Entrez Gene

Basic Information
Gene ID	5550
Name	PREP
Synonymous	prolyl endopeptidase;PREP;prolyl endopeptidase
Definition	dJ355L5.1 (prolyl endopeptidase)\|post-proline cleaving enzyme\|prolyl oligopeptidase
Position	6q22
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1633C>T; p.P545S; 6:105282499-105282499	skin	malignant_melanoma	Substitution - Missense
c.558C>T; p.F186F; 6:105373406-105373406	liver	carcinoma	Substitution - coding silent
c.1272G>A; p.E424E; 6:105323710-105323710	skin	malignant_melanoma	Substitution - coding silent
c.1908C>T; p.L636L; 6:105278369-105278369	breast	carcinoma	Substitution - coding silent
c.1808A>G; p.D603G; 6:105281776-105281776	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1318-1G>A; p.?; 6:105288895-105288895	skin	malignant_melanoma	Unknown
c.2040C>T; p.H680H; 6:105278237-105278237	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2103G>T; p.A701A; 6:105278174-105278174	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.724G>A; p.D242N; 6:105353071-105353071	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.724G>A; p.D242N; 6:105353071-105353071	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.292C>T; p.R98*; 6:105376218-105376218	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.383G>A; p.R128Q; 6:105376127-105376127	stomach	adenocarcinoma	Substitution - Missense
c.1681+1G>T; p.?; 6:105282450-105282450	lung	carcinoma; adenocarcinoma	Unknown
c.560A>G; p.Y187C; 6:105373404-105373404	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.465C>T; p.F155F; 6:105373499-105373499	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.221C>T; p.P74L; 6:105377419-105377419	urinary_tract; bladder	carcinoma	Substitution - Missense
c.54T>C; p.D18D; 6:105397919-105397919	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1494C>T; p.I498I; 6:105285541-105285541	skin	malignant_melanoma	Substitution - coding silent
c.2030A>T; p.K677M; 6:105278247-105278247	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.885T>C; p.N295N; 6:105333444-105333444	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1773C>T; p.I591I; 6:105281811-105281811	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1582G>A; p.D528N; 6:105282550-105282550	breast	carcinoma	Substitution - Missense
c.841A>C; p.K281Q; 6:105333488-105333488	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.390T>C; p.Y130Y; 6:105373574-105373574	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.390T>C; p.Y130Y; 6:105373574-105373574	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1769C>A; p.T590N; 6:105281815-105281815	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.652G>A; p.D218N; 6:105368968-105368968	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.715G>A; p.E239K; 6:105368905-105368905	breast	carcinoma	Substitution - Missense
c.902C>A; p.T301K; 6:105333427-105333427	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1301A>G; p.D434G; 6:105323681-105323681	breast	carcinoma	Substitution - Missense
c.1051T>G; p.L351V; 6:105328991-105328991	thyroid	other; neoplasm	Substitution - Missense
c.1538C>T; p.T513M; 6:105285497-105285497	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.718-2A>T; p.?; 6:105353079-105353079	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.718-2A>T; p.?; 6:105353079-105353079	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.718-2A>T; p.?; 6:105353079-105353079	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.718-2A>T; p.?; 6:105353079-105353079	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.849T>C; p.I283I; 6:105333480-105333480	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.473T>G; p.V158G; 6:105373491-105373491	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.718-2A>T; p.?; 6:105353079-105353079	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.534G>A; p.W178*; 6:105373430-105373430	ovary	other; neoplasm	Substitution - Nonsense
c.1251G>A; p.L417L; 6:105323731-105323731	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.769C>T; p.P257S; 6:105353026-105353026	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1251G>A; p.L417L; 6:105323731-105323731	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.556T>C; p.F186L; 6:105373408-105373408	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1317G>A; p.Q439Q; 6:105323665-105323665	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.103G>A; p.D35N; 6:105397870-105397870	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1385T>C; p.L462S; 6:105288827-105288827	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1340G>A; p.G447D; 6:105288872-105288872	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.735C>A; p.R245R; 6:105353060-105353060	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1943A>G; p.H648R; 6:105278334-105278334	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2008delC; p.L670fs*20; 6:105278269-105278269	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1341T>C; p.G447G; 6:105288871-105288871	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.803A>C; p.Q268P; 6:105352992-105352992	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1634C>T; p.P545L; 6:105282498-105282498	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2035G>T; p.G679C; 6:105278242-105278242	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1214-2A>C; p.?; 6:105323770-105323770	ovary	carcinoma; serous_carcinoma	Unknown
c.1978G>A; p.V660M; 6:105278299-105278299	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1445C>T; p.P482L; 6:105288767-105288767	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1267C>T; p.R423*; 6:105323715-105323715	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1267C>T; p.R423*; 6:105323715-105323715	peritoneum; appendix	other; pseudomyxoma_peritonei	Substitution - Nonsense
c.1416C>T; p.G472G; 6:105288796-105288796	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1374_1375insA; p.G459fs*58; 6:105288837-105288838	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1068C>T; p.D356D; 6:105328974-105328974	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1744G>T; p.D582Y; 6:105281840-105281840	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1446C>T; p.P482P; 6:105288766-105288766	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.2000G>A; p.S667N; 6:105278277-105278277	liver	carcinoma	Substitution - Missense
c.151G>C; p.V51L; 6:105377489-105377489	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.277G>T; p.G93C; 6:105376233-105376233	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; follicular_lymphoma	Substitution - Missense
c.912G>A; p.T304T; 6:105333417-105333417	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.912G>A; p.T304T; 6:105333417-105333417	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.457A>G; p.I153V; 6:105373507-105373507	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.1039A>T; p.N347Y; 6:105329003-105329003	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.437G>A; p.S146N; 6:105373527-105373527	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1956C>G; p.F652L; 6:105278321-105278321	breast	carcinoma	Substitution - Missense
c.893C>T; p.T298M; 6:105333436-105333436	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.622C>T; p.Q208*; 6:105368998-105368998	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.1985G>A; p.R662H; 6:105278292-105278292	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2097C>A; p.F699L; 6:105278180-105278180	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1985G>A; p.R662H; 6:105278292-105278292	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1929C>T; p.R643R; 6:105278348-105278348	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1936C>T; p.P646S; 6:105278341-105278341	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1936C>T; p.P646S; 6:105278341-105278341	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1617G>A; p.K539K; 6:105282515-105282515	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.449G>A; p.W150*; 6:105373515-105373515	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.160C>T; p.L54F; 6:105377480-105377480	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1735G>A; p.G579R; 6:105281849-105281849	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1272G>C; p.E424D; 6:105323710-105323710	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.96A>G; p.E32E; 6:105397877-105397877	liver	carcinoma	Substitution - coding silent
c.96A>G; p.E32E; 6:105397877-105397877	liver	carcinoma	Substitution - coding silent
c.1539G>A; p.T513T; 6:105285496-105285496	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2119G>A; p.D707N; 6:105278158-105278158	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.734G>A; p.R245H; 6:105353061-105353061	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1445C>A; p.P482H; 6:105288767-105288767	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2101G>T; p.A701S; 6:105278176-105278176	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.253C>T; p.R85W; 6:105377387-105377387	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1464G>A; p.R488R; 6:105285571-105285571	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.779G>A; p.R260Q; 6:105353016-105353016	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1298C>T; p.S433F; 6:105323684-105323684	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.779G>A; p.R260Q; 6:105353016-105353016	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.894G>T; p.T298T; 6:105333435-105333435	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.1125C>T; p.F375F; 6:105328917-105328917	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1754A>T; p.K585M; 6:105281830-105281830	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1086G>T; p.Q362H; 6:105328956-105328956	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1215T>C; p.G405G; 6:105323767-105323767	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1562C>T; p.A521V; 6:105282570-105282570	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1374delA; p.G459fs*2; 6:105288838-105288838	stomach	adenocarcinoma	Deletion - Frameshift
c.1374delA; p.G459fs*2; 6:105288838-105288838	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2116G>A; p.V706I; 6:105278161-105278161	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1374delA; p.G459fs*2; 6:105288838-105288838	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2125A>G; p.I709V; 6:105278152-105278152	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1906C>A; p.L636I; 6:105278371-105278371	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1774G>A; p.G592S; 6:105281810-105281810	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.611C>T; p.T204I; 6:105369009-105369009	skin	malignant_melanoma	Substitution - Missense
c.823+1G>A; p.?; 6:105352971-105352971	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.225G>T; p.K75N; 6:105377415-105377415	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1984C>T; p.R662C; 6:105278293-105278293	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.627G>A; p.K209K; 6:105368993-105368993	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.2022G>A; p.V674V; 6:105278255-105278255	skin	malignant_melanoma	Substitution - coding silent
c.733C>T; p.R245C; 6:105353062-105353062	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.937G>T; p.V313L; 6:105333392-105333392	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1710C>A; p.L570L; 6:105281874-105281874	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1307A>G; p.Q436R; 6:105323675-105323675	liver	carcinoma	Substitution - Missense
c.709_710GG>TT; p.G237>?; 6:105368910-105368911	lung	carcinoma; small_cell_carcinoma	Complex
c.1090C>T; p.H364Y; 6:105328952-105328952	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.102C>T; p.P34P; 6:105397871-105397871	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.892A>T; p.T298S; 6:105333437-105333437	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1268G>A; p.R423Q; 6:105323714-105323714	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1268G>A; p.R423Q; 6:105323714-105323714	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1834G>T; p.V612F; 6:105281750-105281750	breast	carcinoma	Substitution - Missense
c.1785G>A; p.W595*; 6:105281799-105281799	skin	malignant_melanoma	Substitution - Nonsense
c.1255C>T; p.P419S; 6:105323727-105323727	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.393G>A; p.A131A; 6:105373571-105373571	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1446C>A; p.P482P; 6:105288766-105288766	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1446C>A; p.P482P; 6:105288766-105288766	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent

COSMIC somatic mutation [Top]