194251	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.978C>T; p.G326G; 11:130194251-130194251	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.978C>T; p.G326G; 11:130194251-130194251	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2237G>T; p.W746L; 11:130208652-130208652	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1932C>T; p.S644S; 11:130200075-130200075	skin; arm	malignant_melanoma	Substitution - coding silent
c.1651G>T; p.G551W; 11:130198588-130198588	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.588G>T; p.V196V; 11:130189886-130189886	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2075G>A; p.R692H; 11:130208490-130208490	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.811C>T; p.R271C; 11:130190630-130190630	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.690G>A; p.T230T; 11:130190509-130190509	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1341C>T; p.Y447Y; 11:130196687-130196687	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.557G>A; p.R186H; 11:130189855-130189855	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.188T>C; p.I63T; 11:130188220-130188220	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2350A>G; p.I784V; 11:130209522-130209522	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2182C>T; p.R728W; 11:130208597-130208597	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.156G>A; p.P52P; 11:130188188-130188188	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1782C>T; p.S594S; 11:130199044-130199044	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1260C>T; p.S420S; 11:130196606-130196606	thyroid	other; neoplasm	Substitution - coding silent
c.689C>T; p.T230M; 11:130190508-130190508	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2430C>T; p.S810S; 11:130209685-130209685	skin	malignant_melanoma	Substitution - coding silent
c.776C>G; p.T259S; 11:130190595-130190595	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2055C>T; p.S685S; 11:130208470-130208470	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1382C>T; p.T461M; 11:130197868-130197868	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.367G>A; p.A123T; 11:130188655-130188655	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1248C>T; p.F416F; 11:130196594-130196594	skin	malignant_melanoma	Substitution - coding silent
c.908T>C; p.L303P; 11:130194181-130194181	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.775A>G; p.T259A; 11:130190594-130190594	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.450C>T; p.S150S; 11:130189748-130189748	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.948G>A; p.L316L; 11:130194221-130194221	skin	malignant_melanoma	Substitution - coding silent
c.896C>T; p.P299L; 11:130194169-130194169	skin	malignant_melanoma	Substitution - Missense
c.864C>T; p.H288H; 11:130190683-130190683	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.792C>T; p.D264D; 11:130190611-130190611	skin	malignant_melanoma	Substitution - coding silent
c.1170C>T; p.P390P; 11:130196395-130196395	autonomic_ganglia	neuroblastoma	Substitution - coding silent
c.1750delA; p.N584fs*47; 11:130199012-130199012	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.1750delA; p.N584fs*47; 11:130199012-130199012	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.1750delA; p.N584fs*47; 11:130199012-130199012	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.1750delA; p.N584fs*47; 11:130199012-130199012	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.1750delA; p.N584fs*47; 11:130199012-130199012	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.1750delA; p.N584fs*47; 11:130199012-130199012	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.1750delA; p.N584fs*47; 11:130199012-130199012	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.1750delA; p.N584fs*47; 11:130199012-130199012	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.1750delA; p.N584fs*47; 11:130199012-130199012	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.1282C>T; p.R428C; 11:130196628-130196628	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.1282C>T; p.R428C; 11:130196628-130196628	pancreas	carcinoma	Substitution - Missense
c.2353A>T; p.T785S; 11:130209525-130209525	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.2258C>T; p.T753I; 11:130208673-130208673	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1160T>C; p.L387P; 11:130196385-130196385	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2086C>T; p.R696C; 11:130208501-130208501	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2086C>T; p.R696C; 11:130208501-130208501	breast	carcinoma	Substitution - Missense
c.780_781CC>TT; p.R261C; 11:130190599-130190600	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1180G>A; p.A394T; 11:130196405-130196405	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1259G>A; p.S420N; 11:130196605-130196605	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1413T>C; p.C471C; 11:130197899-130197899	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2438A>G; p.E813G; 11:130209693-130209693	central_nervous_system; brain	glioma	Substitution - Missense
c.1313C>T; p.T438I; 11:130196659-130196659	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2181G>A; p.V727V; 11:130208596-130208596	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.733C>A; p.Q245K; 11:130190552-130190552	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.190G>T; p.G64C; 11:130188222-130188222	pancreas	other; adenoma	Substitution - Missense
c.876-1G>T; p.?; 11:130194148-130194148	lung	carcinoma; adenocarcinoma	Unknown
c.2358G>A; p.P786P; 11:130209530-130209530	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1214A>G; p.N405S; 11:130196439-130196439	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.2200G>A; p.D734N; 11:130208615-130208615	skin	malignant_melanoma	Substitution - Missense
c.2074C>T; p.R692C; 11:130208489-130208489	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1660T>C; p.S554P; 11:130198597-130198597	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1967A>C; p.H656P; 11:130200110-130200110	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.812G>A; p.R271H; 11:130190631-130190631	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.738G>T; p.W246C; 11:130190557-130190557	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1629G>A; p.Q543Q; 11:130198566-130198566	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1658G>A; p.G553E; 11:130198595-130198595	skin	malignant_melanoma	Substitution - Missense
c.2527C>G; p.P843A; 11:130209782-130209782	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2371G>A; p.V791M; 11:130209543-130209543	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.535G>A; p.V179I; 11:130189833-130189833	pancreas	carcinoma	Substitution - Missense
c.2224G>A; p.G742S; 11:130208639-130208639	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1808-1G>A; p.?; 11:130199950-130199950	large_intestine; rectum	carcinoma; adenocarcinoma	Unknown
c.1435G>A; p.D479N; 11:130197921-130197921	skin	malignant_melanoma	Substitution - Missense
c.2056G>A; p.A686T; 11:130208471-130208471	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.2010G>A; p.T670T; 11:130208425-130208425	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.302T>G; p.F101C; 11:130188590-130188590	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.2010G>A; p.T670T; 11:130208425-130208425	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.749G>A; p.G250E; 11:130190568-130190568	skin	malignant_melanoma	Substitution - Missense
c.749G>A; p.G250E; 11:130190568-130190568	skin	malignant_melanoma	Substitution - Missense
c.1215C>T; p.N405N; 11:130196440-130196440	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.477C>G; p.F159L; 11:130189775-130189775	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1215C>T; p.N405N; 11:130196440-130196440	thyroid	other; neoplasm	Substitution - coding silent
c.1354+1G>A; p.?; 11:130196701-130196701	stomach	carcinoma; diffuse_adenocarcinoma	Unknown
c.1354+1G>A; p.?; 11:130196701-130196701	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.912C>T; p.T304T; 11:130194185-130194185	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1062C>T; p.P354P; 11:130194686-130194686	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.930C>A; p.N310K; 11:130194203-130194203	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.323C>T; p.S108F; 11:130188611-130188611	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2309T>C; p.V770A; 11:130209481-130209481	skin	malignant_melanoma	Substitution - Missense
c.820G>A; p.D274N; 11:130190639-130190639	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.570C>T; p.S190S; 11:130189868-130189868	skin	malignant_melanoma	Substitution - coding silent
c.1854C>T; p.G618G; 11:130199997-130199997	central_nervous_system; brain	glioma	Substitution - coding silent
c.519G>A; p.M173I; 11:130189817-130189817	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1696A>T; p.T566S; 11:130198958-130198958	thyroid	other; neoplasm	Substitution - Missense
c.1850G>T; p.G617V; 11:130199993-130199993	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1749C>T; p.G583G; 11:130199011-130199011	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.155C>T; p.P52L; 11:130188187-130188187	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2306G>A; p.R769H; 11:130209478-130209478	liver	carcinoma	Substitution - Missense
c.1603G>C; p.G535R; 11:130198540-130198540	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1460-9C>T; p.?; 11:130198299-130198299	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Unknown
c.162C>T; p.R54R; 11:130188194-130188194	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.162C>T; p.R54R; 11:130188194-130188194	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.367G>T; p.A123S; 11:130188655-130188655	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.223C>T; p.L75L; 11:130188255-130188255	skin	malignant_melanoma	Substitution - coding silent
c.1524C>T; p.C508C; 11:130198372-130198372	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.939C>G; p.L313L; 11:130194212-130194212	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.2343G>A; p.P781P; 11:130209515-130209515	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1165G>T; p.E389*; 11:130196390-130196390	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.232C>T; p.H78Y; 11:130188264-130188264	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2051G>A; p.R684H; 11:130208466-130208466	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.774C>T; p.L258L; 11:130190593-130190593	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.774C>T; p.L258L; 11:130190593-130190593	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.831_832insGT; p.Y279fs*5; 11:130190650-130190651	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.492C>T; p.H164H; 11:130189790-130189790	skin	malignant_melanoma	Substitution - coding silent
c.2564T>C; p.V855A; 11:130209819-130209819	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1873G>A; p.E625K; 11:130200016-130200016	skin	malignant_melanoma	Substitution - Missense
c.2564T>C; p.V855A; 11:130209819-130209819	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1485G>T; p.T495T; 11:130198333-130198333	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2564T>C; p.V855A; 11:130209819-130209819	large_intestine; colon	carcinoma	Substitution - Missense
c.1537G>A; p.D513N; 11:130198385-130198385	skin	malignant_melanoma	Substitution - Missense

COSMIC somatic mutation [Top]