Entrez Gene

Basic Information
Gene ID	4908
Name	NTF3
Synonymous	neurotrophin 3;NTF3;neurotrophin 3
Definition	nerve growth factor 2\|neurotrophic factor\|neurotrophin-3
Position	12p13
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.228_229ins13; p.P77fs*71; 12:5494442-5494443	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.228_229ins13; p.P77fs*71; 12:5494442-5494443	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.228_229ins13; p.P77fs*71; 12:5494442-5494443	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.228_229ins13; p.P77fs*71; 12:5494442-5494443	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.228_229ins13; p.P77fs*71; 12:5494442-5494443	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.228_229ins13; p.P77fs*71; 12:5494442-5494443	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.228_229ins13; p.P77fs*71; 12:5494442-5494443	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.228_229ins13; p.P77fs*71; 12:5494442-5494443	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.228_229ins13; p.P77fs*71; 12:5494442-5494443	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.228_229ins13; p.P77fs*71; 12:5494442-5494443	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.228_229ins13; p.P77fs*71; 12:5494442-5494443	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.228_229ins13; p.P77fs*71; 12:5494442-5494443	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.228_229ins13; p.P77fs*71; 12:5494442-5494443	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.228_229ins13; p.P77fs*71; 12:5494442-5494443	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.228_229ins13; p.P77fs*71; 12:5494442-5494443	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.228_229ins13; p.P77fs*71; 12:5494442-5494443	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.228_229ins13; p.P77fs*71; 12:5494442-5494443	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.228_229ins13; p.P77fs*71; 12:5494442-5494443	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.228_229ins13; p.P77fs*71; 12:5494442-5494443	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.228_229ins13; p.P77fs*71; 12:5494442-5494443	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.228_229ins13; p.P77fs*71; 12:5494442-5494443	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.228_229ins13; p.P77fs*71; 12:5494442-5494443	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.625G>T; p.D209Y; 12:5494839-5494839	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.169G>A; p.E57K; 12:5494383-5494383	skin	malignant_melanoma	Substitution - Missense
c.281G>A; p.R94Q; 12:5494495-5494495	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.281G>A; p.R94Q; 12:5494495-5494495	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.306G>A; p.P102P; 12:5494520-5494520	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.104T>C; p.I35T; 12:5494318-5494318	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.41G>A; p.R14H; 12:5494255-5494255	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.89C>T; p.S30L; 12:5494303-5494303	skin	malignant_melanoma	Substitution - Missense
c.382G>A; p.V128M; 12:5494596-5494596	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.223G>T; p.G75*; 12:5494437-5494437	lung	carcinoma; non_small_cell_carcinoma	Substitution - Nonsense
c.412C>T; p.R138W; 12:5494626-5494626	liver	carcinoma	Substitution - Missense
c.412C>T; p.R138W; 12:5494626-5494626	liver	carcinoma	Substitution - Missense
c.412C>T; p.R138W; 12:5494626-5494626	pancreas	carcinoma	Substitution - Missense
c.745G>A; p.A249T; 12:5494959-5494959	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.412C>T; p.R138W; 12:5494626-5494626	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.140A>C; p.K47T; 12:5494354-5494354	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.373G>C; p.G125R; 12:5494587-5494587	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.762C>T; p.I254I; 12:5494976-5494976	skin	malignant_melanoma	Substitution - coding silent
c.762C>T; p.I254I; 12:5494976-5494976	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.762C>T; p.I254I; 12:5494976-5494976	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.762C>T; p.I254I; 12:5494976-5494976	skin	malignant_melanoma	Substitution - coding silent
c.588G>A; p.K196K; 12:5494802-5494802	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.436C>T; p.R146*; 12:5494650-5494650	oesophagus	carcinoma; adenocarcinoma	Substitution - Nonsense
c.228_229insC; p.A78fs*66; 12:5494442-5494443	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.79C>T; p.P27S; 12:5494293-5494293	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.97T>C; p.S33P; 12:5494311-5494311	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.639G>A; p.W213*; 12:5494853-5494853	lung	carcinoma; large_cell_carcinoma	Substitution - Nonsense
c.220C>G; p.R74G; 12:5494434-5494434	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.220C>G; p.R74G; 12:5494434-5494434	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.220C>G; p.R74G; 12:5494434-5494434	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.220C>G; p.R74G; 12:5494434-5494434	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.220C>G; p.R74G; 12:5494434-5494434	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.220C>G; p.R74G; 12:5494434-5494434	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.220C>G; p.R74G; 12:5494434-5494434	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.268A>G; p.T90A; 12:5494482-5494482	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.220C>G; p.R74G; 12:5494434-5494434	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.220C>G; p.R74G; 12:5494434-5494434	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.220C>G; p.R74G; 12:5494434-5494434	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.220C>G; p.R74G; 12:5494434-5494434	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.220C>G; p.R74G; 12:5494434-5494434	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.220C>G; p.R74G; 12:5494434-5494434	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.220C>G; p.R74G; 12:5494434-5494434	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.220C>G; p.R74G; 12:5494434-5494434	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.220C>G; p.R74G; 12:5494434-5494434	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.321C>A; p.S107R; 12:5494535-5494535	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.30C>T; p.L10L; 12:5494244-5494244	skin	malignant_melanoma	Substitution - coding silent
c.30C>T; p.L10L; 12:5494244-5494244	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.342C>T; p.P114P; 12:5494556-5494556	skin	malignant_melanoma	Substitution - coding silent
c.331C>G; p.P111A; 12:5494545-5494545	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.721C>T; p.R241W; 12:5494935-5494935	pancreas	NS	Substitution - Missense
c.721C>T; p.R241W; 12:5494935-5494935	stomach	adenocarcinoma	Substitution - Missense
c.721C>T; p.R241W; 12:5494935-5494935	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.721C>T; p.R241W; 12:5494935-5494935	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.368A>G; p.Y123C; 12:5494582-5494582	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.395G>A; p.R132K; 12:5494609-5494609	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.345G>A; p.P115P; 12:5494559-5494559	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.345G>A; p.P115P; 12:5494559-5494559	breast	carcinoma	Substitution - coding silent
c.532G>A; p.E178K; 12:5494746-5494746	skin	malignant_melanoma	Substitution - Missense
c.31G>A; p.A11T; 12:5494245-5494245	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.225A>G; p.G75G; 12:5494439-5494439	thyroid	other; neoplasm	Substitution - coding silent
c.528G>T; p.L176L; 12:5494742-5494742	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.463G>A; p.E155K; 12:5494677-5494677	urinary_tract; bladder	carcinoma	Substitution - Missense
c.580C>T; p.R194*; 12:5494794-5494794	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.712C>T; p.R238W; 12:5494926-5494926	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.712C>T; p.R238W; 12:5494926-5494926	pancreas	carcinoma	Substitution - Missense
c.463G>A; p.E155K; 12:5494677-5494677	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.390G>A; p.A130A; 12:5494604-5494604	skin	malignant_melanoma	Substitution - coding silent
c.390G>A; p.A130A; 12:5494604-5494604	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.340delC; p.P115fs*45; 12:5494554-5494554	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.216G>A; p.P72P; 12:5494430-5494430	pancreas	carcinoma	Substitution - coding silent
c.416A>G; p.Y139C; 12:5494630-5494630	skin	malignant_melanoma	Substitution - Missense
c.441G>C; p.G147G; 12:5494655-5494655	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.750G>C; p.L250F; 12:5494964-5494964	liver	carcinoma	Substitution - Missense
c.419C>T; p.A140V; 12:5494633-5494633	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.419C>T; p.A140V; 12:5494633-5494633	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.750G>C; p.L250F; 12:5494964-5494964	liver	carcinoma	Substitution - Missense
c.324C>A; p.D108E; 12:5494538-5494538	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.370G>A; p.V124M; 12:5494584-5494584	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.692A>G; p.N231S; 12:5494906-5494906	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.113T>C; p.L38P; 12:5494327-5494327	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.271G>A; p.E91K; 12:5494485-5494485	skin	malignant_melanoma	Substitution - Missense
c.271G>A; p.E91K; 12:5494485-5494485	skin	malignant_melanoma	Substitution - Missense
c.52G>T; p.G18C; 12:5494266-5494266	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.417C>T; p.Y139Y; 12:5494631-5494631	central_nervous_system; brain	glioma	Substitution - coding silent
c.581G>C; p.R194P; 12:5494795-5494795	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.270C>T; p.T90T; 12:5494484-5494484	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.305C>A; p.P102Q; 12:5494519-5494519	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.413G>A; p.R138Q; 12:5494627-5494627	skin	malignant_melanoma	Substitution - Missense
c.413G>A; p.R138Q; 12:5494627-5494627	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.481G>A; p.D161N; 12:5494695-5494695	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.686C>T; p.S229L; 12:5494900-5494900	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.274C>T; p.L92L; 12:5494488-5494488	central_nervous_system; brain	glioma	Substitution - coding silent
c.37C>A; p.L13I; 12:5494251-5494251	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.746C>T; p.A249V; 12:5494960-5494960	pancreas	carcinoma	Substitution - Missense
c.305C>T; p.P102L; 12:5494519-5494519	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.305C>T; p.P102L; 12:5494519-5494519	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.763G>C; p.G255R; 12:5494977-5494977	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.100C>A; p.L34I; 12:5494314-5494314	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.122C>T; p.A41V; 12:5494336-5494336	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.253G>A; p.V85M; 12:5494467-5494467	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.252G>A; p.P84P; 12:5494466-5494466	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.208C>A; p.R70R; 12:5494422-5494422	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.252G>A; p.P84P; 12:5494466-5494466	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.48C>T; p.I16I; 12:5494262-5494262	skin	malignant_melanoma	Substitution - coding silent
c.599C>A; p.P200Q; 12:5494813-5494813	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.722G>A; p.R241Q; 12:5494936-5494936	ovary	other; neoplasm	Substitution - Missense
c.722G>A; p.R241Q; 12:5494936-5494936	skin	malignant_melanoma	Substitution - Missense
c.722G>A; p.R241Q; 12:5494936-5494936	skin	malignant_melanoma	Substitution - Missense

COSMIC somatic mutation [Top]