Entrez Gene

Basic Information
Gene ID	5603
Name	MAPK13
Synonymous	mitogen-activated protein kinase 13;MAPK13;mitogen-activated protein kinase 13
Definition	MAP kinase 13\|MAP kinase p38 delta\|mitogen-activated protein kinase p38 delta\|stress-activated protein kinase 4
Position	6p21.31
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.954G>A; p.T318T; 6:36138991-36138991	skin	malignant_melanoma	Substitution - coding silent
c.254T>C; p.I85T; 6:36132625-36132625	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.284C>T; p.S95F; 6:36132655-36132655	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.123G>T; p.S41S; 6:36131274-36131274	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.51A>C; p.T17T; 6:36130633-36130633	thyroid	other; neoplasm	Substitution - coding silent
c.51A>C; p.T17T; 6:36130633-36130633	thyroid	other; neoplasm	Substitution - coding silent
c.51A>C; p.T17T; 6:36130633-36130633	thyroid	other; neoplasm	Substitution - coding silent
c.51A>C; p.T17T; 6:36130633-36130633	breast	carcinoma	Substitution - coding silent
c.51A>C; p.T17T; 6:36130633-36130633	breast	carcinoma	Substitution - coding silent
c.51A>C; p.T17T; 6:36130633-36130633	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.51A>C; p.T17T; 6:36130633-36130633	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.149A>C; p.K50T; 6:36131300-36131300	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.955G>A; p.E319K; 6:36138992-36138992	skin	malignant_melanoma	Substitution - Missense
c.481G>A; p.D161N; 6:36136517-36136517	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.573C>T; p.P191P; 6:36136733-36136733	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.372G>A; p.E124E; 6:36135816-36135816	breast	carcinoma	Substitution - coding silent
c.783C>T; p.S261S; 6:36138722-36138722	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.129C>T; p.I43I; 6:36131280-36131280	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.794C>T; p.T265I; 6:36138733-36138733	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.657G>A; p.G219G; 6:36136925-36136925	skin; trunk	malignant_melanoma; nodular	Substitution - coding silent
c.569delC; p.E192fs*2; 6:36136729-36136729	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.796C>T; p.P266S; 6:36138735-36138735	skin	malignant_melanoma	Substitution - Missense
c.623C>T; p.S208F; 6:36136891-36136891	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.155C>T; p.A52V; 6:36131306-36131306	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.155C>T; p.A52V; 6:36131306-36131306	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.196G>A; p.A66T; 6:36131347-36131347	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.196G>A; p.A66T; 6:36131347-36131347	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.930C>T; p.P310P; 6:36138967-36138967	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.795C>T; p.T265T; 6:36138734-36138734	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.566G>A; p.R189Q; 6:36136726-36136726	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.754G>A; p.D252N; 6:36138436-36138436	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.754G>A; p.D252N; 6:36138436-36138436	prostate	carcinoma	Substitution - Missense
c.375G>C; p.E125D; 6:36135819-36135819	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.946G>T; p.E316*; 6:36138983-36138983	breast	carcinoma; ductal_carcinoma	Substitution - Nonsense
c.1006G>T; p.D336Y; 6:36139043-36139043	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.946G>T; p.E316*; 6:36138983-36138983	breast	carcinoma; ductal_carcinoma	Substitution - Nonsense
c.946G>T; p.E316*; 6:36138983-36138983	breast	carcinoma; ductal_carcinoma	Substitution - Nonsense
c.142G>A; p.G48R; 6:36131293-36131293	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.335C>T; p.T112M; 6:36135779-36135779	large_intestine; colon	adenoma	Substitution - Missense
c.642A>G; p.A214A; 6:36136910-36136910	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1098G>A; p.366; 6:36139373-36139373	skin	malignant_melanoma	Substitution - coding silent
c.918C>T; p.P306P; 6:36138955-36138955	skin	malignant_melanoma	Substitution - coding silent
c.732G>A; p.T244T; 6:36138414-36138414	skin	malignant_melanoma	Substitution - coding silent
c.918C>T; p.P306P; 6:36138955-36138955	skin	malignant_melanoma	Substitution - coding silent
c.823C>T; p.P275S; 6:36138762-36138762	skin	malignant_melanoma	Substitution - Missense
c.1018+1G>A; p.?; 6:36139056-36139056	stomach	carcinoma; adenocarcinoma	Unknown
c.576G>A; p.E192E; 6:36136736-36136736	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.943G>A; p.E315K; 6:36138980-36138980	breast	carcinoma	Substitution - Missense
c.407A>G; p.K136R; 6:36135851-36135851	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.822C>T; p.F274F; 6:36138761-36138761	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.81C>A; p.S27S; 6:36130663-36130663	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.717C>T; p.T239T; 6:36138399-36138399	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.183G>A; p.Q61Q; 6:36131334-36131334	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.551T>C; p.V184A; 6:36136711-36136711	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1076G>A; p.R359H; 6:36139351-36139351	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1078C>T; p.R360W; 6:36139353-36139353	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1079G>A; p.R360Q; 6:36139354-36139354	skin	malignant_melanoma	Substitution - Missense
c.195C>T; p.F65F; 6:36131346-36131346	skin	malignant_melanoma	Substitution - coding silent
c.195C>T; p.F65F; 6:36131346-36131346	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.718G>A; p.G240R; 6:36138400-36138400	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.776T>C; p.I259T; 6:36138715-36138715	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.431C>T; p.A144V; 6:36136032-36136032	liver	carcinoma	Substitution - Missense
c.168G>A; p.L56L; 6:36131319-36131319	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.570C>T; p.A190A; 6:36136730-36136730	skin	malignant_melanoma	Substitution - coding silent
c.431C>T; p.A144V; 6:36136032-36136032	liver	carcinoma	Substitution - Missense
c.647T>C; p.M216T; 6:36136915-36136915	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.438C>T; p.V146V; 6:36136039-36136039	skin	malignant_melanoma	Substitution - coding silent
c.438C>T; p.V146V; 6:36136039-36136039	skin	malignant_melanoma	Substitution - coding silent
c.991G>A; p.E331K; 6:36139028-36139028	skin	malignant_melanoma	Substitution - Missense
c.192C>G; p.I64M; 6:36131343-36131343	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.192C>G; p.I64M; 6:36131343-36131343	urinary_tract; bladder	carcinoma	Substitution - Missense
c.917C>T; p.P306L; 6:36138954-36138954	skin	malignant_melanoma	Substitution - Missense
c.574G>A; p.E192K; 6:36136734-36136734	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.917C>T; p.P306L; 6:36138954-36138954	skin; mucosal	malignant_melanoma	Substitution - Missense
c.907C>A; p.L303I; 6:36138944-36138944	kidney	other; neoplasm	Substitution - Missense
c.907C>A; p.L303I; 6:36138944-36138944	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.547G>A; p.V183M; 6:36136707-36136707	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.496-1G>A; p.?; 6:36136655-36136655	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.1033G>A; p.E345K; 6:36139308-36139308	skin	malignant_melanoma	Substitution - Missense
c.122C>T; p.S41L; 6:36131273-36131273	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.54C>A; p.A18A; 6:36130636-36130636	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.436G>A; p.V146I; 6:36136037-36136037	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.354G>T; p.M118I; 6:36135798-36135798	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.546C>T; p.Y182Y; 6:36136706-36136706	prostate	carcinoma	Substitution - coding silent
c.20A>G; p.K7R; 6:36130602-36130602	urinary_tract; bladder	carcinoma	Substitution - Missense
c.456G>A; p.K152K; 6:36136492-36136492	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.708G>A; p.L236L; 6:36138390-36138390	skin	malignant_melanoma	Substitution - coding silent
c.949G>C; p.E317Q; 6:36138986-36138986	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.949G>C; p.E317Q; 6:36138986-36138986	urinary_tract; bladder	carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]