Cancer metastasis gene database Home
Cancer metastasis database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

5165

Name

PDK3

Synonymous

pyruvate dehydrogenase kinase, isozyme 3;PDK3;pyruvate dehydrogenase kinase, isozyme 3

Definition

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial|pyruvate dehydrogenase kinase, isoenzyme 3|pyruvate dehydrogenase, lipoamide, kinase isozyme 3, mitochondrial

Position

Xp22.11

Gene Type

protein-coding

COSMIC somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1085C>G; p.S362*; 23:24533936-24533936

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Nonsense

c.1085C>G; p.S362*; 23:24533936-24533936

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Nonsense

c.1085C>G; p.S362*; 23:24533936-24533936

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Nonsense

c.654G>T; p.L218L; 23:24518991-24518991

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.970T>C; p.F324L; 23:24531663-24531663

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1084T>A; p.S362T; 23:24533935-24533935

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.992C>T; p.S331F; 23:24531685-24531685

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.728A>C; p.H243P; 23:24526252-24526252

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1148C>T; p.T383M; 23:24533999-24533999

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.335T>A; p.L112Q; 23:24503341-24503341

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.457C>T; p.R153W; 23:24503463-24503463

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.294C>T; p.S98S; 23:24498874-24498874

 prostatecarcinoma; adenocarcinomaSubstitution - coding silent

c.457C>T; p.R153W; 23:24503463-24503463

 upper_aerodigestive_tract; mouthcarcinomaSubstitution - Missense

c.72G>A; p.P24P; 23:24465527-24465527

 lungcarcinoma; bronchioloalveolar_adenocarcinomaSubstitution - coding silent

c.72G>A; p.P24P; 23:24465527-24465527

 lungcarcinoma; bronchioloalveolar_adenocarcinomaSubstitution - coding silent

c.72G>A; p.P24P; 23:24465527-24465527

 lungcarcinoma; bronchioloalveolar_adenocarcinomaSubstitution - coding silent

c.72G>A; p.P24P; 23:24465527-24465527

 lungcarcinoma; bronchioloalveolar_adenocarcinomaSubstitution - coding silent

c.892G>T; p.D298Y; 23:24528115-24528115

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.892G>T; p.D298Y; 23:24528115-24528115

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.835G>T; p.E279*; 23:24527658-24527658

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.577G>A; p.V193M; 23:24505280-24505280

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.196C>T; p.L66F; 23:24494831-24494831

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.203C>G; p.P68R; 23:24494838-24494838

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.61C>T; p.R21C; 23:24465516-24465516

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1086A>G; p.S362S; 23:24533937-24533937

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.134C>A; p.S45*; 23:24494769-24494769

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.728A>G; p.H243R; 23:24526252-24526252

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.137A>G; p.Y46C; 23:24494772-24494772

 pituitary; craniopharyngeal_ductcraniopharyngioma; papillarySubstitution - Missense

c.883C>T; p.R295*; 23:24528106-24528106

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.1133G>A; p.R378H; 23:24533984-24533984

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.955G>T; p.A319S; 23:24528178-24528178

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.685G>T; p.D229Y; 23:24526209-24526209

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.765G>A; p.A255A; 23:24527588-24527588

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.347G>T; p.R116I; 23:24503353-24503353

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.895C>T; p.R299C; 23:24528118-24528118

 skinmalignant_melanomaSubstitution - Missense

c.895C>T; p.R299C; 23:24528118-24528118

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1125C>T; p.S375S; 23:24533976-24533976

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.861C>A; p.D287E; 23:24528084-24528084

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.260G>T; p.S87I; 23:24498840-24498840

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.32C>T; p.P11L; 23:24465487-24465487

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.562G>C; p.D188H; 23:24505265-24505265

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.421C>T; p.P141S; 23:24503427-24503427

 skinmalignant_melanomaSubstitution - Missense

c.517delG; p.G174fs*11; 23:24505220-24505220

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.37C>T; p.P13S; 23:24465492-24465492

 thyroidcarcinomaSubstitution - Missense

c.551T>C; p.I184T; 23:24505254-24505254

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1151C>A; p.P384H; 23:24534002-24534002

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.573T>C; p.C191C; 23:24505276-24505276

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.286A>T; p.N96Y; 23:24498866-24498866

 pancreaspancreatic_intraepithelial_neoplasia_(PanIN)Substitution - Missense

c.286A>T; p.N96Y; 23:24498866-24498866

 pancreascarcinoma; ductal_carcinomaSubstitution - Missense

c.304C>T; p.P102S; 23:24498884-24498884

 skinmalignant_melanomaSubstitution - Missense

c.122G>A; p.C41Y; 23:24494757-24494757

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.469A>G; p.N157D; 23:24503475-24503475

 skinmalignant_melanomaSubstitution - Missense

c.418G>C; p.D140H; 23:24503424-24503424

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.510T>C; p.L170L; 23:24505213-24505213

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.473G>A; p.R158H; 23:24503479-24503479

 livercarcinomaSubstitution - Missense

c.473G>A; p.R158H; 23:24503479-24503479

 livercarcinomaSubstitution - Missense

c.752A>T; p.N251I; 23:24527575-24527575

 central_nervous_system; braingliomaSubstitution - Missense

c.1084T>C; p.S362P; 23:24533935-24533935

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.674-1G>A; p.?; 23:24526197-24526197

 endometriumcarcinoma; endometrioid_carcinomaUnknown

c.666A>C; p.E222D; 23:24519003-24519003

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.656A>C; p.E219A; 23:24518993-24518993

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.656A>C; p.E219A; 23:24518993-24518993

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.656A>C; p.E219A; 23:24518993-24518993

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1124C>T; p.S375F; 23:24533975-24533975

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1124C>T; p.S375F; 23:24533975-24533975

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.595G>A; p.D199N; 23:24505298-24505298

 skinmalignant_melanomaSubstitution - Missense

c.884G>A; p.R295Q; 23:24528107-24528107

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.963+2T>C; p.?; 23:24528188-24528188

 livercarcinomaUnknown

c.299A>G; p.E100G; 23:24498879-24498879

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.379G>A; p.A127T; 23:24503385-24503385

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.689A>C; p.K230T; 23:24526213-24526213

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.378G>A; p.M126I; 23:24503384-24503384

 pancreascarcinomaSubstitution - Missense

c.48C>T; p.I16I; 23:24465503-24465503

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1149G>T; p.T383T; 23:24534000-24534000

 breastcarcinomaSubstitution - coding silent

c.1160A>T; p.D387V; 23:24534011-24534011

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.181A>G; p.M61V; 23:24494816-24494816

 livercarcinomaSubstitution - Missense

c.649G>C; p.E217Q; 23:24518986-24518986

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.838G>T; p.D280Y; 23:24527661-24527661

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.793G>A; p.E265K; 23:24527616-24527616

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.657A>G; p.E219E; 23:24518994-24518994

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.657A>G; p.E219E; 23:24518994-24518994

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.657A>G; p.E219E; 23:24518994-24518994

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.657A>G; p.E219E; 23:24518994-24518994

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1177A>T; p.S393C; 23:24534028-24534028

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.700G>C; p.V234L; 23:24526224-24526224

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense