Entrez Gene

Basic Information
Gene ID	3936
Name	LCP1
Synonymous	lymphocyte cytosolic protein 1 (L-plastin);LCP1;lymphocyte cytosolic protein 1 (L-plastin)
Definition	L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P)\|LCP-1\|Lymphocyte cytosolic protein-1 (plasmin)\|bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin))\|epididymis secretory protein Li 37\|plastin 2\|plastin-2
Position	13q14.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1412C>A; p.A471E; 13:46142382-46142382	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1404G>A; p.K468K; 13:46142390-46142390	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.643G>T; p.D215Y; 13:46152876-46152876	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.542A>G; p.N181S; 13:46154836-46154836	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.428T>C; p.V143A; 13:46156501-46156501	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.146G>A; p.R49K; 13:46158908-46158908	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.146G>A; p.R49K; 13:46158908-46158908	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.1124C>T; p.P375L; 13:46146958-46146958	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1219C>A; p.L407M; 13:46144476-46144476	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.192C>T; p.D64D; 13:46158862-46158862	prostate	carcinoma	Substitution - coding silent
c.981G>A; p.E327E; 13:46147101-46147101	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.953T>A; p.V318D; 13:46148377-46148377	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1462C>T; p.R488C; 13:46142332-46142332	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1763C>A; p.S588Y; 13:46127712-46127712	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.361G>T; p.E121*; 13:46156568-46156568	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1412C>T; p.A471V; 13:46142382-46142382	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1412C>T; p.A471V; 13:46142382-46142382	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1385A>G; p.Y462C; 13:46142409-46142409	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.1626G>A; p.K542K; 13:46134127-46134127	skin	malignant_melanoma	Substitution - coding silent
c.1026G>A; p.E342E; 13:46147056-46147056	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.634G>T; p.G212W; 13:46152885-46152885	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.480C>T; p.G160G; 13:46156449-46156449	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1857C>G; p.L619L; 13:46127618-46127618	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - coding silent
c.942T>G; p.G314G; 13:46148388-46148388	breast	carcinoma	Substitution - coding silent
c.1801C>T; p.P601S; 13:46127674-46127674	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.677G>A; p.G226E; 13:46152842-46152842	skin	malignant_melanoma	Substitution - Missense
c.407A>G; p.N136S; 13:46156522-46156522	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.248G>C; p.S83T; 13:46158632-46158632	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.200G>A; p.G67E; 13:46158854-46158854	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1843G>A; p.V615M; 13:46127632-46127632	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1742A>G; p.N581S; 13:46130823-46130823	ovary	other; neoplasm	Substitution - Missense
c.1165delG; p.A389fs*16; 13:46146917-46146917	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.423G>A; p.R141R; 13:46156506-46156506	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.423G>A; p.R141R; 13:46156506-46156506	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.932A>T; p.D311V; 13:46148398-46148398	prostate	carcinoma	Substitution - Missense
c.652G>C; p.E218Q; 13:46152867-46152867	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1575G>A; p.V525V; 13:46134178-46134178	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1435G>T; p.G479C; 13:46142359-46142359	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.116A>G; p.K39R; 13:46158938-46158938	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1061A>T; p.D354V; 13:46147021-46147021	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1253+2T>A; p.?; 13:46144440-46144440	stomach	carcinoma; adenocarcinoma	Unknown
c.848G>A; p.C283Y; 13:46150970-46150970	large_intestine; colon	carcinoma	Substitution - Missense
c.151C>T; p.R51*; 13:46158903-46158903	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Nonsense
c.848G>A; p.C283Y; 13:46150970-46150970	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1831A>T; p.M611L; 13:46127644-46127644	breast	carcinoma	Substitution - Missense
c.1539C>T; p.G513G; 13:46134214-46134214	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.325C>T; p.Q109*; 13:46158555-46158555	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.812T>A; p.L271Q; 13:46151006-46151006	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.256G>T; p.V86F; 13:46158624-46158624	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1267G>A; p.A423T; 13:46143391-46143391	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1696T>C; p.Y566H; 13:46130869-46130869	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1518C>T; p.I506I; 13:46134235-46134235	skin	malignant_melanoma	Substitution - coding silent
c.204G>A; p.R68R; 13:46158850-46158850	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.236A>G; p.H79R; 13:46158644-46158644	breast	carcinoma	Substitution - Missense
c.646C>G; p.L216V; 13:46152873-46152873	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.646C>G; p.L216V; 13:46152873-46152873	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.152G>A; p.R51Q; 13:46158902-46158902	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1793A>G; p.Y598C; 13:46127682-46127682	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1492C>T; p.L498L; 13:46142302-46142302	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - coding silent
c.1068C>T; p.V356V; 13:46147014-46147014	skin	malignant_melanoma	Substitution - coding silent
c.1716A>C; p.E572D; 13:46130849-46130849	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1172A>G; p.E391G; 13:46146910-46146910	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.99G>T; p.E33D; 13:46158955-46158955	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.815G>C; p.R272T; 13:46151003-46151003	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1181C>A; p.T394K; 13:46144514-46144514	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.696C>G; p.I232M; 13:46152823-46152823	oesophagus	carcinoma	Substitution - Missense
c.337G>A; p.G113S; 13:46158543-46158543	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1669G>A; p.D557N; 13:46130896-46130896	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1118G>T; p.R373I; 13:46146964-46146964	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.421C>T; p.R141W; 13:46156508-46156508	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.421C>T; p.R141W; 13:46156508-46156508	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Missense
c.1368+3A>T; p.?; 13:46143287-46143287	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.1delA; p.?; 13:46159662-46159662	large_intestine	carcinoma; adenocarcinoma	Unknown
c.1delA; p.?; 13:46159662-46159662	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1325T>A; p.V442E; 13:46143333-46143333	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1289A>G; p.Y430C; 13:46143369-46143369	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1525G>T; p.E509*; 13:46134228-46134228	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1689C>A; p.S563S; 13:46130876-46130876	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1505A>C; p.Y502S; 13:46134248-46134248	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.928G>T; p.G310*; 13:46148402-46148402	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1519C>A; p.L507I; 13:46134234-46134234	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.148G>T; p.V50L; 13:46158906-46158906	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1803A>T; p.P601P; 13:46127672-46127672	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1478C>T; p.A493V; 13:46142316-46142316	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1763C>T; p.S588F; 13:46127712-46127712	breast	carcinoma	Substitution - Missense
c.1195A>G; p.T399A; 13:46144500-46144500	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1390G>T; p.V464L; 13:46142404-46142404	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.946C>T; p.P316S; 13:46148384-46148384	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.1255G>A; p.D419N; 13:46143403-46143403	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1224T>C; p.G408G; 13:46144471-46144471	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1413G>A; p.A471A; 13:46142381-46142381	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1413G>A; p.A471A; 13:46142381-46142381	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1682C>A; p.P561Q; 13:46130883-46130883	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.403G>A; p.E135K; 13:46156526-46156526	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1175G>A; p.G392D; 13:46144520-46144520	oesophagus	carcinoma	Substitution - Missense
c.1389G>A; p.A463A; 13:46142405-46142405	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1335G>A; p.P445P; 13:46143323-46143323	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.27G>C; p.E9D; 13:46159636-46159636	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.487C>A; p.L163I; 13:46156442-46156442	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.91T>A; p.F31I; 13:46158963-46158963	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.506T>C; p.L169P; 13:46154872-46154872	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1884A>C; p.*628C; 13:46127591-46127591	large_intestine; colon	carcinoma; adenocarcinoma	Nonstop extension
c.1330_1332delAAA; p.K444delK; 13:46143326-46143328	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - In frame
c.1330_1332delAAA; p.K444delK; 13:46143326-46143328	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - In frame
c.1745A>G; p.N582S; 13:46130820-46130820	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1330_1332delAAA; p.K444delK; 13:46143326-46143328	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - In frame
c.1330_1332delAAA; p.K444delK; 13:46143326-46143328	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - In frame
c.1234C>T; p.R412*; 13:46144461-46144461	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.1010T>A; p.M337K; 13:46147072-46147072	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.779A>C; p.D260A; 13:46151039-46151039	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1763C>G; p.S588C; 13:46127712-46127712	urinary_tract; bladder	carcinoma	Substitution - Missense
c.338G>T; p.G113V; 13:46158542-46158542	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.833T>A; p.L278Q; 13:46150985-46150985	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1489C>T; p.Q497*; 13:46142305-46142305	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.449C>T; p.T150M; 13:46156480-46156480	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1352G>A; p.G451E; 13:46143306-46143306	skin	malignant_melanoma	Substitution - Missense
c.1382A>T; p.N461I; 13:46142412-46142412	skin	malignant_melanoma	Substitution - Missense
c.1318A>G; p.N440D; 13:46143340-46143340	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1318A>G; p.N440D; 13:46143340-46143340	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.357A>G; p.S119S; 13:46158523-46158523	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.335T>G; p.V112G; 13:46158545-46158545	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1073G>A; p.G358E; 13:46147009-46147009	skin	malignant_melanoma	Substitution - Missense
c.1801C>G; p.P601A; 13:46127674-46127674	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1463G>A; p.R488H; 13:46142331-46142331	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1463G>A; p.R488H; 13:46142331-46142331	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.765T>G; p.G255G; 13:46151053-46151053	skin	malignant_melanoma	Substitution - coding silent
c.1463G>A; p.R488H; 13:46142331-46142331	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1597A>G; p.K533E; 13:46134156-46134156	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1383C>A; p.N461K; 13:46142411-46142411	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1768G>T; p.A590S; 13:46127707-46127707	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1103C>T; p.A368V; 13:46146979-46146979	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1421C>T; p.S474F; 13:46142373-46142373	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.727A>C; p.S243R; 13:46152792-46152792	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.339C>A; p.G113G; 13:46158541-46158541	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.727A>C; p.S243R; 13:46152792-46152792	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]