Entrez Gene

Basic Information
Gene ID	54802
Name	TRIT1
Synonymous	tRNA isopentenyltransferase 1;TRIT1;tRNA isopentenyltransferase 1
Definition	IPP transferase\|IPPT\|IPTase\|hGRO1\|isopentenyl-diphosphate:tRNA isopentenyltransferase\|tRNA dimethylallyltransferase, mitochondrial\|tRNA isopentenylpyrophosphate transferase
Position	1p34.2
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.227G>C; p.R76T; 1:39857365-39857365	urinary_tract; bladder	carcinoma	Substitution - Missense
c.606T>A; p.F202L; 1:39850216-39850216	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.606T>A; p.F202L; 1:39850216-39850216	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.606T>A; p.F202L; 1:39850216-39850216	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1314A>G; p.E438E; 1:39841834-39841834	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.606T>A; p.F202L; 1:39850216-39850216	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.315+5C>T; p.?; 1:39857272-39857272	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.315+5C>T; p.?; 1:39857272-39857272	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.706C>A; p.L236I; 1:39848095-39848095	breast	carcinoma	Substitution - Missense
c.706C>A; p.L236I; 1:39848095-39848095	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1272G>C; p.K424N; 1:39841876-39841876	oesophagus	carcinoma	Substitution - Missense
c.1272G>C; p.K424N; 1:39841876-39841876	breast	carcinoma	Substitution - Missense
c.816-1G>T; p.?; 1:39847661-39847661	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.1225G>A; p.E409K; 1:39844110-39844110	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1223G>A; p.R408H; 1:39844112-39844112	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.784C>T; p.R262C; 1:39848017-39848017	liver	carcinoma	Substitution - Missense
c.1098C>T; p.I366I; 1:39844549-39844549	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.433G>A; p.E145K; 1:39852858-39852858	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.749C>T; p.A250V; 1:39848052-39848052	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1118G>A; p.G373D; 1:39844217-39844217	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.806C>T; p.S269L; 1:39847995-39847995	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.894C>T; p.C298C; 1:39847582-39847582	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.24A>T; p.R8R; 1:39883468-39883468	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1175G>T; p.R392I; 1:39844160-39844160	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1248C>A; p.S416S; 1:39841900-39841900	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1086T>A; p.P362P; 1:39844561-39844561	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1347A>C; p.E449D; 1:39841801-39841801	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.344T>A; p.I115N; 1:39854040-39854040	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.845C>T; p.S282L; 1:39847631-39847631	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1124A>T; p.K375M; 1:39844211-39844211	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1028_1029insC; p.V344fs*8; 1:39844618-39844619	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.992A>C; p.N331T; 1:39847234-39847234	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.458A>T; p.E153V; 1:39852833-39852833	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1114C>T; p.Q372*; 1:39844533-39844533	skin	malignant_melanoma	Substitution - Nonsense
c.349A>G; p.I117V; 1:39854035-39854035	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.430A>T; p.T144S; 1:39852861-39852861	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.430A>T; p.T144S; 1:39852861-39852861	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.609C>T; p.L203L; 1:39850213-39850213	skin	malignant_melanoma	Substitution - coding silent
c.609C>T; p.L203L; 1:39850213-39850213	skin	malignant_melanoma	Substitution - coding silent
c.209T>G; p.V70G; 1:39857383-39857383	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1153T>C; p.Y385H; 1:39844182-39844182	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1192G>C; p.D398H; 1:39844143-39844143	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.153C>T; p.I51I; 1:39883339-39883339	skin	malignant_melanoma	Substitution - coding silent
c.1222C>T; p.R408C; 1:39844113-39844113	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1381C>G; p.Q461E; 1:39841767-39841767	breast	carcinoma	Substitution - Missense
c.1051G>A; p.D351N; 1:39844596-39844596	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1331delC; p.P444fs*20; 1:39841817-39841817	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.919C>T; p.L307L; 1:39847557-39847557	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.664T>C; p.S222P; 1:39850158-39850158	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.174+2T>A; p.?; 1:39883316-39883316	breast	carcinoma	Unknown
c.1006+4A>C; p.?; 1:39847216-39847216	stomach	adenocarcinoma	Unknown
c.1402_1403insTT; p.*468fs?; 1:39841745-39841746	stomach	carcinoma; diffuse_adenocarcinoma	Insertion - Frameshift
c.334C>T; p.R112*; 1:39854050-39854050	pancreas	carcinoma	Substitution - Nonsense
c.334C>T; p.R112*; 1:39854050-39854050	pancreas	carcinoma	Substitution - Nonsense
c.334C>T; p.R112*; 1:39854050-39854050	pancreas	carcinoma	Substitution - Nonsense
c.334C>T; p.R112*; 1:39854050-39854050	pancreas	carcinoma	Substitution - Nonsense
c.334C>T; p.R112*; 1:39854050-39854050	pancreas	carcinoma	Substitution - Nonsense
c.334C>T; p.R112*; 1:39854050-39854050	pancreas	carcinoma; ductal_carcinoma	Substitution - Nonsense
c.334C>T; p.R112*; 1:39854050-39854050	pancreas	carcinoma	Substitution - Nonsense
c.857A>G; p.K286R; 1:39847619-39847619	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1078C>A; p.L360I; 1:39844569-39844569	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1023C>T; p.V341V; 1:39844624-39844624	skin	malignant_melanoma	Substitution - coding silent
c.23G>C; p.R8P; 1:39883469-39883469	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1272G>A; p.K424K; 1:39841876-39841876	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.901G>A; p.E301K; 1:39847575-39847575	skin	malignant_melanoma	Substitution - Missense
c.1205G>T; p.R402L; 1:39844130-39844130	central_nervous_system; brain	glioma	Substitution - Missense
c.288_289GG>AA; p.D97N; 1:39857303-39857304	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.33C>T; p.P11P; 1:39883459-39883459	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.33C>T; p.P11P; 1:39883459-39883459	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.33C>T; p.P11P; 1:39883459-39883459	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.33C>T; p.P11P; 1:39883459-39883459	breast	carcinoma	Substitution - coding silent
c.1089T>G; p.A363A; 1:39844558-39844558	breast	carcinoma; ductal_carcinoma	Substitution - coding silent
c.33C>T; p.P11P; 1:39883459-39883459	breast	carcinoma	Substitution - coding silent
c.1298C>A; p.A433D; 1:39841850-39841850	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1002_1003insT; p.S335fs*1; 1:39847223-39847224	stomach	carcinoma; intestinal_adenocarcinoma	Insertion - Frameshift
c.71C>G; p.P24R; 1:39883421-39883421	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.537A>G; p.P179P; 1:39852754-39852754	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.537A>G; p.P179P; 1:39852754-39852754	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.212C>T; p.S71F; 1:39857380-39857380	skin	malignant_melanoma	Substitution - Missense
c.602A>C; p.E201A; 1:39850220-39850220	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.524C>T; p.A175V; 1:39852767-39852767	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1240A>G; p.I414V; 1:39841908-39841908	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.457G>C; p.E153Q; 1:39852834-39852834	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.610delC; p.H204fs*16; 1:39850212-39850212	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.1309A>G; p.I437V; 1:39841839-39841839	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.972A>T; p.K324N; 1:39847254-39847254	ovary	other; neoplasm	Substitution - Missense
c.754C>T; p.L252F; 1:39848047-39848047	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1236G>A; p.A412A; 1:39841912-39841912	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.581A>G; p.E194G; 1:39850241-39850241	skin	malignant_melanoma	Substitution - Missense
c.994C>A; p.R332S; 1:39847232-39847232	skin	malignant_melanoma	Substitution - Missense
c.23G>T; p.R8L; 1:39883469-39883469	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.415-2A>T; p.?; 1:39852878-39852878	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.733G>T; p.D245Y; 1:39848068-39848068	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1307_1308CC>TT; p.T436I; 1:39841840-39841841	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.785G>A; p.R262H; 1:39848016-39848016	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.987delT; p.N331fs*4; 1:39847239-39847239	skin; neck	malignant_melanoma	Deletion - Frameshift
c.449G>A; p.R150Q; 1:39852842-39852842	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.449G>A; p.R150Q; 1:39852842-39852842	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.449G>A; p.R150Q; 1:39852842-39852842	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]