Entrez Gene

Basic Information
Gene ID	5270
Name	SERPINE2
Synonymous	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2;SERPINE2;serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
Definition	glia-derived nexin\|glial-derived neurite promoting factor\|peptidase inhibitor 7\|protease nexin I\|serpin E2
Position	2q36.1
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.622G>A; p.V208M; 2:223991866-223991866	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.686-1G>T; p.?; 2:223984951-223984951	prostate	carcinoma; adenocarcinoma	Unknown
c.51C>T; p.S17S; 2:224001850-224001850	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.341T>C; p.V114A; 2:223998261-223998261	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.628G>T; p.A210S; 2:223991860-223991860	liver	carcinoma	Substitution - Missense
c.341T>C; p.V114A; 2:223998261-223998261	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1127C>T; p.P376L; 2:223977576-223977576	skin	malignant_melanoma	Substitution - Missense
c.206C>T; p.A69V; 2:224001695-224001695	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.250G>T; p.G84C; 2:224001651-224001651	liver	carcinoma	Substitution - Missense
c.817A>G; p.S273G; 2:223984819-223984819	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1178G>A; p.G393E; 2:223975886-223975886	skin	malignant_melanoma	Substitution - Missense
c.742G>A; p.G248R; 2:223984894-223984894	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.989G>A; p.G330E; 2:223980397-223980397	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.792G>A; p.P264P; 2:223984844-223984844	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.339C>T; p.A113A; 2:223998263-223998263	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.209A>G; p.D70G; 2:224001692-224001692	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.339C>T; p.A113A; 2:223998263-223998263	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.870G>A; p.Q290Q; 2:223984766-223984766	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.289A>T; p.K97*; 2:223998313-223998313	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.134C>T; p.S45L; 2:224001767-224001767	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.689C>T; p.S230L; 2:223984947-223984947	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.13C>G; p.L5V; 2:224001888-224001888	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1155T>C; p.P385P; 2:223977548-223977548	liver	carcinoma	Substitution - coding silent
c.389A>G; p.N130S; 2:223998213-223998213	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.619T>G; p.F207V; 2:223991869-223991869	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.783C>T; p.S261S; 2:223984853-223984853	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.477T>C; p.N159N; 2:223998125-223998125	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1027G>A; p.A343T; 2:223980359-223980359	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.207G>A; p.A69A; 2:224001694-224001694	oesophagus	carcinoma	Substitution - coding silent
c.671C>T; p.S224F; 2:223991817-223991817	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.671C>T; p.S224F; 2:223991817-223991817	skin	malignant_melanoma	Substitution - Missense
c.54C>A; p.I18I; 2:224001847-224001847	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.33C>A; p.A11A; 2:224001868-224001868	liver	carcinoma	Substitution - coding silent
c.33C>A; p.A11A; 2:224001868-224001868	liver	carcinoma	Substitution - coding silent
c.651G>A; p.V217V; 2:223991837-223991837	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.766G>A; p.A256T; 2:223984870-223984870	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.102G>T; p.T34T; 2:224001799-224001799	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.732G>T; p.L244L; 2:223984904-223984904	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.82G>A; p.E28K; 2:224001819-224001819	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.628G>A; p.A210T; 2:223991860-223991860	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.891A>C; p.T297T; 2:223982775-223982775	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.374C>T; p.P125L; 2:223998228-223998228	skin	malignant_melanoma	Substitution - Missense
c.41C>T; p.T14M; 2:224001860-224001860	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.664C>A; p.Q222K; 2:223991824-223991824	urinary_tract; bladder	carcinoma	Substitution - Missense
c.121C>T; p.Q41*; 2:224001780-224001780	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Nonsense
c.723C>A; p.F241L; 2:223984913-223984913	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.180G>A; p.S60S; 2:224001721-224001721	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.46C>T; p.P16S; 2:224001855-224001855	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.358T>A; p.S120T; 2:223998244-223998244	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.95C>A; p.S32Y; 2:224001806-224001806	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.550G>A; p.V184I; 2:223991938-223991938	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.801C>A; p.A267A; 2:223984835-223984835	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.690G>A; p.S230S; 2:223984946-223984946	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.406T>C; p.C136R; 2:223998196-223998196	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1033_1034insA; p.I345fs*2; 2:223980352-223980353	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.879G>C; p.L293L; 2:223984757-223984757	autonomic_ganglia	neuroblastoma	Substitution - coding silent
c.340G>A; p.V114M; 2:223998262-223998262	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.340G>A; p.V114M; 2:223998262-223998262	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.340G>A; p.V114M; 2:223998262-223998262	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.340G>A; p.V114M; 2:223998262-223998262	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.177G>A; p.A59A; 2:224001724-224001724	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.177G>A; p.A59A; 2:224001724-224001724	kidney	other; neoplasm	Substitution - coding silent
c.612A>T; p.K204N; 2:223991876-223991876	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.612A>T; p.K204N; 2:223991876-223991876	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.518T>G; p.L173R; 2:223991970-223991970	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.555C>T; p.N185N; 2:223991933-223991933	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.555C>T; p.N185N; 2:223991933-223991933	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.555C>T; p.N185N; 2:223991933-223991933	thyroid	other; neoplasm	Substitution - coding silent
c.839G>A; p.W280*; 2:223984797-223984797	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.927A>C; p.K309N; 2:223982739-223982739	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.931C>A; p.L311I; 2:223982735-223982735	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.636G>A; p.G212G; 2:223991852-223991852	skin	malignant_melanoma	Substitution - coding silent
c.1145G>A; p.R382Q; 2:223977558-223977558	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1145G>A; p.R382Q; 2:223977558-223977558	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.154G>A; p.V52M; 2:224001747-224001747	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1041C>A; p.V347V; 2:223980345-223980345	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.515A>C; p.D172A; 2:223991973-223991973	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.288_290delCAA; p.N96delN; 2:223998312-223998314	breast	carcinoma	Deletion - In frame
c.445G>T; p.A149S; 2:223998157-223998157	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.176C>T; p.A59V; 2:224001725-224001725	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.176C>T; p.A59V; 2:224001725-224001725	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.176C>T; p.A59V; 2:224001725-224001725	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.176C>T; p.A59V; 2:224001725-224001725	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.432G>T; p.E144D; 2:223998170-223998170	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.309G>T; p.K103N; 2:223998293-223998293	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.374C>A; p.P125H; 2:223998228-223998228	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.981A>G; p.I327M; 2:223982685-223982685	breast	carcinoma	Substitution - Missense
c.135G>A; p.S45S; 2:224001766-224001766	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.610A>G; p.K204E; 2:223991878-223991878	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.153C>T; p.I51I; 2:224001748-224001748	breast	carcinoma	Substitution - coding silent
c.153C>T; p.I51I; 2:224001748-224001748	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.421G>T; p.V141L; 2:223998181-223998181	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.361G>A; p.E121K; 2:223998241-223998241	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.486G>A; p.R162R; 2:223998116-223998116	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.598G>A; p.E200K; 2:223991890-223991890	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1103C>A; p.P368H; 2:223977600-223977600	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.243G>A; p.M81I; 2:224001658-224001658	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.261A>G; p.G87G; 2:223998341-223998341	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.407G>A; p.C136Y; 2:223998195-223998195	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1123A>G; p.R375G; 2:223977580-223977580	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.608A>T; p.K203M; 2:223991880-223991880	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.621C>T; p.F207F; 2:223991867-223991867	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.906A>G; p.T302T; 2:223982760-223982760	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent

COSMIC somatic mutation [Top]