Entrez Gene

Basic Information
Gene ID	4758
Name	NEU1
Synonymous	sialidase 1 (lysosomal sialidase);NEU1;sialidase 1 (lysosomal sialidase)
Definition	G9 sialidase\|N-acetyl-alpha-neuraminidase 1\|acetylneuraminyl hydrolase\|exo-alpha-sialidase\|lysosomal sialidase\|sialidase-1
Position	6p21.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.260G>A; p.R87Q; 6:31862091-31862091	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.273C>T; p.L91L; 6:31862078-31862078	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.401C>T; p.P134L; 6:31861402-31861402	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.273C>T; p.L91L; 6:31862078-31862078	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.260G>A; p.R87Q; 6:31862091-31862091	stomach	adenocarcinoma	Substitution - Missense
c.880C>T; p.R294C; 6:31860183-31860183	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1214C>T; p.S405F; 6:31859753-31859753	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.640C>T; p.R214C; 6:31860597-31860597	prostate	carcinoma	Substitution - Missense
c.754G>A; p.G252S; 6:31860483-31860483	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1071G>A; p.R357R; 6:31859896-31859896	skin	malignant_melanoma	Substitution - coding silent
c.991T>G; p.F331V; 6:31860072-31860072	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.839G>A; p.R280Q; 6:31860224-31860224	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1064C>T; p.S355L; 6:31859903-31859903	skin	malignant_melanoma	Substitution - Missense
c.622C>T; p.R208W; 6:31860615-31860615	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.433G>A; p.D145N; 6:31861370-31861370	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.612T>C; p.I204I; 6:31861191-31861191	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.517T>C; p.W173R; 6:31861286-31861286	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.828C>T; p.V276V; 6:31860235-31860235	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.613C>A; p.Q205K; 6:31861190-31861190	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.257C>T; p.P86L; 6:31862094-31862094	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1069C>T; p.R357W; 6:31859898-31859898	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.315G>A; p.G105G; 6:31862036-31862036	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1170C>T; p.Y390Y; 6:31859797-31859797	skin	malignant_melanoma	Substitution - coding silent
c.882C>T; p.R294R; 6:31860181-31860181	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.678C>A; p.D226E; 6:31860559-31860559	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.182A>T; p.E61V; 6:31862169-31862169	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.491G>T; p.C164F; 6:31861312-31861312	kidney	other; neoplasm	Substitution - Missense
c.258G>A; p.P86P; 6:31862093-31862093	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.258G>A; p.P86P; 6:31862093-31862093	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.877C>A; p.L293I; 6:31860186-31860186	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.240G>A; p.P80P; 6:31862111-31862111	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1201A>T; p.T401S; 6:31859766-31859766	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.313G>T; p.G105W; 6:31862038-31862038	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.8G>T; p.G3V; 6:31862769-31862769	central_nervous_system; brain	glioma	Substitution - Missense
c.28C>T; p.L10F; 6:31862749-31862749	breast	carcinoma	Substitution - Missense
c.224A>G; p.D75G; 6:31862127-31862127	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.679G>T; p.G227*; 6:31860558-31860558	skin	malignant_melanoma	Substitution - Nonsense
c.374C>T; p.A125V; 6:31861429-31861429	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.374C>T; p.A125V; 6:31861429-31861429	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.374C>T; p.A125V; 6:31861429-31861429	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.927C>T; p.F309F; 6:31860136-31860136	breast	carcinoma	Substitution - coding silent
c.513G>T; p.L171F; 6:31861290-31861290	skin	malignant_melanoma	Substitution - Missense
c.648C>G; p.I216M; 6:31860589-31860589	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.881G>A; p.R294H; 6:31860182-31860182	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.881G>A; p.R294H; 6:31860182-31860182	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.553C>G; p.R185G; 6:31861250-31861250	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.656G>A; p.G219D; 6:31860581-31860581	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.48G>A; p.G16G; 6:31862729-31862729	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.365C>T; p.S122F; 6:31861438-31861438	skin	malignant_melanoma	Substitution - Missense
c.1050C>T; p.F350F; 6:31859917-31859917	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.661G>T; p.G221W; 6:31860576-31860576	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.905T>C; p.L302P; 6:31860158-31860158	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.530A>G; p.D177G; 6:31861273-31861273	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.530A>G; p.D177G; 6:31861273-31861273	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.261G>A; p.R87R; 6:31862090-31862090	skin	malignant_melanoma	Substitution - coding silent

COSMIC somatic mutation [Top]