Entrez Gene

Basic Information
Gene ID	3985
Name	LIMK2
Synonymous	LIM domain kinase 2;LIMK2;LIM domain kinase 2
Definition	-
Position	22q12.2
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1052A>C; p.K351T; 22:31266994-31266994	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1900C>A; p.R634R; 22:31278424-31278424	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.529G>T; p.A177S; 22:31260055-31260055	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.986G>C; p.C329S; 22:31266077-31266077	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.213C>A; p.F71L; 22:31258387-31258387	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1254C>T; p.R418R; 22:31267901-31267901	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1559G>T; p.G520V; 22:31273452-31273452	ovary	carcinoma; adenocarcinoma	Substitution - Missense
c.1586T>C; p.I529T; 22:31273479-31273479	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.468G>A; p.P156P; 22:31259994-31259994	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1824delG; p.E610fs*17; 22:31278348-31278348	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.758T>C; p.L253P; 22:31262695-31262695	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1260G>T; p.M420I; 22:31267907-31267907	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.503C>T; p.S168F; 22:31260029-31260029	skin	malignant_melanoma	Substitution - Missense
c.839G>T; p.R280M; 22:31262776-31262776	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1253G>A; p.R418H; 22:31267900-31267900	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1220A>G; p.Y407C; 22:31267867-31267867	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1090C>T; p.R364*; 22:31267032-31267032	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1090C>T; p.R364*; 22:31267032-31267032	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1090C>T; p.R364*; 22:31267032-31267032	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1090C>T; p.R364*; 22:31267032-31267032	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1380G>A; p.K460K; 22:31271198-31271198	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1041+7G>A; p.?; 22:31266139-31266139	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Unknown
c.1041+7G>A; p.?; 22:31266139-31266139	central_nervous_system; brain	glioma	Unknown
c.1765G>T; p.E589*; 22:31275301-31275301	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Nonsense
c.912G>C; p.L304L; 22:31266003-31266003	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.946C>T; p.R316C; 22:31266037-31266037	skin	malignant_melanoma	Substitution - Missense
c.1451C>A; p.P484H; 22:31272597-31272597	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.954C>T; p.S318S; 22:31266045-31266045	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.946C>T; p.R316C; 22:31266037-31266037	skin; scalp	malignant_melanoma	Substitution - Missense
c.1173C>T; p.F391F; 22:31267820-31267820	skin	malignant_melanoma	Substitution - coding silent
c.946C>T; p.R316C; 22:31266037-31266037	skin	malignant_melanoma	Substitution - Missense
c.409_410delCT; p.S138fs*22; 22:31259935-31259936	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.657G>T; p.E219D; 22:31262239-31262239	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1541C>T; p.A514V; 22:31272687-31272687	ovary	other; neoplasm	Substitution - Missense
c.1541C>T; p.A514V; 22:31272687-31272687	ovary	other; neoplasm	Substitution - Missense
c.1372C>G; p.L458V; 22:31271190-31271190	pancreas	carcinoma	Substitution - Missense
c.980G>A; p.R327Q; 22:31266071-31266071	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1439G>T; p.R480M; 22:31272585-31272585	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.422C>T; p.S141F; 22:31259948-31259948	skin	malignant_melanoma	Substitution - Missense
c.975C>G; p.I325M; 22:31266066-31266066	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1602C>T; p.I534I; 22:31273495-31273495	skin	malignant_melanoma	Substitution - coding silent
c.979C>T; p.R327W; 22:31266070-31266070	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.571A>G; p.S191G; 22:31262153-31262153	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.817G>A; p.E273K; 22:31262754-31262754	skin	malignant_melanoma	Substitution - Missense
c.1902G>A; p.R634R; 22:31278426-31278426	skin	malignant_melanoma	Substitution - coding silent
c.546G>T; p.V182V; 22:31260072-31260072	skin	malignant_melanoma	Substitution - coding silent
c.1348C>T; p.R450W; 22:31271166-31271166	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.153C>A; p.Y51*; 22:31258327-31258327	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.153C>A; p.Y51*; 22:31258327-31258327	large_intestine; colon	carcinoma	Substitution - Nonsense
c.153C>A; p.Y51*; 22:31258327-31258327	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1800C>A; p.S600S; 22:31278324-31278324	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.22G>A; p.D8N; 22:31225725-31225725	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1608C>T; p.L536L; 22:31273501-31273501	skin	malignant_melanoma	Substitution - coding silent
c.996C>T; p.I332I; 22:31266087-31266087	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1239G>A; p.L413L; 22:31267886-31267886	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.607C>G; p.R203G; 22:31262189-31262189	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.15G>A; p.A5A; 22:31212423-31212423	skin	malignant_melanoma	Substitution - coding silent
c.307G>A; p.V103M; 22:31259175-31259175	breast	carcinoma	Substitution - Missense
c.99G>A; p.W33*; 22:31225802-31225802	oesophagus	carcinoma; adenocarcinoma	Substitution - Nonsense
c.689C>G; p.T230R; 22:31262626-31262626	skin	malignant_melanoma	Substitution - Missense
c.1785G>A; p.S595S; 22:31278309-31278309	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1421G>A; p.R474Q; 22:31272567-31272567	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1725_1727delCTT; p.F577delF; 22:31275261-31275263	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - In frame
c.932G>T; p.R311L; 22:31266023-31266023	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.932G>T; p.R311L; 22:31266023-31266023	central_nervous_system; brainstem	glioma; astrocytoma_Grade_III	Substitution - Missense
c.1901G>T; p.R634L; 22:31278425-31278425	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.607C>T; p.R203C; 22:31262189-31262189	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1201C>T; p.L401L; 22:31267848-31267848	skin	malignant_melanoma	Substitution - coding silent
c.1236A>G; p.T412T; 22:31267883-31267883	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.504C>T; p.S168S; 22:31260030-31260030	skin	malignant_melanoma	Substitution - coding silent
c.1232G>C; p.G411A; 22:31267879-31267879	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.819G>T; p.E273D; 22:31262756-31262756	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1645T>G; p.C549G; 22:31275181-31275181	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.372C>T; p.C124C; 22:31259898-31259898	bone; rib	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.198G>A; p.G66G; 22:31258372-31258372	skin	malignant_melanoma	Substitution - coding silent
c.730C>T; p.L244L; 22:31262667-31262667	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.398T>C; p.M133T; 22:31259924-31259924	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1333A>G; p.M445V; 22:31271151-31271151	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1020_1021CT>AG; p.F341V; 22:31266111-31266112	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.551+2T>C; p.?; 22:31260079-31260079	pancreas	carcinoma	Unknown
c.551+2T>C; p.?; 22:31260079-31260079	pancreas	carcinoma	Unknown
c.551+2T>C; p.?; 22:31260079-31260079	pancreas	carcinoma	Unknown
c.857G>A; p.R286H; 22:31265948-31265948	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1415T>G; p.L472R; 22:31272561-31272561	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1415T>G; p.L472R; 22:31272561-31272561	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.988G>A; p.D330N; 22:31266079-31266079	breast	carcinoma	Substitution - Missense
c.1863G>A; p.E621E; 22:31278387-31278387	autonomic_ganglia	neuroblastoma	Substitution - coding silent
c.1363C>A; p.H455N; 22:31271181-31271181	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.16+1G>T; p.?; 22:31212425-31212425	large_intestine; rectum	carcinoma; adenocarcinoma	Unknown
c.1367A>C; p.N456T; 22:31271185-31271185	skin	malignant_melanoma	Substitution - Missense
c.1606C>G; p.L536V; 22:31273499-31273499	skin	malignant_melanoma	Substitution - Missense
c.901G>C; p.E301Q; 22:31265992-31265992	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1093T>C; p.C365R; 22:31267035-31267035	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.622A>T; p.N208Y; 22:31262204-31262204	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.942C>T; p.S314S; 22:31266033-31266033	skin	malignant_melanoma	Substitution - coding silent
c.646C>T; p.R216*; 22:31262228-31262228	skin; trunk	malignant_melanoma	Substitution - Nonsense
c.453G>A; p.T151T; 22:31259979-31259979	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.262G>A; p.E88K; 22:31259130-31259130	skin	malignant_melanoma	Substitution - Missense
c.1110G>A; p.Q370Q; 22:31267052-31267052	central_nervous_system; brain	glioma	Substitution - coding silent
c.1843C>T; p.L615L; 22:31278367-31278367	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1562A>G; p.K521R; 22:31273455-31273455	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.626G>T; p.G209V; 22:31262208-31262208	breast	carcinoma	Substitution - Missense
c.608G>A; p.R203H; 22:31262190-31262190	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.608G>A; p.R203H; 22:31262190-31262190	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.608G>A; p.R203H; 22:31262190-31262190	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.608G>A; p.R203H; 22:31262190-31262190	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1897A>G; p.T633A; 22:31278421-31278421	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.771G>A; p.M257I; 22:31262708-31262708	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1614G>T; p.E538D; 22:31273507-31273507	ovary	carcinoma	Substitution - Missense
c.1839C>T; p.I613I; 22:31278363-31278363	skin	malignant_melanoma	Substitution - coding silent
c.103G>A; p.G35S; 22:31225806-31225806	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.91G>A; p.E31K; 22:31225794-31225794	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.752C>T; p.A251V; 22:31262689-31262689	breast	carcinoma	Substitution - Missense
c.91G>A; p.E31K; 22:31225794-31225794	skin	malignant_melanoma	Substitution - Missense
c.1044G>T; p.V348V; 22:31266986-31266986	prostate	carcinoma	Substitution - coding silent
c.1332_1333delTA; p.M445fs*71; 22:31271150-31271151	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.905C>T; p.P302L; 22:31265996-31265996	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.599C>A; p.P200H; 22:31262181-31262181	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.558C>G; p.N186K; 22:31262140-31262140	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1265C>T; p.P422L; 22:31268148-31268148	skin	malignant_melanoma	Substitution - Missense
c.1265C>T; p.P422L; 22:31268148-31268148	kidney	Wilms_tumour	Substitution - Missense
c.1578G>A; p.T526T; 22:31273471-31273471	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1563G>A; p.K521K; 22:31273456-31273456	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.452C>T; p.T151M; 22:31259978-31259978	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1478G>A; p.R493H; 22:31272624-31272624	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.452C>T; p.T151M; 22:31259978-31259978	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]