Entrez Gene

Basic Information
Gene ID	60495
Name	HPSE2
Synonymous	heparanase 2 (inactive);HPSE2;heparanase 2 (inactive)
Definition	heparanase 3\|heparanase-like protein\|inactive heparanase-2
Position	10q23-q24
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1368C>A; p.V456V; 10:98490149-98490149	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1167C>T; p.G389G; 10:98620640-98620640	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.546T>C; p.A182A; 10:99144302-99144302	breast	carcinoma	Substitution - coding silent
c.1341C>T; p.L447L; 10:98490176-98490176	skin	malignant_melanoma	Substitution - coding silent
c.1272delT; p.F424fs*28; 10:98614952-98614952	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1272delT; p.F424fs*28; 10:98614952-98614952	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.457C>T; p.R153*; 10:99144391-99144391	skin	malignant_melanoma	Substitution - Nonsense
c.152G>T; p.R51I; 10:99235651-99235651	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1321-1G>T; p.?; 10:98490197-98490197	large_intestine; caecum	carcinoma; adenocarcinoma	Unknown
c.376C>T; p.Q126*; 10:99232420-99232420	liver	carcinoma	Substitution - Nonsense
c.1321-1G>T; p.?; 10:98490197-98490197	skin	malignant_melanoma	Unknown
c.1690C>T; p.R564W; 10:98459663-98459663	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1254G>C; p.V418V; 10:98614970-98614970	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1690C>T; p.R564W; 10:98459663-98459663	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1690C>T; p.R564W; 10:98459663-98459663	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.843G>T; p.K281N; 10:98721770-98721770	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1254G>C; p.V418V; 10:98614970-98614970	breast	carcinoma	Substitution - coding silent
c.204G>A; p.K68K; 10:99235599-99235599	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1025T>G; p.V342G; 10:98641920-98641920	breast	carcinoma	Substitution - Missense
c.275G>T; p.W92L; 10:99235528-99235528	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1280G>T; p.G427V; 10:98614944-98614944	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.972A>C; p.A324A; 10:98693932-98693932	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1574A>T; p.Y525F; 10:98482675-98482675	bone; femur	chondrosarcoma	Substitution - Missense
c.1149G>A; p.V383V; 10:98620658-98620658	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1691G>T; p.R564L; 10:98459662-98459662	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1042T>G; p.F348V; 10:98641903-98641903	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.882G>T; p.R294R; 10:98721731-98721731	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1450T>C; p.C484R; 10:98490067-98490067	skin	malignant_melanoma	Substitution - Missense
c.881G>A; p.R294Q; 10:98721732-98721732	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.831C>T; p.S277S; 10:98721782-98721782	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.118C>T; p.Q40*; 10:99235685-99235685	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.118C>T; p.Q40*; 10:99235685-99235685	liver	carcinoma	Substitution - Nonsense
c.1378C>T; p.H460Y; 10:98490139-98490139	skin; extremity	malignant_melanoma	Substitution - Missense
c.1154C>T; p.T385I; 10:98620653-98620653	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.57_58insC; p.A20fs*45; 10:99235745-99235746	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.890C>T; p.S297F; 10:98721723-98721723	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.485A>C; p.K162T; 10:99144363-99144363	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1089A>C; p.K363N; 10:98641856-98641856	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1222_1223GG>AA; p.G408K; 10:98615001-98615002	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.58_59insC; p.C21fs*44; 10:99235744-99235745	stomach	carcinoma; intestinal_adenocarcinoma	Insertion - Frameshift
c.800G>A; p.R267Q; 10:98721813-98721813	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.820G>A; p.V274I; 10:98721793-98721793	skin	malignant_melanoma	Substitution - Missense
c.800G>A; p.R267Q; 10:98721813-98721813	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.221T>C; p.V74A; 10:99235582-99235582	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1006T>A; p.C336S; 10:98641939-98641939	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1678C>T; p.P560S; 10:98459675-98459675	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.901T>G; p.L301V; 10:98721712-98721712	skin; trunk	malignant_melanoma	Substitution - Missense
c.771G>A; p.W257*; 10:98743896-98743896	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.901T>G; p.L301V; 10:98721712-98721712	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1660A>G; p.T554A; 10:98459693-98459693	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.174G>T; p.K58N; 10:99235629-99235629	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.174G>T; p.K58N; 10:99235629-99235629	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.174G>T; p.K58N; 10:99235629-99235629	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.174G>T; p.K58N; 10:99235629-99235629	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.177C>T; p.T59T; 10:99235626-99235626	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1691G>A; p.R564Q; 10:98459662-98459662	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1691G>A; p.R564Q; 10:98459662-98459662	skin	malignant_melanoma	Substitution - Missense
c.816G>A; p.R272R; 10:98721797-98721797	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1294G>A; p.V432M; 10:98614930-98614930	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.66A>T; p.L22L; 10:99235737-99235737	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.66A>T; p.L22L; 10:99235737-99235737	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.458G>A; p.R153Q; 10:99144390-99144390	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.272G>A; p.G91D; 10:99235531-99235531	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.923G>A; p.R308Q; 10:98721690-98721690	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.460A>T; p.S154C; 10:99144388-99144388	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.600C>T; p.L200L; 10:99144248-99144248	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1220T>C; p.L407S; 10:98615004-98615004	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.617C>A; p.S206Y; 10:98744050-98744050	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.617C>A; p.S206Y; 10:98744050-98744050	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.174G>C; p.K58N; 10:99235629-99235629	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.874C>T; p.P292S; 10:98721739-98721739	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.609A>T; p.T203T; 10:99144239-99144239	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.685C>T; p.R229C; 10:98743982-98743982	breast	carcinoma	Substitution - Missense
c.1232C>A; p.A411D; 10:98614992-98614992	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.1433T>A; p.L478Q; 10:98490084-98490084	large_intestine; caecum	adenoma	Substitution - Missense
c.1020C>A; p.G340G; 10:98641925-98641925	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.595A>G; p.N199D; 10:99144253-99144253	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.396G>C; p.A132A; 10:99232400-99232400	liver	carcinoma	Substitution - coding silent
c.1472A>C; p.N491T; 10:98482777-98482777	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.131G>A; p.R44K; 10:99235672-99235672	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.776T>G; p.L259R; 10:98743891-98743891	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.204G>T; p.K68N; 10:99235599-99235599	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.961A>G; p.M321V; 10:98693943-98693943	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.652G>A; p.G218R; 10:98744015-98744015	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.409G>C; p.G137R; 10:99232387-99232387	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1432C>T; p.L478L; 10:98490085-98490085	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.767C>G; p.S256C; 10:98743900-98743900	breast	carcinoma	Substitution - Missense
c.735G>A; p.L245L; 10:98743932-98743932	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.564_566delTCT; p.L189delL; 10:99144282-99144284	lung	carcinoma; small_cell_carcinoma	Deletion - In frame
c.218C>G; p.T73R; 10:99235585-99235585	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.863G>T; p.S288I; 10:98721750-98721750	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.808C>A; p.H270N; 10:98721805-98721805	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.939C>A; p.V313V; 10:98721674-98721674	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1415G>T; p.R472L; 10:98490102-98490102	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1516C>T; p.R506*; 10:98482733-98482733	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.631T>C; p.Y211H; 10:98744036-98744036	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1516C>T; p.R506*; 10:98482733-98482733	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.631T>C; p.Y211H; 10:98744036-98744036	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.631T>C; p.Y211H; 10:98744036-98744036	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.1372G>A; p.A458T; 10:98490145-98490145	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.494A>G; p.K165R; 10:99144354-99144354	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.761A>G; p.N254S; 10:98743906-98743906	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.799C>T; p.R267W; 10:98721814-98721814	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.799C>T; p.R267W; 10:98721814-98721814	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.799C>T; p.R267W; 10:98721814-98721814	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.799C>T; p.R267W; 10:98721814-98721814	NS	NS	Substitution - Missense
c.1368C>T; p.V456V; 10:98490149-98490149	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1238A>G; p.Q413R; 10:98614986-98614986	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.688C>T; p.R230C; 10:98743979-98743979	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1382T>C; p.V461A; 10:98490135-98490135	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.880C>T; p.R294W; 10:98721733-98721733	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.722C>A; p.A241D; 10:98743945-98743945	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1667C>A; p.P556Q; 10:98459686-98459686	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.39C>A; p.S13S; 10:99235764-99235764	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.404G>A; p.R135H; 10:99232392-99232392	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1251C>T; p.V417V; 10:98614973-98614973	skin	malignant_melanoma	Substitution - coding silent
c.1764_1765insC; p.C589fs*>5; 10:98459588-98459589	breast	carcinoma	Insertion - Frameshift
c.1621C>T; p.Q541*; 10:98459732-98459732	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.992T>G; p.V331G; 10:98693912-98693912	pancreas	carcinoma	Substitution - Missense
c.1774C>T; p.R592*; 10:98459579-98459579	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.927G>A; p.P309P; 10:98721686-98721686	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.821T>C; p.V274A; 10:98721792-98721792	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1336C>A; p.L446I; 10:98490181-98490181	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1173C>T; p.N391N; 10:98620634-98620634	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.212T>C; p.V71A; 10:99235591-99235591	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.197G>A; p.S66N; 10:99235606-99235606	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.880C>A; p.R294R; 10:98721733-98721733	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.136C>G; p.P46A; 10:99235667-99235667	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1682G>A; p.R561H; 10:98459671-98459671	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.479A>T; p.K160I; 10:99144369-99144369	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1682G>A; p.R561H; 10:98459671-98459671	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1682G>A; p.R561H; 10:98459671-98459671	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.13T>A; p.C5S; 10:99235790-99235790	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1260G>T; p.R420R; 10:98614964-98614964	liver	carcinoma	Substitution - coding silent
c.1260G>T; p.R420R; 10:98614964-98614964	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.858G>A; p.L286L; 10:98721755-98721755	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1527G>T; p.K509N; 10:98482722-98482722	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1736A>T; p.Y579F; 10:98459617-98459617	breast	carcinoma	Substitution - Missense
c.907G>T; p.G303C; 10:98721706-98721706	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.6G>A; p.R2R; 10:99235797-99235797	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.698A>C; p.N233T; 10:98743969-98743969	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1673T>C; p.L558S; 10:98459680-98459680	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1120G>T; p.G374*; 10:98620687-98620687	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1406G>A; p.R469Q; 10:98490111-98490111	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1353G>C; p.L451L; 10:98490164-98490164	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1047G>A; p.L349L; 10:98641898-98641898	skin	malignant_melanoma	Substitution - coding silent
c.168_169GG>TT; p.K56>?; 10:99235634-99235635	lung	carcinoma; adenocarcinoma	Complex
c.1034T>G; p.V345G; 10:98641911-98641911	breast	carcinoma	Substitution - Missense
c.1408C>A; p.P470T; 10:98490109-98490109	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.956+2T>C; p.?; 10:98721655-98721655	lung	carcinoma; adenocarcinoma	Unknown
c.744C>T; p.S248S; 10:98743923-98743923	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.618T>C; p.S206S; 10:98744049-98744049	liver	carcinoma	Substitution - coding silent
c.1396C>G; p.R466G; 10:98490121-98490121	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1099-2A>G; p.?; 10:98620710-98620710	lung	carcinoma; adenocarcinoma	Unknown
c.744C>T; p.S248S; 10:98743923-98743923	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.694C>T; p.P232S; 10:98743973-98743973	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.444G>T; p.E148D; 10:99232352-99232352	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1480C>T; p.R494C; 10:98482769-98482769	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1752C>A; p.V584V; 10:98459601-98459601	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1480C>T; p.R494C; 10:98482769-98482769	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.757T>C; p.Y253H; 10:98743910-98743910	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.478A>G; p.K160E; 10:99144370-99144370	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1426G>A; p.D476N; 10:98490091-98490091	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.943G>A; p.A315T; 10:98721670-98721670	oesophagus	carcinoma	Substitution - Missense
c.57delC; p.A20fs*3; 10:99235746-99235746	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.57delC; p.A20fs*3; 10:99235746-99235746	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.902T>A; p.L301*; 10:98721711-98721711	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.1694C>T; p.A565V; 10:98459659-98459659	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1582C>T; p.Q528*; 10:98482667-98482667	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1020C>T; p.G340G; 10:98641925-98641925	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.745G>A; p.A249T; 10:98743922-98743922	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.745G>A; p.A249T; 10:98743922-98743922	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.224A>G; p.N75S; 10:99235579-99235579	pancreas	carcinoma	Substitution - Missense
c.1756G>A; p.A586T; 10:98459597-98459597	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1321-1G>A; p.?; 10:98490197-98490197	skin	malignant_melanoma	Unknown
c.117C>T; p.S39S; 10:99235686-99235686	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.373T>C; p.F125L; 10:99232423-99232423	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]