Entrez Gene

Basic Information
Gene ID	4599
Name	MX1
Synonymous	MX dynamin-like GTPase 1;MX1;MX dynamin-like GTPase 1
Definition	interferon-induced GTP-binding protein Mx1\|interferon-induced protein p78\|interferon-inducible protein p78\|interferon-regulated resistance GTP-binding protein MxA\|myxoma resistance protein 1\|myxovirus (influenza virus) resistance 1, interferon-inducible p
Position	21q22.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.786C>T; p.D262D; 21:41441771-41441771	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.786C>T; p.D262D; 21:41441771-41441771	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1158C>T; p.I386I; 21:41446026-41446026	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1758+2T>C; p.?; 21:41452871-41452871	stomach	carcinoma; intestinal_adenocarcinoma	Unknown
c.1758+2T>C; p.?; 21:41452871-41452871	stomach	adenocarcinoma	Unknown
c.193G>A; p.E65K; 21:41435924-41435924	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1842G>A; p.K614K; 21:41458611-41458611	skin; trunk	malignant_melanoma; nodular	Substitution - coding silent
c.1911C>G; p.S637R; 21:41458680-41458680	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.144G>A; p.K48K; 21:41435875-41435875	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.723G>C; p.R241S; 21:41441018-41441018	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1715C>G; p.S572C; 21:41452826-41452826	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1433-10_1433-9insTT; p.?; 21:41451157-41451158	liver	carcinoma	Unknown
c.1328G>A; p.R443K; 21:41449191-41449191	urinary_tract; bladder	carcinoma	Substitution - Missense
c.970G>A; p.A324T; 21:41443828-41443828	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.446C>T; p.A149V; 21:41439703-41439703	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.934C>T; p.L312L; 21:41443792-41443792	skin	malignant_melanoma	Substitution - coding silent
c.79A>T; p.T27S; 21:41432149-41432149	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.79A>T; p.T27S; 21:41432149-41432149	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; follicular_lymphoma	Substitution - Missense
c.1976A>C; p.Q659P; 21:41458745-41458745	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1976A>C; p.Q659P; 21:41458745-41458745	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1976A>C; p.Q659P; 21:41458745-41458745	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1976A>C; p.Q659P; 21:41458745-41458745	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1976A>C; p.Q659P; 21:41458745-41458745	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1976A>C; p.Q659P; 21:41458745-41458745	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1976A>C; p.Q659P; 21:41458745-41458745	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.160G>A; p.D54N; 21:41435891-41435891	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1976A>C; p.Q659P; 21:41458745-41458745	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1976A>C; p.Q659P; 21:41458745-41458745	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.262G>C; p.E88Q; 21:41435993-41435993	breast	carcinoma	Substitution - Missense
c.1976A>C; p.Q659P; 21:41458745-41458745	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1976A>C; p.Q659P; 21:41458745-41458745	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1963C>T; p.R655C; 21:41458732-41458732	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1963C>T; p.R655C; 21:41458732-41458732	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.505C>A; p.R169R; 21:41439762-41439762	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1818G>A; p.Q606Q; 21:41458587-41458587	pancreas	carcinoma; adenocarcinoma	Substitution - coding silent
c.1800C>T; p.I600I; 21:41458569-41458569	skin	malignant_melanoma	Substitution - coding silent
c.700G>T; p.E234*; 21:41440995-41440995	breast	carcinoma	Substitution - Nonsense
c.842delG; p.G282fs*9; 21:41441827-41441827	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1972delG; p.A658fs*>5; 21:41458741-41458741	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1564C>T; p.R522C; 21:41452675-41452675	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1564C>T; p.R522C; 21:41452675-41452675	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1894G>A; p.E632K; 21:41458663-41458663	skin	malignant_melanoma	Substitution - Missense
c.1015C>T; p.L339L; 21:41445454-41445454	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1322G>A; p.R441H; 21:41449185-41449185	pancreas	carcinoma	Substitution - Missense
c.1322G>A; p.R441H; 21:41449185-41449185	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.255C>T; p.S85S; 21:41435986-41435986	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.787G>A; p.V263M; 21:41441772-41441772	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.930G>C; p.R310S; 21:41443788-41443788	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1299C>T; p.I433I; 21:41449162-41449162	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.978A>C; p.K326N; 21:41443836-41443836	prostate	carcinoma	Substitution - Missense
c.805T>G; p.F269V; 21:41441790-41441790	liver	carcinoma	Substitution - Missense
c.1175G>T; p.G392V; 21:41446043-41446043	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1038C>T; p.I346I; 21:41445477-41445477	skin	malignant_melanoma	Substitution - coding silent
c.1463C>T; p.S488L; 21:41451197-41451197	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.466G>A; p.G156R; 21:41439723-41439723	skin	malignant_melanoma	Substitution - Missense
c.1952C>T; p.T651M; 21:41458721-41458721	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1572C>T; p.H524H; 21:41452683-41452683	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1952C>T; p.T651M; 21:41458721-41458721	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.659A>G; p.N220S; 21:41440954-41440954	thyroid	carcinoma	Substitution - Missense
c.1560G>A; p.L520L; 21:41452671-41452671	breast	carcinoma	Substitution - coding silent
c.303C>T; p.I101I; 21:41437019-41437019	skin	malignant_melanoma	Substitution - coding silent
c.1692C>T; p.F564F; 21:41452803-41452803	skin	malignant_melanoma	Substitution - coding silent
c.106-4C>T; p.?; 21:41435833-41435833	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1509G>A; p.K503K; 21:41451243-41451243	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.790G>T; p.V264L; 21:41441775-41441775	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.669C>T; p.I223I; 21:41440964-41440964	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.286C>T; p.P96S; 21:41436017-41436017	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1204C>T; p.R402W; 21:41446072-41446072	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1204C>T; p.R402W; 21:41446072-41446072	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1542G>A; p.E514E; 21:41452653-41452653	skin	malignant_melanoma	Substitution - coding silent
c.1430C>T; p.T477M; 21:41449293-41449293	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1481A>G; p.E494G; 21:41451215-41451215	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.961C>T; p.P321S; 21:41443819-41443819	skin	malignant_melanoma	Substitution - Missense
c.1927C>G; p.L643V; 21:41458696-41458696	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.1945C>T; p.R649W; 21:41458714-41458714	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.1109delA; p.M372fs*4; 21:41445548-41445548	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.284T>C; p.L95P; 21:41436015-41436015	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.709C>T; p.P237S; 21:41441004-41441004	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1435A>G; p.M479V; 21:41451169-41451169	breast	carcinoma	Substitution - Missense
c.256G>T; p.V86L; 21:41435987-41435987	kidney	carcinoma; renal_cell_carcinoma	Substitution - Missense
c.793C>T; p.R265W; 21:41441778-41441778	large_intestine; colon	NS	Substitution - Missense
c.1268_1270delAAG; p.E424delE; 21:41446136-41446138	large_intestine	carcinoma; adenocarcinoma	Deletion - In frame
c.487A>C; p.T163P; 21:41439744-41439744	breast	carcinoma	Substitution - Missense
c.222C>T; p.A74A; 21:41435953-41435953	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1957G>A; p.A653T; 21:41458726-41458726	skin	malignant_melanoma	Substitution - Missense
c.128G>A; p.S43N; 21:41435859-41435859	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1323T>C; p.R441R; 21:41449186-41449186	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.319C>T; p.L107L; 21:41437035-41437035	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1013C>T; p.S338F; 21:41445452-41445452	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.864C>T; p.D288D; 21:41441849-41441849	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1660A>C; p.K554Q; 21:41452771-41452771	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.159C>A; p.I53I; 21:41435890-41435890	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1855C>A; p.L619I; 21:41458624-41458624	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1503C>T; p.T501T; 21:41451237-41451237	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1849C>T; p.L617L; 21:41458618-41458618	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.77C>T; p.A26V; 21:41432147-41432147	skin	malignant_melanoma	Substitution - Missense
c.1715C>A; p.S572Y; 21:41452826-41452826	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1619G>A; p.G540D; 21:41452730-41452730	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.401C>T; p.S134L; 21:41437117-41437117	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1613A>G; p.Y538C; 21:41452724-41452724	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1346T>G; p.V449G; 21:41449209-41449209	soft_tissue; striated_muscle	rhabdomyosarcoma; alveolar	Substitution - Missense
c.1346T>G; p.V449G; 21:41449209-41449209	soft_tissue; striated_muscle	rhabdomyosarcoma	Substitution - Missense
c.327G>A; p.L109L; 21:41437043-41437043	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1473T>A; p.N491K; 21:41451207-41451207	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1864G>C; p.D622H; 21:41458633-41458633	breast	carcinoma	Substitution - Missense
c.317C>T; p.P106L; 21:41437033-41437033	ovary	other; neoplasm	Substitution - Missense
c.1806C>T; p.F602F; 21:41458575-41458575	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.764G>A; p.G255E; 21:41441749-41441749	skin	malignant_melanoma	Substitution - Missense
c.652C>T; p.P218S; 21:41440947-41440947	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1703C>T; p.S568L; 21:41452814-41452814	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.24C>T; p.I8I; 21:41432094-41432094	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1711G>A; p.D571N; 21:41452822-41452822	skin	malignant_melanoma	Substitution - Missense
c.1623A>G; p.A541A; 21:41452734-41452734	thyroid	other; neoplasm	Substitution - coding silent
c.1623A>G; p.A541A; 21:41452734-41452734	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1623A>G; p.A541A; 21:41452734-41452734	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.614A>G; p.Y205C; 21:41440909-41440909	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1321C>T; p.R441C; 21:41449184-41449184	skin	malignant_melanoma	Substitution - Missense
c.712G>A; p.E238K; 21:41441007-41441007	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1321C>T; p.R441C; 21:41449184-41449184	skin	malignant_melanoma	Substitution - Missense
c.1321C>T; p.R441C; 21:41449184-41449184	skin	malignant_melanoma	Substitution - Missense
c.1969_1970insT; p.A658fs*>6; 21:41458738-41458739	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.1969_1970insT; p.A658fs*>6; 21:41458738-41458739	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.1969_1970insT; p.A658fs*>6; 21:41458738-41458739	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.1969_1970insT; p.A658fs*>6; 21:41458738-41458739	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.1969_1970insT; p.A658fs*>6; 21:41458738-41458739	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.1969_1970insT; p.A658fs*>6; 21:41458738-41458739	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.1969_1970insT; p.A658fs*>6; 21:41458738-41458739	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.1969_1970insT; p.A658fs*>6; 21:41458738-41458739	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.1969_1970insT; p.A658fs*>6; 21:41458738-41458739	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.1969_1970insT; p.A658fs*>6; 21:41458738-41458739	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.1969_1970insT; p.A658fs*>6; 21:41458738-41458739	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.1969_1970insT; p.A658fs*>6; 21:41458738-41458739	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.1969_1970insT; p.A658fs*>6; 21:41458738-41458739	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.1969_1970insT; p.A658fs*>6; 21:41458738-41458739	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.1969_1970insT; p.A658fs*>6; 21:41458738-41458739	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.1969_1970insT; p.A658fs*>6; 21:41458738-41458739	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.1969_1970insT; p.A658fs*>6; 21:41458738-41458739	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.1969_1970insT; p.A658fs*>6; 21:41458738-41458739	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.1969_1970insT; p.A658fs*>6; 21:41458738-41458739	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.1403C>T; p.P468L; 21:41449266-41449266	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.223G>A; p.V75I; 21:41435954-41435954	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.220G>A; p.A74T; 21:41435951-41435951	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1981C>T; p.P661S; 21:41458750-41458750	skin	malignant_melanoma	Substitution - Missense
c.1282A>C; p.I428L; 21:41449145-41449145	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1961G>A; p.R654Q; 21:41458730-41458730	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.83T>C; p.V28A; 21:41432153-41432153	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.801C>T; p.L267L; 21:41441786-41441786	endometrium	carcinoma; serous_carcinoma	Substitution - coding silent
c.1657G>A; p.E553K; 21:41452768-41452768	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1189G>T; p.G397W; 21:41446057-41446057	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.228C>T; p.I76I; 21:41435959-41435959	skin	malignant_melanoma	Substitution - coding silent

COSMIC somatic mutation [Top]