| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 6390 |
Name | SDHB |
Synonymous | succinate dehydrogenase complex, subunit B, iron sulfur (Ip);SDHB;succinate dehydrogenase complex, subunit B, iron sulfur (Ip) |
Definition | iron-sulfur subunit of complex II|succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial |
Position | 1p36.1-p35 |
Gene Type | protein-coding |
COSMIC somatic mutation [Top] | |||
Mutation (CDS; AA; Chr) | Site | Histology | Mutation Type |
|---|---|---|---|
c.113G>A; p.R38H; 1:17044848-17044848 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.74C>T; p.A25V; 1:17044887-17044887 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.793G>C; p.E265Q; 1:17018931-17018931 |
cervix | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.21C>T; p.L7L; 1:17053999-17053999 |
liver | carcinoma; hepatocellular_carcinoma | Substitution - coding silent |
c.219_220GG>AA; p.D74N; 1:17033126-17033127 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.187G>A; p.V63I; 1:17044774-17044774 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.543C>T; p.D181D; 1:17024072-17024072 |
oesophagus | carcinoma; adenocarcinoma | Substitution - coding silent |
c.426T>G; p.D142E; 1:17027863-17027863 |
stomach | carcinoma; intestinal_adenocarcinoma | Substitution - Missense |
c.634C>T; p.L212F; 1:17023981-17023981 |
skin | malignant_melanoma | Substitution - Missense |
c.4G>C; p.A2P; 1:17054016-17054016 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.317A>G; p.N106S; 1:17028706-17028706 |
breast | carcinoma | Substitution - Missense |
c.488C>A; p.S163Y; 1:17027801-17027801 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.278G>A; p.C93Y; 1:17033068-17033068 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.593G>A; p.S198N; 1:17024022-17024022 |
breast | carcinoma; ER-PR-positive_carcinoma | Substitution - Missense |
c.281G>C; p.R94T; 1:17033065-17033065 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.688C>T; p.R230C; 1:17022685-17022685 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.688C>T; p.R230C; 1:17022685-17022685 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.688C>T; p.R230C; 1:17022685-17022685 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.632T>C; p.V211A; 1:17023983-17023983 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.812C>T; p.A271V; 1:17018912-17018912 |
liver | carcinoma | Substitution - Missense |
c.294T>C; p.C98C; 1:17028729-17028729 |
liver | carcinoma | Substitution - coding silent |
c.294T>C; p.C98C; 1:17028729-17028729 |
liver | carcinoma; hepatocellular_carcinoma | Substitution - coding silent |
c.626C>A; p.P209H; 1:17023989-17023989 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.482A>G; p.D161G; 1:17027807-17027807 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.98C>T; p.A33V; 1:17044863-17044863 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.386C>G; p.P129R; 1:17028637-17028637 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma | Substitution - Missense |
c.553G>A; p.E185K; 1:17024062-17024062 |
breast | carcinoma | Substitution - Missense |
c.840T>G; p.V280V; 1:17018884-17018884 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.136C>T; p.R46*; 1:17044825-17044825 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Nonsense |