Entrez Gene

Basic Information
Gene ID	624
Name	BDKRB2
Synonymous	bradykinin receptor B2;BDKRB2;bradykinin receptor B2
Definition	B2 bradykinin receptor\|BK-2 receptor
Position	14q32.1-q32.2
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.654C>T; p.L218L; 14:96240982-96240982	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.436T>C; p.C146R; 14:96240764-96240764	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.177C>T; p.I59I; 14:96240505-96240505	skin	malignant_melanoma	Substitution - coding silent
c.540G>A; p.V180V; 14:96240868-96240868	skin	malignant_melanoma	Substitution - coding silent
c.965A>G; p.Y322C; 14:96241293-96241293	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1133G>T; p.R378L; 14:96241461-96241461	breast	carcinoma	Substitution - Missense
c.1092G>T; p.E364D; 14:96241420-96241420	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.291G>A; p.G97G; 14:96240619-96240619	skin	malignant_melanoma	Substitution - coding silent
c.558G>A; p.L186L; 14:96240886-96240886	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.189C>T; p.F63F; 14:96240517-96240517	skin	malignant_melanoma	Substitution - coding silent
c.399G>A; p.V133V; 14:96240727-96240727	skin	malignant_melanoma	Substitution - coding silent
c.123C>T; p.T41T; 14:96240451-96240451	pancreas	carcinoma	Substitution - coding silent
c.123C>T; p.T41T; 14:96240451-96240451	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.1002C>A; p.I334I; 14:96241330-96241330	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.332C>T; p.P111L; 14:96240660-96240660	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.41G>A; p.R14H; 14:96237148-96237148	urinary_tract; bladder	carcinoma	Substitution - Missense
c.873C>T; p.F291F; 14:96241201-96241201	skin	malignant_melanoma	Substitution - coding silent
c.1032G>T; p.W344C; 14:96241360-96241360	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1032G>T; p.W344C; 14:96241360-96241360	skin	malignant_melanoma	Substitution - Missense
c.1058A>C; p.K353T; 14:96241386-96241386	skin	malignant_melanoma	Substitution - Missense
c.51C>T; p.S17S; 14:96237158-96237158	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - coding silent
c.51C>T; p.S17S; 14:96237158-96237158	skin	malignant_melanoma	Substitution - coding silent
c.1057A>T; p.K353*; 14:96241385-96241385	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.806C>T; p.T269M; 14:96241134-96241134	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.385C>T; p.L129F; 14:96240713-96240713	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.923G>A; p.R308H; 14:96241251-96241251	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.731C>T; p.T244M; 14:96241059-96241059	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.731C>T; p.T244M; 14:96241059-96241059	breast	carcinoma	Substitution - Missense
c.23C>T; p.S8L; 14:96237130-96237130	skin	malignant_melanoma	Substitution - Missense
c.969_980del12; p.S325_N328delSCLN; 14:96241297-96241308	oesophagus; lower_third	carcinoma; adenocarcinoma	Deletion - In frame
c.325G>A; p.G109R; 14:96240653-96240653	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.561C>T; p.L187L; 14:96240889-96240889	skin	malignant_melanoma	Substitution - coding silent
c.507C>T; p.R169R; 14:96240835-96240835	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.552T>C; p.C184C; 14:96240880-96240880	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.552T>C; p.C184C; 14:96240880-96240880	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.117C>T; p.N39N; 14:96240445-96240445	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.545delG; p.C184fs*5; 14:96240873-96240873	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.117C>T; p.N39N; 14:96240445-96240445	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1079C>A; p.P360H; 14:96241407-96241407	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.249C>T; p.C83C; 14:96240577-96240577	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.300C>T; p.A100A; 14:96240628-96240628	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.190C>T; p.L64F; 14:96240518-96240518	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.369G>A; p.W123*; 14:96240697-96240697	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.363C>T; p.F121F; 14:96240691-96240691	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.363C>T; p.F121F; 14:96240691-96240691	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.363C>T; p.F121F; 14:96240691-96240691	skin	malignant_melanoma	Substitution - coding silent
c.579G>T; p.L193L; 14:96240907-96240907	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.363C>T; p.F121F; 14:96240691-96240691	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.475C>T; p.L159L; 14:96240803-96240803	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1119C>A; p.S373S; 14:96241447-96241447	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.241G>A; p.V81I; 14:96240569-96240569	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.464G>A; p.R155H; 14:96240792-96240792	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.277G>C; p.E93Q; 14:96240605-96240605	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.50C>T; p.S17F; 14:96237157-96237157	skin	malignant_melanoma	Substitution - Missense
c.684G>A; p.L228L; 14:96241012-96241012	breast	carcinoma	Substitution - coding silent
c.628G>A; p.A210T; 14:96240956-96240956	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.204C>T; p.F68F; 14:96240532-96240532	skin	malignant_melanoma	Substitution - coding silent
c.515G>A; p.R172H; 14:96240843-96240843	urinary_tract; bladder	carcinoma	Substitution - Missense
c.46G>A; p.D16N; 14:96237153-96237153	skin	malignant_melanoma	Substitution - Missense
c.46G>A; p.D16N; 14:96237153-96237153	skin	malignant_melanoma	Substitution - Missense
c.515G>A; p.R172H; 14:96240843-96240843	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.906C>A; p.S302S; 14:96241234-96241234	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.981C>T; p.L327L; 14:96241309-96241309	breast	carcinoma	Substitution - coding silent
c.31C>A; p.L11M; 14:96237138-96237138	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.587G>A; p.R196Q; 14:96240915-96240915	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.587G>A; p.R196Q; 14:96240915-96240915	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.511G>A; p.V171M; 14:96240839-96240839	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.598G>C; p.E200Q; 14:96240926-96240926	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Missense
c.923G>C; p.R308P; 14:96241251-96241251	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1081A>T; p.I361F; 14:96241409-96241409	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1137G>T; p.Q379H; 14:96241465-96241465	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1158G>A; p.W386*; 14:96241486-96241486	breast	carcinoma; HER-positive_carcinoma	Substitution - Nonsense
c.791C>T; p.T264I; 14:96241119-96241119	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.351C>T; p.I117I; 14:96240679-96240679	skin	malignant_melanoma	Substitution - coding silent
c.580G>T; p.V194L; 14:96240908-96240908	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.627C>A; p.T209T; 14:96240955-96240955	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.991G>A; p.V331M; 14:96241319-96241319	skin	malignant_melanoma	Substitution - Missense
c.315C>T; p.I105I; 14:96240643-96240643	NS	malignant_melanoma	Substitution - coding silent
c.315C>T; p.I105I; 14:96240643-96240643	NS	malignant_melanoma	Substitution - coding silent
c.1137G>A; p.Q379Q; 14:96241465-96241465	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1137G>A; p.Q379Q; 14:96241465-96241465	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.353C>T; p.S118F; 14:96240681-96240681	skin	malignant_melanoma	Substitution - Missense
c.1079C>T; p.P360L; 14:96241407-96241407	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.424T>C; p.Y142H; 14:96240752-96240752	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.832C>T; p.L278L; 14:96241160-96241160	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1101G>A; p.M367I; 14:96241429-96241429	pancreas	carcinoma	Substitution - Missense
c.924C>T; p.R308R; 14:96241252-96241252	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1163G>A; p.G388E; 14:96241491-96241491	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.79G>A; p.D27N; 14:96240407-96240407	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.505C>T; p.R169C; 14:96240833-96240833	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.930C>T; p.I310I; 14:96241258-96241258	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; essential_thrombocythaemia	Substitution - coding silent
c.1133G>A; p.R378H; 14:96241461-96241461	pancreas	carcinoma	Substitution - Missense
c.75C>T; p.S25S; 14:96240403-96240403	liver	carcinoma	Substitution - coding silent
c.973A>T; p.S325C; 14:96241301-96241301	liver	carcinoma	Substitution - Missense
c.973A>T; p.S325C; 14:96241301-96241301	liver	carcinoma	Substitution - Missense
c.75C>T; p.S25S; 14:96240403-96240403	liver	carcinoma	Substitution - coding silent
c.1013G>A; p.R338H; 14:96241341-96241341	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1045G>A; p.G349R; 14:96241373-96241373	central_nervous_system; thalamus	glioma; oligoastrocytoma_Grade_II	Substitution - Missense
c.64G>T; p.A22S; 14:96237171-96237171	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.736C>T; p.Q246*; 14:96241064-96241064	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1053C>T; p.C351C; 14:96241381-96241381	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.301G>A; p.A101T; 14:96240629-96240629	thyroid	carcinoma	Substitution - Missense
c.393C>T; p.R131R; 14:96240721-96240721	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1072T>C; p.S358P; 14:96241400-96241400	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1164G>A; p.G388G; 14:96241492-96241492	skin	malignant_melanoma	Substitution - coding silent
c.1164G>A; p.G388G; 14:96241492-96241492	skin	malignant_melanoma	Substitution - coding silent
c.597G>T; p.K199N; 14:96240925-96240925	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.988C>T; p.L330L; 14:96241316-96241316	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.63G>A; p.T21T; 14:96237170-96237170	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.673A>G; p.N225D; 14:96241001-96241001	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.160G>T; p.G54C; 14:96240488-96240488	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.346A>C; p.T116P; 14:96240674-96240674	breast	carcinoma	Substitution - Missense
c.346A>C; p.T116P; 14:96240674-96240674	skin	malignant_melanoma	Substitution - Missense
c.141C>T; p.C47C; 14:96240469-96240469	skin	malignant_melanoma	Substitution - coding silent
c.906C>T; p.S302S; 14:96241234-96241234	skin	malignant_melanoma	Substitution - coding silent
c.324C>T; p.C108C; 14:96240652-96240652	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.324C>T; p.C108C; 14:96240652-96240652	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.922C>T; p.R308C; 14:96241250-96241250	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.922C>T; p.R308C; 14:96241250-96241250	pancreas	carcinoma	Substitution - Missense
c.383C>T; p.T128M; 14:96240711-96240711	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.383C>T; p.T128M; 14:96240711-96240711	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.383C>T; p.T128M; 14:96240711-96240711	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.35C>A; p.S12Y; 14:96237142-96237142	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.701T>A; p.L234Q; 14:96241029-96241029	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.40C>T; p.R14C; 14:96237147-96237147	skin	malignant_melanoma	Substitution - Missense
c.1018C>G; p.R340G; 14:96241346-96241346	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.492C>T; p.S164S; 14:96240820-96240820	skin	malignant_melanoma	Substitution - coding silent
c.392G>T; p.R131L; 14:96240720-96240720	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.800G>A; p.R267K; 14:96241128-96241128	skin	malignant_melanoma	Substitution - Missense
c.197T>G; p.V66G; 14:96240525-96240525	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1153G>C; p.D385H; 14:96241481-96241481	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.776T>G; p.F259C; 14:96241104-96241104	skin	malignant_melanoma	Substitution - Missense
c.881C>T; p.T294M; 14:96241209-96241209	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]