Entrez Gene

Basic Information
Gene ID	4482
Name	MSRA
Synonymous	methionine sulfoxide reductase A;MSRA;methionine sulfoxide reductase A
Definition	cytosolic methionine-S-sulfoxide reductase\|mitochondrial peptide methionine sulfoxide reductase\|peptide Met(O) reductase\|peptide met (O) reductase\|peptide-methionine (S)-S-oxide reductase
Position	8p23.1
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.307_308CC>TT; p.P103F; 8:10245199-10245200	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.549T>C; p.L183L; 8:10428153-10428153	breast	carcinoma	Substitution - coding silent
c.668G>A; p.G223E; 8:10428272-10428272	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.573C>T; p.I191I; 8:10428177-10428177	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.346G>A; p.A116T; 8:10301548-10301548	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.346G>A; p.A116T; 8:10301548-10301548	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.175G>A; p.E59K; 8:10207865-10207865	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.558C>T; p.H186H; 8:10428162-10428162	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.558C>T; p.H186H; 8:10428162-10428162	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.421C>T; p.H141Y; 8:10301623-10301623	skin; mucosal	malignant_melanoma	Substitution - Missense
c.453C>T; p.N151N; 8:10319899-10319899	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.551C>T; p.S184L; 8:10428155-10428155	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.586C>T; p.R196W; 8:10428190-10428190	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.538C>T; p.Q180*; 8:10319984-10319984	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.362T>C; p.V121A; 8:10301564-10301564	pancreas	carcinoid-endocrine_tumour	Substitution - Missense
c.134C>A; p.P45H; 8:10054650-10054650	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.354C>T; p.V118V; 8:10301556-10301556	skin	malignant_melanoma	Substitution - coding silent
c.354C>T; p.V118V; 8:10301556-10301556	skin	malignant_melanoma	Substitution - coding silent
c.343C>T; p.H115Y; 8:10301545-10301545	skin	malignant_melanoma	Substitution - Missense
c.423C>T; p.H141H; 8:10301625-10301625	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.700delA; p.K235fs?; 8:10428304-10428304	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.700delA; p.K235fs?; 8:10428304-10428304	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.695G>T; p.G232V; 8:10428299-10428299	liver	carcinoma	Substitution - Missense
c.461G>A; p.G154D; 8:10319907-10319907	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.47G>A; p.S16N; 8:10054563-10054563	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.437-1G>A; p.?; 8:10319882-10319882	lung; right_upper_lobe	carcinoma; adenocarcinoma	Unknown
c.269C>A; p.S90*; 8:10245161-10245161	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.218G>T; p.G73V; 8:10245110-10245110	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.131C>T; p.T44I; 8:10054647-10054647	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.77C>T; p.S26L; 8:10054593-10054593	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.613G>A; p.E205K; 8:10428217-10428217	skin	malignant_melanoma	Substitution - Missense
c.660C>T; p.C220C; 8:10428264-10428264	breast	carcinoma	Substitution - coding silent
c.660C>T; p.C220C; 8:10428264-10428264	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.700A>G; p.K234E; 8:10428304-10428304	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.494C>G; p.S165C; 8:10319940-10319940	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.227G>A; p.W76*; 8:10245119-10245119	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.494C>G; p.S165C; 8:10319940-10319940	lung	carcinoma; bronchioloalveolar_adenocarcinoma	Substitution - Missense
c.143C>T; p.A48V; 8:10207833-10207833	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.689C>A; p.P230Q; 8:10428293-10428293	soft_tissue; striated_muscle	rhabdomyosarcoma	Substitution - Missense
c.491C>T; p.T164I; 8:10319937-10319937	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.443G>A; p.R148H; 8:10319889-10319889	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.240G>A; p.R80R; 8:10245132-10245132	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.541A>T; p.K181*; 8:10319987-10319987	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.515C>T; p.A172V; 8:10319961-10319961	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.69G>T; p.M23I; 8:10054585-10054585	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.286G>A; p.A96T; 8:10245178-10245178	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.36C>T; p.L12L; 8:10054552-10054552	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.373C>T; p.P125S; 8:10301575-10301575	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.373C>T; p.P125S; 8:10301575-10301575	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.373C>T; p.P125S; 8:10301575-10301575	large_intestine; colon	carcinoma	Substitution - Missense
c.373C>T; p.P125S; 8:10301575-10301575	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.477G>A; p.S159S; 8:10319923-10319923	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.359G>T; p.R120L; 8:10301561-10301561	skin	malignant_melanoma	Substitution - Missense
c.372G>T; p.Q124H; 8:10301574-10301574	stomach	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]