Entrez Gene

Basic Information
Gene ID	6405
Name	SEMA3F
Synonymous	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F;SEMA3F;sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
Definition	sema III/F\|sema IV\|sema domain, immunoglobulin domain (Ig), short basic domain, secreted, 3F\|semaphorin III/F\|semaphorin IV\|semaphorin-3F
Position	3p21.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.959C>T; p.A320V; 3:50182959-50182959	skin	malignant_melanoma	Substitution - Missense
c.2231A>T; p.Q744L; 3:50187988-50187988	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1828G>A; p.V610M; 3:50186627-50186627	central_nervous_system; brain	glioma	Substitution - Missense
c.959C>T; p.A320V; 3:50182959-50182959	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.262G>A; p.E88K; 3:50173942-50173942	skin	malignant_melanoma	Substitution - Missense
c.2144C>T; p.P715L; 3:50187901-50187901	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1715C>T; p.A572V; 3:50186016-50186016	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1796G>A; p.R599H; 3:50186331-50186331	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1796G>A; p.R599H; 3:50186331-50186331	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1796G>A; p.R599H; 3:50186331-50186331	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1226C>T; p.P409L; 3:50183557-50183557	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.314T>C; p.V105A; 3:50174092-50174092	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1259C>A; p.S420Y; 3:50184617-50184617	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1109C>T; p.A370V; 3:50183440-50183440	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1092C>G; p.S364S; 3:50183423-50183423	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1768C>T; p.R590W; 3:50186303-50186303	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.380G>A; p.R127Q; 3:50174274-50174274	skin	malignant_melanoma	Substitution - Missense
c.2269C>T; p.P757S; 3:50188026-50188026	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1009G>C; p.D337H; 3:50183009-50183009	oesophagus	carcinoma	Substitution - Missense
c.967G>A; p.V323I; 3:50182967-50182967	large_intestine; caecum	adenoma	Substitution - Missense
c.1461C>T; p.R487R; 3:50185447-50185447	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.523C>T; p.R175C; 3:50175162-50175162	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2335C>T; p.R779W; 3:50188092-50188092	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.304G>A; p.E102K; 3:50174082-50174082	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1306C>T; p.R436C; 3:50184664-50184664	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1223G>A; p.R408Q; 3:50183554-50183554	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2176C>T; p.P726S; 3:50187933-50187933	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.401G>T; p.G134V; 3:50174295-50174295	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.702C>T; p.F234F; 3:50182342-50182342	skin	malignant_melanoma	Substitution - coding silent
c.610G>A; p.D204N; 3:50176828-50176828	skin	malignant_melanoma	Substitution - Missense
c.2144C>A; p.P715Q; 3:50187901-50187901	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.577C>T; p.R193*; 3:50176795-50176795	stomach	adenocarcinoma	Substitution - Nonsense
c.2018G>A; p.R673H; 3:50187775-50187775	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.962G>A; p.R321Q; 3:50182962-50182962	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.703C>T; p.R235C; 3:50182343-50182343	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.641T>C; p.I214T; 3:50176859-50176859	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.136C>G; p.H46D; 3:50173816-50173816	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1190G>A; p.W397*; 3:50183521-50183521	skin	malignant_melanoma	Substitution - Nonsense
c.1650G>A; p.A550A; 3:50185951-50185951	stomach	adenocarcinoma	Substitution - coding silent
c.981G>A; p.P327P; 3:50182981-50182981	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.914G>A; p.G305D; 3:50182914-50182914	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.306G>A; p.E102E; 3:50174084-50174084	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2342A>C; p.H781P; 3:50188099-50188099	kidney	Wilms_tumour	Substitution - Missense
c.177C>T; p.I59I; 3:50173857-50173857	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.177C>T; p.I59I; 3:50173857-50173857	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1132G>C; p.D378H; 3:50183463-50183463	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1507T>A; p.L503M; 3:50185493-50185493	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1973G>A; p.R658H; 3:50187730-50187730	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1507T>A; p.L503M; 3:50185493-50185493	thyroid	other; neoplasm	Substitution - Missense
c.198_203delCGACCG; p.D67_R68delDR; 3:50173878-50173883	endometrium	carcinoma; endometrioid_carcinoma	Deletion - In frame
c.1886G>A; p.R629H; 3:50186685-50186685	pancreas	carcinoma	Substitution - Missense
c.10G>T; p.A4S; 3:50159632-50159632	liver	carcinoma	Substitution - Missense
c.80C>A; p.P27Q; 3:50159702-50159702	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.348G>A; p.G116G; 3:50174242-50174242	skin	malignant_melanoma	Substitution - coding silent
c.261C>T; p.R87R; 3:50173941-50173941	breast	carcinoma	Substitution - coding silent
c.261C>T; p.R87R; 3:50173941-50173941	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1869C>T; p.F623F; 3:50186668-50186668	skin	malignant_melanoma	Substitution - coding silent
c.198C>T; p.H66H; 3:50173878-50173878	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1233G>A; p.T411T; 3:50183564-50183564	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1233G>A; p.T411T; 3:50183564-50183564	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1233G>A; p.T411T; 3:50183564-50183564	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.646G>A; p.E216K; 3:50182286-50182286	skin	malignant_melanoma	Substitution - Missense
c.1047C>T; p.D349D; 3:50183214-50183214	skin	malignant_melanoma	Substitution - coding silent
c.255C>T; p.I85I; 3:50173935-50173935	skin	malignant_melanoma	Substitution - coding silent
c.449G>A; p.R150H; 3:50174343-50174343	prostate	carcinoma	Substitution - Missense
c.834C>T; p.F278F; 3:50182714-50182714	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2102C>T; p.A701V; 3:50187859-50187859	skin	malignant_melanoma	Substitution - Missense
c.1197C>T; p.P399P; 3:50183528-50183528	skin	malignant_melanoma	Substitution - coding silent
c.2017C>T; p.R673C; 3:50187774-50187774	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2157C>T; p.G719G; 3:50187914-50187914	central_nervous_system; brain	glioma	Substitution - coding silent
c.583G>A; p.E195K; 3:50176801-50176801	urinary_tract; bladder	carcinoma	Substitution - Missense
c.425G>T; p.C142F; 3:50174319-50174319	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1093G>A; p.V365M; 3:50183424-50183424	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2069C>G; p.T690R; 3:50187826-50187826	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.96C>T; p.V32V; 3:50159718-50159718	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.803C>T; p.A268V; 3:50182683-50182683	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.803C>T; p.A268V; 3:50182683-50182683	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.907G>A; p.D303N; 3:50182907-50182907	skin	malignant_melanoma	Substitution - Missense
c.907G>A; p.D303N; 3:50182907-50182907	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1139G>A; p.R380H; 3:50183470-50183470	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.689A>G; p.D230G; 3:50182329-50182329	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1799G>A; p.G600E; 3:50186334-50186334	skin	malignant_melanoma	Substitution - Missense
c.46G>T; p.A16S; 3:50159668-50159668	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1683C>A; p.A561A; 3:50185984-50185984	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1367G>A; p.R456H; 3:50184725-50184725	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1815C>T; p.A605A; 3:50186614-50186614	skin	malignant_melanoma	Substitution - coding silent
c.2013C>T; p.S671S; 3:50187770-50187770	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.42C>T; p.T14T; 3:50159664-50159664	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.228C>T; p.Y76Y; 3:50173908-50173908	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2031C>A; p.S677S; 3:50187788-50187788	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - coding silent
c.2143C>T; p.P715S; 3:50187900-50187900	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1356_1357CC>TT; p.(=); 3:50184714-50184715	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.1038G>A; p.Q346Q; 3:50183205-50183205	skin	malignant_melanoma	Substitution - coding silent
c.1814-1G>C; p.?; 3:50186612-50186612	breast	carcinoma	Unknown
c.1831G>A; p.E611K; 3:50186630-50186630	skin	malignant_melanoma	Substitution - Missense
c.42C>G; p.T14T; 3:50159664-50159664	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.687T>C; p.T229T; 3:50182327-50182327	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.809G>A; p.R270H; 3:50182689-50182689	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1366C>T; p.R456C; 3:50184724-50184724	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1449G>T; p.L483L; 3:50184807-50184807	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.828_830delCTT; p.F279delF; 3:50182708-50182710	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.1512G>A; p.E504E; 3:50185498-50185498	skin	malignant_melanoma	Substitution - coding silent
c.582C>T; p.L194L; 3:50176800-50176800	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1555delC; p.V520fs*4; 3:50185675-50185675	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.1138C>T; p.R380C; 3:50183469-50183469	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.451G>A; p.A151T; 3:50174345-50174345	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.307G>T; p.E103*; 3:50174085-50174085	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1068C>T; p.Y356Y; 3:50183235-50183235	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.784G>A; p.E262K; 3:50182664-50182664	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1943G>A; p.R648Q; 3:50186742-50186742	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.597C>A; p.G199G; 3:50176815-50176815	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1429C>T; p.R477C; 3:50184787-50184787	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1894C>A; p.Q632K; 3:50186693-50186693	breast	carcinoma	Substitution - Missense
c.1429C>T; p.R477C; 3:50184787-50184787	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1620C>T; p.V540V; 3:50185921-50185921	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1694A>G; p.Y565C; 3:50185995-50185995	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2242G>A; p.G748S; 3:50187999-50187999	skin	malignant_melanoma	Substitution - Missense
c.273T>C; p.I91I; 3:50173953-50173953	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2121C>T; p.F707F; 3:50187878-50187878	skin	malignant_melanoma	Substitution - coding silent
c.203G>A; p.R68H; 3:50173883-50173883	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1937G>A; p.R646Q; 3:50186736-50186736	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.734C>T; p.T245M; 3:50182374-50182374	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1531G>A; p.V511M; 3:50185517-50185517	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.141C>A; p.F47L; 3:50173821-50173821	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1100G>A; p.R367Q; 3:50183431-50183431	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1769G>A; p.R590Q; 3:50186304-50186304	skin	malignant_melanoma	Substitution - Missense
c.642C>T; p.I214I; 3:50176860-50176860	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.888_889CG>TC; p.I296>?; 3:50182768-50182769	lung	carcinoma; adenocarcinoma	Complex
c.2158G>A; p.A720T; 3:50187915-50187915	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2062G>A; p.V688I; 3:50187819-50187819	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.229G>A; p.V77M; 3:50173909-50173909	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1435G>A; p.E479K; 3:50184793-50184793	urinary_tract; bladder	carcinoma	Substitution - Missense
c.765C>G; p.D255E; 3:50182645-50182645	skin; trunk	malignant_melanoma	Substitution - Missense
c.2167C>T; p.P723S; 3:50187924-50187924	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2071C>T; p.R691*; 3:50187828-50187828	breast	carcinoma	Substitution - Nonsense
c.354C>T; p.F118F; 3:50174248-50174248	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1722C>T; p.S574S; 3:50186023-50186023	skin; upper_leg	malignant_melanoma	Substitution - coding silent
c.354C>T; p.F118F; 3:50174248-50174248	skin	malignant_melanoma	Substitution - coding silent
c.1405G>A; p.D469N; 3:50184763-50184763	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.977T>C; p.V326A; 3:50182977-50182977	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1420G>A; p.A474T; 3:50184778-50184778	skin	malignant_melanoma	Substitution - Missense
c.954G>A; p.L318L; 3:50182954-50182954	breast	carcinoma	Substitution - coding silent
c.633G>A; p.S211S; 3:50176851-50176851	pancreas	carcinoma	Substitution - coding silent
c.825T>G; p.L275L; 3:50182705-50182705	skin	malignant_melanoma	Substitution - coding silent
c.1649C>T; p.A550V; 3:50185950-50185950	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.913G>A; p.G305S; 3:50182913-50182913	skin	malignant_melanoma	Substitution - Missense
c.913G>A; p.G305S; 3:50182913-50182913	skin	malignant_melanoma	Substitution - Missense
c.793C>T; p.P265S; 3:50182673-50182673	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.565C>T; p.L189L; 3:50176783-50176783	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.565C>T; p.L189L; 3:50176783-50176783	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.565C>T; p.L189L; 3:50176783-50176783	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1333G>A; p.V445M; 3:50184691-50184691	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1462G>T; p.G488W; 3:50185448-50185448	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.82G>A; p.A28T; 3:50159704-50159704	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1088G>A; p.G363D; 3:50183255-50183255	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.61C>T; p.P21S; 3:50159683-50159683	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]