Entrez Gene

Basic Information
Gene ID	55893
Name	ZNF395
Synonymous	zinc finger protein 395;ZNF395;zinc finger protein 395
Definition	HD gene regulatory region-binding protein 2\|HD-regulating factor 2\|Huntington's disease gene regulatory region-binding protein 2\|huntington disease gene regulatory region-binding protein 2\|papillomavirus regulatory factor 1\|papillomavirus regulatory facto
Position	8p21.1
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.5C>T; p.A2V; 8:28361120-28361120	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.638G>A; p.G213D; 8:28353354-28353354	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1015G>T; p.A339S; 8:28351713-28351713	liver	carcinoma	Substitution - Missense
c.360G>A; p.E120E; 8:28359705-28359705	pancreas	carcinoma	Substitution - coding silent
c.685A>C; p.T229P; 8:28353307-28353307	pancreas	carcinoid-endocrine_tumour	Substitution - Missense
c.1358C>A; p.P453H; 8:28349197-28349197	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1122C>G; p.A374A; 8:28351606-28351606	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.824C>T; p.S275F; 8:28352669-28352669	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1122C>G; p.A374A; 8:28351606-28351606	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.1441G>T; p.G481W; 8:28348820-28348820	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.819+4C>T; p.?; 8:28353169-28353169	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Unknown
c.55G>A; p.V19M; 8:28361070-28361070	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.701A>C; p.H234P; 8:28353291-28353291	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1066A>G; p.T356A; 8:28351662-28351662	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.396C>A; p.P132P; 8:28359669-28359669	thyroid	other; neoplasm	Substitution - coding silent
c.174delC; p.K59fs*46; 8:28360951-28360951	lung	carcinoma; small_cell_carcinoma	Deletion - Frameshift
c.1407A>C; p.P469P; 8:28349148-28349148	breast	carcinoma	Substitution - coding silent
c.123C>T; p.A41A; 8:28361002-28361002	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1521C>A; p.A507A; 8:28348740-28348740	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.96A>C; p.P32P; 8:28361029-28361029	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.684C>T; p.S228S; 8:28353308-28353308	skin	malignant_melanoma	Substitution - coding silent
c.1500G>C; p.T500T; 8:28348761-28348761	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.584-5G>A; p.?; 8:28353413-28353413	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.519G>A; p.V173V; 8:28356734-28356734	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1472G>T; p.G491V; 8:28348789-28348789	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.42C>T; p.L14L; 8:28361083-28361083	skin	malignant_melanoma	Substitution - coding silent
c.315C>T; p.T105T; 8:28359750-28359750	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.727G>A; p.G243R; 8:28353265-28353265	skin	malignant_melanoma	Substitution - Missense
c.1323_1324delTC; p.P442fs*42; 8:28350066-28350067	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.1129T>A; p.S377T; 8:28351599-28351599	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1152G>T; p.P384P; 8:28351576-28351576	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1416C>A; p.A472A; 8:28349139-28349139	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1472G>A; p.G491D; 8:28348789-28348789	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.187A>G; p.K63E; 8:28360938-28360938	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.167A>T; p.E56V; 8:28360958-28360958	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1322C>G; p.S441C; 8:28350068-28350068	breast	carcinoma	Substitution - Missense
c.795C>T; p.D265D; 8:28353197-28353197	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1017_1019delTGC; p.A341delA; 8:28351709-28351711	breast	carcinoma	Deletion - In frame
c.1017_1019delTGC; p.A341delA; 8:28351709-28351711	bone; ilium	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Deletion - In frame
c.1237C>G; p.L413V; 8:28350153-28350153	prostate	carcinoma	Substitution - Missense
c.1017_1019delTGC; p.A341delA; 8:28351709-28351711	stomach	carcinoma; diffuse_adenocarcinoma	Deletion - In frame
c.1017_1019delTGC; p.A341delA; 8:28351709-28351711	endometrium	carcinoma; endometrioid_carcinoma	Deletion - In frame
c.1017_1019delTGC; p.A341delA; 8:28351709-28351711	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Deletion - In frame
c.1538A>G; p.D513G; 8:28348723-28348723	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1380G>T; p.M460I; 8:28349175-28349175	breast	carcinoma	Substitution - Missense
c.842A>G; p.K281R; 8:28352651-28352651	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.558T>A; p.P186P; 8:28356695-28356695	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.28G>A; p.G10R; 8:28361097-28361097	NS	malignant_melanoma	Substitution - Missense
c.28G>A; p.G10R; 8:28361097-28361097	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.28G>A; p.G10R; 8:28361097-28361097	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.124G>A; p.A42T; 8:28361001-28361001	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1458C>T; p.C486C; 8:28348803-28348803	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.483C>T; p.D161D; 8:28356770-28356770	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1417C>T; p.Q473*; 8:28349138-28349138	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.1037C>T; p.P346L; 8:28351691-28351691	skin	malignant_melanoma	Substitution - Missense
c.1426G>A; p.A476T; 8:28349129-28349129	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1019_1020insTGC; p.A341_G342insA; 8:28351708-28351709	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - In frame
c.1456T>C; p.C486R; 8:28348805-28348805	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.353G>T; p.R118M; 8:28359712-28359712	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1507C>T; p.R503W; 8:28348754-28348754	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.98C>T; p.P33L; 8:28361027-28361027	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.393T>C; p.C131C; 8:28359672-28359672	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.749A>G; p.Q250R; 8:28353243-28353243	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.316G>A; p.V106I; 8:28359749-28359749	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.264A>T; p.Q88H; 8:28359801-28359801	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1152G>A; p.P384P; 8:28351576-28351576	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1090C>T; p.L364L; 8:28351638-28351638	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1499C>T; p.T500M; 8:28348762-28348762	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1395C>T; p.I465I; 8:28349160-28349160	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1396G>A; p.V466I; 8:28349159-28349159	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.690delC; p.S231fs*46; 8:28353302-28353302	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1179C>T; p.L393L; 8:28351549-28351549	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1179C>T; p.L393L; 8:28351549-28351549	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1524C>T; p.C508C; 8:28348737-28348737	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1492T>C; p.W498R; 8:28348769-28348769	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.473G>A; p.R158K; 8:28359592-28359592	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1353C>T; p.S451S; 8:28349202-28349202	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1353C>T; p.S451S; 8:28349202-28349202	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1048A>C; p.T350P; 8:28351680-28351680	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1050C>A; p.T350T; 8:28351678-28351678	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1452G>A; p.K484K; 8:28348809-28348809	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.446T>C; p.V149A; 8:28359619-28359619	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1534C>G; p.L512V; 8:28348727-28348727	urinary_tract; bladder	carcinoma	Substitution - Missense
c.558T>C; p.P186P; 8:28356695-28356695	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1459C>T; p.R487C; 8:28348802-28348802	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1441G>A; p.G481R; 8:28348820-28348820	skin	malignant_melanoma	Substitution - Missense
c.754G>A; p.D252N; 8:28353238-28353238	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.754G>A; p.D252N; 8:28353238-28353238	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.700delC; p.H234fs*43; 8:28353292-28353292	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.700delC; p.H234fs*43; 8:28353292-28353292	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.700delC; p.H234fs*43; 8:28353292-28353292	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1071delC; p.S358fs*2; 8:28351657-28351657	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.757C>T; p.H253Y; 8:28353235-28353235	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1017T>C; p.A339A; 8:28351711-28351711	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.695C>T; p.P232L; 8:28353297-28353297	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.695C>T; p.P232L; 8:28353297-28353297	large_intestine; colon	carcinoma	Substitution - Missense
c.695C>T; p.P232L; 8:28353297-28353297	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1422T>C; p.S474S; 8:28349133-28349133	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1199C>T; p.S400F; 8:28351529-28351529	skin	malignant_melanoma	Substitution - Missense
c.1351A>G; p.S451G; 8:28349204-28349204	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1173G>C; p.G391G; 8:28351555-28351555	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1406C>T; p.P469L; 8:28349149-28349149	skin	malignant_melanoma	Substitution - Missense
c.484G>A; p.A162T; 8:28356769-28356769	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.216G>A; p.Q72Q; 8:28360909-28360909	breast	carcinoma	Substitution - coding silent
c.1140A>G; p.E380E; 8:28351588-28351588	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.700_701insC; p.H234fs*19; 8:28353291-28353292	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.700_701insC; p.H234fs*19; 8:28353291-28353292	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.700_701insC; p.H234fs*19; 8:28353291-28353292	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.902T>A; p.V301D; 8:28352591-28352591	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.700_701insC; p.H234fs*19; 8:28353291-28353292	large_intestine; rectum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.459C>T; p.I153I; 8:28359606-28359606	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.74C>T; p.S25L; 8:28361051-28361051	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1169C>T; p.S390L; 8:28351559-28351559	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1169C>T; p.S390L; 8:28351559-28351559	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.543T>C; p.P181P; 8:28356710-28356710	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent

COSMIC somatic mutation [Top]