Entrez Gene

Basic Information
Gene ID	54474
Name	KRT20
Synonymous	keratin 20, type I;KRT20;keratin 20, type I
Definition	cytokeratin 20\|cytokeratin-20\|keratin, type I cytoskeletal 20\|keratin-20\|protein IT
Position	17q21.2
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.10A>C; p.S4R; 17:40885176-40885176	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.717G>A; p.M239I; 17:40880175-40880175	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.341G>A; p.G114D; 17:40884845-40884845	kidney	other; neoplasm	Substitution - Missense
c.1054G>A; p.E352K; 17:40878230-40878230	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1054G>A; p.E352K; 17:40878230-40878230	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.155C>T; p.T52M; 17:40885031-40885031	liver	carcinoma	Substitution - Missense
c.172G>A; p.D58N; 17:40885014-40885014	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.172G>A; p.D58N; 17:40885014-40885014	skin	malignant_melanoma	Substitution - Missense
c.420G>A; p.R140R; 17:40882625-40882625	skin	malignant_melanoma	Substitution - coding silent
c.264G>A; p.V88V; 17:40884922-40884922	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1218A>C; p.E406D; 17:40876418-40876418	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1091A>G; p.E364G; 17:40878193-40878193	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1042C>T; p.R348C; 17:40878242-40878242	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1042C>T; p.R348C; 17:40878242-40878242	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1042C>T; p.R348C; 17:40878242-40878242	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.714C>A; p.I238I; 17:40880178-40880178	skin	malignant_melanoma	Substitution - coding silent
c.721G>A; p.E241K; 17:40880171-40880171	skin	malignant_melanoma	Substitution - Missense
c.592A>G; p.N198D; 17:40880652-40880652	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.128delG; p.G43fs*11; 17:40885058-40885058	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1140-4_1140-3insA; p.?; 17:40877420-40877421	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Unknown
c.1140-4_1140-3insA; p.?; 17:40877420-40877421	central_nervous_system; brainstem	glioma; oligoastrocytoma_Grade_II	Unknown
c.1140-4delA; p.?; 17:40877421-40877421	oesophagus; lower_third	carcinoma; adenocarcinoma	Unknown
c.298G>A; p.V100M; 17:40884888-40884888	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.867G>A; p.L289L; 17:40879864-40879864	skin	malignant_melanoma	Substitution - coding silent
c.125G>A; p.R42Q; 17:40885061-40885061	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.125G>A; p.R42Q; 17:40885061-40885061	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1236C>T; p.V412V; 17:40876400-40876400	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.423T>C; p.C141C; 17:40882622-40882622	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.318C>T; p.Y106Y; 17:40884868-40884868	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.248G>A; p.S83N; 17:40884938-40884938	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.171C>T; p.S57S; 17:40885015-40885015	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.245C>T; p.A82V; 17:40884941-40884941	breast	carcinoma	Substitution - Missense
c.1181T>A; p.I394K; 17:40876455-40876455	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.177C>A; p.L59L; 17:40885009-40885009	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.949A>G; p.T317A; 17:40878335-40878335	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1010C>A; p.A337D; 17:40878274-40878274	breast	carcinoma	Substitution - Missense
c.1085G>T; p.R362L; 17:40878199-40878199	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.183C>A; p.G61G; 17:40885003-40885003	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.467G>A; p.R156K; 17:40882578-40882578	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.383G>A; p.R128Q; 17:40884803-40884803	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1085G>A; p.R362Q; 17:40878199-40878199	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.247A>G; p.S83G; 17:40884939-40884939	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.82C>T; p.R28C; 17:40885104-40885104	central_nervous_system; brain	glioma	Substitution - Missense
c.254T>A; p.L85Q; 17:40884932-40884932	central_nervous_system; brain	glioma	Substitution - Missense
c.837A>G; p.L279L; 17:40879894-40879894	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.775G>C; p.E259Q; 17:40880117-40880117	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.246G>A; p.A82A; 17:40884940-40884940	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.986A>T; p.Q329L; 17:40878298-40878298	pancreas	carcinoma	Substitution - Missense
c.97C>A; p.P33T; 17:40885089-40885089	skin	malignant_melanoma	Substitution - Missense
c.246G>A; p.A82A; 17:40884940-40884940	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.986A>T; p.Q329L; 17:40878298-40878298	pancreas	carcinoma	Substitution - Missense
c.83G>A; p.R28H; 17:40885103-40885103	liver	carcinoma	Substitution - Missense
c.986A>T; p.Q329L; 17:40878298-40878298	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.855A>G; p.Q285Q; 17:40879876-40879876	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.905C>A; p.S302Y; 17:40879826-40879826	ovary	other; neoplasm	Substitution - Missense
c.569T>C; p.L190S; 17:40880675-40880675	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1167G>A; p.L389L; 17:40877390-40877390	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.742G>T; p.V248F; 17:40880150-40880150	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.141C>T; p.S47S; 17:40885045-40885045	skin	malignant_melanoma	Substitution - coding silent
c.125_126GG>AA; p.R42Q; 17:40885060-40885061	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.141C>T; p.S47S; 17:40885045-40885045	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1098A>C; p.E366D; 17:40878186-40878186	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.523G>A; p.G175S; 17:40880721-40880721	liver	carcinoma	Substitution - Missense
c.371T>C; p.I124T; 17:40884815-40884815	urinary_tract; bladder	carcinoma	Substitution - Missense
c.526C>A; p.L176M; 17:40880718-40880718	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1210G>A; p.V404M; 17:40876426-40876426	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.88G>A; p.G30R; 17:40885098-40885098	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.1232A>G; p.K411R; 17:40876404-40876404	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.982C>A; p.L328I; 17:40878302-40878302	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.314G>A; p.W105*; 17:40884872-40884872	thyroid	other; neoplasm	Substitution - Nonsense
c.847G>A; p.E283K; 17:40879884-40879884	skin	malignant_melanoma	Substitution - Missense
c.345C>T; p.R115R; 17:40884841-40884841	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.990G>A; p.S330S; 17:40878294-40878294	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.990G>A; p.S330S; 17:40878294-40878294	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.640G>T; p.G214C; 17:40880252-40880252	kidney	carcinoma	Substitution - Missense
c.959G>A; p.R320H; 17:40878325-40878325	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.621G>A; p.E207E; 17:40880623-40880623	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.316T>C; p.Y106H; 17:40884870-40884870	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.34C>A; p.L12M; 17:40885152-40885152	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.744C>T; p.V248V; 17:40880148-40880148	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.239G>A; p.R80H; 17:40884947-40884947	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1006G>A; p.E336K; 17:40878278-40878278	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.634G>A; p.V212I; 17:40880258-40880258	skin	malignant_melanoma	Substitution - Missense
c.1065C>T; p.I355I; 17:40878219-40878219	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.505G>T; p.V169L; 17:40880739-40880739	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1135G>A; p.V379I; 17:40878149-40878149	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.963C>T; p.Y321Y; 17:40878321-40878321	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.957C>A; p.A319A; 17:40878327-40878327	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.92C>T; p.T31M; 17:40885094-40885094	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.92C>T; p.T31M; 17:40885094-40885094	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.643C>A; p.L215I; 17:40880249-40880249	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.766G>A; p.E256K; 17:40880126-40880126	skin; nipple	malignant_melanoma	Substitution - Missense
c.110G>A; p.G37E; 17:40885076-40885076	skin	malignant_melanoma	Substitution - Missense
c.872G>A; p.R291H; 17:40879859-40879859	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.110G>A; p.G37E; 17:40885076-40885076	skin	malignant_melanoma	Substitution - Missense
c.328G>A; p.A110T; 17:40884858-40884858	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.726G>A; p.M242I; 17:40880166-40880166	skin	malignant_melanoma	Substitution - Missense

COSMIC somatic mutation [Top]