Entrez Gene

Basic Information
Gene ID	4824
Name	NKX3-1
Synonymous	NK3 homeobox 1;NKX3-1;NK3 homeobox 1
Definition	NK homeobox, family 3, A\|NK3 transcription factor homolog A\|NK3 transcription factor related, locus 1\|homeobox protein NK-3 homolog A\|homeobox protein Nkx-3.1
Position	8p21.2
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.637G>A; p.V213M; 8:23681289-23681289	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.315C>T; p.D105D; 8:23681611-23681611	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.538A>G; p.K180E; 8:23681388-23681388	breast	carcinoma	Substitution - Missense
c.594G>A; p.P198P; 8:23681332-23681332	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.377G>A; p.R126H; 8:23681549-23681549	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.493G>A; p.E165K; 8:23681433-23681433	skin	malignant_melanoma	Substitution - Missense
c.493G>A; p.E165K; 8:23681433-23681433	skin	malignant_melanoma	Substitution - Missense
c.652C>T; p.P218S; 8:23681274-23681274	skin	malignant_melanoma	Substitution - Missense
c.619C>T; p.R207W; 8:23681307-23681307	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.340C>T; p.P114S; 8:23681586-23681586	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.511T>C; p.W171R; 8:23681415-23681415	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.692C>T; p.P231L; 8:23681234-23681234	skin	malignant_melanoma	Substitution - Missense
c.678G>A; p.V226V; 8:23681248-23681248	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.383G>A; p.R128Q; 8:23681543-23681543	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.383G>A; p.R128Q; 8:23681543-23681543	skin	malignant_melanoma	Substitution - Missense
c.14C>T; p.P5L; 8:23682876-23682876	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.466C>T; p.H156Y; 8:23681460-23681460	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.376C>T; p.R126C; 8:23681550-23681550	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.376C>T; p.R126C; 8:23681550-23681550	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.191G>A; p.G64E; 8:23682699-23682699	skin	malignant_melanoma	Substitution - Missense
c.644A>G; p.N215S; 8:23681282-23681282	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.463G>A; p.A155T; 8:23681463-23681463	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.463G>A; p.A155T; 8:23681463-23681463	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.591G>C; p.L197F; 8:23681335-23681335	breast	carcinoma	Substitution - Missense
c.543A>G; p.R181R; 8:23681383-23681383	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.631G>A; p.V211I; 8:23681295-23681295	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.574G>A; p.E192K; 8:23681352-23681352	skin	malignant_melanoma	Substitution - Missense
c.401C>T; p.T134I; 8:23681525-23681525	central_nervous_system; brain	glioma	Substitution - Missense
c.436C>G; p.Q146E; 8:23681490-23681490	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.530A>G; p.Y177C; 8:23681396-23681396	prostate	adenoma	Substitution - Missense
c.530A>G; p.Y177C; 8:23681396-23681396	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.530A>G; p.Y177C; 8:23681396-23681396	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.530A>G; p.Y177C; 8:23681396-23681396	prostate	carcinoma	Substitution - Missense
c.542G>A; p.R181Q; 8:23681384-23681384	skin	malignant_melanoma	Substitution - Missense
c.562C>T; p.L188L; 8:23681364-23681364	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.550C>A; p.L184I; 8:23681376-23681376	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.227T>C; p.L76P; 8:23682663-23682663	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.370C>T; p.Q124*; 8:23681556-23681556	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.679G>C; p.G227R; 8:23681247-23681247	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.167C>T; p.P56L; 8:23682723-23682723	skin; ear	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.398A>C; p.H133P; 8:23681528-23681528	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.133C>A; p.R45S; 8:23682757-23682757	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.526C>T; p.R176C; 8:23681400-23681400	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.526C>T; p.R176C; 8:23681400-23681400	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]