Entrez Gene

Basic Information
Gene ID	55135
Name	WRAP53
Synonymous	WD repeat containing, antisense to TP53;WRAP53;WD repeat containing, antisense to TP53
Definition	WD repeat-containing protein 79\|WD repeat-containing protein WRAP53\|WD40 protein Wrap53\|WD40 repeat-containing protein antisense to TP53\|WD40 repeat-containing protein encoding RNA antisense to p53\|telomerase Cajal body protein 1
Position	17p13.1
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1357C>T; p.P453S; 17:7703081-7703081	breast	carcinoma	Substitution - Missense
c.1357C>T; p.P453S; 17:7703081-7703081	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.154C>T; p.R52W; 17:7688802-7688802	skin	malignant_melanoma	Substitution - Missense
c.1269G>C; p.P423P; 17:7702993-7702993	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.838G>A; p.A280T; 17:7701672-7701672	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.912C>T; p.S304S; 17:7701746-7701746	skin	malignant_melanoma	Substitution - coding silent
c.1558delG; p.A522fs*26; 17:7703397-7703397	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1024T>C; p.C342R; 17:7702412-7702412	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1176C>A; p.L392L; 17:7702754-7702754	breast	carcinoma	Substitution - coding silent
c.1565C>G; p.A522G; 17:7703404-7703404	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1565C>G; p.A522G; 17:7703404-7703404	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1619C>T; p.T540M; 17:7703458-7703458	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1246C>T; p.R416C; 17:7702824-7702824	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1416C>T; p.S472S; 17:7703255-7703255	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.234C>T; p.P78P; 17:7688882-7688882	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.259A>G; p.S87G; 17:7688907-7688907	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1418T>G; p.L473R; 17:7703257-7703257	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.834G>A; p.T278T; 17:7701668-7701668	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.639A>G; p.E213E; 17:7689698-7689698	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.450C>T; p.F150F; 17:7689242-7689242	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.450C>T; p.F150F; 17:7689242-7689242	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.450C>T; p.F150F; 17:7689242-7689242	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.450C>T; p.F150F; 17:7689242-7689242	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1566G>C; p.A522A; 17:7703405-7703405	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1627G>T; p.G543C; 17:7703466-7703466	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.76T>C; p.S26P; 17:7688724-7688724	central_nervous_system; brain	glioma	Substitution - Missense
c.801C>T; p.S267S; 17:7701528-7701528	skin	malignant_melanoma	Substitution - coding silent
c.618G>T; p.G206G; 17:7689677-7689677	ovary	other; neoplasm	Substitution - coding silent
c.618G>T; p.G206G; 17:7689677-7689677	ovary	other; neoplasm	Substitution - coding silent
c.1507C>T; p.L503F; 17:7703346-7703346	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1524C>T; p.V508V; 17:7703363-7703363	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1130C>T; p.P377L; 17:7702518-7702518	skin	malignant_melanoma	Substitution - Missense
c.144G>C; p.G48G; 17:7688792-7688792	prostate	carcinoma	Substitution - coding silent
c.64C>G; p.P22A; 17:7688712-7688712	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.936C>T; p.C312C; 17:7701770-7701770	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1142G>C; p.R381P; 17:7702530-7702530	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.540C>T; p.D180D; 17:7689599-7689599	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1001G>T; p.S334I; 17:7702389-7702389	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1397G>A; p.G466D; 17:7703121-7703121	large_intestine; colon	carcinoma	Substitution - Missense
c.1399G>C; p.V467L; 17:7703123-7703123	breast	carcinoma	Substitution - Missense
c.1442G>A; p.G481D; 17:7703281-7703281	skin	malignant_melanoma	Substitution - Missense
c.944G>A; p.R315Q; 17:7701778-7701778	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.642+6G>A; p.?; 17:7689707-7689707	pancreas	carcinoid-endocrine_tumour	Unknown
c.1257C>T; p.F419F; 17:7702835-7702835	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.656G>A; p.R219Q; 17:7700754-7700754	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.861G>A; p.P287P; 17:7701695-7701695	skin	malignant_melanoma	Substitution - coding silent
c.1264G>A; p.D422N; 17:7702842-7702842	skin	malignant_melanoma	Substitution - Missense
c.222T>C; p.S74S; 17:7688870-7688870	thyroid	carcinoma	Substitution - coding silent
c.1303G>T; p.G435W; 17:7703027-7703027	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1380G>A; p.Q460Q; 17:7703104-7703104	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.855C>T; p.F285F; 17:7701689-7701689	skin	malignant_melanoma	Substitution - coding silent
c.180C>G; p.G60G; 17:7688828-7688828	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1486G>C; p.E496Q; 17:7703325-7703325	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.279C>T; p.I93I; 17:7688927-7688927	breast	carcinoma	Substitution - coding silent
c.1565delC; p.A522fs*26; 17:7703404-7703404	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1565delC; p.A522fs*26; 17:7703404-7703404	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.59C>T; p.P20L; 17:7688707-7688707	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.929G>A; p.R310Q; 17:7701763-7701763	skin	malignant_melanoma	Substitution - Missense
c.1646delA; p.*549fs?; 17:7703485-7703485	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1558_1559insG; p.A522fs*8; 17:7703397-7703398	stomach	carcinoma; intestinal_adenocarcinoma	Insertion - Frameshift
c.429C>T; p.D143D; 17:7689077-7689077	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1268C>T; p.P423L; 17:7702846-7702846	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1515G>A; p.T505T; 17:7703354-7703354	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.655C>T; p.R219*; 17:7700753-7700753	skin	malignant_melanoma	Substitution - Nonsense
c.1308T>C; p.A436A; 17:7703032-7703032	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1136G>C; p.G379A; 17:7702524-7702524	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1557_1558insGG; p.A522fs*27; 17:7703396-7703397	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.78T>G; p.S26S; 17:7688726-7688726	liver	carcinoma	Substitution - coding silent
c.78T>G; p.S26S; 17:7688726-7688726	liver	carcinoma	Substitution - coding silent
c.432C>T; p.T144T; 17:7689224-7689224	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.846G>A; p.S282S; 17:7701680-7701680	thyroid	carcinoma	Substitution - coding silent
c.364G>A; p.E122K; 17:7689012-7689012	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.7A>C; p.T3P; 17:7688655-7688655	prostate	carcinoma	Substitution - Missense
c.495C>T; p.S165S; 17:7689287-7689287	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1494G>T; p.L498L; 17:7703333-7703333	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.166G>A; p.D56N; 17:7688814-7688814	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.202C>G; p.R68G; 17:7688850-7688850	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.507G>T; p.E169D; 17:7689299-7689299	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.727T>G; p.S243A; 17:7700825-7700825	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.796G>A; p.A266T; 17:7701523-7701523	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.223C>A; p.L75I; 17:7688871-7688871	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.221C>A; p.S74Y; 17:7688869-7688869	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.629_630insA; p.Y211fs*14; 17:7689688-7689689	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.775G>A; p.A259T; 17:7701502-7701502	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1302C>T; p.S434S; 17:7703026-7703026	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent

COSMIC somatic mutation [Top]