Entrez Gene

Basic Information
Gene ID	55898
Name	UNC45A
Synonymous	unc-45 homolog A (C. elegans);UNC45A;unc-45 homolog A (C. elegans)
Definition	general cell UNC45\|protein unc-45 homolog A\|smooth muscle cell associated protein-1
Position	15q26.1
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.2506C>T; p.R836W; 15:90953239-90953239	breast	carcinoma	Substitution - Missense
c.2506C>T; p.R836W; 15:90953239-90953239	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2506C>T; p.R836W; 15:90953239-90953239	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.2302C>T; p.R768W; 15:90950614-90950614	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.443C>T; p.S148L; 15:90939747-90939747	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1738-1G>A; p.?; 15:90948653-90948653	urinary_tract; bladder	carcinoma	Unknown
c.1831G>C; p.E611Q; 15:90948747-90948747	central_nervous_system; brain	glioma	Substitution - Missense
c.2489A>T; p.D830V; 15:90953222-90953222	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1229G>A; p.G410E; 15:90946643-90946643	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.44delC; p.A18fs*85; 15:90935368-90935368	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.779T>C; p.L260P; 15:90942528-90942528	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1978A>G; p.T660A; 15:90949415-90949415	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2045G>A; p.G682D; 15:90949692-90949692	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.600G>C; p.L200F; 15:90940386-90940386	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.921C>T; p.V307V; 15:90942976-90942976	skin	malignant_melanoma	Substitution - coding silent
c.1105A>G; p.M369V; 15:90944969-90944969	liver	carcinoma	Substitution - Missense
c.817A>T; p.K273*; 15:90942566-90942566	skin	malignant_melanoma	Substitution - Nonsense
c.196G>T; p.A66S; 15:90935688-90935688	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1985C>T; p.S662F; 15:90949422-90949422	skin	malignant_melanoma	Substitution - Missense
c.1731C>T; p.L577L; 15:90948277-90948277	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.803T>A; p.L268H; 15:90942552-90942552	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.243A>T; p.A81A; 15:90935975-90935975	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1013G>T; p.W338L; 15:90943068-90943068	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1703C>T; p.A568V; 15:90948249-90948249	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2450A>G; p.N817S; 15:90953183-90953183	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.2564G>A; p.R855H; 15:90953297-90953297	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.2564G>A; p.R855H; 15:90953297-90953297	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.2107G>T; p.V703L; 15:90950187-90950187	liver	carcinoma	Substitution - Missense
c.1991G>C; p.R664T; 15:90949428-90949428	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2107G>T; p.V703L; 15:90950187-90950187	liver	carcinoma	Substitution - Missense
c.2421+2T>C; p.?; 15:90953048-90953048	stomach	carcinoma; adenocarcinoma	Unknown
c.1168A>G; p.N390D; 15:90945032-90945032	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2441C>A; p.A814D; 15:90953174-90953174	pancreas	carcinoma	Substitution - Missense
c.1527A>G; p.G509G; 15:90947822-90947822	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2210T>C; p.L737P; 15:90950522-90950522	pancreas	carcinoma	Substitution - Missense
c.2210T>C; p.L737P; 15:90950522-90950522	pancreas	carcinoma	Substitution - Missense
c.2325G>T; p.K775N; 15:90952950-90952950	breast	carcinoma	Substitution - Missense
c.1800T>A; p.Y600*; 15:90948716-90948716	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2654T>C; p.V885A; 15:90953535-90953535	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1819C>T; p.P607S; 15:90948735-90948735	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.251-4T>C; p.?; 15:90936281-90936281	oesophagus; lower_third	carcinoma; adenocarcinoma	Unknown
c.1704G>A; p.A568A; 15:90948250-90948250	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.445A>G; p.T149A; 15:90939749-90939749	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1649G>A; p.G550D; 15:90948195-90948195	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.679C>G; p.Q227E; 15:90940465-90940465	urinary_tract; bladder	carcinoma	Substitution - Missense
c.651T>C; p.R217R; 15:90940437-90940437	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.356T>C; p.V119A; 15:90936390-90936390	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1055G>A; p.G352D; 15:90944919-90944919	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1502G>T; p.G501V; 15:90947797-90947797	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.2350A>G; p.M784V; 15:90952975-90952975	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1635C>T; p.R545R; 15:90948181-90948181	breast	carcinoma	Substitution - coding silent
c.1249A>T; p.T417S; 15:90946663-90946663	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2540C>T; p.S847F; 15:90953273-90953273	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1145T>C; p.L382P; 15:90945009-90945009	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.689C>T; p.T230I; 15:90942438-90942438	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.646C>T; p.L216L; 15:90940432-90940432	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1592G>A; p.R531Q; 15:90947887-90947887	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2437G>A; p.E813K; 15:90953170-90953170	breast	carcinoma	Substitution - Missense
c.849C>T; p.I283I; 15:90942598-90942598	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.520G>T; p.A174S; 15:90940306-90940306	liver	carcinoma	Substitution - Missense
c.2292C>T; p.S764S; 15:90950604-90950604	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2292C>T; p.S764S; 15:90950604-90950604	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.520G>T; p.A174S; 15:90940306-90940306	liver	carcinoma	Substitution - Missense
c.62T>A; p.V21E; 15:90935554-90935554	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2492A>T; p.D831V; 15:90953225-90953225	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.171G>T; p.Q57H; 15:90935663-90935663	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2102C>T; p.T701M; 15:90950182-90950182	breast	carcinoma	Substitution - Missense
c.1099A>C; p.S367R; 15:90944963-90944963	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.1099A>C; p.S367R; 15:90944963-90944963	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Missense
c.2499G>T; p.L833L; 15:90953232-90953232	breast	carcinoma	Substitution - coding silent
c.2829A>T; p.G943G; 15:90953710-90953710	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.367C>G; p.P123A; 15:90936401-90936401	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1246C>T; p.Q416*; 15:90946660-90946660	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1596-6C>T; p.?; 15:90948136-90948136	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.1275A>T; p.P425P; 15:90946689-90946689	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.601C>T; p.Q201*; 15:90940387-90940387	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.2192A>G; p.Y731C; 15:90950504-90950504	breast	carcinoma	Substitution - Missense
c.187A>G; p.N63D; 15:90935679-90935679	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.880C>T; p.L294F; 15:90942935-90942935	pancreas	carcinoma	Substitution - Missense
c.2530A>T; p.M844L; 15:90953263-90953263	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2075C>T; p.A692V; 15:90950155-90950155	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1894G>A; p.V632M; 15:90949331-90949331	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1439C>T; p.S480L; 15:90946853-90946853	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2517C>T; p.A839A; 15:90953250-90953250	skin	malignant_melanoma	Substitution - coding silent
c.653C>T; p.T218M; 15:90940439-90940439	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2517C>T; p.A839A; 15:90953250-90953250	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.397C>T; p.R133W; 15:90936431-90936431	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.32C>A; p.P11H; 15:90935356-90935356	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2387C>G; p.T796R; 15:90953012-90953012	thyroid	other; neoplasm	Substitution - Missense
c.1501G>T; p.G501*; 15:90947796-90947796	lung	carcinoma; non_small_cell_carcinoma	Substitution - Nonsense
c.2642G>A; p.R881Q; 15:90953523-90953523	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2642G>A; p.R881Q; 15:90953523-90953523	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1187_1188delAA; p.N397fs*7; 15:90945051-90945052	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2314C>T; p.L772L; 15:90952939-90952939	skin	malignant_melanoma	Substitution - coding silent
c.1500+3G>A; p.?; 15:90946917-90946917	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.1250C>T; p.T417M; 15:90946664-90946664	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.718C>T; p.R240W; 15:90942467-90942467	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1282G>A; p.A428T; 15:90946696-90946696	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1065G>A; p.Q355Q; 15:90944929-90944929	ovary	other; neoplasm	Substitution - coding silent
c.1011C>G; p.L337L; 15:90943066-90943066	NS	NS	Substitution - coding silent
c.1977G>A; p.L659L; 15:90949414-90949414	lung	carcinoid-endocrine_tumour; typical	Substitution - coding silent
c.2322G>T; p.E774D; 15:90952947-90952947	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.276C>G; p.V92V; 15:90936310-90936310	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.885C>T; p.I295I; 15:90942940-90942940	skin	malignant_melanoma	Substitution - coding silent
c.605G>A; p.R202H; 15:90940391-90940391	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.605G>A; p.R202H; 15:90940391-90940391	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.605G>A; p.R202H; 15:90940391-90940391	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1875C>T; p.P625P; 15:90948791-90948791	skin	malignant_melanoma	Substitution - coding silent
c.756T>C; p.A252A; 15:90942505-90942505	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1199A>G; p.K400R; 15:90945063-90945063	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1830G>T; p.V610V; 15:90948746-90948746	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2452G>A; p.D818N; 15:90953185-90953185	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1093G>A; p.A365T; 15:90944957-90944957	prostate	carcinoma	Substitution - Missense
c.399G>T; p.R133R; 15:90936433-90936433	breast	carcinoma	Substitution - coding silent
c.2061G>T; p.Q687H; 15:90949708-90949708	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.575T>C; p.F192S; 15:90940361-90940361	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1530G>T; p.G510G; 15:90947825-90947825	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.649C>T; p.R217C; 15:90940435-90940435	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1120C>G; p.L374V; 15:90944984-90944984	urinary_tract; bladder	carcinoma	Substitution - Missense
c.447G>A; p.T149T; 15:90939751-90939751	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.779T>G; p.L260R; 15:90942528-90942528	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.830G>A; p.R277Q; 15:90942579-90942579	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2084C>T; p.P695L; 15:90950164-90950164	skin; extremity	malignant_melanoma	Substitution - Missense
c.866G>T; p.R289L; 15:90942921-90942921	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1595+7C>A; p.?; 15:90947897-90947897	stomach	carcinoma; diffuse_adenocarcinoma	Unknown
c.1758C>T; p.L586L; 15:90948674-90948674	skin	malignant_melanoma	Substitution - coding silent

COSMIC somatic mutation [Top]