Entrez Gene

Basic Information
Gene ID	5721
Name	PSME2
Synonymous	proteasome (prosome, macropain) activator subunit 2 (PA28 beta);PSME2;proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
Definition	11S regulator complex beta subunit\|11S regulator complex subunit beta\|MCP activator, 31-kD subunit\|REG-beta\|activator of multicatalytic protease subunit 2\|cell migration-inducing protein 22\|proteasome activator 28 subunit beta\|proteasome activator 28-beta
Position	14q11.2
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.263-2A>T; p.?; 14:24145157-24145157	lung	carcinoma; adenocarcinoma	Unknown
c.427C>T; p.Q143*; 14:24144402-24144402	skin	malignant_melanoma	Substitution - Nonsense
c.292G>T; p.E98*; 14:24145126-24145126	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.562C>T; p.R188W; 14:24143662-24143662	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.562C>T; p.R188W; 14:24143662-24143662	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.562C>T; p.R188W; 14:24143662-24143662	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.455C>T; p.A152V; 14:24144234-24144234	skin	malignant_melanoma	Substitution - Missense
c.66G>A; p.Q22Q; 14:24146223-24146223	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.459C>T; p.V153V; 14:24144230-24144230	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.564G>A; p.R188R; 14:24143660-24143660	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.5C>T; p.A2V; 14:24146577-24146577	prostate	carcinoma	Substitution - Missense
c.105C>A; p.F35L; 14:24145749-24145749	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.598G>T; p.G200W; 14:24143626-24143626	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.540G>T; p.K180N; 14:24143987-24143987	ovary	carcinoma	Substitution - Missense
c.182G>A; p.R61Q; 14:24145428-24145428	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.263-7C>T; p.?; 14:24145162-24145162	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.49-1G>T; p.?; 14:24146241-24146241	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.51G>T; p.V17V; 14:24146238-24146238	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.51G>T; p.V17V; 14:24146238-24146238	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.51G>T; p.V17V; 14:24146238-24146238	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.51G>T; p.V17V; 14:24146238-24146238	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.51G>T; p.V17V; 14:24146238-24146238	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.51G>T; p.V17V; 14:24146238-24146238	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.51G>T; p.V17V; 14:24146238-24146238	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.51G>T; p.V17V; 14:24146238-24146238	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.388C>T; p.P130S; 14:24144441-24144441	skin	malignant_melanoma	Substitution - Missense
c.490A>G; p.I164V; 14:24144199-24144199	urinary_tract; bladder	carcinoma	Substitution - Missense
c.259G>T; p.E87*; 14:24145246-24145246	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.85G>C; p.E29Q; 14:24145769-24145769	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.536C>T; p.S179F; 14:24143991-24143991	skin	malignant_melanoma	Substitution - Missense
c.247C>G; p.Q83E; 14:24145258-24145258	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.457G>A; p.V153I; 14:24144232-24144232	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.248A>T; p.Q83L; 14:24145257-24145257	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.291T>G; p.N97K; 14:24145127-24145127	skin	malignant_melanoma	Substitution - Missense
c.467A>G; p.K156R; 14:24144222-24144222	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.199C>T; p.P67S; 14:24145411-24145411	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.360G>T; p.L120L; 14:24145058-24145058	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.305C>T; p.S102F; 14:24145113-24145113	skin	malignant_melanoma	Substitution - Missense
c.392A>G; p.K131R; 14:24144437-24144437	skin	malignant_melanoma	Substitution - Missense
c.510A>G; p.E170E; 14:24144017-24144017	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.101G>T; p.R34I; 14:24145753-24145753	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.666C>A; p.S222R; 14:24143463-24143463	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]