Entrez Gene

Basic Information
Gene ID	55366
Name	LGR4
Synonymous	leucine-rich repeat containing G protein-coupled receptor 4;LGR4;leucine-rich repeat containing G protein-coupled receptor 4
Definition	G protein-coupled receptor 48\|leucine-rich repeat-containing G-protein coupled receptor 4
Position	11p14-p13
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.2565G>A; p.L855L; 11:27368158-27368158	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2565G>A; p.L855L; 11:27368158-27368158	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.542C>T; p.A181V; 11:27385328-27385328	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2248G>A; p.A750T; 11:27368475-27368475	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1641C>A; p.F547L; 11:27369082-27369082	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1112C>T; p.S371F; 11:27376368-27376368	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.226G>T; p.A76S; 11:27412820-27412820	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.573C>T; p.S191S; 11:27385297-27385297	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.389C>T; p.A130V; 11:27391106-27391106	skin	malignant_melanoma	Substitution - Missense
c.2370delT; p.P791fs*6; 11:27368353-27368353	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1391T>A; p.V464E; 11:27372387-27372387	skin	malignant_melanoma	Substitution - Missense
c.1732G>A; p.G578S; 11:27368991-27368991	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1969A>C; p.N657H; 11:27368754-27368754	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1418T>A; p.F473Y; 11:27372360-27372360	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1977C>T; p.L659L; 11:27368746-27368746	thyroid	carcinoma	Substitution - coding silent
c.266C>T; p.A89V; 11:27392510-27392510	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.266C>T; p.A89V; 11:27392510-27392510	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.266C>T; p.A89V; 11:27392510-27392510	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2782C>T; p.R928*; 11:27367941-27367941	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2782C>T; p.R928*; 11:27367941-27367941	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2782C>T; p.R928*; 11:27367941-27367941	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2584G>A; p.E862K; 11:27368139-27368139	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2509C>A; p.L837M; 11:27368214-27368214	skin	malignant_melanoma	Substitution - Missense
c.1112C>A; p.S371Y; 11:27376368-27376368	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1112C>A; p.S371Y; 11:27376368-27376368	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1169C>T; p.S390F; 11:27376311-27376311	skin	malignant_melanoma	Substitution - Missense
c.1401T>G; p.A467A; 11:27372377-27372377	breast	carcinoma	Substitution - coding silent
c.2480C>A; p.S827*; 11:27368243-27368243	liver	carcinoma	Substitution - Nonsense
c.376C>T; p.R126*; 11:27391119-27391119	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.831-1G>C; p.?; 11:27380712-27380712	kidney	carcinoma; papillary_renal_cell_carcinoma	Unknown
c.1715C>T; p.S572L; 11:27369008-27369008	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2530G>C; p.D844H; 11:27368193-27368193	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2765A>T; p.Q922L; 11:27367958-27367958	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.2765A>T; p.Q922L; 11:27367958-27367958	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1968C>A; p.S656R; 11:27368755-27368755	breast	carcinoma	Substitution - Missense
c.1715C>T; p.S572L; 11:27369008-27369008	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.729T>G; p.A243A; 11:27382217-27382217	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.618-10delT; p.?; 11:27384417-27384417	oesophagus; lower_third	carcinoma; adenocarcinoma	Unknown
c.2449C>T; p.R817*; 11:27368274-27368274	pancreas	carcinoma	Substitution - Nonsense
c.2449C>T; p.R817*; 11:27368274-27368274	pancreas	carcinoma	Substitution - Nonsense
c.2449C>T; p.R817*; 11:27368274-27368274	pancreas	carcinoma	Substitution - Nonsense
c.1297C>A; p.L433M; 11:27373633-27373633	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.703A>G; p.N235D; 11:27382243-27382243	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.608T>G; p.L203R; 11:27385262-27385262	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.608T>G; p.L203R; 11:27385262-27385262	large_intestine; colon	carcinoma	Substitution - Missense
c.2122G>A; p.V708I; 11:27368601-27368601	NS	NS	Substitution - Missense
c.608T>G; p.L203R; 11:27385262-27385262	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2292G>A; p.A764A; 11:27368431-27368431	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2104C>G; p.P702A; 11:27368619-27368619	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.367G>A; p.E123K; 11:27391128-27391128	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.982G>A; p.G328S; 11:27378758-27378758	skin	malignant_melanoma	Substitution - Missense
c.2376G>A; p.L792L; 11:27368347-27368347	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.466C>T; p.R156W; 11:27385404-27385404	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.466C>T; p.R156W; 11:27385404-27385404	breast	carcinoma	Substitution - Missense
c.1961G>T; p.G654V; 11:27368762-27368762	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1048T>G; p.L350V; 11:27377219-27377219	skin	malignant_melanoma	Substitution - Missense
c.1580-3delT; p.?; 11:27369146-27369146	stomach	adenocarcinoma	Unknown
c.1580-3delT; p.?; 11:27369146-27369146	stomach	adenocarcinoma	Unknown
c.1580-3delT; p.?; 11:27369146-27369146	stomach	adenocarcinoma	Unknown
c.2165C>G; p.A722G; 11:27368558-27368558	skin	malignant_melanoma	Substitution - Missense
c.539A>G; p.Q180R; 11:27385331-27385331	breast	carcinoma	Substitution - Missense
c.1753T>C; p.L585L; 11:27368970-27368970	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1253T>G; p.L418R; 11:27373975-27373975	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.448G>C; p.E150Q; 11:27385422-27385422	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1092C>A; p.C364*; 11:27377175-27377175	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.684G>A; p.E228E; 11:27384341-27384341	breast	carcinoma	Substitution - coding silent
c.2275T>C; p.F759L; 11:27368448-27368448	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.485A>G; p.D162G; 11:27385385-27385385	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2412C>T; p.F804F; 11:27368311-27368311	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1718C>T; p.S573F; 11:27369005-27369005	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.910C>T; p.R304C; 11:27380332-27380332	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.910C>T; p.R304C; 11:27380332-27380332	skin	malignant_melanoma	Substitution - Missense
c.910C>T; p.R304C; 11:27380332-27380332	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.910C>T; p.R304C; 11:27380332-27380332	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2353G>C; p.V785L; 11:27368370-27368370	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.2822G>T; p.R941L; 11:27367901-27367901	oesophagus	carcinoma	Substitution - Missense
c.2822G>T; p.R941L; 11:27367901-27367901	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1816G>A; p.A606T; 11:27368907-27368907	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2034T>G; p.C678W; 11:27368689-27368689	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.514C>T; p.P172S; 11:27385356-27385356	skin	malignant_melanoma	Substitution - Missense
c.2450G>A; p.R817Q; 11:27368273-27368273	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.347A>G; p.Q116R; 11:27391148-27391148	skin	malignant_melanoma	Substitution - Missense
c.2774C>T; p.A925V; 11:27367949-27367949	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2708C>T; p.S903L; 11:27368015-27368015	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2421G>C; p.K807N; 11:27368302-27368302	breast	carcinoma	Substitution - Missense
c.2300C>T; p.S767L; 11:27368423-27368423	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.255G>C; p.E85D; 11:27412791-27412791	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2588C>T; p.S863L; 11:27368135-27368135	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2574C>T; p.C858C; 11:27368149-27368149	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.789C>T; p.I263I; 11:27380936-27380936	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2588C>T; p.S863L; 11:27368135-27368135	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.2338G>A; p.E780K; 11:27368385-27368385	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1763G>A; p.G588E; 11:27368960-27368960	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1808delG; p.G603fs*18; 11:27368915-27368915	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1240C>T; p.P414S; 11:27373988-27373988	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.564G>C; p.K188N; 11:27385306-27385306	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1759A>G; p.M587V; 11:27368964-27368964	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2155T>G; p.L719V; 11:27368568-27368568	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2051G>A; p.R684K; 11:27368672-27368672	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.759-10A>G; p.?; 11:27380976-27380976	liver	carcinoma	Unknown
c.2370T>C; p.F790F; 11:27368353-27368353	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.759-10A>G; p.?; 11:27380976-27380976	liver	carcinoma	Unknown
c.1398T>C; p.Y466Y; 11:27372380-27372380	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2351C>T; p.S784F; 11:27368372-27368372	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2351C>T; p.S784F; 11:27368372-27368372	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.1382C>T; p.S461F; 11:27372396-27372396	skin	malignant_melanoma	Substitution - Missense
c.2677G>C; p.E893Q; 11:27368046-27368046	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2270G>T; p.C757F; 11:27368453-27368453	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.715G>A; p.E239K; 11:27382231-27382231	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.596A>C; p.N199T; 11:27385274-27385274	liver	carcinoma	Substitution - Missense
c.596A>C; p.N199T; 11:27385274-27385274	liver	carcinoma	Substitution - Missense
c.2055G>A; p.G685G; 11:27368668-27368668	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1817C>T; p.A606V; 11:27368906-27368906	breast	carcinoma	Substitution - Missense
c.274G>A; p.D92N; 11:27392502-27392502	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1087G>T; p.G363C; 11:27377180-27377180	thyroid	other; neoplasm	Substitution - Missense
c.1166T>G; p.I389R; 11:27376314-27376314	lung	carcinoid-endocrine_tumour	Substitution - Missense
c.1946A>T; p.D649V; 11:27368777-27368777	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.2337C>T; p.P779P; 11:27368386-27368386	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2737G>C; p.D913H; 11:27367986-27367986	central_nervous_system; brain	glioma	Substitution - Missense
c.964G>A; p.E322K; 11:27380278-27380278	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2700C>T; p.G900G; 11:27368023-27368023	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1414G>A; p.A472T; 11:27372364-27372364	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2608G>C; p.V870L; 11:27368115-27368115	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.602C>A; p.S201*; 11:27385268-27385268	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2728G>T; p.D910Y; 11:27367995-27367995	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.524A>T; p.N175I; 11:27385346-27385346	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.648G>C; p.L216L; 11:27384377-27384377	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1453G>A; p.E485K; 11:27372325-27372325	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.819C>G; p.L273L; 11:27380906-27380906	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.375T>G; p.I125M; 11:27391120-27391120	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.819C>G; p.L273L; 11:27380906-27380906	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.2474C>A; p.S825*; 11:27368249-27368249	liver	carcinoma	Substitution - Nonsense
c.877C>T; p.H293Y; 11:27380665-27380665	NS	NS	Substitution - Missense
c.2474C>A; p.S825*; 11:27368249-27368249	liver	carcinoma	Substitution - Nonsense
c.543G>T; p.A181A; 11:27385327-27385327	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2570_2573delTTTG; p.V857fs*9; 11:27368150-27368153	skin; trunk	malignant_melanoma	Deletion - Frameshift
c.1121G>A; p.R374H; 11:27376359-27376359	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2127G>A; p.T709T; 11:27368596-27368596	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2084C>T; p.P695L; 11:27368639-27368639	skin	malignant_melanoma	Substitution - Missense
c.2035T>G; p.F679V; 11:27368688-27368688	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.797G>T; p.G266V; 11:27380928-27380928	NS	NS	Substitution - Missense
c.2599A>G; p.T867A; 11:27368124-27368124	liver	carcinoma	Substitution - Missense
c.286A>T; p.I96F; 11:27392490-27392490	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.759-1G>C; p.?; 11:27380967-27380967	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.2102C>T; p.T701M; 11:27368621-27368621	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1899A>G; p.I633M; 11:27368824-27368824	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1996delG; p.A666fs*6; 11:27368727-27368727	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1506T>C; p.D502D; 11:27371688-27371688	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1545T>C; p.H515H; 11:27371649-27371649	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.2181A>G; p.K727K; 11:27368542-27368542	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2392C>T; p.P798S; 11:27368331-27368331	skin	malignant_melanoma	Substitution - Missense
c.253G>T; p.E85*; 11:27412793-27412793	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1159G>A; p.G387S; 11:27376321-27376321	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.848C>A; p.P283H; 11:27380694-27380694	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.436G>A; p.E146K; 11:27385434-27385434	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1986C>T; p.F662F; 11:27368737-27368737	breast	carcinoma	Substitution - coding silent
c.1962G>C; p.G654G; 11:27368761-27368761	pancreas	carcinoid-endocrine_tumour	Substitution - coding silent
c.427T>C; p.S143P; 11:27385443-27385443	stomach	adenocarcinoma	Substitution - Missense
c.2335C>T; p.P779S; 11:27368388-27368388	skin	malignant_melanoma	Substitution - Missense
c.1775G>A; p.G592D; 11:27368948-27368948	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]