Entrez Gene

Basic Information
Gene ID	6664
Name	SOX11
Synonymous	SRY (sex determining region Y)-box 11;SOX11;SRY (sex determining region Y)-box 11
Definition	SRY (sex-determining region Y)-box 11\|SRY-related HMG-box gene 11\|transcription factor SOX-11
Position	2p25
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.903G>A; p.A301A; 2:5693624-5693624	skin	malignant_melanoma	Substitution - coding silent
c.903G>A; p.A301A; 2:5693624-5693624	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.263A>T; p.K88I; 2:5692984-5692984	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.179C>T; p.S60F; 2:5692900-5692900	skin	malignant_melanoma	Substitution - Missense
c.179C>T; p.S60F; 2:5692900-5692900	skin	malignant_melanoma	Substitution - Missense
c.151C>T; p.R51W; 2:5692872-5692872	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.138G>T; p.S46S; 2:5692859-5692859	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1308C>A; p.D436E; 2:5694029-5694029	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.63G>C; p.T21T; 2:5692784-5692784	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1192G>T; p.D398Y; 2:5693913-5693913	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.695A>T; p.D232V; 2:5693416-5693416	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1041C>T; p.S347S; 2:5693762-5693762	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1041C>T; p.S347S; 2:5693762-5693762	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.361C>T; p.R121W; 2:5693082-5693082	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.678C>T; p.D226D; 2:5693399-5693399	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.22T>A; p.L8M; 2:5692743-5692743	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1045A>G; p.S349G; 2:5693766-5693766	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.423C>A; p.S141R; 2:5693144-5693144	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1153G>A; p.A385T; 2:5693874-5693874	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1118C>T; p.A373V; 2:5693839-5693839	pancreas	carcinoid-endocrine_tumour	Substitution - Missense
c.1153G>A; p.A385T; 2:5693874-5693874	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.306G>A; p.A102A; 2:5693027-5693027	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.169A>G; p.M57V; 2:5692890-5692890	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.298C>T; p.R100W; 2:5693019-5693019	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Missense
c.298C>T; p.R100W; 2:5693019-5693019	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.400G>T; p.A134S; 2:5693121-5693121	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1283A>G; p.D428G; 2:5694004-5694004	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1305C>T; p.S435S; 2:5694026-5694026	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.291G>A; p.P97P; 2:5693012-5693012	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.53C>T; p.A18V; 2:5692774-5692774	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.291G>A; p.P97P; 2:5693012-5693012	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1284C>G; p.D428E; 2:5694005-5694005	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.495G>T; p.K165N; 2:5693216-5693216	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.158T>A; p.M53K; 2:5692879-5692879	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1158G>A; p.A386A; 2:5693879-5693879	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.71G>A; p.G24D; 2:5692792-5692792	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1267G>A; p.E423K; 2:5693988-5693988	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1013C>A; p.S338*; 2:5693734-5693734	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.105C>T; p.D35D; 2:5692826-5692826	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.33G>C; p.E11D; 2:5692754-5692754	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1234G>T; p.E412*; 2:5693955-5693955	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1234G>T; p.E412*; 2:5693955-5693955	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.818C>T; p.A273V; 2:5693539-5693539	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.290C>T; p.P97L; 2:5693011-5693011	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.274G>T; p.D92Y; 2:5692995-5692995	liver	carcinoma	Substitution - Missense
c.274G>T; p.D92Y; 2:5692995-5692995	liver	carcinoma	Substitution - Missense
c.137C>T; p.S46L; 2:5692858-5692858	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.137C>T; p.S46L; 2:5692858-5692858	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.343G>T; p.D115Y; 2:5693064-5693064	breast	carcinoma	Substitution - Missense
c.430G>A; p.G144S; 2:5693151-5693151	pancreas	carcinoma	Substitution - Missense
c.343G>A; p.D115N; 2:5693064-5693064	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.156G>T; p.P52P; 2:5692877-5692877	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.714G>C; p.Q238H; 2:5693435-5693435	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1125C>T; p.S375S; 2:5693846-5693846	pancreas	carcinoma	Substitution - coding silent
c.301G>T; p.E101*; 2:5693022-5693022	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.190C>T; p.R64C; 2:5692911-5692911	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.374A>G; p.K125R; 2:5693095-5693095	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.215_216CG>AT; p.P72>?; 2:5692936-5692937	lung	carcinoma; adenocarcinoma	Complex
c.700G>A; p.E234K; 2:5693421-5693421	skin	malignant_melanoma	Substitution - Missense
c.700G>A; p.E234K; 2:5693421-5693421	skin	malignant_melanoma	Substitution - Missense
c.255G>A; p.K85K; 2:5692976-5692976	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.95T>G; p.V32G; 2:5692816-5692816	central_nervous_system; brain	glioma; oligodendroglioma_Grade_III	Substitution - Missense
c.24G>T; p.L8F; 2:5692745-5692745	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.611G>A; p.R204H; 2:5693332-5693332	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1069G>A; p.D357N; 2:5693790-5693790	skin	malignant_melanoma	Substitution - Missense
c.611G>A; p.R204H; 2:5693332-5693332	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.978C>G; p.L326L; 2:5693699-5693699	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.978C>G; p.L326L; 2:5693699-5693699	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.978C>G; p.L326L; 2:5693699-5693699	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.978C>G; p.L326L; 2:5693699-5693699	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.978C>G; p.L326L; 2:5693699-5693699	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.978C>G; p.L326L; 2:5693699-5693699	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.978C>G; p.L326L; 2:5693699-5693699	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.712C>A; p.Q238K; 2:5693433-5693433	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.978C>G; p.L326L; 2:5693699-5693699	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.573C>T; p.Y191Y; 2:5693294-5693294	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.978C>G; p.L326L; 2:5693699-5693699	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.978C>G; p.L326L; 2:5693699-5693699	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.978C>G; p.L326L; 2:5693699-5693699	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.978C>G; p.L326L; 2:5693699-5693699	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.978C>G; p.L326L; 2:5693699-5693699	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.310C>A; p.R104R; 2:5693031-5693031	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.135G>A; p.A45A; 2:5692856-5692856	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.893G>A; p.R298Q; 2:5693614-5693614	kidney	other; neoplasm	Substitution - Missense
c.364delA; p.K123fs*83; 2:5693085-5693085	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.364delA; p.K123fs*83; 2:5693085-5693085	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.364delA; p.K123fs*83; 2:5693085-5693085	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.657C>T; p.C219C; 2:5693378-5693378	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.657C>T; p.C219C; 2:5693378-5693378	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.249G>A; p.L83L; 2:5692970-5692970	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.925A>G; p.S309G; 2:5693646-5693646	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.304G>A; p.A102T; 2:5693025-5693025	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1067A>T; p.E356V; 2:5693788-5693788	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1234G>A; p.E412K; 2:5693955-5693955	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.329T>A; p.M110K; 2:5693050-5693050	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.879_880insC; p.Y294fs*104; 2:5693600-5693601	stomach	carcinoma; diffuse_adenocarcinoma	Insertion - Frameshift
c.103G>A; p.D35N; 2:5692824-5692824	central_nervous_system; brain	glioma; oligodendroglioma_Grade_III	Substitution - Missense
c.75A>G; p.E25E; 2:5692796-5692796	skin	malignant_melanoma	Substitution - coding silent
c.134C>T; p.A45V; 2:5692855-5692855	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.154C>A; p.P52T; 2:5692875-5692875	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.18G>C; p.E6D; 2:5692739-5692739	urinary_tract; bladder	carcinoma	Substitution - Missense
c.301G>C; p.E101Q; 2:5693022-5693022	NS	malignant_melanoma	Substitution - Missense
c.1008G>A; p.S336S; 2:5693729-5693729	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.18G>C; p.E6D; 2:5692739-5692739	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.301G>C; p.E101Q; 2:5693022-5693022	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.216G>A; p.P72P; 2:5692937-5692937	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.950A>G; p.N317S; 2:5693671-5693671	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1114A>G; p.S372G; 2:5693835-5693835	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.87C>T; p.C29C; 2:5692808-5692808	ovary	other; neoplasm	Substitution - coding silent
c.87C>T; p.C29C; 2:5692808-5692808	ovary	other; neoplasm	Substitution - coding silent
c.74A>C; p.E25A; 2:5692795-5692795	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1185G>A; p.V395V; 2:5693906-5693906	liver	carcinoma	Substitution - coding silent
c.1064G>A; p.G355D; 2:5693785-5693785	liver	carcinoma	Substitution - Missense
c.1064G>A; p.G355D; 2:5693785-5693785	liver	carcinoma	Substitution - Missense
c.1185G>A; p.V395V; 2:5693906-5693906	liver	carcinoma	Substitution - coding silent
c.366A>G; p.K122K; 2:5693087-5693087	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.349A>G; p.K117E; 2:5693070-5693070	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.589G>A; p.D197N; 2:5693310-5693310	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.961C>A; p.Q321K; 2:5693682-5693682	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.589G>A; p.D197N; 2:5693310-5693310	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.266T>C; p.M89T; 2:5692987-5692987	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.266T>C; p.M89T; 2:5692987-5692987	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.477C>A; p.T159T; 2:5693198-5693198	liver	carcinoma	Substitution - coding silent
c.477C>A; p.T159T; 2:5693198-5693198	liver	carcinoma	Substitution - coding silent
c.1284C>A; p.D428E; 2:5694005-5694005	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.879C>A; p.L293L; 2:5693600-5693600	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.179C>A; p.S60Y; 2:5692900-5692900	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.298C>A; p.R100R; 2:5693019-5693019	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1247A>G; p.Y416C; 2:5693968-5693968	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1119G>A; p.A373A; 2:5693840-5693840	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1232T>C; p.F411S; 2:5693953-5693953	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.132G>A; p.T44T; 2:5692853-5692853	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1149delC; p.G384fs*38; 2:5693870-5693870	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1179G>A; p.S393S; 2:5693900-5693900	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.237C>G; p.I79M; 2:5692958-5692958	ovary	other; neoplasm	Substitution - Missense
c.873G>T; p.A291A; 2:5693594-5693594	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.690C>T; p.D230D; 2:5693411-5693411	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.305C>T; p.A102V; 2:5693026-5693026	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1281G>A; p.G427G; 2:5694002-5694002	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.673_675delGAC; p.D233delD; 2:5693394-5693396	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.673_675delGAC; p.D233delD; 2:5693394-5693396	large_intestine	carcinoma; adenocarcinoma	Deletion - In frame
c.673_675delGAC; p.D233delD; 2:5693394-5693396	pancreas	carcinoma; acinar_carcinoma	Deletion - In frame
c.279C>T; p.S93S; 2:5693000-5693000	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.279C>T; p.S93S; 2:5693000-5693000	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.438C>A; p.G146G; 2:5693159-5693159	lung	carcinoma; adenocarcinoma	Substitution - coding silent

COSMIC somatic mutation [Top]