Entrez Gene

Basic Information
Gene ID	49860
Name	CRNN
Synonymous	cornulin;CRNN;cornulin
Definition	53 kDa putative calcium-binding protein\|53 kDa squamous epithelial-induced stress protein\|58 kDa heat shock protein\|squamous epithelial heat shock protein 53\|tumor-related protein
Position	1q21
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.137T>A; p.V46E; 1:152412097-152412097	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.50G>A; p.R17H; 1:152412184-152412184	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.50G>A; p.R17H; 1:152412184-152412184	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1035A>G; p.G345G; 1:152410047-152410047	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1035A>G; p.G345G; 1:152410047-152410047	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.246C>A; p.A82A; 1:152410836-152410836	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.377C>T; p.A126V; 1:152410705-152410705	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.906G>A; p.V302V; 1:152410176-152410176	skin	malignant_melanoma	Substitution - coding silent
c.1394C>A; p.S465Y; 1:152409688-152409688	breast	carcinoma	Substitution - Missense
c.377C>T; p.A126V; 1:152410705-152410705	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.377C>T; p.A126V; 1:152410705-152410705	central_nervous_system; brain	glioma	Substitution - Missense
c.457C>T; p.Q153*; 1:152410625-152410625	skin	malignant_melanoma	Substitution - Nonsense
c.457C>T; p.Q153*; 1:152410625-152410625	skin	malignant_melanoma	Substitution - Nonsense
c.457C>T; p.Q153*; 1:152410625-152410625	skin	malignant_melanoma	Substitution - Nonsense
c.920G>T; p.S307I; 1:152410162-152410162	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.858T>C; p.H286H; 1:152410224-152410224	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.413G>A; p.R138K; 1:152410669-152410669	skin	malignant_melanoma	Substitution - Missense
c.182T>A; p.L61Q; 1:152410900-152410900	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1357C>T; p.L453F; 1:152409725-152409725	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.77C>A; p.T26K; 1:152412157-152412157	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1270C>T; p.R424C; 1:152409812-152409812	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.223C>T; p.L75L; 1:152410859-152410859	skin	malignant_melanoma	Substitution - coding silent
c.622C>A; p.P208T; 1:152410460-152410460	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.651G>A; p.Q217Q; 1:152410431-152410431	skin	malignant_melanoma	Substitution - coding silent
c.329C>T; p.S110L; 1:152410753-152410753	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1431G>T; p.E477D; 1:152409651-152409651	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.329C>T; p.S110L; 1:152410753-152410753	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1291G>A; p.G431R; 1:152409791-152409791	skin	malignant_melanoma	Substitution - Missense
c.365A>C; p.E122A; 1:152410717-152410717	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.809C>T; p.T270I; 1:152410273-152410273	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.184G>A; p.D62N; 1:152410898-152410898	skin	malignant_melanoma	Substitution - Missense
c.541C>T; p.P181S; 1:152410541-152410541	skin	malignant_melanoma	Substitution - Missense
c.93G>A; p.G31G; 1:152412141-152412141	skin	malignant_melanoma	Substitution - coding silent
c.344A>G; p.E115G; 1:152410738-152410738	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.211T>C; p.F71L; 1:152410871-152410871	liver	carcinoma	Substitution - Missense
c.1001G>A; p.G334D; 1:152410081-152410081	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.211T>C; p.F71L; 1:152410871-152410871	liver	carcinoma	Substitution - Missense
c.247C>G; p.Q83E; 1:152410835-152410835	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.94G>C; p.E32Q; 1:152412140-152412140	breast	carcinoma	Substitution - Missense
c.1004G>A; p.R335K; 1:152410078-152410078	skin	malignant_melanoma	Substitution - Missense
c.820_821GG>AA; p.G274N; 1:152410261-152410262	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.413G>T; p.R138I; 1:152410669-152410669	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1325G>T; p.W442L; 1:152409757-152409757	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1325G>T; p.W442L; 1:152409757-152409757	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1340C>A; p.S447*; 1:152409742-152409742	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1464C>T; p.S488S; 1:152409618-152409618	skin	malignant_melanoma	Substitution - coding silent
c.171C>T; p.V57V; 1:152410911-152410911	skin	malignant_melanoma	Substitution - coding silent
c.1403A>G; p.Q468R; 1:152409679-152409679	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.522G>C; p.Q174H; 1:152410560-152410560	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.486G>A; p.A162A; 1:152410596-152410596	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.340G>A; p.G114S; 1:152410742-152410742	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.882C>T; p.H294H; 1:152410200-152410200	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.882C>T; p.H294H; 1:152410200-152410200	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.486G>A; p.A162A; 1:152410596-152410596	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.397G>A; p.E133K; 1:152410685-152410685	skin	malignant_melanoma	Substitution - Missense
c.606G>A; p.Q202Q; 1:152410476-152410476	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.606G>A; p.Q202Q; 1:152410476-152410476	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.397G>A; p.E133K; 1:152410685-152410685	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.920G>A; p.S307N; 1:152410162-152410162	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1086A>C; p.R362S; 1:152409996-152409996	breast	carcinoma	Substitution - Missense
c.502G>C; p.D168H; 1:152410580-152410580	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1221G>A; p.G407G; 1:152409861-152409861	skin	malignant_melanoma	Substitution - coding silent
c.1373delG; p.G458fs*33; 1:152409709-152409709	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1297A>C; p.R433R; 1:152409785-152409785	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.282G>T; p.E94D; 1:152410800-152410800	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.107T>C; p.L36P; 1:152412127-152412127	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.837C>T; p.S279S; 1:152410245-152410245	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.990C>T; p.I330I; 1:152410092-152410092	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.990C>T; p.I330I; 1:152410092-152410092	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - coding silent
c.778G>A; p.A260T; 1:152410304-152410304	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1156A>T; p.R386*; 1:152409926-152409926	pancreas	carcinoma; ductal_carcinoma	Substitution - Nonsense
c.1153C>T; p.Q385*; 1:152409929-152409929	skin	malignant_melanoma	Substitution - Nonsense
c.271G>A; p.E91K; 1:152410811-152410811	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.766C>T; p.Q256*; 1:152410316-152410316	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Nonsense
c.292G>A; p.G98S; 1:152410790-152410790	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.538A>G; p.S180G; 1:152410544-152410544	skin	malignant_melanoma	Substitution - Missense
c.538A>G; p.S180G; 1:152410544-152410544	skin	malignant_melanoma	Substitution - Missense
c.1105G>T; p.G369*; 1:152409977-152409977	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.62C>T; p.T21M; 1:152412172-152412172	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.62C>T; p.T21M; 1:152412172-152412172	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1333G>A; p.D445N; 1:152409749-152409749	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1081G>A; p.D361N; 1:152410001-152410001	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.555C>A; p.L185L; 1:152410527-152410527	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.716C>A; p.T239N; 1:152410366-152410366	breast	carcinoma	Substitution - Missense
c.1120C>A; p.Q374K; 1:152409962-152409962	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.81G>A; p.A27A; 1:152412153-152412153	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.81G>A; p.A27A; 1:152412153-152412153	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.81G>A; p.A27A; 1:152412153-152412153	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.625G>A; p.E209K; 1:152410457-152410457	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.858_859TG>CA; p.A287T; 1:152410223-152410224	urinary_tract; bladder	carcinoma	Substitution - Missense
c.936C>T; p.S312S; 1:152410146-152410146	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.670G>A; p.G224S; 1:152410412-152410412	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.199G>T; p.G67W; 1:152410883-152410883	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.838C>A; p.Q280K; 1:152410244-152410244	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1266A>G; p.P422P; 1:152409816-152409816	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1177C>T; p.P393S; 1:152409905-152409905	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1438G>A; p.G480S; 1:152409644-152409644	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1033G>A; p.G345R; 1:152410049-152410049	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1074G>A; p.V358V; 1:152410008-152410008	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.401G>A; p.G134E; 1:152410681-152410681	breast	carcinoma	Substitution - Missense
c.589G>A; p.E197K; 1:152410493-152410493	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.980G>A; p.G327E; 1:152410102-152410102	skin	malignant_melanoma	Substitution - Missense
c.125C>T; p.A42V; 1:152412109-152412109	skin	malignant_melanoma	Substitution - Missense
c.39G>C; p.E13D; 1:152412195-152412195	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.972G>C; p.Q324H; 1:152410110-152410110	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1039A>G; p.T347A; 1:152410043-152410043	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1039A>G; p.T347A; 1:152410043-152410043	skin	malignant_melanoma	Substitution - Missense
c.166G>A; p.E56K; 1:152410916-152410916	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1215G>A; p.Q405Q; 1:152409867-152409867	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.55G>C; p.A19P; 1:152412179-152412179	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.99G>A; p.L33L; 1:152412135-152412135	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.216G>A; p.K72K; 1:152410866-152410866	skin; upper_back	malignant_melanoma	Substitution - coding silent
c.218A>G; p.E73G; 1:152410864-152410864	skin	malignant_melanoma	Substitution - Missense
c.216G>A; p.K72K; 1:152410866-152410866	skin; trunk	malignant_melanoma; nodular	Substitution - coding silent
c.1376A>G; p.N459S; 1:152409706-152409706	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.520C>T; p.Q174*; 1:152410562-152410562	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1316G>T; p.G439V; 1:152409766-152409766	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.437G>A; p.G146E; 1:152410645-152410645	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.686G>A; p.G229E; 1:152410396-152410396	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.568G>A; p.E190K; 1:152410514-152410514	liver	carcinoma	Substitution - Missense
c.1271G>A; p.R424H; 1:152409811-152409811	breast	carcinoma	Substitution - Missense
c.1271G>A; p.R424H; 1:152409811-152409811	central_nervous_system; brain	glioma	Substitution - Missense
c.939C>T; p.T313T; 1:152410143-152410143	skin	malignant_melanoma	Substitution - coding silent
c.519C>T; p.S173S; 1:152410563-152410563	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.564G>A; p.Q188Q; 1:152410518-152410518	skin	malignant_melanoma	Substitution - coding silent
c.36C>T; p.I12I; 1:152412198-152412198	breast	carcinoma	Substitution - coding silent
c.1429G>T; p.E477*; 1:152409653-152409653	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.36C>T; p.I12I; 1:152412198-152412198	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.36C>T; p.I12I; 1:152412198-152412198	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.167A>G; p.E56G; 1:152410915-152410915	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.902C>T; p.T301I; 1:152410180-152410180	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.549A>G; p.I183M; 1:152410533-152410533	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.600G>A; p.R200R; 1:152410482-152410482	skin	malignant_melanoma	Substitution - coding silent
c.552delA; p.Q184fs*23; 1:152410530-152410530	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelofibrosis	Deletion - Frameshift
c.600G>A; p.R200R; 1:152410482-152410482	skin	malignant_melanoma	Substitution - coding silent
c.284G>A; p.G95E; 1:152410798-152410798	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1223C>A; p.A408E; 1:152409859-152409859	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.528G>T; p.Q176H; 1:152410554-152410554	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.1359C>T; p.L453L; 1:152409723-152409723	skin	malignant_melanoma	Substitution - coding silent
c.760A>C; p.S254R; 1:152410322-152410322	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.324G>A; p.G108G; 1:152410758-152410758	skin	malignant_melanoma	Substitution - coding silent
c.343G>A; p.E115K; 1:152410739-152410739	skin	malignant_melanoma	Substitution - Missense
c.1199C>T; p.P400L; 1:152409883-152409883	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1199C>T; p.P400L; 1:152409883-152409883	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.249G>T; p.Q83H; 1:152410833-152410833	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1431G>A; p.E477E; 1:152409651-152409651	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1071T>C; p.T357T; 1:152410011-152410011	breast	carcinoma	Substitution - coding silent
c.788A>G; p.D263G; 1:152410294-152410294	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.993C>T; p.H331H; 1:152410089-152410089	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.993C>T; p.H331H; 1:152410089-152410089	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1246G>A; p.E416K; 1:152409836-152409836	breast	carcinoma	Substitution - Missense
c.1195G>T; p.V399L; 1:152409887-152409887	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.981G>T; p.G327G; 1:152410101-152410101	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.645G>A; p.R215R; 1:152410437-152410437	skin	malignant_melanoma	Substitution - coding silent
c.1366G>A; p.D456N; 1:152409716-152409716	skin	malignant_melanoma	Substitution - Missense
c.1220G>A; p.G407E; 1:152409862-152409862	skin	malignant_melanoma	Substitution - Missense
c.1136C>T; p.T379M; 1:152409946-152409946	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.747G>A; p.Q249Q; 1:152410335-152410335	skin	malignant_melanoma	Substitution - coding silent
c.1219G>T; p.G407W; 1:152409863-152409863	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.542C>T; p.P181L; 1:152410540-152410540	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.717C>A; p.T239T; 1:152410365-152410365	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.346G>A; p.G116R; 1:152410736-152410736	skin	malignant_melanoma	Substitution - Missense
c.346G>A; p.G116R; 1:152410736-152410736	skin	malignant_melanoma	Substitution - Missense
c.485C>T; p.A162V; 1:152410597-152410597	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.844G>T; p.V282L; 1:152410238-152410238	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1202G>A; p.G401E; 1:152409880-152409880	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.381G>A; p.G127G; 1:152410701-152410701	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.330G>A; p.S110S; 1:152410752-152410752	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.99G>T; p.L33L; 1:152412135-152412135	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.709G>T; p.G237C; 1:152410373-152410373	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1436G>A; p.R479Q; 1:152409646-152409646	skin	malignant_melanoma	Substitution - Missense
c.1436G>A; p.R479Q; 1:152409646-152409646	skin	malignant_melanoma	Substitution - Missense
c.1286G>A; p.G429E; 1:152409796-152409796	skin	malignant_melanoma	Substitution - Missense

COSMIC somatic mutation [Top]