Entrez Gene

Basic Information
Gene ID	55630
Name	SLC39A4
Synonymous	solute carrier family 39 (zinc transporter), member 4;SLC39A4;solute carrier family 39 (zinc transporter), member 4
Definition	zinc transporter ZIP4\|zrt- and Irt-like protein 4
Position	8q24.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1822G>A; p.A608T; 8:144412660-144412660	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.499C>T; p.L167L; 8:144415395-144415395	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.284G>A; p.R95H; 8:144416000-144416000	oesophagus	carcinoma	Substitution - Missense
c.297C>T; p.A99A; 8:144415987-144415987	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.869C>T; p.P290L; 8:144414832-144414832	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.850G>A; p.E284K; 8:144414851-144414851	breast	carcinoma	Substitution - Missense
c.1864C>T; p.L622L; 8:144412618-144412618	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.293C>T; p.A98V; 8:144415991-144415991	ovary	other; neoplasm	Substitution - Missense
c.1321C>T; p.H441Y; 8:144413848-144413848	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.1321C>T; p.H441Y; 8:144413848-144413848	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1796A>G; p.Y599C; 8:144412778-144412778	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.79G>A; p.G27S; 8:144416711-144416711	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1002G>T; p.T334T; 8:144414409-144414409	thyroid	other; neoplasm	Substitution - coding silent
c.59C>T; p.A20V; 8:144416731-144416731	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.82C>A; p.L28M; 8:144416708-144416708	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.766C>T; p.L256F; 8:144415012-144415012	skin	malignant_melanoma	Substitution - Missense
c.1860C>T; p.L620L; 8:144412622-144412622	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1383G>A; p.Q461Q; 8:144413786-144413786	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1754G>T; p.S585I; 8:144412820-144412820	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.90_101del12; p.L31_S34delLLTS; 8:144416689-144416700	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - In frame
c.251C>T; p.P84L; 8:144416033-144416033	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.764C>A; p.P255H; 8:144415014-144415014	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.519G>C; p.A173A; 8:144415375-144415375	ovary	other; neoplasm	Substitution - coding silent
c.1066delG; p.V356fs*10; 8:144414345-144414345	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1818C>A; p.L606L; 8:144412664-144412664	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1526T>C; p.F509S; 8:144413338-144413338	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.609G>A; p.Q203Q; 8:144415285-144415285	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.779G>A; p.S260N; 8:144414999-144414999	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1890C>T; p.G630G; 8:144412592-144412592	prostate	carcinoma	Substitution - coding silent
c.1710C>A; p.F570L; 8:144412864-144412864	liver	carcinoma	Substitution - Missense
c.1710C>A; p.F570L; 8:144412864-144412864	liver	carcinoma	Substitution - Missense
c.1142C>T; p.T381M; 8:144414269-144414269	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.22G>A; p.E8K; 8:144416768-144416768	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1880G>C; p.G627A; 8:144412602-144412602	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1399G>C; p.E467Q; 8:144413770-144413770	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.94C>G; p.L32V; 8:144416696-144416696	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1931A>G; p.D644G; 8:144412551-144412551	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1008C>T; p.L336L; 8:144414403-144414403	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1546G>T; p.G516C; 8:144413318-144413318	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.710C>T; p.A237V; 8:144415068-144415068	skin	malignant_melanoma	Substitution - Missense
c.1300G>A; p.G434R; 8:144413869-144413869	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1810G>A; p.D604N; 8:144412764-144412764	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.1396_1397insC; p.H466fs*20; 8:144413772-144413773	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1069A>G; p.T357A; 8:144414342-144414342	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1069A>G; p.T357A; 8:144414342-144414342	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1069A>G; p.T357A; 8:144414342-144414342	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.225C>T; p.G75G; 8:144416059-144416059	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1069A>G; p.T357A; 8:144414342-144414342	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1451_1452CT>TC; p.P484L; 8:144413535-144413536	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1732G>A; p.A578T; 8:144412842-144412842	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.277G>A; p.V93I; 8:144416007-144416007	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1143G>A; p.T381T; 8:144414268-144414268	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1711G>T; p.A571S; 8:144412863-144412863	liver	carcinoma	Substitution - Missense
c.1711G>T; p.A571S; 8:144412863-144412863	liver	carcinoma	Substitution - Missense
c.1367_1368delCC; p.P456fs*29; 8:144413801-144413802	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.252G>A; p.P84P; 8:144416032-144416032	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1710C>T; p.F570F; 8:144412864-144412864	breast	carcinoma	Substitution - coding silent
c.543C>T; p.G181G; 8:144415351-144415351	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.242G>A; p.G81E; 8:144416042-144416042	skin	malignant_melanoma	Substitution - Missense
c.897C>T; p.A299A; 8:144414804-144414804	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.320C>T; p.P107L; 8:144415964-144415964	skin	malignant_melanoma	Substitution - Missense
c.1845G>A; p.P615P; 8:144412637-144412637	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1769T>C; p.L590P; 8:144412805-144412805	thyroid	other; neoplasm	Substitution - Missense
c.1845G>A; p.P615P; 8:144412637-144412637	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.878G>C; p.W293S; 8:144414823-144414823	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.878G>C; p.W293S; 8:144414823-144414823	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.112G>A; p.A38T; 8:144416678-144416678	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1662C>T; p.S554S; 8:144412912-144412912	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1272G>C; p.L424L; 8:144413973-144413973	central_nervous_system; brain	glioma	Substitution - coding silent
c.402G>A; p.K134K; 8:144415882-144415882	skin	malignant_melanoma	Substitution - coding silent
c.1756G>A; p.E586K; 8:144412818-144412818	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.345G>A; p.R115R; 8:144415939-144415939	skin	malignant_melanoma	Substitution - coding silent
c.1635C>T; p.F545F; 8:144412939-144412939	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1635C>T; p.F545F; 8:144412939-144412939	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.948C>G; p.P316P; 8:144414753-144414753	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1844C>A; p.P615Q; 8:144412638-144412638	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.1694C>T; p.S565F; 8:144412880-144412880	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.540C>T; p.G180G; 8:144415354-144415354	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.977-4C>T; p.?; 8:144414438-144414438	liver	carcinoma	Unknown
c.874G>A; p.A292T; 8:144414827-144414827	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.977-4C>T; p.?; 8:144414438-144414438	liver	carcinoma	Unknown
c.803C>T; p.T268M; 8:144414975-144414975	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.803C>T; p.T268M; 8:144414975-144414975	pancreas	carcinoma	Substitution - Missense
c.798G>T; p.W266C; 8:144414980-144414980	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1098C>A; p.S366R; 8:144414313-144414313	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1850C>T; p.P617L; 8:144412632-144412632	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.689G>A; p.R230H; 8:144415089-144415089	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.813G>A; p.L271L; 8:144414888-144414888	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.172G>A; p.A58T; 8:144416618-144416618	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.172G>A; p.A58T; 8:144416618-144416618	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.72G>A; p.P24P; 8:144416718-144416718	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1912_1914delCTG; p.L638delL; 8:144412568-144412570	oesophagus	carcinoma; adenocarcinoma	Deletion - In frame
c.1260C>A; p.F420L; 8:144413985-144413985	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.911A>T; p.Q304L; 8:144414790-144414790	breast	carcinoma	Substitution - Missense
c.697delG; p.V233fs*39; 8:144415081-144415081	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.615C>T; p.F205F; 8:144415279-144415279	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.615C>T; p.F205F; 8:144415279-144415279	skin	malignant_melanoma	Substitution - coding silent
c.1696G>A; p.A566T; 8:144412878-144412878	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1857C>T; p.L619L; 8:144412625-144412625	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.340G>A; p.A114T; 8:144415944-144415944	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.340G>A; p.A114T; 8:144415944-144415944	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1910T>C; p.L637P; 8:144412572-144412572	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.340G>A; p.A114T; 8:144415944-144415944	breast	carcinoma	Substitution - Missense
c.340G>A; p.A114T; 8:144415944-144415944	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.340G>A; p.A114T; 8:144415944-144415944	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1264C>A; p.L422I; 8:144413981-144413981	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.132G>A; p.L44L; 8:144416658-144416658	skin	malignant_melanoma	Substitution - coding silent
c.1474+2T>G; p.?; 8:144413511-144413511	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.398C>T; p.P133L; 8:144415886-144415886	skin	malignant_melanoma	Substitution - Missense
c.87G>T; p.L29L; 8:144416703-144416703	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.279C>T; p.V93V; 8:144416005-144416005	skin	malignant_melanoma	Substitution - coding silent

COSMIC somatic mutation [Top]